Elongation of fatty acids protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

long chain polyunsaturated fatty acid elongation enzyme-like protein

Species:

Leishmania major

UniProt:

Q4Q5G6_LEIMA

TriTrypDb:

LmjF.32.1160 , LMJLV39_320017600 , LMJSD75_320017600

Length:

381

Annotations

LeishMANIAdb annotations

Related to ELOVL5 proteins found in multicellular animals. Probably also involved in very long chain fatty acid biosynthesis in ER.. Localization: ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

Q4Q5G6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5G6

Function

Biological processes
Term	Name	Level	Count
GO:0000038	very long-chain fatty acid metabolic process	5	2
GO:0006082	organic acid metabolic process	3	10
GO:0006629	lipid metabolic process	3	10
GO:0006631	fatty acid metabolic process	4	10
GO:0006633	fatty acid biosynthetic process	5	10
GO:0006643	membrane lipid metabolic process	4	2
GO:0006665	sphingolipid metabolic process	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	10
GO:0008610	lipid biosynthetic process	4	10
GO:0009058	biosynthetic process	2	10
GO:0009987	cellular process	1	10
GO:0016053	organic acid biosynthetic process	4	10
GO:0019367	fatty acid elongation, saturated fatty acid	7	2
GO:0019368	fatty acid elongation, unsaturated fatty acid	7	2
GO:0019752	carboxylic acid metabolic process	5	10
GO:0030148	sphingolipid biosynthetic process	5	2
GO:0030497	fatty acid elongation	6	2
GO:0032787	monocarboxylic acid metabolic process	6	10
GO:0034625	fatty acid elongation, monounsaturated fatty acid	8	2
GO:0034626	fatty acid elongation, polyunsaturated fatty acid	8	2
GO:0042761	very long-chain fatty acid biosynthetic process	6	2
GO:0043436	oxoacid metabolic process	4	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0044249	cellular biosynthetic process	3	10
GO:0044255	cellular lipid metabolic process	3	10
GO:0044281	small molecule metabolic process	2	10
GO:0044283	small molecule biosynthetic process	3	10
GO:0046394	carboxylic acid biosynthetic process	5	10
GO:0046467	membrane lipid biosynthetic process	4	2
GO:0071704	organic substance metabolic process	2	10
GO:0072330	monocarboxylic acid biosynthetic process	6	10
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901566	organonitrogen compound biosynthetic process	4	2
GO:1901576	organic substance biosynthetic process	3	10

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0004312	fatty acid synthase activity	5	10
GO:0009922	fatty acid elongase activity	6	10
GO:0016740	transferase activity	2	10
GO:0016746	acyltransferase activity	3	10
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	10
GO:0102756	very-long-chain 3-ketoacyl-CoA synthase activity	5	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	308	310	PF00675	0.467
CLV_NRD_NRD_1	361	363	PF00675	0.470
CLV_PCSK_KEX2_1	308	310	PF00082	0.420
CLV_PCSK_SKI1_1	149	153	PF00082	0.478
CLV_PCSK_SKI1_1	237	241	PF00082	0.261
DEG_MDM2_SWIB_1	192	200	PF02201	0.414
DOC_MAPK_gen_1	350	359	PF00069	0.527
DOC_MAPK_MEF2A_6	353	361	PF00069	0.535
DOC_MAPK_RevD_3	289	304	PF00069	0.339
DOC_PP1_RVXF_1	150	156	PF00149	0.261
DOC_PP1_RVXF_1	159	166	PF00149	0.315
DOC_PP1_RVXF_1	42	48	PF00149	0.360
DOC_PP2B_LxvP_1	200	203	PF13499	0.414
DOC_USP7_MATH_1	314	318	PF00917	0.673
DOC_USP7_MATH_1	324	328	PF00917	0.594
DOC_USP7_MATH_1	38	42	PF00917	0.326
DOC_WW_Pin1_4	141	146	PF00397	0.361
LIG_14-3-3_CanoR_1	59	64	PF00244	0.359
LIG_Actin_WH2_2	262	277	PF00022	0.422
LIG_BRCT_BRCA1_1	61	65	PF00533	0.343
LIG_CaMK_CASK_1	265	271	PF00069	0.456
LIG_CSL_BTD_1	267	270	PF09270	0.414
LIG_deltaCOP1_diTrp_1	147	155	PF00928	0.263
LIG_EH1_1	75	83	PF00400	0.364
LIG_eIF4E_1	120	126	PF01652	0.407
LIG_eIF4E_1	224	230	PF01652	0.342
LIG_FHA_1	103	109	PF00498	0.550
LIG_FHA_1	188	194	PF00498	0.397
LIG_FHA_1	88	94	PF00498	0.350
LIG_GBD_Chelix_1	108	116	PF00786	0.456
LIG_IRF3_LxIS_1	123	128	PF10401	0.414
LIG_LIR_Gen_1	118	127	PF02991	0.371
LIG_LIR_Gen_1	181	186	PF02991	0.351
LIG_LIR_Gen_1	206	217	PF02991	0.278
LIG_LIR_Gen_1	262	270	PF02991	0.430
LIG_LIR_Nem_3	118	123	PF02991	0.371
LIG_LIR_Nem_3	181	185	PF02991	0.315
LIG_LIR_Nem_3	262	267	PF02991	0.383
LIG_MYND_1	70	74	PF01753	0.332
LIG_PCNA_PIPBox_1	288	297	PF02747	0.371
LIG_Pex14_1	253	257	PF04695	0.456
LIG_Pex14_2	192	196	PF04695	0.339
LIG_Pex14_2	53	57	PF04695	0.356
LIG_PTB_Apo_2	299	306	PF02174	0.460
LIG_SH2_CRK	120	124	PF00017	0.400
LIG_SH2_CRK	177	181	PF00017	0.462
LIG_SH2_GRB2like	71	74	PF00017	0.328
LIG_SH2_SRC	71	74	PF00017	0.332
LIG_SH2_STAP1	209	213	PF00017	0.332
LIG_SH2_STAP1	264	268	PF00017	0.315
LIG_SH2_STAP1	276	280	PF00017	0.261
LIG_SH2_STAT5	158	161	PF00017	0.315
LIG_SH2_STAT5	225	228	PF00017	0.300
LIG_SH2_STAT5	71	74	PF00017	0.297
LIG_SH2_STAT5	84	87	PF00017	0.306
LIG_SH3_3	264	270	PF00018	0.419
LIG_SUMO_SIM_anti_2	167	174	PF11976	0.414
LIG_TRAF2_1	270	273	PF00917	0.306
LIG_TYR_ITIM	82	87	PF00017	0.456
LIG_UBA3_1	153	161	PF00899	0.339
LIG_UBA3_1	170	174	PF00899	0.341
MOD_CK1_1	102	108	PF00069	0.444
MOD_CK1_1	207	213	PF00069	0.456
MOD_CK2_1	141	147	PF00069	0.414
MOD_GlcNHglycan	127	130	PF01048	0.371
MOD_GlcNHglycan	209	212	PF01048	0.315
MOD_GlcNHglycan	214	217	PF01048	0.315
MOD_GlcNHglycan	23	26	PF01048	0.458
MOD_GlcNHglycan	232	235	PF01048	0.339
MOD_GlcNHglycan	261	264	PF01048	0.389
MOD_GlcNHglycan	276	279	PF01048	0.389
MOD_GlcNHglycan	316	319	PF01048	0.557
MOD_GlcNHglycan	33	36	PF01048	0.407
MOD_GSK3_1	115	122	PF00069	0.298
MOD_GSK3_1	27	34	PF00069	0.438
MOD_GSK3_1	320	327	PF00069	0.654
MOD_GSK3_1	83	90	PF00069	0.339
MOD_NEK2_1	119	124	PF00069	0.325
MOD_NEK2_1	125	130	PF00069	0.347
MOD_NEK2_1	157	162	PF00069	0.315
MOD_NEK2_1	21	26	PF00069	0.540
MOD_NEK2_1	212	217	PF00069	0.361
MOD_NEK2_1	245	250	PF00069	0.358
MOD_NEK2_1	27	32	PF00069	0.475
MOD_NEK2_1	39	44	PF00069	0.255
MOD_NEK2_1	87	92	PF00069	0.372
MOD_NEK2_2	99	104	PF00069	0.400
MOD_PKA_1	303	309	PF00069	0.523
MOD_Plk_1	39	45	PF00069	0.523
MOD_Plk_4	115	121	PF00069	0.315
MOD_Plk_4	132	138	PF00069	0.315
MOD_Plk_4	165	171	PF00069	0.314
MOD_Plk_4	178	184	PF00069	0.315
MOD_Plk_4	187	193	PF00069	0.285
MOD_Plk_4	204	210	PF00069	0.315
MOD_Plk_4	225	231	PF00069	0.329
MOD_Plk_4	77	83	PF00069	0.379
MOD_ProDKin_1	141	147	PF00069	0.456
MOD_SUMO_for_1	349	352	PF00179	0.513
MOD_SUMO_rev_2	272	277	PF00179	0.378
MOD_SUMO_rev_2	352	360	PF00179	0.569
TRG_DiLeu_BaEn_1	356	361	PF01217	0.589
TRG_DiLeu_BaLyEn_6	89	94	PF01217	0.435
TRG_ENDOCYTIC_2	120	123	PF00928	0.400
TRG_ENDOCYTIC_2	177	180	PF00928	0.317
TRG_ENDOCYTIC_2	209	212	PF00928	0.381
TRG_ENDOCYTIC_2	224	227	PF00928	0.295
TRG_ENDOCYTIC_2	264	267	PF00928	0.414
TRG_ENDOCYTIC_2	29	32	PF00928	0.421
TRG_ENDOCYTIC_2	84	87	PF00928	0.345
TRG_ER_diArg_1	334	337	PF00400	0.455
TRG_ER_diArg_1	58	61	PF00400	0.418

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0C5PHQ7	Tachysurus fulvidraco	30%	100%
A0A0N0P994	Leptomonas seymouri	65%	100%
A0A0S4JCZ3	Bodo saltans	52%	100%
A0A0S4JH58	Bodo saltans	31%	100%
A0A0S4KMP5	Bodo saltans	48%	100%
A0A1X0NUJ4	Trypanosomatidae	54%	100%
A0A3Q8I9X8	Leishmania donovani	25%	100%
A0A3Q8IC05	Leishmania donovani	28%	100%
A0A3Q8IT78	Leishmania donovani	92%	100%
A0A3S7WT03	Leishmania donovani	26%	100%
A4H7M6	Leishmania braziliensis	27%	100%
A4HKA3	Leishmania braziliensis	78%	100%
A4HW12	Leishmania infantum	25%	100%
A4I7T3	Leishmania infantum	92%	100%
D4A612	Rattus norvegicus	30%	100%
E9AGL0	Leishmania infantum	26%	100%
E9APR9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9B2P1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q3S8M4	Macaca mulatta	32%	100%
Q4QFR5	Leishmania major	27%	100%
Q95K73	Macaca fascicularis	32%	100%
Q9EQC4	Mus musculus	30%	100%
Q9GZR5	Homo sapiens	33%	100%
Q9JLJ5	Mus musculus	31%	100%
Q9VHX7	Drosophila melanogaster	30%	100%