Maf-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Maf-like protein

Gene product:

Maf-like protein, putative

Species:

Leishmania major

UniProt:

Q4Q5H9_LEIMA

TriTrypDb:

LmjF.32.1030 , LMJLV39_320016200 , LMJSD75_320016200

Length:

221

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q5H9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5H9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0016462	pyrophosphatase activity	5	10
GO:0016787	hydrolase activity	2	10
GO:0016817	hydrolase activity, acting on acid anhydrides	3	10
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	10
GO:0047429	nucleoside triphosphate diphosphatase activity	6	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	15	17	PF00675	0.280
CLV_PCSK_KEX2_1	14	16	PF00082	0.281
CLV_PCSK_KEX2_1	177	179	PF00082	0.314
CLV_PCSK_KEX2_1	77	79	PF00082	0.291
CLV_PCSK_PC1ET2_1	177	179	PF00082	0.301
CLV_PCSK_PC1ET2_1	77	79	PF00082	0.291
CLV_PCSK_SKI1_1	200	204	PF00082	0.314
CLV_PCSK_SKI1_1	74	78	PF00082	0.260
DEG_APCC_DBOX_1	199	207	PF00400	0.514
DEG_Nend_UBRbox_3	1	3	PF02207	0.530
DOC_MAPK_gen_1	177	183	PF00069	0.514
DOC_MAPK_gen_1	74	84	PF00069	0.381
DOC_MAPK_MEF2A_6	57	65	PF00069	0.381
DOC_MAPK_MEF2A_6	77	86	PF00069	0.498
DOC_WW_Pin1_4	30	35	PF00397	0.493
LIG_Actin_WH2_2	149	166	PF00022	0.441
LIG_AP2alpha_2	45	47	PF02296	0.450
LIG_BRCT_BRCA1_1	43	47	PF00533	0.491
LIG_FHA_1	121	127	PF00498	0.450
LIG_FHA_1	24	30	PF00498	0.500
LIG_FHA_1	48	54	PF00498	0.437
LIG_FHA_2	185	191	PF00498	0.514
LIG_LIR_Apic_2	28	34	PF02991	0.514
LIG_LIR_Gen_1	26	34	PF02991	0.436
LIG_LIR_Gen_1	85	92	PF02991	0.432
LIG_LIR_Nem_3	143	148	PF02991	0.478
LIG_LIR_Nem_3	26	30	PF02991	0.419
LIG_LIR_Nem_3	85	89	PF02991	0.432
LIG_NRP_CendR_1	220	221	PF00754	0.468
LIG_SH2_CRK	27	31	PF00017	0.514
LIG_SH2_GRB2like	113	116	PF00017	0.467
LIG_SH2_NCK_1	27	31	PF00017	0.514
LIG_SH2_STAP1	27	31	PF00017	0.514
LIG_SH2_STAT5	31	34	PF00017	0.516
LIG_SH3_3	132	138	PF00018	0.461
LIG_SH3_3	203	209	PF00018	0.475
LIG_TRAF2_1	187	190	PF00917	0.519
LIG_TYR_ITSM	141	148	PF00017	0.514
MOD_CK2_1	184	190	PF00069	0.521
MOD_Cter_Amidation	218	221	PF01082	0.463
MOD_GlcNHglycan	10	13	PF01048	0.252
MOD_GSK3_1	117	124	PF00069	0.477
MOD_GSK3_1	133	140	PF00069	0.447
MOD_GSK3_1	210	217	PF00069	0.454
MOD_GSK3_1	41	48	PF00069	0.488
MOD_GSK3_1	78	85	PF00069	0.512
MOD_N-GLC_1	138	143	PF02516	0.286
MOD_NEK2_1	47	52	PF00069	0.474
MOD_NEK2_2	195	200	PF00069	0.501
MOD_PK_1	78	84	PF00069	0.501
MOD_PKA_2	41	47	PF00069	0.511
MOD_Plk_1	138	144	PF00069	0.504
MOD_Plk_1	149	155	PF00069	0.524
MOD_Plk_1	195	201	PF00069	0.521
MOD_Plk_2-3	184	190	PF00069	0.501
MOD_Plk_4	117	123	PF00069	0.480
MOD_Plk_4	140	146	PF00069	0.450
MOD_ProDKin_1	30	36	PF00069	0.493
MOD_SUMO_rev_2	175	183	PF00179	0.493
MOD_SUMO_rev_2	33	41	PF00179	0.452
TRG_ENDOCYTIC_2	145	148	PF00928	0.514
TRG_ENDOCYTIC_2	27	30	PF00928	0.475
TRG_ER_diArg_1	13	16	PF00400	0.520
TRG_Pf-PMV_PEXEL_1	16	20	PF00026	0.293
TRG_Pf-PMV_PEXEL_1	200	204	PF00026	0.323
TRG_Pf-PMV_PEXEL_1	51	55	PF00026	0.359

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PGQ1	Leptomonas seymouri	67%	100%
A0A0S4KKD9	Bodo saltans	28%	80%
A0A1X0NW04	Trypanosomatidae	37%	100%
A0A3Q8IGW3	Leishmania donovani	92%	100%
A0A3R7M9P1	Trypanosoma rangeli	38%	100%
A4HK85	Leishmania braziliensis	85%	100%
A4I7S0	Leishmania infantum	92%	100%
B0B7R8	Chlamydia trachomatis serovar L2 (strain 434/Bu / ATCC VR-902B)	28%	100%
B0BBY3	Chlamydia trachomatis serovar L2b (strain UCH-1/proctitis)	28%	100%
B2J6P8	Nostoc punctiforme (strain ATCC 29133 / PCC 73102)	26%	100%
D0A9X9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9B2M8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
O84353	Chlamydia trachomatis (strain D/UW-3/Cx)	28%	100%
P58632	Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)	24%	100%
Q253S7	Chlamydia felis (strain Fe/C-56)	26%	100%
Q3KM09	Chlamydia trachomatis serovar A (strain ATCC VR-571B / DSM 19440 / HAR-13)	28%	100%
Q46BZ6	Methanosarcina barkeri (strain Fusaro / DSM 804)	27%	100%
Q54TC5	Dictyostelium discoideum	35%	100%
Q823U1	Chlamydia caviae (strain ATCC VR-813 / DSM 19441 / 03DC25 / GPIC)	25%	100%
Q9PK45	Chlamydia muridarum (strain MoPn / Nigg)	28%	100%
Q9RV24	Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)	29%	100%