PPR_long domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pentatricopeptide repeat domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q5G1_LEIMA

TriTrypDb:

LmjF.32.1210 , LMJLV39_320018100 , LMJSD75_320018100

Length:

801

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q5G1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5G1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	15	17	PF00675	0.584
CLV_NRD_NRD_1	301	303	PF00675	0.450
CLV_NRD_NRD_1	381	383	PF00675	0.691
CLV_NRD_NRD_1	453	455	PF00675	0.511
CLV_NRD_NRD_1	709	711	PF00675	0.534
CLV_NRD_NRD_1	771	773	PF00675	0.368
CLV_PCSK_KEX2_1	101	103	PF00082	0.484
CLV_PCSK_KEX2_1	14	16	PF00082	0.492
CLV_PCSK_KEX2_1	301	303	PF00082	0.452
CLV_PCSK_KEX2_1	5	7	PF00082	0.622
CLV_PCSK_KEX2_1	709	711	PF00082	0.501
CLV_PCSK_KEX2_1	771	773	PF00082	0.385
CLV_PCSK_PC1ET2_1	101	103	PF00082	0.484
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.649
CLV_PCSK_SKI1_1	101	105	PF00082	0.508
CLV_PCSK_SKI1_1	145	149	PF00082	0.427
CLV_PCSK_SKI1_1	151	155	PF00082	0.335
CLV_PCSK_SKI1_1	36	40	PF00082	0.574
CLV_PCSK_SKI1_1	491	495	PF00082	0.431
CLV_PCSK_SKI1_1	552	556	PF00082	0.425
CLV_PCSK_SKI1_1	619	623	PF00082	0.458
CLV_PCSK_SKI1_1	709	713	PF00082	0.404
CLV_PCSK_SKI1_1	771	775	PF00082	0.462
CLV_PCSK_SKI1_1	780	784	PF00082	0.406
DEG_APCC_DBOX_1	770	778	PF00400	0.504
DEG_APCC_KENBOX_2	123	127	PF00400	0.539
DOC_CKS1_1	495	500	PF01111	0.467
DOC_CKS1_1	783	788	PF01111	0.544
DOC_CYCLIN_RxL_1	369	381	PF00134	0.479
DOC_CYCLIN_RxL_1	729	739	PF00134	0.276
DOC_CYCLIN_RxL_1	777	785	PF00134	0.485
DOC_MAPK_gen_1	454	460	PF00069	0.583
DOC_MAPK_gen_1	5	13	PF00069	0.643
DOC_PP1_RVXF_1	474	481	PF00149	0.476
DOC_PP1_SILK_1	728	733	PF00149	0.387
DOC_PP2B_LxvP_1	198	201	PF13499	0.373
DOC_PP2B_LxvP_1	377	380	PF13499	0.479
DOC_PP4_FxxP_1	23	26	PF00568	0.660
DOC_PP4_FxxP_1	783	786	PF00568	0.471
DOC_USP7_MATH_1	387	391	PF00917	0.759
DOC_USP7_MATH_1	548	552	PF00917	0.461
DOC_USP7_MATH_1	591	595	PF00917	0.579
DOC_USP7_MATH_1	644	648	PF00917	0.581
DOC_USP7_MATH_1	65	69	PF00917	0.653
DOC_USP7_MATH_1	756	760	PF00917	0.531
DOC_WW_Pin1_4	494	499	PF00397	0.487
DOC_WW_Pin1_4	782	787	PF00397	0.525
LIG_14-3-3_CanoR_1	105	112	PF00244	0.489
LIG_14-3-3_CanoR_1	83	91	PF00244	0.495
LIG_Actin_WH2_2	223	238	PF00022	0.395
LIG_APCC_ABBA_1	112	117	PF00400	0.362
LIG_APCC_ABBA_1	224	229	PF00400	0.369
LIG_APCC_ABBA_1	353	358	PF00400	0.474
LIG_APCC_ABBA_1	734	739	PF00400	0.289
LIG_APCC_ABBAyCdc20_2	66	72	PF00400	0.587
LIG_BIR_III_4	767	771	PF00653	0.493
LIG_BRCT_BRCA1_1	257	261	PF00533	0.261
LIG_Clathr_ClatBox_1	466	470	PF01394	0.457
LIG_eIF4E_1	149	155	PF01652	0.346
LIG_FHA_1	187	193	PF00498	0.381
LIG_FHA_1	221	227	PF00498	0.360
LIG_FHA_1	361	367	PF00498	0.564
LIG_FHA_1	44	50	PF00498	0.497
LIG_FHA_1	536	542	PF00498	0.389
LIG_FHA_1	559	565	PF00498	0.520
LIG_FHA_1	574	580	PF00498	0.370
LIG_FHA_1	731	737	PF00498	0.510
LIG_FHA_1	758	764	PF00498	0.412
LIG_FHA_1	93	99	PF00498	0.380
LIG_FHA_2	111	117	PF00498	0.493
LIG_FHA_2	280	286	PF00498	0.331
LIG_FHA_2	37	43	PF00498	0.641
LIG_GBD_Chelix_1	317	325	PF00786	0.425
LIG_LIR_Apic_2	20	26	PF02991	0.642
LIG_LIR_Gen_1	113	123	PF02991	0.271
LIG_LIR_Gen_1	134	142	PF02991	0.340
LIG_LIR_Gen_1	169	180	PF02991	0.260
LIG_LIR_Gen_1	206	215	PF02991	0.278
LIG_LIR_Gen_1	229	239	PF02991	0.328
LIG_LIR_Gen_1	241	249	PF02991	0.240
LIG_LIR_Gen_1	256	265	PF02991	0.375
LIG_LIR_Gen_1	275	283	PF02991	0.200
LIG_LIR_Gen_1	44	55	PF02991	0.494
LIG_LIR_Gen_1	518	527	PF02991	0.503
LIG_LIR_Gen_1	557	567	PF02991	0.377
LIG_LIR_Gen_1	57	65	PF02991	0.336
LIG_LIR_Gen_1	654	664	PF02991	0.255
LIG_LIR_Gen_1	690	699	PF02991	0.461
LIG_LIR_Gen_1	93	103	PF02991	0.387
LIG_LIR_Nem_3	113	118	PF02991	0.249
LIG_LIR_Nem_3	134	139	PF02991	0.341
LIG_LIR_Nem_3	169	175	PF02991	0.256
LIG_LIR_Nem_3	206	210	PF02991	0.293
LIG_LIR_Nem_3	229	235	PF02991	0.343
LIG_LIR_Nem_3	241	245	PF02991	0.229
LIG_LIR_Nem_3	256	262	PF02991	0.375
LIG_LIR_Nem_3	275	280	PF02991	0.200
LIG_LIR_Nem_3	350	356	PF02991	0.433
LIG_LIR_Nem_3	44	50	PF02991	0.524
LIG_LIR_Nem_3	57	63	PF02991	0.361
LIG_LIR_Nem_3	654	659	PF02991	0.281
LIG_LIR_Nem_3	673	679	PF02991	0.509
LIG_LIR_Nem_3	689	695	PF02991	0.476
LIG_LIR_Nem_3	93	99	PF02991	0.389
LIG_NRBOX	463	469	PF00104	0.469
LIG_PALB2_WD40_1	628	636	PF16756	0.499
LIG_Pex14_1	331	335	PF04695	0.467
LIG_PTB_Apo_2	147	154	PF02174	0.478
LIG_Rb_pABgroove_1	109	117	PF01858	0.459
LIG_REV1ctd_RIR_1	618	628	PF16727	0.473
LIG_SH2_CRK	136	140	PF00017	0.351
LIG_SH2_CRK	156	160	PF00017	0.401
LIG_SH2_CRK	172	176	PF00017	0.277
LIG_SH2_CRK	207	211	PF00017	0.293
LIG_SH2_CRK	242	246	PF00017	0.312
LIG_SH2_CRK	277	281	PF00017	0.277
LIG_SH2_CRK	47	51	PF00017	0.531
LIG_SH2_CRK	614	618	PF00017	0.419
LIG_SH2_CRK	656	660	PF00017	0.393
LIG_SH2_CRK	727	731	PF00017	0.334
LIG_SH2_CRK	743	747	PF00017	0.384
LIG_SH2_CRK	784	788	PF00017	0.559
LIG_SH2_CRK	96	100	PF00017	0.364
LIG_SH2_GRB2like	232	235	PF00017	0.331
LIG_SH2_NCK_1	149	153	PF00017	0.393
LIG_SH2_NCK_1	567	571	PF00017	0.514
LIG_SH2_NCK_1	669	673	PF00017	0.480
LIG_SH2_NCK_1	784	788	PF00017	0.559
LIG_SH2_SRC	545	548	PF00017	0.439
LIG_SH2_STAP1	220	224	PF00017	0.363
LIG_SH2_STAP1	255	259	PF00017	0.277
LIG_SH2_STAP1	56	60	PF00017	0.391
LIG_SH2_STAP1	560	564	PF00017	0.456
LIG_SH2_STAP1	567	571	PF00017	0.503
LIG_SH2_STAP1	656	660	PF00017	0.454
LIG_SH2_STAT5	178	181	PF00017	0.349
LIG_SH2_STAT5	232	235	PF00017	0.331
LIG_SH2_STAT5	279	282	PF00017	0.340
LIG_SH2_STAT5	290	293	PF00017	0.338
LIG_SH2_STAT5	335	338	PF00017	0.474
LIG_SH2_STAT5	443	446	PF00017	0.444
LIG_SH2_STAT5	56	59	PF00017	0.392
LIG_SH2_STAT5	560	563	PF00017	0.469
LIG_SH2_STAT5	656	659	PF00017	0.365
LIG_SH2_STAT5	663	666	PF00017	0.332
LIG_SH2_STAT5	693	696	PF00017	0.402
LIG_SH2_STAT5	784	787	PF00017	0.567
LIG_SH3_3	364	370	PF00018	0.409
LIG_SH3_3	783	789	PF00018	0.574
LIG_Sin3_3	27	34	PF02671	0.496
LIG_SUMO_SIM_par_1	279	285	PF11976	0.363
LIG_SUMO_SIM_par_1	465	470	PF11976	0.505
LIG_SUMO_SIM_par_1	732	739	PF11976	0.287
LIG_TRAF2_1	219	222	PF00917	0.494
LIG_TRAF2_1	572	575	PF00917	0.552
LIG_TRFH_1	163	167	PF08558	0.517
LIG_TYR_ITAM	229	245	PF00017	0.331
LIG_TYR_ITIM	154	159	PF00017	0.401
LIG_TYR_ITIM	230	235	PF00017	0.331
LIG_TYR_ITIM	725	730	PF00017	0.452
LIG_UBA3_1	111	119	PF00899	0.419
LIG_UBA3_1	191	196	PF00899	0.411
LIG_UBA3_1	230	236	PF00899	0.331
MOD_CK1_1	241	247	PF00069	0.372
MOD_CK1_1	378	384	PF00069	0.743
MOD_CK1_1	456	462	PF00069	0.537
MOD_CK1_1	558	564	PF00069	0.446
MOD_CK1_1	59	65	PF00069	0.490
MOD_CK1_1	688	694	PF00069	0.493
MOD_CK2_1	279	285	PF00069	0.412
MOD_CK2_1	515	521	PF00069	0.478
MOD_CK2_1	65	71	PF00069	0.665
MOD_CK2_1	680	686	PF00069	0.561
MOD_Cter_Amidation	769	772	PF01082	0.361
MOD_GlcNHglycan	144	148	PF01048	0.503
MOD_GlcNHglycan	216	219	PF01048	0.420
MOD_GlcNHglycan	297	300	PF01048	0.592
MOD_GlcNHglycan	448	452	PF01048	0.485
MOD_GlcNHglycan	455	458	PF01048	0.438
MOD_GlcNHglycan	636	639	PF01048	0.482
MOD_GlcNHglycan	646	649	PF01048	0.460
MOD_GSK3_1	291	298	PF00069	0.537
MOD_GSK3_1	32	39	PF00069	0.694
MOD_GSK3_1	339	346	PF00069	0.490
MOD_GSK3_1	456	463	PF00069	0.507
MOD_GSK3_1	603	610	PF00069	0.604
MOD_GSK3_1	640	647	PF00069	0.628
MOD_GSK3_1	726	733	PF00069	0.401
MOD_LATS_1	81	87	PF00433	0.536
MOD_N-GLC_1	125	130	PF02516	0.500
MOD_N-GLC_1	460	465	PF02516	0.406
MOD_N-GLC_1	644	649	PF02516	0.634
MOD_NEK2_1	1	6	PF00069	0.681
MOD_NEK2_1	214	219	PF00069	0.407
MOD_NEK2_1	317	322	PF00069	0.323
MOD_NEK2_1	453	458	PF00069	0.549
MOD_NEK2_1	460	465	PF00069	0.344
MOD_NEK2_1	555	560	PF00069	0.396
MOD_NEK2_1	613	618	PF00069	0.456
MOD_NEK2_2	110	115	PF00069	0.469
MOD_NEK2_2	220	225	PF00069	0.370
MOD_NEK2_2	65	70	PF00069	0.586
MOD_PIKK_1	90	96	PF00454	0.507
MOD_PK_1	339	345	PF00069	0.503
MOD_PKA_1	101	107	PF00069	0.442
MOD_PKA_2	101	107	PF00069	0.529
MOD_PKA_2	291	297	PF00069	0.539
MOD_PKA_2	300	306	PF00069	0.473
MOD_PKA_2	453	459	PF00069	0.523
MOD_PKA_2	548	554	PF00069	0.472
MOD_PKA_2	634	640	PF00069	0.616
MOD_PKB_1	14	22	PF00069	0.556
MOD_Plk_1	124	130	PF00069	0.477
MOD_Plk_1	143	149	PF00069	0.256
MOD_Plk_1	220	226	PF00069	0.384
MOD_Plk_1	255	261	PF00069	0.252
MOD_Plk_1	375	381	PF00069	0.647
MOD_Plk_1	43	49	PF00069	0.614
MOD_Plk_1	460	466	PF00069	0.406
MOD_Plk_1	573	579	PF00069	0.446
MOD_Plk_1	703	709	PF00069	0.286
MOD_Plk_1	757	763	PF00069	0.534
MOD_Plk_4	132	138	PF00069	0.489
MOD_Plk_4	171	177	PF00069	0.280
MOD_Plk_4	186	192	PF00069	0.293
MOD_Plk_4	209	215	PF00069	0.337
MOD_Plk_4	241	247	PF00069	0.369
MOD_Plk_4	317	323	PF00069	0.331
MOD_Plk_4	339	345	PF00069	0.370
MOD_Plk_4	555	561	PF00069	0.430
MOD_Plk_4	59	65	PF00069	0.466
MOD_Plk_4	591	597	PF00069	0.541
MOD_Plk_4	613	619	PF00069	0.501
MOD_Plk_4	654	660	PF00069	0.504
MOD_Plk_4	688	694	PF00069	0.403
MOD_Plk_4	726	732	PF00069	0.374
MOD_ProDKin_1	494	500	PF00069	0.479
MOD_ProDKin_1	782	788	PF00069	0.535
MOD_SUMO_for_1	118	121	PF00179	0.415
MOD_SUMO_rev_2	116	120	PF00179	0.433
MOD_SUMO_rev_2	193	198	PF00179	0.414
TRG_DiLeu_BaEn_1	134	139	PF01217	0.466
TRG_DiLeu_BaEn_1	490	495	PF01217	0.434
TRG_DiLeu_BaEn_3	44	50	PF01217	0.462
TRG_DiLeu_BaEn_4	193	199	PF01217	0.412
TRG_ENDOCYTIC_2	115	118	PF00928	0.380
TRG_ENDOCYTIC_2	136	139	PF00928	0.364
TRG_ENDOCYTIC_2	156	159	PF00928	0.337
TRG_ENDOCYTIC_2	172	175	PF00928	0.286
TRG_ENDOCYTIC_2	207	210	PF00928	0.277
TRG_ENDOCYTIC_2	232	235	PF00928	0.334
TRG_ENDOCYTIC_2	242	245	PF00928	0.265
TRG_ENDOCYTIC_2	277	280	PF00928	0.279
TRG_ENDOCYTIC_2	356	359	PF00928	0.353
TRG_ENDOCYTIC_2	47	50	PF00928	0.566
TRG_ENDOCYTIC_2	520	523	PF00928	0.497
TRG_ENDOCYTIC_2	560	563	PF00928	0.376
TRG_ENDOCYTIC_2	614	617	PF00928	0.329
TRG_ENDOCYTIC_2	656	659	PF00928	0.365
TRG_ENDOCYTIC_2	669	672	PF00928	0.370
TRG_ENDOCYTIC_2	692	695	PF00928	0.378
TRG_ENDOCYTIC_2	727	730	PF00928	0.336
TRG_ENDOCYTIC_2	743	746	PF00928	0.374
TRG_ENDOCYTIC_2	96	99	PF00928	0.367
TRG_ER_diArg_1	13	16	PF00400	0.622
TRG_ER_diArg_1	301	304	PF00400	0.484
TRG_ER_diArg_1	708	710	PF00400	0.516
TRG_ER_diArg_1	771	773	PF00400	0.425
TRG_Pf-PMV_PEXEL_1	772	776	PF00026	0.384

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAW5	Leptomonas seymouri	57%	100%
A0A0S4JD08	Bodo saltans	32%	95%
A0A1X0NW71	Trypanosomatidae	41%	100%
A0A3S7X5H9	Leishmania donovani	95%	100%
A0A422P1H7	Trypanosoma rangeli	39%	100%
A4HKA8	Leishmania braziliensis	79%	100%
A4I7T8	Leishmania infantum	95%	100%
D0A9Z8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	97%
E9B2P6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q0WPZ6	Arabidopsis thaliana	21%	92%
Q76C99	Oryza sativa subsp. indica	21%	100%
Q9CAN6	Arabidopsis thaliana	20%	100%
Q9FIT7	Arabidopsis thaliana	21%	82%
Q9SH60	Arabidopsis thaliana	22%	100%
V5BL80	Trypanosoma cruzi	42%	100%