HECT-type E3 ubiquitin transferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

HECT-domain (ubiquitin-transferase), putative

Species:

Leishmania major

UniProt:

Q4Q5H3_LEIMA

TriTrypDb:

LmjF.32.1090 , LMJLV39_320016800 , LMJSD75_320016800

Length:

1628

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

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Expansion

Sequence features

Q4Q5H3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

No structure information available for this entry

Related structures:

Function

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Biological processes
Term	Name	Level	Count
GO:0000209	protein polyubiquitination	8	2
GO:0006508	proteolysis	4	12
GO:0006511	ubiquitin-dependent protein catabolic process	7	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009056	catabolic process	2	12
GO:0009057	macromolecule catabolic process	4	12
GO:0009987	cellular process	1	12
GO:0010498	proteasomal protein catabolic process	5	2
GO:0016567	protein ubiquitination	7	2

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004842	ubiquitin-protein transferase activity	4	12
GO:0005488	binding	1	12
GO:0008270	zinc ion binding	6	9
GO:0016740	transferase activity	2	12
GO:0016746	acyltransferase activity	3	1
GO:0016874	ligase activity	2	1
GO:0019787	ubiquitin-like protein transferase activity	3	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	201	205	PF00656	0.547
CLV_C14_Caspase3-7	326	330	PF00656	0.638
CLV_C14_Caspase3-7	423	427	PF00656	0.686
CLV_C14_Caspase3-7	885	889	PF00656	0.780
CLV_C14_Caspase3-7	911	915	PF00656	0.810
CLV_NRD_NRD_1	1199	1201	PF00675	0.334
CLV_NRD_NRD_1	1218	1220	PF00675	0.368
CLV_NRD_NRD_1	1304	1306	PF00675	0.356
CLV_NRD_NRD_1	1574	1576	PF00675	0.344
CLV_NRD_NRD_1	19	21	PF00675	0.490

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P999	Leptomonas seymouri	62%	97%
A0A0S4J9N1	Bodo saltans	29%	95%
A0A1X0NUK1	Trypanosomatidae	37%	99%
A0A3S7X5C8	Leishmania donovani	94%	100%
A0A422P1G3	Trypanosoma rangeli	34%	100%
A4HK91	Leishmania braziliensis	80%	100%
A4I7S6	Leishmania infantum	94%	100%
D0A9Y5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9B2N4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5DHK1	Trypanosoma cruzi	29%	100%

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