Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q5G7_LEIMA

TriTrypDb:

LmjF.32.1150 , LMJLV39_320017400 , LMJSD75_320017400

Length:

305

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q5G7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5G7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	218	222	PF00082	0.621
DEG_SPOP_SBC_1	87	91	PF00917	0.432
DOC_MAPK_gen_1	74	81	PF00069	0.405
DOC_MAPK_RevD_3	235	250	PF00069	0.472
DOC_PP1_RVXF_1	160	166	PF00149	0.388
DOC_PP1_RVXF_1	241	248	PF00149	0.378
DOC_PP4_FxxP_1	30	33	PF00568	0.440
DOC_USP7_MATH_1	2	6	PF00917	0.696
DOC_USP7_MATH_1	87	91	PF00917	0.522
DOC_USP7_MATH_2	124	130	PF00917	0.390
DOC_WW_Pin1_4	238	243	PF00397	0.481
LIG_14-3-3_CanoR_1	14	21	PF00244	0.473
LIG_14-3-3_CanoR_1	52	61	PF00244	0.375
LIG_Actin_WH2_2	245	261	PF00022	0.385
LIG_APCC_ABBA_1	65	70	PF00400	0.349
LIG_BIR_II_1	1	5	PF00653	0.594
LIG_BIR_III_1	1	5	PF00653	0.463
LIG_BIR_III_3	1	5	PF00653	0.463
LIG_BRCT_BRCA1_1	129	133	PF00533	0.359
LIG_Clathr_ClatBox_1	286	290	PF01394	0.413
LIG_deltaCOP1_diTrp_1	226	235	PF00928	0.458
LIG_FHA_1	150	156	PF00498	0.361
LIG_FHA_1	219	225	PF00498	0.543
LIG_FHA_1	232	238	PF00498	0.307
LIG_FHA_2	194	200	PF00498	0.663
LIG_FHA_2	205	211	PF00498	0.692
LIG_FHA_2	221	227	PF00498	0.360
LIG_FHA_2	286	292	PF00498	0.566
LIG_FHA_2	52	58	PF00498	0.493
LIG_FHA_2	89	95	PF00498	0.534
LIG_GBD_Chelix_1	104	112	PF00786	0.393
LIG_LIR_Apic_2	27	33	PF02991	0.504
LIG_LIR_Gen_1	102	109	PF02991	0.446
LIG_LIR_Nem_3	102	106	PF02991	0.458
LIG_LIR_Nem_3	226	232	PF02991	0.417
LIG_LIR_Nem_3	254	258	PF02991	0.499
LIG_LIR_Nem_3	73	79	PF02991	0.352
LIG_MYND_1	142	146	PF01753	0.491
LIG_PDZ_Class_1	300	305	PF00595	0.486
LIG_Pex14_2	133	137	PF04695	0.322
LIG_REV1ctd_RIR_1	79	86	PF16727	0.425
LIG_SH2_CRK	21	25	PF00017	0.403
LIG_SH2_CRK	26	30	PF00017	0.452
LIG_SH2_STAP1	26	30	PF00017	0.344
LIG_SH2_STAT5	269	272	PF00017	0.301
LIG_SH2_STAT5	78	81	PF00017	0.425
LIG_SH3_1	250	256	PF00018	0.484
LIG_SH3_3	250	256	PF00018	0.496
LIG_TYR_ITIM	24	29	PF00017	0.255
LIG_UBA3_1	236	243	PF00899	0.263
LIG_WRC_WIRS_1	155	160	PF05994	0.302
LIG_WRC_WIRS_1	232	237	PF05994	0.402
LIG_WRC_WIRS_1	78	83	PF05994	0.362
MOD_CDK_SPK_2	238	243	PF00069	0.452
MOD_CK1_1	187	193	PF00069	0.580
MOD_CK2_1	193	199	PF00069	0.660
MOD_CK2_1	204	210	PF00069	0.741
MOD_CK2_1	220	226	PF00069	0.374
MOD_CK2_1	238	244	PF00069	0.428
MOD_CK2_1	285	291	PF00069	0.538
MOD_GlcNHglycan	186	189	PF01048	0.602
MOD_GlcNHglycan	218	221	PF01048	0.580
MOD_GlcNHglycan	54	57	PF01048	0.501
MOD_GSK3_1	107	114	PF00069	0.388
MOD_GSK3_1	154	161	PF00069	0.309
MOD_GSK3_1	195	202	PF00069	0.725
MOD_GSK3_1	2	9	PF00069	0.568
MOD_GSK3_1	216	223	PF00069	0.652
MOD_N-GLC_1	170	175	PF02516	0.528
MOD_NEK2_1	12	17	PF00069	0.532
MOD_NEK2_1	158	163	PF00069	0.321
MOD_NEK2_1	236	241	PF00069	0.265
MOD_NEK2_1	278	283	PF00069	0.343
MOD_NEK2_2	220	225	PF00069	0.669
MOD_NEK2_2	77	82	PF00069	0.361
MOD_PIKK_1	107	113	PF00454	0.459
MOD_PKA_2	13	19	PF00069	0.421
MOD_PKA_2	51	57	PF00069	0.384
MOD_Plk_1	170	176	PF00069	0.488
MOD_Plk_1	279	285	PF00069	0.393
MOD_Plk_2-3	199	205	PF00069	0.707
MOD_Plk_4	154	160	PF00069	0.370
MOD_Plk_4	231	237	PF00069	0.251
MOD_Plk_4	6	12	PF00069	0.522
MOD_Plk_4	77	83	PF00069	0.334
MOD_ProDKin_1	238	244	PF00069	0.477
MOD_SUMO_rev_2	145	155	PF00179	0.352
MOD_SUMO_rev_2	183	188	PF00179	0.400
MOD_SUMO_rev_2	266	276	PF00179	0.411
MOD_SUMO_rev_2	70	76	PF00179	0.385
TRG_DiLeu_BaLyEn_6	139	144	PF01217	0.481
TRG_ENDOCYTIC_2	21	24	PF00928	0.403
TRG_ENDOCYTIC_2	26	29	PF00928	0.447
TRG_ENDOCYTIC_2	78	81	PF00928	0.440
TRG_ER_diArg_1	162	165	PF00400	0.539
TRG_Pf-PMV_PEXEL_1	222	226	PF00026	0.483

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9E0	Leptomonas seymouri	55%	100%
A0A0S4J915	Bodo saltans	31%	100%
A0A1X0NV05	Trypanosomatidae	36%	100%
A0A3R7N1Z4	Trypanosoma rangeli	37%	100%
A0A3S7X5F5	Leishmania donovani	87%	100%
A4HKA2	Leishmania braziliensis	69%	100%
A4I7T2	Leishmania infantum	88%	100%
D0A9Z3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9B2P0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
V5BGN1	Trypanosoma cruzi	40%	100%