GRIP domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q5H8_LEIMA

TriTrypDb:

LmjF.32.1040 , LMJLV39_320016300 , LMJSD75_320016300

Length:

604

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

Q4Q5H8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5H8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	224	228	PF00656	0.751
CLV_C14_Caspase3-7	342	346	PF00656	0.798
CLV_C14_Caspase3-7	406	410	PF00656	0.657
CLV_NRD_NRD_1	119	121	PF00675	0.486
CLV_NRD_NRD_1	279	281	PF00675	0.527
CLV_NRD_NRD_1	296	298	PF00675	0.345
CLV_NRD_NRD_1	452	454	PF00675	0.429
CLV_NRD_NRD_1	565	567	PF00675	0.492
CLV_NRD_NRD_1	598	600	PF00675	0.667
CLV_NRD_NRD_1	85	87	PF00675	0.340
CLV_PCSK_KEX2_1	279	281	PF00082	0.507
CLV_PCSK_KEX2_1	296	298	PF00082	0.330
CLV_PCSK_KEX2_1	306	308	PF00082	0.518
CLV_PCSK_KEX2_1	451	453	PF00082	0.506
CLV_PCSK_KEX2_1	565	567	PF00082	0.490
CLV_PCSK_KEX2_1	598	600	PF00082	0.734
CLV_PCSK_PC1ET2_1	306	308	PF00082	0.451
CLV_PCSK_PC1ET2_1	451	453	PF00082	0.493
CLV_PCSK_SKI1_1	107	111	PF00082	0.430
CLV_PCSK_SKI1_1	265	269	PF00082	0.532
CLV_PCSK_SKI1_1	356	360	PF00082	0.576
CLV_PCSK_SKI1_1	519	523	PF00082	0.495
CLV_Separin_Metazoa	75	79	PF03568	0.674
DEG_Nend_UBRbox_3	1	3	PF02207	0.658
DOC_CYCLIN_RxL_1	1	12	PF00134	0.658
DOC_CYCLIN_yCln2_LP_2	496	502	PF00134	0.614
DOC_MAPK_gen_1	354	362	PF00069	0.737
DOC_MAPK_gen_1	413	423	PF00069	0.546
DOC_MAPK_gen_1	43	51	PF00069	0.642
DOC_MAPK_gen_1	535	544	PF00069	0.666
DOC_MAPK_gen_1	565	574	PF00069	0.669
DOC_MAPK_gen_1	86	94	PF00069	0.539
DOC_MAPK_MEF2A_6	107	116	PF00069	0.726
DOC_PP1_RVXF_1	111	117	PF00149	0.731
DOC_PP1_RVXF_1	2	9	PF00149	0.660
DOC_PP2B_LxvP_1	482	485	PF13499	0.705
DOC_PP2B_LxvP_1	496	499	PF13499	0.596
DOC_PP4_FxxP_1	27	30	PF00568	0.600
DOC_USP7_MATH_1	151	155	PF00917	0.767
DOC_USP7_MATH_1	156	160	PF00917	0.765
DOC_USP7_MATH_1	289	293	PF00917	0.708
DOC_USP7_MATH_1	558	562	PF00917	0.691
DOC_WW_Pin1_4	162	167	PF00397	0.794
DOC_WW_Pin1_4	168	173	PF00397	0.633
DOC_WW_Pin1_4	325	330	PF00397	0.770
DOC_WW_Pin1_4	344	349	PF00397	0.770
DOC_WW_Pin1_4	53	58	PF00397	0.705
LIG_14-3-3_CanoR_1	322	330	PF00244	0.783
LIG_14-3-3_CanoR_1	4	9	PF00244	0.728
LIG_14-3-3_CanoR_1	453	461	PF00244	0.690
LIG_14-3-3_CanoR_1	538	543	PF00244	0.678
LIG_14-3-3_CanoR_1	78	88	PF00244	0.684
LIG_14-3-3_CterR_2	599	604	PF00244	0.388
LIG_Actin_WH2_2	102	117	PF00022	0.723
LIG_APCC_ABBA_1	92	97	PF00400	0.541
LIG_BIR_III_2	345	349	PF00653	0.734
LIG_BRCT_BRCA1_1	153	157	PF00533	0.748
LIG_BRCT_BRCA1_1	9	13	PF00533	0.637
LIG_Clathr_ClatBox_1	359	363	PF01394	0.802
LIG_EH1_1	131	139	PF00400	0.576
LIG_FHA_1	169	175	PF00498	0.701
LIG_FHA_1	539	545	PF00498	0.609
LIG_FHA_2	126	132	PF00498	0.598
LIG_FHA_2	309	315	PF00498	0.769
LIG_FHA_2	520	526	PF00498	0.688
LIG_LIR_Gen_1	206	216	PF02991	0.680
LIG_LIR_Gen_1	580	591	PF02991	0.335
LIG_LIR_Nem_3	206	212	PF02991	0.614
LIG_LIR_Nem_3	44	48	PF02991	0.607
LIG_LIR_Nem_3	580	586	PF02991	0.379
LIG_PDZ_Class_2	599	604	PF00595	0.388
LIG_Pex14_2	358	362	PF04695	0.636
LIG_SH2_NCK_1	209	213	PF00017	0.676
LIG_SH2_NCK_1	517	521	PF00017	0.734
LIG_SH2_SRC	209	212	PF00017	0.678
LIG_SH2_STAP1	248	252	PF00017	0.663
LIG_SH2_STAP1	517	521	PF00017	0.704
LIG_SH2_STAT5	178	181	PF00017	0.642
LIG_SH2_STAT5	585	588	PF00017	0.357
LIG_SH3_1	565	571	PF00018	0.696
LIG_SH3_3	147	153	PF00018	0.799
LIG_SH3_3	26	32	PF00018	0.634
LIG_SH3_3	499	505	PF00018	0.734
LIG_SH3_3	565	571	PF00018	0.696
LIG_SUMO_SIM_anti_2	392	398	PF11976	0.547
LIG_SUMO_SIM_par_1	47	56	PF11976	0.733
LIG_TRAF2_1	196	199	PF00917	0.723
LIG_TRAF2_1	403	406	PF00917	0.567
LIG_TRAF2_1	417	420	PF00917	0.651
LIG_UBA3_1	34	43	PF00899	0.590
LIG_WRC_WIRS_1	359	364	PF05994	0.636
LIG_WRC_WIRS_1	42	47	PF05994	0.653
MOD_CK1_1	125	131	PF00069	0.569
MOD_CK1_1	219	225	PF00069	0.662
MOD_CK1_1	328	334	PF00069	0.724
MOD_CK1_1	344	350	PF00069	0.768
MOD_CK1_1	361	367	PF00069	0.702
MOD_CK1_1	37	43	PF00069	0.624
MOD_CK1_1	454	460	PF00069	0.655
MOD_CK1_1	486	492	PF00069	0.735
MOD_CK1_1	7	13	PF00069	0.651
MOD_CK1_1	82	88	PF00069	0.711
MOD_CK2_1	125	131	PF00069	0.596
MOD_CK2_1	178	184	PF00069	0.640
MOD_CK2_1	193	199	PF00069	0.653
MOD_CK2_1	247	253	PF00069	0.663
MOD_CK2_1	285	291	PF00069	0.774
MOD_CK2_1	308	314	PF00069	0.722
MOD_CK2_1	399	405	PF00069	0.603
MOD_CK2_1	414	420	PF00069	0.621
MOD_CK2_1	506	512	PF00069	0.682
MOD_CK2_1	69	75	PF00069	0.684
MOD_GlcNHglycan	160	163	PF01048	0.493
MOD_GlcNHglycan	195	198	PF01048	0.416
MOD_GlcNHglycan	218	221	PF01048	0.445
MOD_GlcNHglycan	269	272	PF01048	0.362
MOD_GlcNHglycan	287	290	PF01048	0.505
MOD_GlcNHglycan	316	319	PF01048	0.552
MOD_GlcNHglycan	330	333	PF01048	0.608
MOD_GlcNHglycan	400	404	PF01048	0.504
MOD_GlcNHglycan	453	456	PF01048	0.462
MOD_GlcNHglycan	485	488	PF01048	0.485
MOD_GlcNHglycan	553	556	PF01048	0.532
MOD_GlcNHglycan	560	563	PF01048	0.496
MOD_GlcNHglycan	592	595	PF01048	0.646
MOD_GSK3_1	122	129	PF00069	0.737
MOD_GSK3_1	152	159	PF00069	0.789
MOD_GSK3_1	174	181	PF00069	0.672
MOD_GSK3_1	198	205	PF00069	0.755
MOD_GSK3_1	247	254	PF00069	0.715
MOD_GSK3_1	281	288	PF00069	0.779
MOD_GSK3_1	321	328	PF00069	0.807
MOD_GSK3_1	33	40	PF00069	0.592
MOD_GSK3_1	395	402	PF00069	0.707
MOD_GSK3_1	4	11	PF00069	0.722
MOD_GSK3_1	483	490	PF00069	0.762
MOD_N-GLC_1	126	131	PF02516	0.547
MOD_N-GLC_1	314	319	PF02516	0.529
MOD_N-GLC_1	332	337	PF02516	0.518
MOD_N-GLC_1	414	419	PF02516	0.443
MOD_N-GLC_1	506	511	PF02516	0.499
MOD_NEK2_1	122	127	PF00069	0.630
MOD_NEK2_1	130	135	PF00069	0.627
MOD_NEK2_1	157	162	PF00069	0.746
MOD_NEK2_1	174	179	PF00069	0.525
MOD_NEK2_1	216	221	PF00069	0.714
MOD_NEK2_1	323	328	PF00069	0.720
MOD_NEK2_1	34	39	PF00069	0.668
MOD_NEK2_1	41	46	PF00069	0.665
MOD_NEK2_1	506	511	PF00069	0.686
MOD_NEK2_1	544	549	PF00069	0.685
MOD_NEK2_1	6	11	PF00069	0.722
MOD_NEK2_2	178	183	PF00069	0.681
MOD_PIKK_1	198	204	PF00454	0.688
MOD_PIKK_1	321	327	PF00454	0.777
MOD_PIKK_1	332	338	PF00454	0.740
MOD_PIKK_1	463	469	PF00454	0.715
MOD_PIKK_1	544	550	PF00454	0.694
MOD_PIKK_1	60	66	PF00454	0.757
MOD_PK_1	99	105	PF00069	0.611
MOD_PKA_1	451	457	PF00069	0.659
MOD_PKA_2	151	157	PF00069	0.755
MOD_PKA_2	216	222	PF00069	0.594
MOD_PKA_2	321	327	PF00069	0.778
MOD_PKA_2	451	457	PF00069	0.659
MOD_PKA_2	544	550	PF00069	0.784
MOD_Plk_1	107	113	PF00069	0.676
MOD_Plk_1	126	132	PF00069	0.578
MOD_Plk_1	174	180	PF00069	0.658
MOD_Plk_1	198	204	PF00069	0.698
MOD_Plk_1	308	314	PF00069	0.655
MOD_Plk_1	414	420	PF00069	0.642
MOD_Plk_1	506	512	PF00069	0.725
MOD_Plk_2-3	101	107	PF00069	0.715
MOD_Plk_2-3	414	420	PF00069	0.601
MOD_Plk_4	174	180	PF00069	0.629
MOD_Plk_4	247	253	PF00069	0.663
MOD_Plk_4	37	43	PF00069	0.664
MOD_Plk_4	478	484	PF00069	0.632
MOD_Plk_4	506	512	PF00069	0.677
MOD_Plk_4	577	583	PF00069	0.452
MOD_ProDKin_1	162	168	PF00069	0.793
MOD_ProDKin_1	325	331	PF00069	0.771
MOD_ProDKin_1	344	350	PF00069	0.765
MOD_ProDKin_1	53	59	PF00069	0.708
MOD_SUMO_for_1	273	276	PF00179	0.678
MOD_SUMO_rev_2	454	461	PF00179	0.681
TRG_DiLeu_BaEn_1	264	269	PF01217	0.683
TRG_DiLeu_BaEn_1	392	397	PF01217	0.549
TRG_DiLeu_BaEn_4	198	204	PF01217	0.722
TRG_DiLeu_BaLyEn_6	169	174	PF01217	0.671
TRG_DiLeu_BaLyEn_6	30	35	PF01217	0.609
TRG_ENDOCYTIC_2	209	212	PF00928	0.678
TRG_ENDOCYTIC_2	248	251	PF00928	0.662
TRG_ENDOCYTIC_2	585	588	PF00928	0.460
TRG_ENDOCYTIC_2	95	98	PF00928	0.658
TRG_ER_diArg_1	111	114	PF00400	0.640
TRG_ER_diArg_1	21	24	PF00400	0.608
TRG_ER_diArg_1	295	297	PF00400	0.710
TRG_ER_diArg_1	442	445	PF00400	0.542
TRG_ER_diArg_1	564	566	PF00400	0.744
TRG_ER_diArg_1	597	599	PF00400	0.458
TRG_NES_CRM1_1	184	198	PF08389	0.667
TRG_Pf-PMV_PEXEL_1	120	124	PF00026	0.471
TRG_Pf-PMV_PEXEL_1	296	300	PF00026	0.503
TRG_Pf-PMV_PEXEL_1	388	392	PF00026	0.450
TRG_Pf-PMV_PEXEL_1	416	420	PF00026	0.509
TRG_Pf-PMV_PEXEL_1	445	449	PF00026	0.441
TRG_Pf-PMV_PEXEL_1	86	91	PF00026	0.375

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4B6	Leptomonas seymouri	38%	100%
A0A3S5ISI9	Trypanosoma rangeli	26%	100%
A0A3S7X5F4	Leishmania donovani	85%	100%
A4HK86	Leishmania braziliensis	59%	100%
A4I7S1	Leishmania infantum	85%	97%
E9B2M9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	85%