Putative proteasome regulatory non-ATP-ase subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

proteasome regulatory non-ATP-ase subunit, putative

Species:

Leishmania major

UniProt:

Q4Q5G2_LEIMA

TriTrypDb:

LmjF.32.1200 , LMJLV39_320018000 , LMJSD75_320018000

Length:

274

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 12

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005654	nucleoplasm	2	2
GO:0005737	cytoplasm	2	2
GO:0008541	proteasome regulatory particle, lid subcomplex	2	2
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2
GO:0005838	proteasome regulatory particle	2	10

Expansion

Sequence features

Q4Q5G2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5G2

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	12
GO:0006511	ubiquitin-dependent protein catabolic process	7	2
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009056	catabolic process	2	2
GO:0009057	macromolecule catabolic process	4	2
GO:0009987	cellular process	1	2
GO:0010498	proteasomal protein catabolic process	5	2
GO:0019538	protein metabolic process	3	12
GO:0019941	modification-dependent protein catabolic process	6	2
GO:0030163	protein catabolic process	4	2
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	2
GO:0043170	macromolecule metabolic process	3	12
GO:0043632	modification-dependent macromolecule catabolic process	5	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	12
GO:0044248	cellular catabolic process	3	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0044265	obsolete cellular macromolecule catabolic process	4	2
GO:0051603	proteolysis involved in protein catabolic process	5	2
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901565	organonitrogen compound catabolic process	4	2
GO:1901575	organic substance catabolic process	3	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	11	13	PF00675	0.453
CLV_NRD_NRD_1	171	173	PF00675	0.375
CLV_NRD_NRD_1	42	44	PF00675	0.487
CLV_PCSK_KEX2_1	229	231	PF00082	0.260
CLV_PCSK_KEX2_1	41	43	PF00082	0.486
CLV_PCSK_PC1ET2_1	229	231	PF00082	0.342
CLV_PCSK_PC1ET2_1	41	43	PF00082	0.486
CLV_PCSK_SKI1_1	167	171	PF00082	0.324
CLV_PCSK_SKI1_1	19	23	PF00082	0.482
DOC_CYCLIN_yClb5_NLxxxL_5	115	124	PF00134	0.471
DOC_MAPK_gen_1	41	47	PF00069	0.422
DOC_MAPK_MEF2A_6	68	75	PF00069	0.494
DOC_MAPK_NFAT4_5	68	76	PF00069	0.493
DOC_PP1_RVXF_1	41	48	PF00149	0.507
DOC_PP2B_LxvP_1	206	209	PF13499	0.575
DOC_PP4_FxxP_1	50	53	PF00568	0.451
DOC_SPAK_OSR1_1	151	155	PF12202	0.482
DOC_WW_Pin1_4	106	111	PF00397	0.447
LIG_Actin_WH2_2	7	24	PF00022	0.483
LIG_BIR_II_1	1	5	PF00653	0.539
LIG_FHA_1	237	243	PF00498	0.630
LIG_FHA_2	188	194	PF00498	0.575
LIG_FHA_2	242	248	PF00498	0.474
LIG_FHA_2	57	63	PF00498	0.485
LIG_LIR_Apic_2	49	53	PF02991	0.443
LIG_LIR_Gen_1	109	120	PF02991	0.418
LIG_LIR_Gen_1	146	156	PF02991	0.519
LIG_LIR_Gen_1	162	169	PF02991	0.501
LIG_LIR_Gen_1	69	77	PF02991	0.481
LIG_LIR_Gen_1	88	98	PF02991	0.361
LIG_LIR_Nem_3	109	115	PF02991	0.446
LIG_LIR_Nem_3	146	152	PF02991	0.519
LIG_LIR_Nem_3	162	168	PF02991	0.487
LIG_LIR_Nem_3	177	183	PF02991	0.487
LIG_LIR_Nem_3	201	206	PF02991	0.498
LIG_LIR_Nem_3	69	73	PF02991	0.470
LIG_LIR_Nem_3	86	90	PF02991	0.379
LIG_LRP6_Inhibitor_1	116	122	PF00058	0.375
LIG_NRBOX	119	125	PF00104	0.471
LIG_Pex14_2	87	91	PF04695	0.368
LIG_SH2_CRK	165	169	PF00017	0.485
LIG_SH2_CRK	203	207	PF00017	0.496
LIG_SH2_GRB2like	90	93	PF00017	0.371
LIG_SH2_NCK_1	98	102	PF00017	0.449
LIG_SH2_SRC	180	183	PF00017	0.482
LIG_SH2_STAT3	90	93	PF00017	0.371
LIG_SH2_STAT5	112	115	PF00017	0.540
LIG_SH2_STAT5	149	152	PF00017	0.501
LIG_SH2_STAT5	159	162	PF00017	0.513
LIG_SH2_STAT5	180	183	PF00017	0.485
LIG_SH2_STAT5	70	73	PF00017	0.489
LIG_SH2_STAT5	90	93	PF00017	0.358
LIG_SH3_3	104	110	PF00018	0.482
LIG_SUMO_SIM_par_1	213	220	PF11976	0.498
LIG_TYR_ITIM	96	101	PF00017	0.463
LIG_UBA3_1	36	41	PF00899	0.418
LIG_WRC_WIRS_1	47	52	PF05994	0.422
LIG_WRC_WIRS_1	84	89	PF05994	0.408
MOD_CK2_1	131	137	PF00069	0.471
MOD_CK2_1	56	62	PF00069	0.504
MOD_GlcNHglycan	1	4	PF01048	0.641
MOD_GlcNHglycan	234	237	PF01048	0.316
MOD_GlcNHglycan	77	80	PF01048	0.367
MOD_GSK3_1	232	239	PF00069	0.508
MOD_GSK3_1	54	61	PF00069	0.537
MOD_NEK2_1	124	129	PF00069	0.538
MOD_NEK2_1	161	166	PF00069	0.471
MOD_NEK2_1	168	173	PF00069	0.471
MOD_NEK2_1	187	192	PF00069	0.472
MOD_NEK2_1	7	12	PF00069	0.582
MOD_PK_1	204	210	PF00069	0.501
MOD_Plk_1	187	193	PF00069	0.491
MOD_Plk_1	246	252	PF00069	0.657
MOD_Plk_1	5	11	PF00069	0.577
MOD_Plk_1	62	68	PF00069	0.451
MOD_Plk_2-3	131	137	PF00069	0.538
MOD_Plk_2-3	83	89	PF00069	0.409
MOD_Plk_4	46	52	PF00069	0.453
MOD_ProDKin_1	106	112	PF00069	0.440
MOD_SUMO_for_1	228	231	PF00179	0.553
MOD_SUMO_rev_2	16	21	PF00179	0.563
MOD_SUMO_rev_2	218	223	PF00179	0.538
TRG_DiLeu_BaLyEn_6	119	124	PF01217	0.471
TRG_ENDOCYTIC_2	112	115	PF00928	0.408
TRG_ENDOCYTIC_2	149	152	PF00928	0.501
TRG_ENDOCYTIC_2	165	168	PF00928	0.523
TRG_ENDOCYTIC_2	180	183	PF00928	0.505
TRG_ENDOCYTIC_2	203	206	PF00928	0.501
TRG_ENDOCYTIC_2	70	73	PF00928	0.481
TRG_ENDOCYTIC_2	98	101	PF00928	0.416
TRG_ER_diArg_1	42	44	PF00400	0.544
TRG_NLS_MonoExtC_3	171	176	PF00514	0.575
TRG_Pf-PMV_PEXEL_1	12	16	PF00026	0.467
TRG_Pf-PMV_PEXEL_1	158	162	PF00026	0.271
TRG_Pf-PMV_PEXEL_1	213	218	PF00026	0.341

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4A9	Leptomonas seymouri	83%	100%
A0A0S4J927	Bodo saltans	51%	79%
A0A1X0NUT6	Trypanosomatidae	59%	100%
A0A3R7M9M8	Trypanosoma rangeli	62%	100%
A0A3S7X5G0	Leishmania donovani	98%	100%
A4HKA7	Leishmania braziliensis	90%	100%
A4I7T7	Leishmania infantum	98%	100%
D0A9Z7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
E9B2P5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
P02889	Dictyostelium discoideum	35%	100%
P32496	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	100%
P48556	Homo sapiens	37%	78%
P50524	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	100%
Q23449	Caenorhabditis elegans	34%	100%
Q3SYT7	Bos taurus	37%	95%
Q5RE15	Pongo abelii	37%	95%
Q9CX56	Mus musculus	37%	78%
Q9SGW3	Arabidopsis thaliana	36%	100%
V5DHL8	Trypanosoma cruzi	62%	100%