Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q5G5_LEIMA

TriTrypDb:

LmjF.32.1170 , LMJLV39_320017700 , LMJSD75_320017700

Length:

414

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

Q4Q5G5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5G5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	310	314	PF00656	0.728
CLV_C14_Caspase3-7	322	326	PF00656	0.572
CLV_NRD_NRD_1	108	110	PF00675	0.463
CLV_NRD_NRD_1	132	134	PF00675	0.347
CLV_NRD_NRD_1	167	169	PF00675	0.553
CLV_NRD_NRD_1	272	274	PF00675	0.426
CLV_PCSK_KEX2_1	108	110	PF00082	0.463
CLV_PCSK_KEX2_1	132	134	PF00082	0.413
CLV_PCSK_KEX2_1	166	168	PF00082	0.559
CLV_PCSK_KEX2_1	272	274	PF00082	0.426
CLV_PCSK_SKI1_1	167	171	PF00082	0.537
CLV_PCSK_SKI1_1	272	276	PF00082	0.444
CLV_PCSK_SKI1_1	36	40	PF00082	0.536
DEG_APCC_DBOX_1	165	173	PF00400	0.414
DEG_Nend_UBRbox_4	1	3	PF02207	0.394
DEG_SPOP_SBC_1	83	87	PF00917	0.282
DOC_CKS1_1	237	242	PF01111	0.387
DOC_CYCLIN_RxL_1	162	175	PF00134	0.379
DOC_CYCLIN_RxL_1	269	277	PF00134	0.554
DOC_CYCLIN_yCln2_LP_2	396	402	PF00134	0.330
DOC_MAPK_gen_1	132	141	PF00069	0.595
DOC_MAPK_gen_1	166	172	PF00069	0.349
DOC_MAPK_MEF2A_6	132	141	PF00069	0.579
DOC_PP1_RVXF_1	42	49	PF00149	0.340
DOC_PP2B_LxvP_1	194	197	PF13499	0.316
DOC_SPAK_OSR1_1	190	194	PF12202	0.395
DOC_USP7_MATH_1	125	129	PF00917	0.599
DOC_USP7_MATH_1	171	175	PF00917	0.367
DOC_USP7_MATH_1	199	203	PF00917	0.472
DOC_USP7_MATH_1	238	242	PF00917	0.425
DOC_USP7_MATH_1	278	282	PF00917	0.702
DOC_USP7_MATH_1	47	51	PF00917	0.352
DOC_USP7_MATH_1	52	56	PF00917	0.363
DOC_USP7_MATH_1	65	69	PF00917	0.433
DOC_USP7_MATH_1	84	88	PF00917	0.332
DOC_WW_Pin1_4	233	238	PF00397	0.509
DOC_WW_Pin1_4	323	328	PF00397	0.611
DOC_WW_Pin1_4	359	364	PF00397	0.713
DOC_WW_Pin1_4	8	13	PF00397	0.394
LIG_14-3-3_CanoR_1	152	157	PF00244	0.363
LIG_14-3-3_CanoR_1	51	60	PF00244	0.438
LIG_BRCT_BRCA1_1	67	71	PF00533	0.509
LIG_BRCT_BRCA1_1	86	90	PF00533	0.328
LIG_deltaCOP1_diTrp_1	175	185	PF00928	0.437
LIG_deltaCOP1_diTrp_1	66	71	PF00928	0.427
LIG_DLG_GKlike_1	152	159	PF00625	0.343
LIG_FHA_1	129	135	PF00498	0.570
LIG_FHA_1	141	147	PF00498	0.273
LIG_FHA_1	181	187	PF00498	0.359
LIG_FHA_1	303	309	PF00498	0.745
LIG_FHA_1	362	368	PF00498	0.605
LIG_FHA_1	93	99	PF00498	0.238
LIG_FHA_2	237	243	PF00498	0.386
LIG_FHA_2	308	314	PF00498	0.753
LIG_LIR_Gen_1	153	164	PF02991	0.299
LIG_LIR_Gen_1	228	237	PF02991	0.451
LIG_LIR_Gen_1	257	264	PF02991	0.414
LIG_LIR_Gen_1	377	387	PF02991	0.397
LIG_LIR_Gen_1	85	96	PF02991	0.297
LIG_LIR_Nem_3	153	159	PF02991	0.315
LIG_LIR_Nem_3	175	181	PF02991	0.446
LIG_LIR_Nem_3	224	229	PF02991	0.458
LIG_LIR_Nem_3	257	261	PF02991	0.373
LIG_LIR_Nem_3	377	383	PF02991	0.320
LIG_LIR_Nem_3	85	91	PF02991	0.297
LIG_NRBOX	133	139	PF00104	0.621
LIG_NRBOX	266	272	PF00104	0.466
LIG_NRBOX	392	398	PF00104	0.330
LIG_PDZ_Class_2	409	414	PF00595	0.508
LIG_Pex14_1	188	192	PF04695	0.386
LIG_PTB_Apo_2	42	49	PF02174	0.340
LIG_SH2_CRK	147	151	PF00017	0.375
LIG_SH2_CRK	156	160	PF00017	0.326
LIG_SH2_CRK	229	233	PF00017	0.444
LIG_SH2_CRK	246	250	PF00017	0.188
LIG_SH2_CRK	268	272	PF00017	0.550
LIG_SH2_CRK	380	384	PF00017	0.282
LIG_SH2_STAP1	380	384	PF00017	0.357
LIG_SH2_STAT5	156	159	PF00017	0.293
LIG_SH2_STAT5	192	195	PF00017	0.359
LIG_SH2_STAT5	366	369	PF00017	0.567
LIG_SH3_3	231	237	PF00018	0.479
LIG_SH3_3	321	327	PF00018	0.657
LIG_SH3_3	357	363	PF00018	0.613
LIG_SUMO_SIM_anti_2	257	263	PF11976	0.410
LIG_SUMO_SIM_anti_2	406	411	PF11976	0.283
LIG_SUMO_SIM_par_1	11	16	PF11976	0.373
LIG_SUMO_SIM_par_1	137	143	PF11976	0.388
LIG_SUMO_SIM_par_1	401	406	PF11976	0.333
LIG_SUMO_SIM_par_1	407	413	PF11976	0.309
LIG_TRAF2_1	297	300	PF00917	0.688
LIG_TRAF2_1	30	33	PF00917	0.421
LIG_TYR_ITSM	380	387	PF00017	0.355
LIG_WRC_WIRS_1	24	29	PF05994	0.387
LIG_WRC_WIRS_1	90	95	PF05994	0.366
MOD_CK1_1	11	17	PF00069	0.457
MOD_CK1_1	128	134	PF00069	0.624
MOD_CK1_1	198	204	PF00069	0.461
MOD_CK1_1	23	29	PF00069	0.411
MOD_CK1_1	236	242	PF00069	0.471
MOD_CK1_1	277	283	PF00069	0.666
MOD_CK1_1	362	368	PF00069	0.588
MOD_CK1_1	374	380	PF00069	0.328
MOD_CK1_1	55	61	PF00069	0.534
MOD_CK1_1	92	98	PF00069	0.311
MOD_CK2_1	236	242	PF00069	0.390
MOD_CK2_1	27	33	PF00069	0.443
MOD_CMANNOS	182	185	PF00535	0.600
MOD_CMANNOS	369	372	PF00535	0.413
MOD_GlcNHglycan	112	115	PF01048	0.469
MOD_GlcNHglycan	127	130	PF01048	0.265
MOD_GlcNHglycan	159	162	PF01048	0.537
MOD_GlcNHglycan	197	200	PF01048	0.667
MOD_GlcNHglycan	201	204	PF01048	0.695
MOD_GlcNHglycan	276	279	PF01048	0.494
MOD_GlcNHglycan	280	283	PF01048	0.526
MOD_GlcNHglycan	29	32	PF01048	0.604
MOD_GlcNHglycan	348	351	PF01048	0.446
MOD_GlcNHglycan	355	358	PF01048	0.381
MOD_GlcNHglycan	57	60	PF01048	0.647
MOD_GSK3_1	124	131	PF00069	0.661
MOD_GSK3_1	195	202	PF00069	0.421
MOD_GSK3_1	23	30	PF00069	0.394
MOD_GSK3_1	232	239	PF00069	0.500
MOD_GSK3_1	250	257	PF00069	0.183
MOD_GSK3_1	274	281	PF00069	0.671
MOD_GSK3_1	302	309	PF00069	0.738
MOD_GSK3_1	319	326	PF00069	0.654
MOD_GSK3_1	4	11	PF00069	0.423
MOD_GSK3_1	54	61	PF00069	0.519
MOD_GSK3_1	78	85	PF00069	0.345
MOD_N-GLC_1	125	130	PF02516	0.424
MOD_N-GLC_1	232	237	PF02516	0.648
MOD_N-GLC_2	117	119	PF02516	0.419
MOD_NEK2_1	232	237	PF00069	0.432
MOD_NEK2_1	254	259	PF00069	0.297
MOD_NEK2_1	274	279	PF00069	0.711
MOD_NEK2_1	54	59	PF00069	0.529
MOD_NEK2_1	82	87	PF00069	0.303
MOD_PIKK_1	4	10	PF00454	0.383
MOD_PKA_2	110	116	PF00069	0.650
MOD_PKA_2	284	290	PF00069	0.749
MOD_PKA_2	346	352	PF00069	0.716
MOD_Plk_1	319	325	PF00069	0.692
MOD_Plk_1	65	71	PF00069	0.562
MOD_Plk_4	319	325	PF00069	0.682
MOD_Plk_4	362	368	PF00069	0.561
MOD_Plk_4	379	385	PF00069	0.402
MOD_Plk_4	78	84	PF00069	0.346
MOD_Plk_4	89	95	PF00069	0.267
MOD_ProDKin_1	233	239	PF00069	0.506
MOD_ProDKin_1	323	329	PF00069	0.606
MOD_ProDKin_1	359	365	PF00069	0.707
MOD_ProDKin_1	8	14	PF00069	0.392
TRG_DiLeu_BaEn_4	32	38	PF01217	0.337
TRG_DiLeu_BaLyEn_6	133	138	PF01217	0.563
TRG_DiLeu_BaLyEn_6	165	170	PF01217	0.425
TRG_DiLeu_BaLyEn_6	388	393	PF01217	0.316
TRG_ENDOCYTIC_2	147	150	PF00928	0.304
TRG_ENDOCYTIC_2	156	159	PF00928	0.268
TRG_ENDOCYTIC_2	229	232	PF00928	0.439
TRG_ENDOCYTIC_2	246	249	PF00928	0.241
TRG_ENDOCYTIC_2	268	271	PF00928	0.554
TRG_ENDOCYTIC_2	380	383	PF00928	0.302
TRG_ENDOCYTIC_2	384	387	PF00928	0.309
TRG_ER_diArg_1	107	109	PF00400	0.604
TRG_ER_diArg_1	132	134	PF00400	0.547
TRG_ER_diArg_1	165	168	PF00400	0.322
TRG_ER_diArg_1	271	273	PF00400	0.624

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEL3	Leptomonas seymouri	43%	100%
A0A1X0NUK5	Trypanosomatidae	28%	100%
A0A3Q8ID27	Leishmania donovani	91%	100%
A0A422P1F3	Trypanosoma rangeli	28%	100%
A4HKA4	Leishmania braziliensis	69%	100%
A4I7T4	Leishmania infantum	91%	100%
D0A9Z4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9B2P2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
V5DHL3	Trypanosoma cruzi	26%	100%