Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q5G3_LEIMA

TriTrypDb:

LmjF.32.1190 , LMJLV39_320017900 , LMJSD75_320017900

Length:

566

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q5G3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5G3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	450	454	PF00656	0.689
CLV_NRD_NRD_1	103	105	PF00675	0.775
CLV_NRD_NRD_1	351	353	PF00675	0.717
CLV_NRD_NRD_1	441	443	PF00675	0.712
CLV_NRD_NRD_1	445	447	PF00675	0.691
CLV_NRD_NRD_1	517	519	PF00675	0.727
CLV_PCSK_KEX2_1	102	104	PF00082	0.767
CLV_PCSK_KEX2_1	351	353	PF00082	0.729
CLV_PCSK_KEX2_1	441	443	PF00082	0.712
CLV_PCSK_KEX2_1	445	447	PF00082	0.691
CLV_PCSK_KEX2_1	515	517	PF00082	0.729
CLV_PCSK_PC1ET2_1	515	517	PF00082	0.729
CLV_PCSK_PC7_1	347	353	PF00082	0.737
CLV_PCSK_PC7_1	441	447	PF00082	0.803
CLV_PCSK_SKI1_1	117	121	PF00082	0.580
DEG_ODPH_VHL_1	109	121	PF01847	0.579
DOC_ANK_TNKS_1	212	219	PF00023	0.708
DOC_CKS1_1	258	263	PF01111	0.669
DOC_MAPK_gen_1	441	449	PF00069	0.570
DOC_MAPK_gen_1	55	65	PF00069	0.767
DOC_MAPK_MEF2A_6	267	276	PF00069	0.813
DOC_MAPK_MEF2A_6	58	65	PF00069	0.809
DOC_PP1_RVXF_1	218	225	PF00149	0.690
DOC_PP1_RVXF_1	492	499	PF00149	0.687
DOC_PP2B_LxvP_1	329	332	PF13499	0.770
DOC_PP2B_LxvP_1	411	414	PF13499	0.727
DOC_PP4_FxxP_1	202	205	PF00568	0.530
DOC_USP7_MATH_1	132	136	PF00917	0.720
DOC_USP7_MATH_1	148	152	PF00917	0.483
DOC_USP7_MATH_1	187	191	PF00917	0.675
DOC_USP7_MATH_1	298	302	PF00917	0.753
DOC_USP7_MATH_1	350	354	PF00917	0.614
DOC_USP7_MATH_1	414	418	PF00917	0.739
DOC_USP7_MATH_1	468	472	PF00917	0.636
DOC_USP7_MATH_1	523	527	PF00917	0.622
DOC_USP7_MATH_1	83	87	PF00917	0.700
DOC_USP7_MATH_1	90	94	PF00917	0.633
DOC_WW_Pin1_4	130	135	PF00397	0.618
DOC_WW_Pin1_4	169	174	PF00397	0.811
DOC_WW_Pin1_4	225	230	PF00397	0.659
DOC_WW_Pin1_4	254	259	PF00397	0.733
DOC_WW_Pin1_4	294	299	PF00397	0.747
DOC_WW_Pin1_4	306	311	PF00397	0.539
DOC_WW_Pin1_4	373	378	PF00397	0.688
DOC_WW_Pin1_4	433	438	PF00397	0.642
DOC_WW_Pin1_4	454	459	PF00397	0.781
DOC_WW_Pin1_4	65	70	PF00397	0.802
DOC_WW_Pin1_4	79	84	PF00397	0.709
LIG_14-3-3_CanoR_1	223	231	PF00244	0.684
LIG_14-3-3_CanoR_1	290	295	PF00244	0.661
LIG_14-3-3_CanoR_1	303	310	PF00244	0.655
LIG_14-3-3_CanoR_1	311	321	PF00244	0.565
LIG_14-3-3_CanoR_1	325	329	PF00244	0.663
LIG_14-3-3_CanoR_1	351	358	PF00244	0.600
LIG_14-3-3_CanoR_1	77	85	PF00244	0.731
LIG_AP_GAE_1	244	250	PF02883	0.546
LIG_BRCT_BRCA1_1	134	138	PF00533	0.728
LIG_BRCT_BRCA1_1	198	202	PF00533	0.769
LIG_BRCT_BRCA1_1	428	432	PF00533	0.715
LIG_BRCT_BRCA1_1	435	439	PF00533	0.673
LIG_BRCT_BRCA1_1	9	13	PF00533	0.650
LIG_BRCT_BRCA1_1	92	96	PF00533	0.711
LIG_FHA_1	116	122	PF00498	0.623
LIG_FHA_1	231	237	PF00498	0.683
LIG_FHA_1	384	390	PF00498	0.762
LIG_FHA_1	491	497	PF00498	0.547
LIG_FHA_2	153	159	PF00498	0.719
LIG_FHA_2	317	323	PF00498	0.578
LIG_Integrin_RGD_1	213	215	PF01839	0.714
LIG_LIR_Apic_2	199	205	PF02991	0.531
LIG_LIR_Gen_1	193	202	PF02991	0.541
LIG_LIR_Gen_1	244	255	PF02991	0.766
LIG_LIR_Gen_1	301	310	PF02991	0.772
LIG_LIR_Nem_3	193	198	PF02991	0.640
LIG_LIR_Nem_3	301	307	PF02991	0.775
LIG_PCNA_PIPBox_1	28	37	PF02747	0.405
LIG_PCNA_yPIPBox_3	16	24	PF02747	0.441
LIG_PCNA_yPIPBox_3	27	35	PF02747	0.351
LIG_SH2_CRK	304	308	PF00017	0.582
LIG_SH2_STAP1	304	308	PF00017	0.582
LIG_SH2_STAT3	317	320	PF00017	0.503
LIG_SH2_STAT3	35	38	PF00017	0.525
LIG_SH2_STAT5	317	320	PF00017	0.500
LIG_SH3_1	108	114	PF00018	0.741
LIG_SH3_3	108	114	PF00018	0.742
LIG_SH3_3	180	186	PF00018	0.571
LIG_SH3_3	255	261	PF00018	0.664
LIG_SH3_3	304	310	PF00018	0.688
LIG_SH3_3	410	416	PF00018	0.627
LIG_SH3_3	417	423	PF00018	0.622
LIG_SH3_3	470	476	PF00018	0.790
LIG_SUMO_SIM_anti_2	273	278	PF11976	0.766
LIG_TRAF2_1	242	245	PF00917	0.696
LIG_TRAF2_1	481	484	PF00917	0.802
LIG_WRC_WIRS_1	231	236	PF05994	0.681
LIG_WW_3	474	478	PF00397	0.706
MOD_CDC14_SPxK_1	133	136	PF00782	0.744
MOD_CDK_SPK_2	306	311	PF00069	0.643
MOD_CDK_SPxK_1	130	136	PF00069	0.752
MOD_CDK_SPxK_1	373	379	PF00069	0.688
MOD_CK1_1	125	131	PF00069	0.698
MOD_CK1_1	190	196	PF00069	0.700
MOD_CK1_1	225	231	PF00069	0.678
MOD_CK1_1	302	308	PF00069	0.640
MOD_CK1_1	309	315	PF00069	0.600
MOD_CK1_1	316	322	PF00069	0.556
MOD_CK1_1	454	460	PF00069	0.749
MOD_CK1_1	485	491	PF00069	0.574
MOD_CK1_1	526	532	PF00069	0.666
MOD_CK2_1	152	158	PF00069	0.674
MOD_CK2_1	260	266	PF00069	0.719
MOD_CK2_1	316	322	PF00069	0.611
MOD_CK2_1	324	330	PF00069	0.595
MOD_CK2_1	360	366	PF00069	0.731
MOD_CK2_1	478	484	PF00069	0.742
MOD_GlcNHglycan	148	151	PF01048	0.661
MOD_GlcNHglycan	162	165	PF01048	0.559
MOD_GlcNHglycan	188	192	PF01048	0.704
MOD_GlcNHglycan	198	201	PF01048	0.718
MOD_GlcNHglycan	280	283	PF01048	0.672
MOD_GlcNHglycan	304	307	PF01048	0.544
MOD_GlcNHglycan	337	340	PF01048	0.692
MOD_GlcNHglycan	358	361	PF01048	0.682
MOD_GlcNHglycan	405	408	PF01048	0.749
MOD_GlcNHglycan	470	473	PF01048	0.629
MOD_GlcNHglycan	483	487	PF01048	0.720
MOD_GlcNHglycan	509	512	PF01048	0.744
MOD_GlcNHglycan	526	529	PF01048	0.567
MOD_GlcNHglycan	85	88	PF01048	0.586
MOD_GSK3_1	148	155	PF00069	0.726
MOD_GSK3_1	169	176	PF00069	0.711
MOD_GSK3_1	190	197	PF00069	0.732
MOD_GSK3_1	232	239	PF00069	0.679
MOD_GSK3_1	290	297	PF00069	0.704
MOD_GSK3_1	298	305	PF00069	0.638
MOD_GSK3_1	306	313	PF00069	0.557
MOD_GSK3_1	356	363	PF00069	0.596
MOD_GSK3_1	379	386	PF00069	0.761
MOD_GSK3_1	399	406	PF00069	0.497
MOD_GSK3_1	426	433	PF00069	0.714
MOD_GSK3_1	447	454	PF00069	0.746
MOD_GSK3_1	478	485	PF00069	0.792
MOD_GSK3_1	498	505	PF00069	0.766
MOD_GSK3_1	77	84	PF00069	0.797
MOD_GSK3_1	90	97	PF00069	0.635
MOD_LATS_1	221	227	PF00433	0.694
MOD_N-GLC_1	400	405	PF02516	0.710
MOD_N-GLC_1	461	466	PF02516	0.818
MOD_NEK2_1	1	6	PF00069	0.712
MOD_NEK2_1	299	304	PF00069	0.608
MOD_NEK2_1	324	329	PF00069	0.578
MOD_NEK2_1	356	361	PF00069	0.636
MOD_NEK2_1	389	394	PF00069	0.705
MOD_PIKK_1	316	322	PF00454	0.616
MOD_PIKK_1	350	356	PF00454	0.818
MOD_PIKK_1	448	454	PF00454	0.806
MOD_PIKK_1	77	83	PF00454	0.736
MOD_PK_1	7	13	PF00069	0.541
MOD_PKA_2	140	146	PF00069	0.702
MOD_PKA_2	222	228	PF00069	0.689
MOD_PKA_2	289	295	PF00069	0.639
MOD_PKA_2	302	308	PF00069	0.664
MOD_PKA_2	310	316	PF00069	0.584
MOD_PKA_2	324	330	PF00069	0.663
MOD_PKA_2	335	341	PF00069	0.699
MOD_PKA_2	350	356	PF00069	0.568
MOD_PKA_2	498	504	PF00069	0.670
MOD_Plk_1	236	242	PF00069	0.664
MOD_Plk_1	343	349	PF00069	0.704
MOD_Plk_1	400	406	PF00069	0.693
MOD_Plk_1	426	432	PF00069	0.580
MOD_Plk_1	482	488	PF00069	0.604
MOD_Plk_4	190	196	PF00069	0.785
MOD_Plk_4	313	319	PF00069	0.577
MOD_Plk_4	324	330	PF00069	0.658
MOD_Plk_4	360	366	PF00069	0.710
MOD_Plk_4	559	565	PF00069	0.644
MOD_ProDKin_1	130	136	PF00069	0.615
MOD_ProDKin_1	169	175	PF00069	0.814
MOD_ProDKin_1	225	231	PF00069	0.660
MOD_ProDKin_1	254	260	PF00069	0.736
MOD_ProDKin_1	294	300	PF00069	0.745
MOD_ProDKin_1	306	312	PF00069	0.534
MOD_ProDKin_1	373	379	PF00069	0.688
MOD_ProDKin_1	433	439	PF00069	0.643
MOD_ProDKin_1	454	460	PF00069	0.782
MOD_ProDKin_1	65	71	PF00069	0.804
MOD_ProDKin_1	79	85	PF00069	0.704
MOD_SUMO_rev_2	19	29	PF00179	0.568
TRG_DiLeu_BaLyEn_6	455	460	PF01217	0.686
TRG_ENDOCYTIC_2	304	307	PF00928	0.678
TRG_ER_diArg_1	102	104	PF00400	0.774
TRG_ER_diArg_1	105	108	PF00400	0.770
TRG_ER_diArg_1	129	132	PF00400	0.601
TRG_ER_diArg_1	384	387	PF00400	0.560
TRG_ER_diArg_1	440	442	PF00400	0.712
TRG_ER_diArg_1	445	447	PF00400	0.685
TRG_ER_diArg_1	516	518	PF00400	0.729
TRG_ER_diArg_1	63	66	PF00400	0.712
TRG_NLS_MonoCore_2	514	519	PF00514	0.826
TRG_NLS_MonoExtC_3	514	519	PF00514	0.733
TRG_Pf-PMV_PEXEL_1	22	26	PF00026	0.629
TRG_Pf-PMV_PEXEL_1	32	36	PF00026	0.490
TRG_Pf-PMV_PEXEL_1	387	391	PF00026	0.744

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P995	Leptomonas seymouri	29%	100%
A0A3S7X5D7	Leishmania donovani	82%	100%
A4HKA6	Leishmania braziliensis	55%	100%
A4I7T6	Leishmania infantum	83%	100%
E9B2P4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%