LeishMANIAdb
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Kinetoplast polyadenylation/uridylation factor 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Kinetoplast polyadenylation/uridylation factor 2
Gene product:
kinetoplast polyadenylation/uridylation factor 2, putative
Species:
Leishmania major
UniProt:
Q4Q5G8_LEIMA
TriTrypDb:
LmjF.32.1140 , LMJLV39_320017300 * , LMJSD75_320017300 *
Length:
684

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 2
GO:0005739 mitochondrion 5 2
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2
GO:0110165 cellular anatomical entity 1 2

Expansion

Sequence features

Q4Q5G8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5G8

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 2
GO:0006378 mRNA polyadenylation 7 2
GO:0006396 RNA processing 6 2
GO:0006397 mRNA processing 7 2
GO:0006725 cellular aromatic compound metabolic process 3 2
GO:0006807 nitrogen compound metabolic process 2 2
GO:0008152 metabolic process 1 2
GO:0009894 regulation of catabolic process 4 2
GO:0009987 cellular process 1 2
GO:0010468 regulation of gene expression 5 2
GO:0010608 post-transcriptional regulation of gene expression 6 2
GO:0016070 RNA metabolic process 5 2
GO:0016071 mRNA metabolic process 6 2
GO:0019219 regulation of nucleobase-containing compound metabolic process 5 2
GO:0019222 regulation of metabolic process 3 2
GO:0031123 RNA 3'-end processing 7 2
GO:0031124 mRNA 3'-end processing 8 2
GO:0031323 regulation of cellular metabolic process 4 2
GO:0031329 regulation of cellular catabolic process 5 2
GO:0034641 cellular nitrogen compound metabolic process 3 2
GO:0043170 macromolecule metabolic process 3 2
GO:0043487 regulation of RNA stability 3 2
GO:0043488 regulation of mRNA stability 4 2
GO:0043631 RNA polyadenylation 6 2
GO:0044237 cellular metabolic process 2 2
GO:0044238 primary metabolic process 2 2
GO:0046483 heterocycle metabolic process 3 2
GO:0050789 regulation of biological process 2 2
GO:0050794 regulation of cellular process 3 2
GO:0051171 regulation of nitrogen compound metabolic process 4 2
GO:0051252 regulation of RNA metabolic process 5 2
GO:0060255 regulation of macromolecule metabolic process 4 2
GO:0061013 regulation of mRNA catabolic process 6 2
GO:0065007 biological regulation 1 2
GO:0065008 regulation of biological quality 2 2
GO:0071704 organic substance metabolic process 2 2
GO:0080090 regulation of primary metabolic process 4 2
GO:0090304 nucleic acid metabolic process 4 2
GO:1901360 organic cyclic compound metabolic process 3 2
GO:1903311 regulation of mRNA metabolic process 6 2
Molecular functions
Term Name Level Count
GO:0005488 binding 1 2
GO:0043021 ribonucleoprotein complex binding 3 2
GO:0043022 ribosome binding 4 2
GO:0044877 protein-containing complex binding 2 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 346 350 PF00656 0.760
CLV_NRD_NRD_1 100 102 PF00675 0.624
CLV_NRD_NRD_1 183 185 PF00675 0.462
CLV_NRD_NRD_1 268 270 PF00675 0.498
CLV_NRD_NRD_1 312 314 PF00675 0.552
CLV_NRD_NRD_1 322 324 PF00675 0.522
CLV_NRD_NRD_1 381 383 PF00675 0.456
CLV_NRD_NRD_1 653 655 PF00675 0.555
CLV_PCSK_KEX2_1 100 102 PF00082 0.730
CLV_PCSK_KEX2_1 268 270 PF00082 0.568
CLV_PCSK_KEX2_1 322 324 PF00082 0.562
CLV_PCSK_KEX2_1 335 337 PF00082 0.648
CLV_PCSK_KEX2_1 381 383 PF00082 0.456
CLV_PCSK_KEX2_1 653 655 PF00082 0.484
CLV_PCSK_PC1ET2_1 335 337 PF00082 0.436
CLV_PCSK_SKI1_1 139 143 PF00082 0.602
CLV_PCSK_SKI1_1 184 188 PF00082 0.532
CLV_PCSK_SKI1_1 227 231 PF00082 0.420
CLV_PCSK_SKI1_1 296 300 PF00082 0.613
DEG_APCC_DBOX_1 106 114 PF00400 0.634
DEG_APCC_DBOX_1 183 191 PF00400 0.563
DEG_Nend_UBRbox_2 1 3 PF02207 0.598
DOC_ANK_TNKS_1 321 328 PF00023 0.600
DOC_CYCLIN_RxL_1 221 231 PF00134 0.378
DOC_MAPK_gen_1 322 330 PF00069 0.562
DOC_MAPK_gen_1 391 401 PF00069 0.533
DOC_USP7_MATH_1 161 165 PF00917 0.741
DOC_USP7_MATH_1 35 39 PF00917 0.697
DOC_USP7_MATH_1 383 387 PF00917 0.561
DOC_USP7_MATH_1 41 45 PF00917 0.625
DOC_USP7_MATH_1 492 496 PF00917 0.482
DOC_USP7_MATH_1 51 55 PF00917 0.563
DOC_USP7_MATH_1 550 554 PF00917 0.722
DOC_USP7_MATH_1 632 636 PF00917 0.666
DOC_USP7_MATH_1 66 70 PF00917 0.751
DOC_USP7_MATH_1 73 77 PF00917 0.830
DOC_USP7_UBL2_3 304 308 PF12436 0.325
DOC_WW_Pin1_4 350 355 PF00397 0.677
DOC_WW_Pin1_4 556 561 PF00397 0.735
DOC_WW_Pin1_4 69 74 PF00397 0.687
DOC_WW_Pin1_4 78 83 PF00397 0.809
LIG_14-3-3_CanoR_1 107 111 PF00244 0.600
LIG_14-3-3_CanoR_1 167 172 PF00244 0.613
LIG_14-3-3_CanoR_1 240 245 PF00244 0.512
LIG_14-3-3_CanoR_1 268 273 PF00244 0.563
LIG_14-3-3_CanoR_1 276 282 PF00244 0.628
LIG_14-3-3_CanoR_1 322 330 PF00244 0.484
LIG_14-3-3_CanoR_1 382 392 PF00244 0.563
LIG_14-3-3_CanoR_1 511 519 PF00244 0.522
LIG_14-3-3_CanoR_1 540 548 PF00244 0.694
LIG_14-3-3_CanoR_1 569 574 PF00244 0.529
LIG_14-3-3_CanoR_1 634 644 PF00244 0.560
LIG_14-3-3_CanoR_1 8 14 PF00244 0.685
LIG_14-3-3_CterR_2 681 684 PF00244 0.622
LIG_APCC_ABBA_1 646 651 PF00400 0.436
LIG_BIR_III_2 79 83 PF00653 0.708
LIG_BRCT_BRCA1_1 176 180 PF00533 0.524
LIG_BRCT_BRCA1_1 55 59 PF00533 0.682
LIG_deltaCOP1_diTrp_1 120 130 PF00928 0.499
LIG_FHA_1 129 135 PF00498 0.564
LIG_FHA_1 35 41 PF00498 0.665
LIG_FHA_1 387 393 PF00498 0.451
LIG_FHA_1 497 503 PF00498 0.414
LIG_FHA_1 519 525 PF00498 0.470
LIG_FHA_1 576 582 PF00498 0.397
LIG_FHA_1 608 614 PF00498 0.429
LIG_FHA_1 661 667 PF00498 0.480
LIG_FHA_2 344 350 PF00498 0.773
LIG_FHA_2 362 368 PF00498 0.420
LIG_FHA_2 424 430 PF00498 0.522
LIG_FHA_2 450 456 PF00498 0.812
LIG_FHA_2 471 477 PF00498 0.472
LIG_FHA_2 531 537 PF00498 0.578
LIG_LIR_Gen_1 177 188 PF02991 0.503
LIG_LIR_Gen_1 2 9 PF02991 0.589
LIG_LIR_Gen_1 239 250 PF02991 0.415
LIG_LIR_Gen_1 407 415 PF02991 0.500
LIG_LIR_Gen_1 501 510 PF02991 0.387
LIG_LIR_Gen_1 514 524 PF02991 0.383
LIG_LIR_Gen_1 578 586 PF02991 0.386
LIG_LIR_Nem_3 177 183 PF02991 0.497
LIG_LIR_Nem_3 2 6 PF02991 0.609
LIG_LIR_Nem_3 248 253 PF02991 0.494
LIG_LIR_Nem_3 375 379 PF02991 0.428
LIG_LIR_Nem_3 407 411 PF02991 0.464
LIG_LIR_Nem_3 473 478 PF02991 0.569
LIG_LIR_Nem_3 501 506 PF02991 0.440
LIG_LIR_Nem_3 514 519 PF02991 0.340
LIG_LIR_Nem_3 578 582 PF02991 0.397
LIG_LIR_Nem_3 593 599 PF02991 0.351
LIG_NRBOX 505 511 PF00104 0.489
LIG_PTB_Apo_2 414 421 PF02174 0.443
LIG_PTB_Phospho_1 414 420 PF10480 0.442
LIG_RPA_C_Fungi 317 329 PF08784 0.561
LIG_SH2_CRK 408 412 PF00017 0.456
LIG_SH2_PTP2 420 423 PF00017 0.577
LIG_SH2_STAP1 408 412 PF00017 0.456
LIG_SH2_STAP1 579 583 PF00017 0.386
LIG_SH2_STAP1 599 603 PF00017 0.210
LIG_SH2_STAP1 614 618 PF00017 0.438
LIG_SH2_STAT3 108 111 PF00017 0.569
LIG_SH2_STAT3 588 591 PF00017 0.524
LIG_SH2_STAT5 223 226 PF00017 0.388
LIG_SH2_STAT5 420 423 PF00017 0.505
LIG_SH2_STAT5 508 511 PF00017 0.500
LIG_SH2_STAT5 588 591 PF00017 0.488
LIG_SH3_2 95 100 PF14604 0.592
LIG_SH3_3 138 144 PF00018 0.639
LIG_SH3_3 189 195 PF00018 0.598
LIG_SH3_3 278 284 PF00018 0.701
LIG_SH3_3 79 85 PF00018 0.607
LIG_SH3_3 92 98 PF00018 0.645
LIG_SUMO_SIM_anti_2 562 567 PF11976 0.529
LIG_SUMO_SIM_anti_2 615 620 PF11976 0.564
LIG_SUMO_SIM_par_1 615 620 PF11976 0.537
LIG_TRAF2_2 192 197 PF00917 0.663
LIG_TYR_ITIM 406 411 PF00017 0.541
LIG_UBA3_1 298 304 PF00899 0.545
LIG_UBA3_1 395 403 PF00899 0.608
LIG_UBA3_1 506 513 PF00899 0.460
LIG_WRC_WIRS_1 659 664 PF05994 0.554
LIG_WW_3 190 194 PF00397 0.652
MOD_CDC14_SPxK_1 72 75 PF00782 0.577
MOD_CDK_SPxK_1 69 75 PF00069 0.575
MOD_CK1_1 170 176 PF00069 0.580
MOD_CK1_1 203 209 PF00069 0.617
MOD_CK1_1 289 295 PF00069 0.608
MOD_CK1_1 386 392 PF00069 0.471
MOD_CK1_1 459 465 PF00069 0.729
MOD_CK1_1 559 565 PF00069 0.608
MOD_CK1_1 635 641 PF00069 0.580
MOD_CK1_1 69 75 PF00069 0.790
MOD_CK2_1 170 176 PF00069 0.623
MOD_CK2_1 361 367 PF00069 0.638
MOD_CK2_1 423 429 PF00069 0.608
MOD_CK2_1 449 455 PF00069 0.644
MOD_CK2_1 470 476 PF00069 0.508
MOD_CK2_1 51 57 PF00069 0.671
MOD_CK2_1 530 536 PF00069 0.527
MOD_CMANNOS 570 573 PF00535 0.575
MOD_GlcNHglycan 131 134 PF01048 0.445
MOD_GlcNHglycan 154 157 PF01048 0.713
MOD_GlcNHglycan 247 250 PF01048 0.463
MOD_GlcNHglycan 37 40 PF01048 0.724
MOD_GlcNHglycan 43 46 PF01048 0.695
MOD_GlcNHglycan 458 461 PF01048 0.799
MOD_GlcNHglycan 467 471 PF01048 0.680
MOD_GlcNHglycan 47 50 PF01048 0.672
MOD_GlcNHglycan 494 497 PF01048 0.501
MOD_GlcNHglycan 550 553 PF01048 0.675
MOD_GlcNHglycan 633 637 PF01048 0.554
MOD_GlcNHglycan 68 71 PF01048 0.764
MOD_GSK3_1 161 168 PF00069 0.753
MOD_GSK3_1 170 177 PF00069 0.657
MOD_GSK3_1 286 293 PF00069 0.638
MOD_GSK3_1 382 389 PF00069 0.444
MOD_GSK3_1 41 48 PF00069 0.662
MOD_GSK3_1 437 444 PF00069 0.671
MOD_GSK3_1 456 463 PF00069 0.802
MOD_GSK3_1 466 473 PF00069 0.628
MOD_GSK3_1 492 499 PF00069 0.549
MOD_GSK3_1 635 642 PF00069 0.519
MOD_GSK3_1 654 661 PF00069 0.409
MOD_GSK3_1 670 677 PF00069 0.581
MOD_GSK3_1 69 76 PF00069 0.773
MOD_N-GLC_1 171 176 PF02516 0.634
MOD_N-GLC_1 654 659 PF02516 0.362
MOD_NEK2_1 129 134 PF00069 0.406
MOD_NEK2_1 215 220 PF00069 0.449
MOD_NEK2_1 245 250 PF00069 0.503
MOD_NEK2_1 267 272 PF00069 0.573
MOD_NEK2_1 288 293 PF00069 0.608
MOD_NEK2_1 468 473 PF00069 0.607
MOD_NEK2_1 602 607 PF00069 0.491
MOD_NEK2_1 662 667 PF00069 0.532
MOD_PIKK_1 437 443 PF00454 0.733
MOD_PK_1 167 173 PF00069 0.500
MOD_PK_1 240 246 PF00069 0.560
MOD_PKA_1 268 274 PF00069 0.531
MOD_PKA_2 106 112 PF00069 0.614
MOD_PKA_2 197 203 PF00069 0.675
MOD_PKA_2 215 221 PF00069 0.360
MOD_PKA_2 267 273 PF00069 0.516
MOD_PKA_2 321 327 PF00069 0.512
MOD_PKA_2 343 349 PF00069 0.756
MOD_PKA_2 383 389 PF00069 0.544
MOD_PKA_2 539 545 PF00069 0.651
MOD_PKA_2 568 574 PF00069 0.535
MOD_PKA_2 7 13 PF00069 0.686
MOD_PKB_1 674 682 PF00069 0.585
MOD_Plk_1 256 262 PF00069 0.484
MOD_Plk_4 407 413 PF00069 0.497
MOD_Plk_4 518 524 PF00069 0.498
MOD_Plk_4 561 567 PF00069 0.570
MOD_Plk_4 640 646 PF00069 0.559
MOD_ProDKin_1 350 356 PF00069 0.676
MOD_ProDKin_1 556 562 PF00069 0.727
MOD_ProDKin_1 69 75 PF00069 0.692
MOD_ProDKin_1 78 84 PF00069 0.804
TRG_DiLeu_BaEn_1 505 510 PF01217 0.481
TRG_DiLeu_BaEn_2 175 181 PF01217 0.452
TRG_ENDOCYTIC_2 222 225 PF00928 0.375
TRG_ENDOCYTIC_2 408 411 PF00928 0.429
TRG_ENDOCYTIC_2 579 582 PF00928 0.397
TRG_ENDOCYTIC_2 599 602 PF00928 0.202
TRG_ENDOCYTIC_2 614 617 PF00928 0.329
TRG_ENDOCYTIC_2 649 652 PF00928 0.424
TRG_ER_diArg_1 267 269 PF00400 0.562
TRG_ER_diArg_1 380 382 PF00400 0.451
TRG_ER_diArg_1 585 588 PF00400 0.509
TRG_ER_diArg_1 652 654 PF00400 0.536
TRG_ER_diArg_1 99 101 PF00400 0.775
TRG_NES_CRM1_1 390 404 PF08389 0.533
TRG_Pf-PMV_PEXEL_1 227 231 PF00026 0.501
TRG_Pf-PMV_PEXEL_1 286 290 PF00026 0.622
TRG_Pf-PMV_PEXEL_1 300 305 PF00026 0.465

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PGR3 Leptomonas seymouri 48% 91%
A0A1X0NVZ4 Trypanosomatidae 33% 100%
A0A3Q8IG45 Leishmania donovani 88% 100%
A0A3R7NTQ6 Trypanosoma rangeli 32% 100%
A4HKA1 Leishmania braziliensis 68% 90%
A4I7T1 Leishmania infantum 88% 100%
D0A9Z2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 31% 100%
E9B2N9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 83% 99%
V5BQR4 Trypanosoma cruzi 29% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS