LeishMANIAdb
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Mitochondrial carrier protein-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Mitochondrial carrier protein-like protein
Gene product:
mitochondrial carrier protein-like protein
Species:
Leishmania major
UniProt:
Q4Q5H0_LEIMA
TriTrypDb:
LmjF.32.1120 , LMJLV39_320017100 * , LMJSD75_320017100
Length:
337

Annotations

LeishMANIAdb annotations

Homologous to eukaryotic mitochondrial carriers responsible for FAD and/or folate uptake. In some organisms, homologs also transport thiamine.. Localization: Mitochondrial (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 24
NetGPI no yes: 0, no: 24
Cellular components
Term Name Level Count
GO:0005739 mitochondrion 5 3
GO:0016020 membrane 2 25
GO:0043226 organelle 2 3
GO:0043227 membrane-bounded organelle 3 3
GO:0043229 intracellular organelle 3 3
GO:0043231 intracellular membrane-bounded organelle 4 3
GO:0110165 cellular anatomical entity 1 25

Expansion

Sequence features

Q4Q5H0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5H0

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 25
GO:0006811 monoatomic ion transport 4 3
GO:0006820 monoatomic anion transport 5 3
GO:0006835 dicarboxylic acid transport 7 3
GO:0009987 cellular process 1 25
GO:0015711 organic anion transport 5 3
GO:0015849 organic acid transport 5 3
GO:0015884 folic acid transport 5 3
GO:0034220 monoatomic ion transmembrane transport 3 3
GO:0035461 vitamin transmembrane transport 3 3
GO:0042886 amide transport 5 3
GO:0046942 carboxylic acid transport 6 3
GO:0051179 localization 1 25
GO:0051180 vitamin transport 4 3
GO:0051234 establishment of localization 2 25
GO:0055085 transmembrane transport 2 25
GO:0071702 organic substance transport 4 25
GO:0071705 nitrogen compound transport 4 25
GO:0072337 modified amino acid transport 5 3
GO:0098656 monoatomic anion transmembrane transport 4 3
GO:0098838 folate transmembrane transport 4 3
GO:1903825 organic acid transmembrane transport 3 3
GO:1904947 folate import into mitochondrion 4 3
GO:1905039 carboxylic acid transmembrane transport 4 3
GO:1990542 mitochondrial transmembrane transport 3 3
GO:0006862 nucleotide transport 6 22
GO:0015748 organophosphate ester transport 5 22
GO:0015931 nucleobase-containing compound transport 5 22
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 3
GO:0005342 organic acid transmembrane transporter activity 3 3
GO:0008509 monoatomic anion transmembrane transporter activity 4 3
GO:0008514 organic anion transmembrane transporter activity 5 3
GO:0008517 folic acid transmembrane transporter activity 4 3
GO:0015075 monoatomic ion transmembrane transporter activity 3 3
GO:0015215 nucleotide transmembrane transporter activity 4 3
GO:0015230 FAD transmembrane transporter activity 5 3
GO:0015605 organophosphate ester transmembrane transporter activity 3 3
GO:0015932 nucleobase-containing compound transmembrane transporter activity 3 3
GO:0022857 transmembrane transporter activity 2 3
GO:0042887 amide transmembrane transporter activity 3 3
GO:0046943 carboxylic acid transmembrane transporter activity 4 3
GO:0072349 modified amino acid transmembrane transporter activity 3 3
GO:0090482 vitamin transmembrane transporter activity 3 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 42 46 PF00656 0.204
CLV_MEL_PAP_1 143 149 PF00089 0.265
CLV_NRD_NRD_1 100 102 PF00675 0.310
CLV_NRD_NRD_1 113 115 PF00675 0.430
CLV_NRD_NRD_1 238 240 PF00675 0.534
CLV_PCSK_KEX2_1 100 102 PF00082 0.426
CLV_PCSK_KEX2_1 112 114 PF00082 0.402
CLV_PCSK_KEX2_1 238 240 PF00082 0.618
CLV_PCSK_PC1ET2_1 112 114 PF00082 0.444
CLV_PCSK_SKI1_1 255 259 PF00082 0.304
CLV_PCSK_SKI1_1 285 289 PF00082 0.292
CLV_PCSK_SKI1_1 317 321 PF00082 0.348
CLV_PCSK_SKI1_1 4 8 PF00082 0.353
DEG_APCC_DBOX_1 284 292 PF00400 0.470
DOC_CYCLIN_yCln2_LP_2 30 36 PF00134 0.351
DOC_MAPK_gen_1 238 244 PF00069 0.457
DOC_MAPK_HePTP_8 235 249 PF00069 0.204
DOC_PP1_RVXF_1 36 42 PF00149 0.309
DOC_PP2B_LxvP_1 216 219 PF13499 0.240
DOC_PP4_FxxP_1 126 129 PF00568 0.526
DOC_PP4_FxxP_1 222 225 PF00568 0.306
DOC_PP4_FxxP_1 6 9 PF00568 0.519
DOC_USP7_MATH_1 116 120 PF00917 0.644
DOC_WW_Pin1_4 128 133 PF00397 0.502
LIG_14-3-3_CanoR_1 100 106 PF00244 0.567
LIG_14-3-3_CanoR_1 125 129 PF00244 0.689
LIG_14-3-3_CanoR_1 185 191 PF00244 0.326
LIG_14-3-3_CanoR_1 208 216 PF00244 0.234
LIG_Actin_WH2_2 316 332 PF00022 0.413
LIG_APCC_ABBA_1 321 326 PF00400 0.416
LIG_BIR_II_1 1 5 PF00653 0.668
LIG_FHA_1 154 160 PF00498 0.341
LIG_FHA_1 178 184 PF00498 0.330
LIG_FHA_1 198 204 PF00498 0.249
LIG_FHA_1 24 30 PF00498 0.281
LIG_FHA_1 252 258 PF00498 0.285
LIG_FHA_1 277 283 PF00498 0.392
LIG_FHA_2 102 108 PF00498 0.469
LIG_FHA_2 40 46 PF00498 0.204
LIG_LIR_Apic_2 124 129 PF02991 0.533
LIG_LIR_Apic_2 3 9 PF02991 0.531
LIG_LIR_Gen_1 139 147 PF02991 0.527
LIG_LIR_Gen_1 318 328 PF02991 0.383
LIG_LIR_Nem_3 139 143 PF02991 0.499
LIG_LIR_Nem_3 205 210 PF02991 0.308
LIG_LIR_Nem_3 281 287 PF02991 0.432
LIG_LIR_Nem_3 318 323 PF02991 0.187
LIG_LIR_Nem_3 56 60 PF02991 0.206
LIG_PCNA_PIPBox_1 297 306 PF02747 0.353
LIG_PCNA_yPIPBox_3 292 304 PF02747 0.353
LIG_Pex14_2 320 324 PF04695 0.166
LIG_REV1ctd_RIR_1 75 83 PF16727 0.413
LIG_SH2_CRK 227 231 PF00017 0.297
LIG_SH2_CRK 57 61 PF00017 0.243
LIG_SH2_CRK 95 99 PF00017 0.318
LIG_SH2_STAP1 136 140 PF00017 0.467
LIG_SH2_STAP1 325 329 PF00017 0.236
LIG_SH2_STAT3 99 102 PF00017 0.501
LIG_SH2_STAT5 97 100 PF00017 0.306
LIG_SH3_3 126 132 PF00018 0.515
LIG_SH3_3 157 163 PF00018 0.327
LIG_SH3_3 258 264 PF00018 0.166
LIG_SUMO_SIM_anti_2 241 246 PF11976 0.285
LIG_SUMO_SIM_par_1 264 270 PF11976 0.347
LIG_WRC_WIRS_1 187 192 PF05994 0.263
LIG_WRC_WIRS_1 284 289 PF05994 0.455
MOD_CK1_1 121 127 PF00069 0.683
MOD_CK1_1 154 160 PF00069 0.307
MOD_CK1_1 177 183 PF00069 0.289
MOD_CK1_1 251 257 PF00069 0.307
MOD_CK2_1 101 107 PF00069 0.591
MOD_GlcNHglycan 118 121 PF01048 0.452
MOD_GlcNHglycan 156 159 PF01048 0.342
MOD_GlcNHglycan 174 179 PF01048 0.438
MOD_GlcNHglycan 210 213 PF01048 0.438
MOD_GSK3_1 124 131 PF00069 0.672
MOD_GSK3_1 147 154 PF00069 0.321
MOD_GSK3_1 194 201 PF00069 0.258
MOD_GSK3_1 283 290 PF00069 0.461
MOD_GSK3_1 307 314 PF00069 0.295
MOD_GSK3_1 40 47 PF00069 0.238
MOD_GSK3_1 81 88 PF00069 0.417
MOD_NEK2_1 14 19 PF00069 0.273
MOD_NEK2_1 147 152 PF00069 0.313
MOD_NEK2_1 166 171 PF00069 0.251
MOD_NEK2_1 194 199 PF00069 0.237
MOD_NEK2_1 226 231 PF00069 0.266
MOD_NEK2_1 287 292 PF00069 0.455
MOD_NEK2_1 311 316 PF00069 0.318
MOD_PIKK_1 17 23 PF00454 0.313
MOD_PIKK_1 40 46 PF00454 0.228
MOD_PKA_2 124 130 PF00069 0.692
MOD_PKA_2 304 310 PF00069 0.514
MOD_PKA_2 39 45 PF00069 0.217
MOD_PKB_1 38 46 PF00069 0.225
MOD_Plk_1 240 246 PF00069 0.274
MOD_Plk_4 240 246 PF00069 0.254
MOD_Plk_4 25 31 PF00069 0.275
MOD_ProDKin_1 128 134 PF00069 0.498
TRG_ENDOCYTIC_2 227 230 PF00928 0.236
TRG_ENDOCYTIC_2 284 287 PF00928 0.443
TRG_ENDOCYTIC_2 325 328 PF00928 0.248
TRG_ENDOCYTIC_2 57 60 PF00928 0.251
TRG_ENDOCYTIC_2 95 98 PF00928 0.318
TRG_ER_diArg_1 237 239 PF00400 0.426
TRG_ER_diArg_1 37 40 PF00400 0.249
TRG_ER_diArg_1 99 101 PF00400 0.438

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P2Z6 Leptomonas seymouri 24% 94%
A0A0N0P4V4 Leptomonas seymouri 27% 95%
A0A0N0P7T5 Leptomonas seymouri 23% 100%
A0A0N0P7X0 Leptomonas seymouri 24% 100%
A0A0N0P7Y4 Leptomonas seymouri 22% 100%
A0A0N0P8W6 Leptomonas seymouri 21% 99%
A0A0N1IMP5 Leptomonas seymouri 68% 100%
A0A0N1PFJ3 Leptomonas seymouri 39% 93%
A0A0S4IZG7 Bodo saltans 21% 97%
A0A0S4J045 Bodo saltans 24% 95%
A0A0S4J9F4 Bodo saltans 42% 100%
A0A0S4JHC1 Bodo saltans 27% 97%
A0A1D6N272 Zea mays 24% 100%
A0A1X0NTK9 Trypanosomatidae 21% 100%
A0A1X0NUM8 Trypanosomatidae 42% 100%
A0A1X0NUU7 Trypanosomatidae 50% 100%
A0A1X0P6S2 Trypanosomatidae 31% 100%
A0A1X0PA63 Trypanosomatidae 24% 87%
A0A3Q8I9Y9 Leishmania donovani 22% 100%
A0A3Q8IFU6 Leishmania donovani 89% 100%
A0A3Q8IIC0 Leishmania donovani 22% 100%
A0A3Q8IKX9 Leishmania donovani 41% 100%
A0A3R7LCB2 Trypanosoma rangeli 49% 100%
A0A3R7P246 Trypanosoma rangeli 41% 100%
A0A3S5H800 Leishmania donovani 25% 93%
A0A3S7WVJ8 Leishmania donovani 26% 98%
A0A3S7WYS1 Leishmania donovani 25% 100%
A0A422N763 Trypanosoma rangeli 29% 99%
A4H7Y2 Leishmania braziliensis 23% 100%
A4HA67 Leishmania braziliensis 25% 98%
A4HDW8 Leishmania braziliensis 22% 100%
A4HK93 Leishmania braziliensis 40% 92%
A4HK94 Leishmania braziliensis 76% 100%
A4HN00 Leishmania braziliensis 25% 93%
A4HN69 Leishmania braziliensis 28% 100%
A4HWA9 Leishmania infantum 22% 100%
A4HYC8 Leishmania infantum 26% 98%
A4I163 Leishmania infantum 25% 100%
A4I7S8 Leishmania infantum 41% 100%
A4I7S9 Leishmania infantum 89% 100%
A4IBM3 Leishmania infantum 24% 93%
A4IBT7 Leishmania infantum 22% 100%
B0G159 Dictyostelium discoideum 24% 71%
B4F8I5 Zea mays 24% 100%
B4FIJ0 Zea mays 24% 100%
C9ZM27 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 24% 88%
C9ZNU5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 23% 100%
C9ZYS8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 24% 100%
C9ZZ11 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 26% 100%
D0A9Y8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 40% 97%
D0A9Z0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 44% 99%
E8NHL5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 93%
E9ACE1 Leishmania major 22% 100%
E9AFF7 Leishmania major 26% 100%
E9AFM4 Leishmania major 24% 100%
E9AQ09 Leishmania mexicana (strain MHOM/GT/2001/U1103) 21% 100%
E9AS62 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 98%
E9AX97 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 100%
E9B0N4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 100%
E9B2N6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 40% 100%
E9B2N7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 100%
E9B6S7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 24% 100%
F1RFX9 Sus scrofa 24% 100%
O04200 Arabidopsis thaliana 26% 100%
O04619 Arabidopsis thaliana 22% 96%
O13660 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 22% 100%
O22261 Arabidopsis thaliana 24% 100%
O43808 Homo sapiens 23% 100%
O70579 Mus musculus 23% 100%
O95258 Homo sapiens 25% 100%
P0CAT2 Danio rerio 23% 100%
P22292 Bos taurus 25% 100%
P32332 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 20% 100%
P39953 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 25% 100%
P40464 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 24% 100%
P40556 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 22% 90%
P90992 Caenorhabditis elegans 21% 100%
P97700 Rattus norvegicus 24% 100%
Q02978 Homo sapiens 24% 100%
Q08CI8 Danio rerio 24% 100%
Q08DK7 Bos taurus 24% 100%
Q09461 Caenorhabditis elegans 22% 94%
Q1LZB3 Bos taurus 22% 100%
Q287T7 Danio rerio 22% 100%
Q29RM1 Bos taurus 21% 100%
Q3TZX3 Mus musculus 21% 100%
Q4Q5H1 Leishmania major 41% 100%
Q4QA75 Leishmania major 25% 100%
Q4QDA4 Leishmania major 25% 98%
Q4QFH2 Leishmania major 21% 100%
Q505J6 Rattus norvegicus 21% 100%
Q54EV4 Dictyostelium discoideum 22% 100%
Q54FU9 Dictyostelium discoideum 21% 100%
Q54QN2 Dictyostelium discoideum 24% 100%
Q552L9 Dictyostelium discoideum 23% 92%
Q5NVC1 Pongo abelii 21% 100%
Q5PQM9 Rattus norvegicus 26% 100%
Q5SVS4 Homo sapiens 25% 100%
Q5XGI1 Xenopus tropicalis 24% 100%
Q5XHA0 Xenopus tropicalis 22% 71%
Q5ZKP7 Gallus gallus 22% 100%
Q66L49 Danio rerio 21% 71%
Q6DG32 Danio rerio 23% 100%
Q6GQ22 Xenopus laevis 24% 100%
Q6IZB5 Cricetulus griseus 23% 100%
Q6P036 Danio rerio 24% 100%
Q75A82 Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) 22% 99%
Q76P23 Dictyostelium discoideum 21% 100%
Q7K566 Drosophila melanogaster 25% 100%
Q7XA87 Arabidopsis thaliana 28% 100%
Q86AV5 Dictyostelium discoideum 21% 100%
Q86I81 Dictyostelium discoideum 21% 100%
Q8BMG8 Mus musculus 24% 100%
Q8BW66 Mus musculus 22% 100%
Q8HXE3 Macaca fascicularis 25% 100%
Q8R0Z5 Mus musculus 22% 93%
Q8RWA5 Arabidopsis thaliana 22% 93%
Q8RXZ9 Arabidopsis thaliana 24% 100%
Q922G0 Mus musculus 23% 100%
Q944H5 Arabidopsis thaliana 24% 82%
Q95J75 Macaca fascicularis 24% 100%
Q96A46 Homo sapiens 23% 93%
Q96CQ1 Homo sapiens 23% 100%
Q9BSK2 Homo sapiens 22% 100%
Q9CR58 Mus musculus 26% 100%
Q9CR62 Mus musculus 25% 100%
Q9DB41 Mus musculus 21% 100%
Q9FI43 Arabidopsis thaliana 23% 69%
Q9FI73 Arabidopsis thaliana 24% 99%
Q9GMZ1 Canis lupus familiaris 23% 100%
Q9H2D1 Homo sapiens 23% 100%
Q9HC21 Homo sapiens 22% 100%
Q9P6L7 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 23% 93%
Q9SUV1 Arabidopsis thaliana 20% 86%
Q9VQ37 Drosophila melanogaster 23% 92%
Q9Z2B2 Mus musculus 26% 100%
Q9ZWG1 Arabidopsis thaliana 23% 100%
V5B150 Trypanosoma cruzi 46% 100%
V5BDR1 Trypanosoma cruzi 24% 100%
V5BGM6 Trypanosoma cruzi 43% 100%
V5BKU8 Trypanosoma cruzi 23% 88%
V5BTA6 Trypanosoma cruzi 26% 100%
V5BTE8 Trypanosoma cruzi 30% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS