Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

STE group serine/threonine-protein kinase, putative

Species:

Leishmania major

UniProt:

Q4Q5I0_LEIMA

TriTrypDb:

LmjF.32.1020 , LMJLV39_320016100 , LMJSD75_320016100

Length:

811

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q5I0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5I0

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	10
GO:0006793	phosphorus metabolic process	3	10
GO:0006796	phosphate-containing compound metabolic process	4	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0009987	cellular process	1	10
GO:0016310	phosphorylation	5	10
GO:0019538	protein metabolic process	3	10
GO:0036211	protein modification process	4	10
GO:0043170	macromolecule metabolic process	3	10
GO:0043412	macromolecule modification	4	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0071704	organic substance metabolic process	2	10
GO:1901564	organonitrogen compound metabolic process	3	10

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	10
GO:0003824	catalytic activity	1	10
GO:0004672	protein kinase activity	3	10
GO:0004674	protein serine/threonine kinase activity	4	2
GO:0005488	binding	1	10
GO:0005524	ATP binding	5	10
GO:0016301	kinase activity	4	10
GO:0016740	transferase activity	2	10
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	10
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	10
GO:0017076	purine nucleotide binding	4	10
GO:0030554	adenyl nucleotide binding	5	10
GO:0032553	ribonucleotide binding	3	10
GO:0032555	purine ribonucleotide binding	4	10
GO:0032559	adenyl ribonucleotide binding	5	10
GO:0035639	purine ribonucleoside triphosphate binding	4	10
GO:0036094	small molecule binding	2	10
GO:0043167	ion binding	2	10
GO:0043168	anion binding	3	10
GO:0097159	organic cyclic compound binding	2	10
GO:0097367	carbohydrate derivative binding	2	10
GO:0140096	catalytic activity, acting on a protein	2	10
GO:1901265	nucleoside phosphate binding	3	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	169	171	PF00675	0.707
CLV_NRD_NRD_1	354	356	PF00675	0.743
CLV_NRD_NRD_1	611	613	PF00675	0.350
CLV_NRD_NRD_1	7	9	PF00675	0.589
CLV_NRD_NRD_1	772	774	PF00675	0.646
CLV_NRD_NRD_1	782	784	PF00675	0.620
CLV_PCSK_FUR_1	2	6	PF00082	0.650
CLV_PCSK_KEX2_1	354	356	PF00082	0.782
CLV_PCSK_KEX2_1	4	6	PF00082	0.639
CLV_PCSK_KEX2_1	543	545	PF00082	0.485
CLV_PCSK_KEX2_1	611	613	PF00082	0.351
CLV_PCSK_KEX2_1	755	757	PF00082	0.506
CLV_PCSK_KEX2_1	772	774	PF00082	0.586
CLV_PCSK_KEX2_1	92	94	PF00082	0.682
CLV_PCSK_PC1ET2_1	4	6	PF00082	0.714
CLV_PCSK_PC1ET2_1	543	545	PF00082	0.485
CLV_PCSK_PC1ET2_1	755	757	PF00082	0.581
CLV_PCSK_PC1ET2_1	92	94	PF00082	0.682
CLV_PCSK_SKI1_1	250	254	PF00082	0.717
CLV_PCSK_SKI1_1	354	358	PF00082	0.653
CLV_PCSK_SKI1_1	428	432	PF00082	0.546
CLV_PCSK_SKI1_1	524	528	PF00082	0.574
CLV_PCSK_SKI1_1	540	544	PF00082	0.221
CLV_PCSK_SKI1_1	558	562	PF00082	0.454
CLV_Separin_Metazoa	487	491	PF03568	0.537
DEG_APCC_DBOX_1	557	565	PF00400	0.485
DEG_Nend_UBRbox_1	1	4	PF02207	0.643
DOC_CKS1_1	295	300	PF01111	0.720
DOC_CYCLIN_yClb3_PxF_3	243	249	PF00134	0.529
DOC_CYCLIN_yCln2_LP_2	723	729	PF00134	0.369
DOC_MAPK_gen_1	4	14	PF00069	0.523
DOC_MAPK_MEF2A_6	459	466	PF00069	0.452
DOC_MAPK_MEF2A_6	544	553	PF00069	0.344
DOC_MAPK_MEF2A_6	707	715	PF00069	0.408
DOC_PP1_RVXF_1	691	698	PF00149	0.344
DOC_PP2B_LxvP_1	221	224	PF13499	0.660
DOC_USP7_MATH_1	175	179	PF00917	0.712
DOC_USP7_MATH_1	189	193	PF00917	0.526
DOC_USP7_MATH_1	207	211	PF00917	0.659
DOC_USP7_MATH_1	232	236	PF00917	0.651
DOC_USP7_MATH_1	267	271	PF00917	0.750
DOC_USP7_MATH_1	451	455	PF00917	0.556
DOC_USP7_MATH_1	65	69	PF00917	0.732
DOC_USP7_UBL2_3	424	428	PF12436	0.562
DOC_USP7_UBL2_3	751	755	PF12436	0.562
DOC_WW_Pin1_4	181	186	PF00397	0.740
DOC_WW_Pin1_4	243	248	PF00397	0.680
DOC_WW_Pin1_4	282	287	PF00397	0.758
DOC_WW_Pin1_4	288	293	PF00397	0.626
DOC_WW_Pin1_4	294	299	PF00397	0.620
DOC_WW_Pin1_4	300	305	PF00397	0.657
DOC_WW_Pin1_4	47	52	PF00397	0.611
DOC_WW_Pin1_4	519	524	PF00397	0.536
DOC_WW_Pin1_4	543	548	PF00397	0.365
DOC_WW_Pin1_4	94	99	PF00397	0.742
LIG_14-3-3_CanoR_1	202	206	PF00244	0.632
LIG_14-3-3_CanoR_1	313	319	PF00244	0.757
LIG_14-3-3_CanoR_1	490	500	PF00244	0.555
LIG_14-3-3_CanoR_1	529	533	PF00244	0.524
LIG_14-3-3_CanoR_1	716	720	PF00244	0.345
LIG_14-3-3_CanoR_1	783	793	PF00244	0.519
LIG_14-3-3_CterR_2	809	811	PF00244	0.729
LIG_Actin_WH2_2	702	718	PF00022	0.426
LIG_APCC_ABBA_1	119	124	PF00400	0.606
LIG_APCC_ABBAyCdc20_2	9	15	PF00400	0.522
LIG_BRCT_BRCA1_1	245	249	PF00533	0.722
LIG_BRCT_BRCA1_1	261	265	PF00533	0.732
LIG_BRCT_BRCA1_1	316	320	PF00533	0.772
LIG_BRCT_BRCA1_1	697	701	PF00533	0.369
LIG_BRCT_BRCA1_1	749	753	PF00533	0.440
LIG_BRCT_BRCA1_2	749	755	PF00533	0.548
LIG_FHA_1	171	177	PF00498	0.734
LIG_FHA_1	297	303	PF00498	0.781
LIG_FHA_1	313	319	PF00498	0.633
LIG_FHA_1	412	418	PF00498	0.553
LIG_FHA_1	690	696	PF00498	0.461
LIG_FHA_1	775	781	PF00498	0.596
LIG_FHA_1	788	794	PF00498	0.438
LIG_FHA_2	128	134	PF00498	0.599
LIG_FHA_2	151	157	PF00498	0.582
LIG_FHA_2	529	535	PF00498	0.572
LIG_FHA_2	75	81	PF00498	0.764
LIG_LIR_Apic_2	260	266	PF02991	0.575
LIG_LIR_Apic_2	530	535	PF02991	0.529
LIG_LIR_Apic_2	618	624	PF02991	0.344
LIG_LIR_Gen_1	101	112	PF02991	0.641
LIG_LIR_Gen_1	317	327	PF02991	0.542
LIG_LIR_Gen_1	569	578	PF02991	0.346
LIG_LIR_Gen_1	699	709	PF02991	0.372
LIG_LIR_Nem_3	10	16	PF02991	0.522
LIG_LIR_Nem_3	101	107	PF02991	0.690
LIG_LIR_Nem_3	110	116	PF02991	0.625
LIG_LIR_Nem_3	246	252	PF02991	0.734
LIG_LIR_Nem_3	262	268	PF02991	0.584
LIG_LIR_Nem_3	317	323	PF02991	0.776
LIG_LIR_Nem_3	494	499	PF02991	0.519
LIG_LIR_Nem_3	569	574	PF02991	0.344
LIG_LIR_Nem_3	677	682	PF02991	0.344
LIG_LIR_Nem_3	698	704	PF02991	0.369
LIG_LIR_Nem_3	787	792	PF02991	0.512
LIG_LIR_Nem_3	803	808	PF02991	0.714
LIG_Pex14_1	233	237	PF04695	0.651
LIG_Pex14_1	697	701	PF04695	0.369
LIG_Pex14_2	675	679	PF04695	0.444
LIG_Pex14_2	727	731	PF04695	0.485
LIG_SH2_CRK	263	267	PF00017	0.575
LIG_SH2_CRK	520	524	PF00017	0.588
LIG_SH2_CRK	571	575	PF00017	0.346
LIG_SH2_CRK	702	706	PF00017	0.444
LIG_SH2_STAP1	702	706	PF00017	0.419
LIG_SH2_STAP1	789	793	PF00017	0.650
LIG_SH2_STAT3	444	447	PF00017	0.486
LIG_SH2_STAT3	792	795	PF00017	0.632
LIG_SH2_STAT5	13	16	PF00017	0.522
LIG_SH2_STAT5	444	447	PF00017	0.561
LIG_SH2_STAT5	789	792	PF00017	0.609
LIG_SH3_1	241	247	PF00018	0.524
LIG_SH3_2	185	190	PF14604	0.537
LIG_SH3_2	220	225	PF14604	0.731
LIG_SH3_3	182	188	PF00018	0.680
LIG_SH3_3	214	220	PF00018	0.677
LIG_SH3_3	241	247	PF00018	0.570
LIG_SH3_3	292	298	PF00018	0.645
LIG_SUMO_SIM_par_1	291	297	PF11976	0.703
LIG_TRAF2_1	153	156	PF00917	0.619
LIG_TRAF2_1	360	363	PF00917	0.728
LIG_TRAF2_1	484	487	PF00917	0.571
LIG_TYR_ITSM	567	574	PF00017	0.444
LIG_UBA3_1	685	693	PF00899	0.419
LIG_WRC_WIRS_1	249	254	PF05994	0.696
LIG_WRC_WIRS_1	468	473	PF05994	0.399
LIG_WW_1	441	444	PF00397	0.479
MOD_CDK_SPK_2	519	524	PF00069	0.594
MOD_CDK_SPxxK_3	243	250	PF00069	0.723
MOD_CK1_1	127	133	PF00069	0.629
MOD_CK1_1	150	156	PF00069	0.630
MOD_CK1_1	256	262	PF00069	0.720
MOD_CK1_1	276	282	PF00069	0.505
MOD_CK1_1	285	291	PF00069	0.573
MOD_CK1_1	300	306	PF00069	0.582
MOD_CK1_1	312	318	PF00069	0.657
MOD_CK1_1	319	325	PF00069	0.470
MOD_CK1_1	328	334	PF00069	0.622
MOD_CK1_1	367	373	PF00069	0.566
MOD_CK1_1	58	64	PF00069	0.760
MOD_CK1_1	689	695	PF00069	0.412
MOD_CK1_1	69	75	PF00069	0.758
MOD_CK1_1	787	793	PF00069	0.644
MOD_CK2_1	127	133	PF00069	0.611
MOD_CK2_1	150	156	PF00069	0.632
MOD_CK2_1	232	238	PF00069	0.661
MOD_CK2_1	528	534	PF00069	0.616
MOD_CK2_1	598	604	PF00069	0.408
MOD_CK2_1	69	75	PF00069	0.788
MOD_Cter_Amidation	168	171	PF01082	0.533
MOD_GlcNHglycan	163	166	PF01048	0.653
MOD_GlcNHglycan	177	180	PF01048	0.608
MOD_GlcNHglycan	181	184	PF01048	0.523
MOD_GlcNHglycan	203	206	PF01048	0.688
MOD_GlcNHglycan	209	212	PF01048	0.730
MOD_GlcNHglycan	275	278	PF01048	0.770
MOD_GlcNHglycan	299	302	PF01048	0.739
MOD_GlcNHglycan	336	339	PF01048	0.793
MOD_GlcNHglycan	500	503	PF01048	0.499
MOD_GlcNHglycan	504	507	PF01048	0.477
MOD_GlcNHglycan	9	12	PF01048	0.755
MOD_GSK3_1	125	132	PF00069	0.631
MOD_GSK3_1	175	182	PF00069	0.706
MOD_GSK3_1	189	196	PF00069	0.620
MOD_GSK3_1	197	204	PF00069	0.714
MOD_GSK3_1	253	260	PF00069	0.731
MOD_GSK3_1	281	288	PF00069	0.682
MOD_GSK3_1	293	300	PF00069	0.571
MOD_GSK3_1	308	315	PF00069	0.631
MOD_GSK3_1	327	334	PF00069	0.616
MOD_GSK3_1	431	438	PF00069	0.557
MOD_GSK3_1	47	54	PF00069	0.619
MOD_GSK3_1	478	485	PF00069	0.580
MOD_GSK3_1	498	505	PF00069	0.635
MOD_GSK3_1	55	62	PF00069	0.660
MOD_GSK3_1	65	72	PF00069	0.666
MOD_GSK3_1	711	718	PF00069	0.401
MOD_GSK3_1	796	803	PF00069	0.672
MOD_LATS_1	754	760	PF00433	0.574
MOD_N-GLC_1	107	112	PF02516	0.592
MOD_N-GLC_1	308	313	PF02516	0.713
MOD_N-GLC_1	367	372	PF02516	0.543
MOD_N-GLC_1	411	416	PF02516	0.624
MOD_N-GLC_1	69	74	PF02516	0.787
MOD_N-GLC_1	695	700	PF02516	0.398
MOD_N-GLC_1	86	91	PF02516	0.532
MOD_NEK2_1	193	198	PF00069	0.682
MOD_NEK2_1	201	206	PF00069	0.681
MOD_NEK2_1	248	253	PF00069	0.755
MOD_NEK2_1	257	262	PF00069	0.721
MOD_NEK2_1	308	313	PF00069	0.673
MOD_NEK2_1	314	319	PF00069	0.637
MOD_NEK2_1	332	337	PF00069	0.698
MOD_NEK2_1	435	440	PF00069	0.564
MOD_NEK2_1	489	494	PF00069	0.447
MOD_NEK2_1	52	57	PF00069	0.726
MOD_NEK2_1	527	532	PF00069	0.496
MOD_NEK2_1	59	64	PF00069	0.694
MOD_NEK2_1	686	691	PF00069	0.344
MOD_NEK2_1	7	12	PF00069	0.714
MOD_NEK2_1	715	720	PF00069	0.485
MOD_NEK2_1	767	772	PF00069	0.525
MOD_NEK2_2	232	237	PF00069	0.623
MOD_NEK2_2	697	702	PF00069	0.408
MOD_PIKK_1	268	274	PF00454	0.546
MOD_PIKK_1	383	389	PF00454	0.482
MOD_PIKK_1	489	495	PF00454	0.443
MOD_PK_1	460	466	PF00069	0.518
MOD_PKA_1	170	176	PF00069	0.670
MOD_PKA_2	201	207	PF00069	0.626
MOD_PKA_2	312	318	PF00069	0.748
MOD_PKA_2	489	495	PF00069	0.543
MOD_PKA_2	528	534	PF00069	0.517
MOD_PKA_2	59	65	PF00069	0.621
MOD_PKA_2	7	13	PF00069	0.628
MOD_PKA_2	715	721	PF00069	0.344
MOD_Plk_1	367	373	PF00069	0.532
MOD_Plk_1	428	434	PF00069	0.549
MOD_Plk_1	569	575	PF00069	0.321
MOD_Plk_1	69	75	PF00069	0.767
MOD_Plk_1	711	717	PF00069	0.498
MOD_Plk_1	800	806	PF00069	0.748
MOD_Plk_1	86	92	PF00069	0.742
MOD_Plk_2-3	534	540	PF00069	0.405
MOD_Plk_4	232	238	PF00069	0.625
MOD_Plk_4	328	334	PF00069	0.771
MOD_Plk_4	386	392	PF00069	0.528
MOD_Plk_4	428	434	PF00069	0.549
MOD_Plk_4	460	466	PF00069	0.518
MOD_Plk_4	551	557	PF00069	0.344
MOD_Plk_4	569	575	PF00069	0.344
MOD_Plk_4	598	604	PF00069	0.453
MOD_Plk_4	615	621	PF00069	0.363
MOD_Plk_4	681	687	PF00069	0.377
MOD_Plk_4	697	703	PF00069	0.237
MOD_Plk_4	800	806	PF00069	0.732
MOD_ProDKin_1	181	187	PF00069	0.740
MOD_ProDKin_1	243	249	PF00069	0.683
MOD_ProDKin_1	282	288	PF00069	0.760
MOD_ProDKin_1	294	300	PF00069	0.619
MOD_ProDKin_1	47	53	PF00069	0.615
MOD_ProDKin_1	519	525	PF00069	0.540
MOD_ProDKin_1	543	549	PF00069	0.365
MOD_ProDKin_1	94	100	PF00069	0.742
MOD_SUMO_for_1	542	545	PF00179	0.485
MOD_SUMO_rev_2	120	128	PF00179	0.613
MOD_SUMO_rev_2	235	243	PF00179	0.722
MOD_SUMO_rev_2	454	462	PF00179	0.588
MOD_SUMO_rev_2	572	581	PF00179	0.321
MOD_SUMO_rev_2	747	753	PF00179	0.540
MOD_SUMO_rev_2	97	105	PF00179	0.769
TRG_DiLeu_BaEn_1	133	138	PF01217	0.575
TRG_DiLeu_LyEn_5	133	138	PF01217	0.650
TRG_ENDOCYTIC_2	13	16	PF00928	0.522
TRG_ENDOCYTIC_2	571	574	PF00928	0.369
TRG_ENDOCYTIC_2	682	685	PF00928	0.373
TRG_ENDOCYTIC_2	702	705	PF00928	0.374
TRG_ER_diArg_1	391	394	PF00400	0.521
TRG_ER_diArg_1	437	440	PF00400	0.617
TRG_NES_CRM1_1	550	566	PF08389	0.408
TRG_Pf-PMV_PEXEL_1	136	140	PF00026	0.655

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9E7	Leptomonas seymouri	64%	99%
A0A1X0NW98	Trypanosomatidae	40%	100%
A0A3Q8ID17	Leishmania donovani	95%	100%
A0A3R7KXA1	Trypanosoma rangeli	43%	100%
A4HK84	Leishmania braziliensis	78%	98%
A4I7R9	Leishmania infantum	95%	100%
E9B2M7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5BQQ4	Trypanosoma cruzi	41%	100%