Homologous to eukaryotic mitochondrial carriers responsible for FAD and/or folate uptake. In some organisms, homologs also transport thiamine.. Localization: Mitochondrial (by homology)
Source | Evidence on protein | Close homologs |
---|---|---|
Cuervo et al. | no | yes: 0 |
Hassani et al. | no | yes: 0 |
Forrest at al. (metacyclic) | no | yes: 0 |
Forrest at al. (procyclic) | no | yes: 0 |
Silverman et al. | no | yes: 0 |
Pissara et al. | no | yes: 0 |
Source | Evidence on protein | Close homologs |
---|---|---|
Pires et al. | no | yes: 0 |
Source | Evidence on protein | Close homologs |
---|---|---|
Silverman et al. | no | yes: 0 |
Source | Evidence on protein | Close homologs |
---|---|---|
Jamdhade et al. | no | yes: 0 |
Source | Evidence on protein | Close homologs |
---|---|---|
DeepLoc | ||
SignalP6 | no | yes: 0, no: 24 |
NetGPI | no | yes: 0, no: 24 |
Term | Name | Level | Count |
---|---|---|---|
GO:0005739 | mitochondrion | 5 | 3 |
GO:0016020 | membrane | 2 | 25 |
GO:0043226 | organelle | 2 | 3 |
GO:0043227 | membrane-bounded organelle | 3 | 3 |
GO:0043229 | intracellular organelle | 3 | 3 |
GO:0043231 | intracellular membrane-bounded organelle | 4 | 3 |
GO:0110165 | cellular anatomical entity | 1 | 25 |
Related structures:
AlphaFold database: Q4Q5H0
Term | Name | Level | Count |
---|---|---|---|
GO:0006810 | transport | 3 | 25 |
GO:0006811 | monoatomic ion transport | 4 | 3 |
GO:0006820 | monoatomic anion transport | 5 | 3 |
GO:0006835 | dicarboxylic acid transport | 7 | 3 |
GO:0009987 | cellular process | 1 | 25 |
GO:0015711 | organic anion transport | 5 | 3 |
GO:0015849 | organic acid transport | 5 | 3 |
GO:0015884 | folic acid transport | 5 | 3 |
GO:0034220 | monoatomic ion transmembrane transport | 3 | 3 |
GO:0035461 | vitamin transmembrane transport | 3 | 3 |
GO:0042886 | amide transport | 5 | 3 |
GO:0046942 | carboxylic acid transport | 6 | 3 |
GO:0051179 | localization | 1 | 25 |
GO:0051180 | vitamin transport | 4 | 3 |
GO:0051234 | establishment of localization | 2 | 25 |
GO:0055085 | transmembrane transport | 2 | 25 |
GO:0071702 | organic substance transport | 4 | 25 |
GO:0071705 | nitrogen compound transport | 4 | 25 |
GO:0072337 | modified amino acid transport | 5 | 3 |
GO:0098656 | monoatomic anion transmembrane transport | 4 | 3 |
GO:0098838 | folate transmembrane transport | 4 | 3 |
GO:1903825 | organic acid transmembrane transport | 3 | 3 |
GO:1904947 | folate import into mitochondrion | 4 | 3 |
GO:1905039 | carboxylic acid transmembrane transport | 4 | 3 |
GO:1990542 | mitochondrial transmembrane transport | 3 | 3 |
GO:0006862 | nucleotide transport | 6 | 22 |
GO:0015748 | organophosphate ester transport | 5 | 22 |
GO:0015931 | nucleobase-containing compound transport | 5 | 22 |
Term | Name | Level | Count |
---|---|---|---|
GO:0005215 | transporter activity | 1 | 3 |
GO:0005342 | organic acid transmembrane transporter activity | 3 | 3 |
GO:0008509 | monoatomic anion transmembrane transporter activity | 4 | 3 |
GO:0008514 | organic anion transmembrane transporter activity | 5 | 3 |
GO:0008517 | folic acid transmembrane transporter activity | 4 | 3 |
GO:0015075 | monoatomic ion transmembrane transporter activity | 3 | 3 |
GO:0015215 | nucleotide transmembrane transporter activity | 4 | 3 |
GO:0015230 | FAD transmembrane transporter activity | 5 | 3 |
GO:0015605 | organophosphate ester transmembrane transporter activity | 3 | 3 |
GO:0015932 | nucleobase-containing compound transmembrane transporter activity | 3 | 3 |
GO:0022857 | transmembrane transporter activity | 2 | 3 |
GO:0042887 | amide transmembrane transporter activity | 3 | 3 |
GO:0046943 | carboxylic acid transmembrane transporter activity | 4 | 3 |
GO:0072349 | modified amino acid transmembrane transporter activity | 3 | 3 |
GO:0090482 | vitamin transmembrane transporter activity | 3 | 3 |
Leishmania | From | To | Domain/Motif | Score |
---|---|---|---|---|
CLV_C14_Caspase3-7 | 42 | 46 | PF00656 | 0.204 |
CLV_MEL_PAP_1 | 143 | 149 | PF00089 | 0.265 |
CLV_NRD_NRD_1 | 100 | 102 | PF00675 | 0.310 |
CLV_NRD_NRD_1 | 113 | 115 | PF00675 | 0.430 |
CLV_NRD_NRD_1 | 238 | 240 | PF00675 | 0.534 |
CLV_PCSK_KEX2_1 | 100 | 102 | PF00082 | 0.426 |
CLV_PCSK_KEX2_1 | 112 | 114 | PF00082 | 0.402 |
CLV_PCSK_KEX2_1 | 238 | 240 | PF00082 | 0.618 |
CLV_PCSK_PC1ET2_1 | 112 | 114 | PF00082 | 0.444 |
CLV_PCSK_SKI1_1 | 255 | 259 | PF00082 | 0.304 |
CLV_PCSK_SKI1_1 | 285 | 289 | PF00082 | 0.292 |
CLV_PCSK_SKI1_1 | 317 | 321 | PF00082 | 0.348 |
CLV_PCSK_SKI1_1 | 4 | 8 | PF00082 | 0.353 |
DEG_APCC_DBOX_1 | 284 | 292 | PF00400 | 0.470 |
DOC_CYCLIN_yCln2_LP_2 | 30 | 36 | PF00134 | 0.351 |
DOC_MAPK_gen_1 | 238 | 244 | PF00069 | 0.457 |
DOC_MAPK_HePTP_8 | 235 | 249 | PF00069 | 0.204 |
DOC_PP1_RVXF_1 | 36 | 42 | PF00149 | 0.309 |
DOC_PP2B_LxvP_1 | 216 | 219 | PF13499 | 0.240 |
DOC_PP4_FxxP_1 | 126 | 129 | PF00568 | 0.526 |
DOC_PP4_FxxP_1 | 222 | 225 | PF00568 | 0.306 |
DOC_PP4_FxxP_1 | 6 | 9 | PF00568 | 0.519 |
DOC_USP7_MATH_1 | 116 | 120 | PF00917 | 0.644 |
DOC_WW_Pin1_4 | 128 | 133 | PF00397 | 0.502 |
LIG_14-3-3_CanoR_1 | 100 | 106 | PF00244 | 0.567 |
LIG_14-3-3_CanoR_1 | 125 | 129 | PF00244 | 0.689 |
LIG_14-3-3_CanoR_1 | 185 | 191 | PF00244 | 0.326 |
LIG_14-3-3_CanoR_1 | 208 | 216 | PF00244 | 0.234 |
LIG_Actin_WH2_2 | 316 | 332 | PF00022 | 0.413 |
LIG_APCC_ABBA_1 | 321 | 326 | PF00400 | 0.416 |
LIG_BIR_II_1 | 1 | 5 | PF00653 | 0.668 |
LIG_FHA_1 | 154 | 160 | PF00498 | 0.341 |
LIG_FHA_1 | 178 | 184 | PF00498 | 0.330 |
LIG_FHA_1 | 198 | 204 | PF00498 | 0.249 |
LIG_FHA_1 | 24 | 30 | PF00498 | 0.281 |
LIG_FHA_1 | 252 | 258 | PF00498 | 0.285 |
LIG_FHA_1 | 277 | 283 | PF00498 | 0.392 |
LIG_FHA_2 | 102 | 108 | PF00498 | 0.469 |
LIG_FHA_2 | 40 | 46 | PF00498 | 0.204 |
LIG_LIR_Apic_2 | 124 | 129 | PF02991 | 0.533 |
LIG_LIR_Apic_2 | 3 | 9 | PF02991 | 0.531 |
LIG_LIR_Gen_1 | 139 | 147 | PF02991 | 0.527 |
LIG_LIR_Gen_1 | 318 | 328 | PF02991 | 0.383 |
LIG_LIR_Nem_3 | 139 | 143 | PF02991 | 0.499 |
LIG_LIR_Nem_3 | 205 | 210 | PF02991 | 0.308 |
LIG_LIR_Nem_3 | 281 | 287 | PF02991 | 0.432 |
LIG_LIR_Nem_3 | 318 | 323 | PF02991 | 0.187 |
LIG_LIR_Nem_3 | 56 | 60 | PF02991 | 0.206 |
LIG_PCNA_PIPBox_1 | 297 | 306 | PF02747 | 0.353 |
LIG_PCNA_yPIPBox_3 | 292 | 304 | PF02747 | 0.353 |
LIG_Pex14_2 | 320 | 324 | PF04695 | 0.166 |
LIG_REV1ctd_RIR_1 | 75 | 83 | PF16727 | 0.413 |
LIG_SH2_CRK | 227 | 231 | PF00017 | 0.297 |
LIG_SH2_CRK | 57 | 61 | PF00017 | 0.243 |
LIG_SH2_CRK | 95 | 99 | PF00017 | 0.318 |
LIG_SH2_STAP1 | 136 | 140 | PF00017 | 0.467 |
LIG_SH2_STAP1 | 325 | 329 | PF00017 | 0.236 |
LIG_SH2_STAT3 | 99 | 102 | PF00017 | 0.501 |
LIG_SH2_STAT5 | 97 | 100 | PF00017 | 0.306 |
LIG_SH3_3 | 126 | 132 | PF00018 | 0.515 |
LIG_SH3_3 | 157 | 163 | PF00018 | 0.327 |
LIG_SH3_3 | 258 | 264 | PF00018 | 0.166 |
LIG_SUMO_SIM_anti_2 | 241 | 246 | PF11976 | 0.285 |
LIG_SUMO_SIM_par_1 | 264 | 270 | PF11976 | 0.347 |
LIG_WRC_WIRS_1 | 187 | 192 | PF05994 | 0.263 |
LIG_WRC_WIRS_1 | 284 | 289 | PF05994 | 0.455 |
MOD_CK1_1 | 121 | 127 | PF00069 | 0.683 |
MOD_CK1_1 | 154 | 160 | PF00069 | 0.307 |
MOD_CK1_1 | 177 | 183 | PF00069 | 0.289 |
MOD_CK1_1 | 251 | 257 | PF00069 | 0.307 |
MOD_CK2_1 | 101 | 107 | PF00069 | 0.591 |
MOD_GlcNHglycan | 118 | 121 | PF01048 | 0.452 |
MOD_GlcNHglycan | 156 | 159 | PF01048 | 0.342 |
MOD_GlcNHglycan | 174 | 179 | PF01048 | 0.438 |
MOD_GlcNHglycan | 210 | 213 | PF01048 | 0.438 |
MOD_GSK3_1 | 124 | 131 | PF00069 | 0.672 |
MOD_GSK3_1 | 147 | 154 | PF00069 | 0.321 |
MOD_GSK3_1 | 194 | 201 | PF00069 | 0.258 |
MOD_GSK3_1 | 283 | 290 | PF00069 | 0.461 |
MOD_GSK3_1 | 307 | 314 | PF00069 | 0.295 |
MOD_GSK3_1 | 40 | 47 | PF00069 | 0.238 |
MOD_GSK3_1 | 81 | 88 | PF00069 | 0.417 |
MOD_NEK2_1 | 14 | 19 | PF00069 | 0.273 |
MOD_NEK2_1 | 147 | 152 | PF00069 | 0.313 |
MOD_NEK2_1 | 166 | 171 | PF00069 | 0.251 |
MOD_NEK2_1 | 194 | 199 | PF00069 | 0.237 |
MOD_NEK2_1 | 226 | 231 | PF00069 | 0.266 |
MOD_NEK2_1 | 287 | 292 | PF00069 | 0.455 |
MOD_NEK2_1 | 311 | 316 | PF00069 | 0.318 |
MOD_PIKK_1 | 17 | 23 | PF00454 | 0.313 |
MOD_PIKK_1 | 40 | 46 | PF00454 | 0.228 |
MOD_PKA_2 | 124 | 130 | PF00069 | 0.692 |
MOD_PKA_2 | 304 | 310 | PF00069 | 0.514 |
MOD_PKA_2 | 39 | 45 | PF00069 | 0.217 |
MOD_PKB_1 | 38 | 46 | PF00069 | 0.225 |
MOD_Plk_1 | 240 | 246 | PF00069 | 0.274 |
MOD_Plk_4 | 240 | 246 | PF00069 | 0.254 |
MOD_Plk_4 | 25 | 31 | PF00069 | 0.275 |
MOD_ProDKin_1 | 128 | 134 | PF00069 | 0.498 |
TRG_ENDOCYTIC_2 | 227 | 230 | PF00928 | 0.236 |
TRG_ENDOCYTIC_2 | 284 | 287 | PF00928 | 0.443 |
TRG_ENDOCYTIC_2 | 325 | 328 | PF00928 | 0.248 |
TRG_ENDOCYTIC_2 | 57 | 60 | PF00928 | 0.251 |
TRG_ENDOCYTIC_2 | 95 | 98 | PF00928 | 0.318 |
TRG_ER_diArg_1 | 237 | 239 | PF00400 | 0.426 |
TRG_ER_diArg_1 | 37 | 40 | PF00400 | 0.249 |
TRG_ER_diArg_1 | 99 | 101 | PF00400 | 0.438 |
Protein | Taxonomy | Sequence identity | Coverage |
---|---|---|---|
A0A0N0P2Z6 | Leptomonas seymouri | 24% | 94% |
A0A0N0P4V4 | Leptomonas seymouri | 27% | 95% |
A0A0N0P7T5 | Leptomonas seymouri | 23% | 100% |
A0A0N0P7X0 | Leptomonas seymouri | 24% | 100% |
A0A0N0P7Y4 | Leptomonas seymouri | 22% | 100% |
A0A0N0P8W6 | Leptomonas seymouri | 21% | 99% |
A0A0N1IMP5 | Leptomonas seymouri | 68% | 100% |
A0A0N1PFJ3 | Leptomonas seymouri | 39% | 93% |
A0A0S4IZG7 | Bodo saltans | 21% | 97% |
A0A0S4J045 | Bodo saltans | 24% | 95% |
A0A0S4J9F4 | Bodo saltans | 42% | 100% |
A0A0S4JHC1 | Bodo saltans | 27% | 97% |
A0A1D6N272 | Zea mays | 24% | 100% |
A0A1X0NTK9 | Trypanosomatidae | 21% | 100% |
A0A1X0NUM8 | Trypanosomatidae | 42% | 100% |
A0A1X0NUU7 | Trypanosomatidae | 50% | 100% |
A0A1X0P6S2 | Trypanosomatidae | 31% | 100% |
A0A1X0PA63 | Trypanosomatidae | 24% | 87% |
A0A3Q8I9Y9 | Leishmania donovani | 22% | 100% |
A0A3Q8IFU6 | Leishmania donovani | 89% | 100% |
A0A3Q8IIC0 | Leishmania donovani | 22% | 100% |
A0A3Q8IKX9 | Leishmania donovani | 41% | 100% |
A0A3R7LCB2 | Trypanosoma rangeli | 49% | 100% |
A0A3R7P246 | Trypanosoma rangeli | 41% | 100% |
A0A3S5H800 | Leishmania donovani | 25% | 93% |
A0A3S7WVJ8 | Leishmania donovani | 26% | 98% |
A0A3S7WYS1 | Leishmania donovani | 25% | 100% |
A0A422N763 | Trypanosoma rangeli | 29% | 99% |
A4H7Y2 | Leishmania braziliensis | 23% | 100% |
A4HA67 | Leishmania braziliensis | 25% | 98% |
A4HDW8 | Leishmania braziliensis | 22% | 100% |
A4HK93 | Leishmania braziliensis | 40% | 92% |
A4HK94 | Leishmania braziliensis | 76% | 100% |
A4HN00 | Leishmania braziliensis | 25% | 93% |
A4HN69 | Leishmania braziliensis | 28% | 100% |
A4HWA9 | Leishmania infantum | 22% | 100% |
A4HYC8 | Leishmania infantum | 26% | 98% |
A4I163 | Leishmania infantum | 25% | 100% |
A4I7S8 | Leishmania infantum | 41% | 100% |
A4I7S9 | Leishmania infantum | 89% | 100% |
A4IBM3 | Leishmania infantum | 24% | 93% |
A4IBT7 | Leishmania infantum | 22% | 100% |
B0G159 | Dictyostelium discoideum | 24% | 71% |
B4F8I5 | Zea mays | 24% | 100% |
B4FIJ0 | Zea mays | 24% | 100% |
C9ZM27 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 24% | 88% |
C9ZNU5 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 23% | 100% |
C9ZYS8 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 24% | 100% |
C9ZZ11 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 26% | 100% |
D0A9Y8 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 40% | 97% |
D0A9Z0 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 44% | 99% |
E8NHL5 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 26% | 93% |
E9ACE1 | Leishmania major | 22% | 100% |
E9AFF7 | Leishmania major | 26% | 100% |
E9AFM4 | Leishmania major | 24% | 100% |
E9AQ09 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 21% | 100% |
E9AS62 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 25% | 98% |
E9AX97 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 25% | 100% |
E9B0N4 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 26% | 100% |
E9B2N6 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 40% | 100% |
E9B2N7 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 86% | 100% |
E9B6S7 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 24% | 100% |
F1RFX9 | Sus scrofa | 24% | 100% |
O04200 | Arabidopsis thaliana | 26% | 100% |
O04619 | Arabidopsis thaliana | 22% | 96% |
O13660 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | 22% | 100% |
O22261 | Arabidopsis thaliana | 24% | 100% |
O43808 | Homo sapiens | 23% | 100% |
O70579 | Mus musculus | 23% | 100% |
O95258 | Homo sapiens | 25% | 100% |
P0CAT2 | Danio rerio | 23% | 100% |
P22292 | Bos taurus | 25% | 100% |
P32332 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 20% | 100% |
P39953 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 25% | 100% |
P40464 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 24% | 100% |
P40556 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 22% | 90% |
P90992 | Caenorhabditis elegans | 21% | 100% |
P97700 | Rattus norvegicus | 24% | 100% |
Q02978 | Homo sapiens | 24% | 100% |
Q08CI8 | Danio rerio | 24% | 100% |
Q08DK7 | Bos taurus | 24% | 100% |
Q09461 | Caenorhabditis elegans | 22% | 94% |
Q1LZB3 | Bos taurus | 22% | 100% |
Q287T7 | Danio rerio | 22% | 100% |
Q29RM1 | Bos taurus | 21% | 100% |
Q3TZX3 | Mus musculus | 21% | 100% |
Q4Q5H1 | Leishmania major | 41% | 100% |
Q4QA75 | Leishmania major | 25% | 100% |
Q4QDA4 | Leishmania major | 25% | 98% |
Q4QFH2 | Leishmania major | 21% | 100% |
Q505J6 | Rattus norvegicus | 21% | 100% |
Q54EV4 | Dictyostelium discoideum | 22% | 100% |
Q54FU9 | Dictyostelium discoideum | 21% | 100% |
Q54QN2 | Dictyostelium discoideum | 24% | 100% |
Q552L9 | Dictyostelium discoideum | 23% | 92% |
Q5NVC1 | Pongo abelii | 21% | 100% |
Q5PQM9 | Rattus norvegicus | 26% | 100% |
Q5SVS4 | Homo sapiens | 25% | 100% |
Q5XGI1 | Xenopus tropicalis | 24% | 100% |
Q5XHA0 | Xenopus tropicalis | 22% | 71% |
Q5ZKP7 | Gallus gallus | 22% | 100% |
Q66L49 | Danio rerio | 21% | 71% |
Q6DG32 | Danio rerio | 23% | 100% |
Q6GQ22 | Xenopus laevis | 24% | 100% |
Q6IZB5 | Cricetulus griseus | 23% | 100% |
Q6P036 | Danio rerio | 24% | 100% |
Q75A82 | Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) | 22% | 99% |
Q76P23 | Dictyostelium discoideum | 21% | 100% |
Q7K566 | Drosophila melanogaster | 25% | 100% |
Q7XA87 | Arabidopsis thaliana | 28% | 100% |
Q86AV5 | Dictyostelium discoideum | 21% | 100% |
Q86I81 | Dictyostelium discoideum | 21% | 100% |
Q8BMG8 | Mus musculus | 24% | 100% |
Q8BW66 | Mus musculus | 22% | 100% |
Q8HXE3 | Macaca fascicularis | 25% | 100% |
Q8R0Z5 | Mus musculus | 22% | 93% |
Q8RWA5 | Arabidopsis thaliana | 22% | 93% |
Q8RXZ9 | Arabidopsis thaliana | 24% | 100% |
Q922G0 | Mus musculus | 23% | 100% |
Q944H5 | Arabidopsis thaliana | 24% | 82% |
Q95J75 | Macaca fascicularis | 24% | 100% |
Q96A46 | Homo sapiens | 23% | 93% |
Q96CQ1 | Homo sapiens | 23% | 100% |
Q9BSK2 | Homo sapiens | 22% | 100% |
Q9CR58 | Mus musculus | 26% | 100% |
Q9CR62 | Mus musculus | 25% | 100% |
Q9DB41 | Mus musculus | 21% | 100% |
Q9FI43 | Arabidopsis thaliana | 23% | 69% |
Q9FI73 | Arabidopsis thaliana | 24% | 99% |
Q9GMZ1 | Canis lupus familiaris | 23% | 100% |
Q9H2D1 | Homo sapiens | 23% | 100% |
Q9HC21 | Homo sapiens | 22% | 100% |
Q9P6L7 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | 23% | 93% |
Q9SUV1 | Arabidopsis thaliana | 20% | 86% |
Q9VQ37 | Drosophila melanogaster | 23% | 92% |
Q9Z2B2 | Mus musculus | 26% | 100% |
Q9ZWG1 | Arabidopsis thaliana | 23% | 100% |
V5B150 | Trypanosoma cruzi | 46% | 100% |
V5BDR1 | Trypanosoma cruzi | 24% | 100% |
V5BGM6 | Trypanosoma cruzi | 43% | 100% |
V5BKU8 | Trypanosoma cruzi | 23% | 88% |
V5BTA6 | Trypanosoma cruzi | 26% | 100% |
V5BTE8 | Trypanosoma cruzi | 30% | 99% |