Putative small nuclear ribonucleoprotein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

small nuclear ribonucleoprotein, putative

Species:

Leishmania major

UniProt:

Q4Q5H5_LEIMA

TriTrypDb:

LmjF.32.1070 , LMJLV39_320016600 , LMJSD75_320016600

Length:

Annotations

Annotations by Jardim et al.

Nucleic acid binding, small nuclear ribonucleo

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005681	spliceosomal complex	3	2
GO:0005682	U5 snRNP	5	2
GO:0005684	U2-type spliceosomal complex	4	2
GO:0005685	U1 snRNP	5	2
GO:0005686	U2 snRNP	5	2
GO:0005687	U4 snRNP	5	2
GO:0005689	U12-type spliceosomal complex	4	2
GO:0030532	small nuclear ribonucleoprotein complex	3	2
GO:0032991	protein-containing complex	1	8
GO:0034719	SMN-Sm protein complex	3	2
GO:0035770	ribonucleoprotein granule	3	2
GO:0036464	cytoplasmic ribonucleoprotein granule	4	2
GO:0043186	P granule	5	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0071004	U2-type prespliceosome	5	2
GO:0071010	prespliceosome	4	2
GO:0071011	precatalytic spliceosome	4	2
GO:0071013	catalytic step 2 spliceosome	3	2
GO:0097525	spliceosomal snRNP complex	4	2
GO:0097526	spliceosomal tri-snRNP complex	5	2
GO:0099080	supramolecular complex	2	2
GO:0110165	cellular anatomical entity	1	2
GO:0120114	Sm-like protein family complex	2	2
GO:0140513	nuclear protein-containing complex	2	2
GO:1902494	catalytic complex	2	2
GO:1990904	ribonucleoprotein complex	2	8

Expansion

Sequence features

Q4Q5H5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5H5

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	2
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	2
GO:0000398	mRNA splicing, via spliceosome	8	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006396	RNA processing	6	2
GO:0006397	mRNA processing	7	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0008380	RNA splicing	7	2
GO:0009987	cellular process	1	2
GO:0016070	RNA metabolic process	5	2
GO:0016071	mRNA metabolic process	6	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	16	18	PF00082	0.261
CLV_PCSK_PC1ET2_1	16	18	PF00082	0.261
CLV_PCSK_SKI1_1	60	64	PF00082	0.315
DOC_MAPK_gen_1	16	22	PF00069	0.461
DOC_USP7_MATH_1	53	57	PF00917	0.508
LIG_FHA_1	63	69	PF00498	0.461
LIG_SUMO_SIM_par_1	71	78	PF11976	0.519
MOD_GlcNHglycan	28	31	PF01048	0.272
MOD_GlcNHglycan	70	73	PF01048	0.303
MOD_GlcNHglycan	77	80	PF01048	0.528
MOD_NEK2_1	47	52	PF00069	0.503
MOD_NEK2_1	63	68	PF00069	0.515
MOD_PKA_2	68	74	PF00069	0.503
MOD_Plk_4	37	43	PF00069	0.461
MOD_Plk_4	63	69	PF00069	0.509

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ICM1	Leptomonas seymouri	84%	99%
A0A3Q8IGP1	Leishmania donovani	100%	100%
A4HK89	Leishmania braziliensis	85%	99%
A4I7S4	Leishmania infantum	100%	100%
D0A9Y3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	99%
E9B2N2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
O74499	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	72%
O74966	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	100%
P40204	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	38%	100%
P53905	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	36%	70%
P62308	Homo sapiens	39%	100%
P62309	Mus musculus	39%	100%
Q0W8R9	Methanocella arvoryzae (strain DSM 22066 / NBRC 105507 / MRE50)	34%	100%
Q3ZBL0	Bos taurus	39%	100%
Q54RX0	Dictyostelium discoideum	33%	95%
Q9N4G9	Caenorhabditis elegans	36%	100%
Q9VXE0	Drosophila melanogaster	36%	100%