ANK_REP_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ankyrin repeats (3 copies), putative

Species:

Leishmania major

UniProt:

Q4Q5G4_LEIMA

TriTrypDb:

LmjF.32.1180 , LMJLV39_320017800 , LMJSD75_320017800

Length:

660

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q5G4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5G4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	348	352	PF00656	0.570
CLV_C14_Caspase3-7	508	512	PF00656	0.755
CLV_C14_Caspase3-7	546	550	PF00656	0.623
CLV_C14_Caspase3-7	609	613	PF00656	0.712
CLV_MEL_PAP_1	146	152	PF00089	0.532
CLV_NRD_NRD_1	206	208	PF00675	0.725
CLV_NRD_NRD_1	25	27	PF00675	0.496
CLV_NRD_NRD_1	441	443	PF00675	0.715
CLV_NRD_NRD_1	506	508	PF00675	0.698
CLV_PCSK_KEX2_1	206	208	PF00082	0.729
CLV_PCSK_KEX2_1	221	223	PF00082	0.557
CLV_PCSK_KEX2_1	25	27	PF00082	0.496
CLV_PCSK_KEX2_1	441	443	PF00082	0.715
CLV_PCSK_KEX2_1	506	508	PF00082	0.681
CLV_PCSK_KEX2_1	648	650	PF00082	0.657
CLV_PCSK_PC1ET2_1	221	223	PF00082	0.746
CLV_PCSK_PC1ET2_1	648	650	PF00082	0.657
CLV_PCSK_PC7_1	202	208	PF00082	0.827
CLV_PCSK_PC7_1	437	443	PF00082	0.708
CLV_PCSK_SKI1_1	121	125	PF00082	0.559
CLV_PCSK_SKI1_1	163	167	PF00082	0.688
CLV_PCSK_SKI1_1	206	210	PF00082	0.708
CLV_PCSK_SKI1_1	249	253	PF00082	0.704
CLV_PCSK_SKI1_1	353	357	PF00082	0.603
DEG_Nend_UBRbox_3	1	3	PF02207	0.675
DEG_SCF_FBW7_1	481	486	PF00400	0.593
DEG_SCF_FBW7_1	541	548	PF00400	0.649
DOC_MAPK_MEF2A_6	255	263	PF00069	0.551
DOC_MAPK_MEF2A_6	281	288	PF00069	0.605
DOC_PP2B_LxvP_1	102	105	PF13499	0.426
DOC_PP2B_LxvP_1	169	172	PF13499	0.779
DOC_PP2B_LxvP_1	481	484	PF13499	0.590
DOC_USP7_MATH_1	105	109	PF00917	0.463
DOC_USP7_MATH_1	233	237	PF00917	0.765
DOC_USP7_MATH_1	311	315	PF00917	0.691
DOC_USP7_MATH_1	376	380	PF00917	0.590
DOC_USP7_MATH_1	409	413	PF00917	0.746
DOC_USP7_MATH_1	423	427	PF00917	0.686
DOC_USP7_MATH_1	605	609	PF00917	0.707
DOC_USP7_MATH_1	655	659	PF00917	0.711
DOC_USP7_MATH_2	471	477	PF00917	0.693
DOC_USP7_UBL2_3	346	350	PF12436	0.739
DOC_WW_Pin1_4	141	146	PF00397	0.657
DOC_WW_Pin1_4	15	20	PF00397	0.592
DOC_WW_Pin1_4	163	168	PF00397	0.635
DOC_WW_Pin1_4	206	211	PF00397	0.748
DOC_WW_Pin1_4	291	296	PF00397	0.751
DOC_WW_Pin1_4	407	412	PF00397	0.760
DOC_WW_Pin1_4	419	424	PF00397	0.630
DOC_WW_Pin1_4	443	448	PF00397	0.769
DOC_WW_Pin1_4	467	472	PF00397	0.675
DOC_WW_Pin1_4	479	484	PF00397	0.668
DOC_WW_Pin1_4	485	490	PF00397	0.700
DOC_WW_Pin1_4	523	528	PF00397	0.780
DOC_WW_Pin1_4	537	542	PF00397	0.602
DOC_WW_Pin1_4	584	589	PF00397	0.734
DOC_WW_Pin1_4	73	78	PF00397	0.411
LIG_14-3-3_CanoR_1	182	187	PF00244	0.756
LIG_14-3-3_CanoR_1	392	398	PF00244	0.648
LIG_14-3-3_CanoR_1	41	45	PF00244	0.513
LIG_14-3-3_CanoR_1	583	588	PF00244	0.653
LIG_14-3-3_CanoR_1	633	638	PF00244	0.599
LIG_Actin_WH2_2	110	126	PF00022	0.565
LIG_APCC_ABBA_1	282	287	PF00400	0.632
LIG_APCC_ABBAyCdc20_2	281	287	PF00400	0.642
LIG_BRCT_BRCA1_1	5	9	PF00533	0.583
LIG_CSL_BTD_1	292	295	PF09270	0.552
LIG_deltaCOP1_diTrp_1	372	377	PF00928	0.615
LIG_deltaCOP1_diTrp_1	513	517	PF00928	0.646
LIG_eIF4E_1	11	17	PF01652	0.535
LIG_FHA_1	101	107	PF00498	0.557
LIG_FHA_1	126	132	PF00498	0.424
LIG_FHA_1	164	170	PF00498	0.744
LIG_FHA_1	394	400	PF00498	0.740
LIG_FHA_1	408	414	PF00498	0.574
LIG_FHA_1	480	486	PF00498	0.732
LIG_FHA_1	612	618	PF00498	0.676
LIG_FHA_2	295	301	PF00498	0.599
LIG_FHA_2	544	550	PF00498	0.755
LIG_LIR_Gen_1	6	17	PF02991	0.551
LIG_LIR_Nem_3	21	27	PF02991	0.446
LIG_LIR_Nem_3	290	296	PF02991	0.692
LIG_LIR_Nem_3	329	335	PF02991	0.705
LIG_LIR_Nem_3	372	377	PF02991	0.691
LIG_LIR_Nem_3	457	463	PF02991	0.575
LIG_LIR_Nem_3	472	477	PF02991	0.684
LIG_LIR_Nem_3	6	12	PF02991	0.585
LIG_NRBOX	12	18	PF00104	0.516
LIG_NRBOX	132	138	PF00104	0.595
LIG_RPA_C_Fungi	260	272	PF08784	0.622
LIG_SH2_CRK	332	336	PF00017	0.660
LIG_SH2_CRK	58	62	PF00017	0.436
LIG_SH2_SRC	27	30	PF00017	0.568
LIG_SH2_STAP1	393	397	PF00017	0.717
LIG_SH2_STAT5	11	14	PF00017	0.543
LIG_SH2_STAT5	27	30	PF00017	0.366
LIG_SH2_STAT5	296	299	PF00017	0.630
LIG_SH2_STAT5	389	392	PF00017	0.599
LIG_SH3_2	201	206	PF14604	0.720
LIG_SH3_3	195	201	PF00018	0.729
LIG_SH3_3	320	326	PF00018	0.730
LIG_SH3_3	370	376	PF00018	0.579
LIG_SH3_3	87	93	PF00018	0.505
LIG_SUMO_SIM_par_1	128	134	PF11976	0.375
LIG_TRAF2_1	171	174	PF00917	0.777
LIG_TRAF2_1	19	22	PF00917	0.557
LIG_TRAF2_1	264	267	PF00917	0.594
LIG_TRAF2_1	470	473	PF00917	0.593
LIG_WRC_WIRS_1	634	639	PF05994	0.530
MOD_CK1_1	155	161	PF00069	0.693
MOD_CK1_1	236	242	PF00069	0.743
MOD_CK1_1	244	250	PF00069	0.638
MOD_CK1_1	294	300	PF00069	0.622
MOD_CK1_1	3	9	PF00069	0.662
MOD_CK1_1	40	46	PF00069	0.389
MOD_CK1_1	446	452	PF00069	0.762
MOD_CK1_1	571	577	PF00069	0.677
MOD_CK1_1	595	601	PF00069	0.772
MOD_CK2_1	105	111	PF00069	0.643
MOD_CK2_1	15	21	PF00069	0.533
MOD_CK2_1	261	267	PF00069	0.599
MOD_CK2_1	294	300	PF00069	0.790
MOD_CK2_1	442	448	PF00069	0.810
MOD_CK2_1	467	473	PF00069	0.669
MOD_CK2_1	545	551	PF00069	0.771
MOD_DYRK1A_RPxSP_1	163	167	PF00069	0.571
MOD_GlcNHglycan	132	136	PF01048	0.516
MOD_GlcNHglycan	157	160	PF01048	0.689
MOD_GlcNHglycan	222	225	PF01048	0.729
MOD_GlcNHglycan	235	238	PF01048	0.649
MOD_GlcNHglycan	243	246	PF01048	0.671
MOD_GlcNHglycan	249	252	PF01048	0.677
MOD_GlcNHglycan	313	316	PF01048	0.646
MOD_GlcNHglycan	448	451	PF01048	0.705
MOD_GlcNHglycan	558	561	PF01048	0.766
MOD_GlcNHglycan	594	597	PF01048	0.863
MOD_GlcNHglycan	6	9	PF01048	0.633
MOD_GlcNHglycan	640	643	PF01048	0.702
MOD_GlcNHglycan	657	660	PF01048	0.522
MOD_GSK3_1	100	107	PF00069	0.501
MOD_GSK3_1	109	116	PF00069	0.546
MOD_GSK3_1	151	158	PF00069	0.736
MOD_GSK3_1	216	223	PF00069	0.717
MOD_GSK3_1	3	10	PF00069	0.597
MOD_GSK3_1	393	400	PF00069	0.640
MOD_GSK3_1	409	416	PF00069	0.683
MOD_GSK3_1	419	426	PF00069	0.660
MOD_GSK3_1	442	449	PF00069	0.789
MOD_GSK3_1	463	470	PF00069	0.655
MOD_GSK3_1	479	486	PF00069	0.828
MOD_GSK3_1	537	544	PF00069	0.783
MOD_GSK3_1	564	571	PF00069	0.632
MOD_GSK3_1	592	599	PF00069	0.799
MOD_LATS_1	35	41	PF00433	0.558
MOD_LATS_1	581	587	PF00433	0.598
MOD_N-GLC_1	109	114	PF02516	0.574
MOD_N-GLC_1	453	458	PF02516	0.757
MOD_NEK2_1	117	122	PF00069	0.504
MOD_NEK2_1	150	155	PF00069	0.654
MOD_NEK2_1	226	231	PF00069	0.691
MOD_NEK2_1	399	404	PF00069	0.777
MOD_NEK2_1	453	458	PF00069	0.722
MOD_NEK2_1	626	631	PF00069	0.716
MOD_NEK2_1	638	643	PF00069	0.635
MOD_NEK2_2	597	602	PF00069	0.763
MOD_PIKK_1	216	222	PF00454	0.616
MOD_PIKK_1	543	549	PF00454	0.733
MOD_PIKK_1	568	574	PF00454	0.741
MOD_PIKK_1	600	606	PF00454	0.758
MOD_PIKK_1	626	632	PF00454	0.665
MOD_PKA_2	181	187	PF00069	0.775
MOD_PKA_2	391	397	PF00069	0.643
MOD_PKA_2	40	46	PF00069	0.513
MOD_PKA_2	638	644	PF00069	0.713
MOD_Plk_1	131	137	PF00069	0.538
MOD_Plk_1	328	334	PF00069	0.737
MOD_Plk_2-3	473	479	PF00069	0.703
MOD_Plk_4	113	119	PF00069	0.523
MOD_Plk_4	40	46	PF00069	0.411
MOD_Plk_4	409	415	PF00069	0.806
MOD_Plk_4	612	618	PF00069	0.589
MOD_Plk_4	633	639	PF00069	0.586
MOD_ProDKin_1	141	147	PF00069	0.657
MOD_ProDKin_1	15	21	PF00069	0.596
MOD_ProDKin_1	163	169	PF00069	0.638
MOD_ProDKin_1	206	212	PF00069	0.746
MOD_ProDKin_1	291	297	PF00069	0.752
MOD_ProDKin_1	407	413	PF00069	0.761
MOD_ProDKin_1	419	425	PF00069	0.627
MOD_ProDKin_1	443	449	PF00069	0.770
MOD_ProDKin_1	467	473	PF00069	0.676
MOD_ProDKin_1	479	485	PF00069	0.670
MOD_ProDKin_1	523	529	PF00069	0.785
MOD_ProDKin_1	537	543	PF00069	0.606
MOD_ProDKin_1	584	590	PF00069	0.734
MOD_ProDKin_1	73	79	PF00069	0.411
MOD_SUMO_rev_2	302	311	PF00179	0.718
MOD_SUMO_rev_2	466	471	PF00179	0.675
TRG_DiLeu_BaEn_1	132	137	PF01217	0.585
TRG_DiLeu_BaEn_3	433	439	PF01217	0.788
TRG_DiLeu_BaEn_4	173	179	PF01217	0.793
TRG_DiLeu_BaLyEn_6	142	147	PF01217	0.661
TRG_DiLeu_BaLyEn_6	164	169	PF01217	0.766
TRG_DiLeu_BaLyEn_6	90	95	PF01217	0.576
TRG_ENDOCYTIC_2	27	30	PF00928	0.568
TRG_ENDOCYTIC_2	332	335	PF00928	0.700
TRG_ENDOCYTIC_2	58	61	PF00928	0.513
TRG_ENDOCYTIC_2	634	637	PF00928	0.668
TRG_ER_diArg_1	206	208	PF00400	0.830
TRG_ER_diArg_1	24	26	PF00400	0.524
TRG_ER_diArg_1	440	442	PF00400	0.718
TRG_ER_diArg_1	505	507	PF00400	0.722
TRG_Pf-PMV_PEXEL_1	353	358	PF00026	0.702

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P9L2	Leptomonas seymouri	36%	100%
A0A3S7X5E8	Leishmania donovani	87%	100%
A4HKA5	Leishmania braziliensis	58%	99%
A4I7T5	Leishmania infantum	87%	100%
E9B2P3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%