DUF4709 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q5G0_LEIMA

TriTrypDb:

LmjF.32.1220 , LMJLV39_320018200 , LMJSD75_320018200

Length:

797

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q5G0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5G0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	161	165	PF00656	0.541
CLV_NRD_NRD_1	10	12	PF00675	0.592
CLV_NRD_NRD_1	104	106	PF00675	0.480
CLV_NRD_NRD_1	157	159	PF00675	0.608
CLV_NRD_NRD_1	17	19	PF00675	0.569
CLV_NRD_NRD_1	269	271	PF00675	0.528
CLV_NRD_NRD_1	320	322	PF00675	0.436
CLV_NRD_NRD_1	361	363	PF00675	0.632
CLV_NRD_NRD_1	741	743	PF00675	0.658
CLV_NRD_NRD_1	763	765	PF00675	0.580
CLV_NRD_NRD_1	771	773	PF00675	0.658
CLV_NRD_NRD_1	777	779	PF00675	0.655
CLV_PCSK_FUR_1	8	12	PF00082	0.610
CLV_PCSK_KEX2_1	10	12	PF00082	0.591
CLV_PCSK_KEX2_1	104	106	PF00082	0.480
CLV_PCSK_KEX2_1	146	148	PF00082	0.432
CLV_PCSK_KEX2_1	156	158	PF00082	0.477
CLV_PCSK_KEX2_1	16	18	PF00082	0.584
CLV_PCSK_KEX2_1	269	271	PF00082	0.528
CLV_PCSK_KEX2_1	361	363	PF00082	0.577
CLV_PCSK_KEX2_1	715	717	PF00082	0.527
CLV_PCSK_KEX2_1	771	773	PF00082	0.545
CLV_PCSK_PC1ET2_1	146	148	PF00082	0.524
CLV_PCSK_PC1ET2_1	715	717	PF00082	0.615
CLV_PCSK_PC1ET2_1	771	773	PF00082	0.545
CLV_PCSK_SKI1_1	143	147	PF00082	0.487
CLV_PCSK_SKI1_1	157	161	PF00082	0.512
CLV_PCSK_SKI1_1	185	189	PF00082	0.542
CLV_PCSK_SKI1_1	259	263	PF00082	0.528
CLV_PCSK_SKI1_1	322	326	PF00082	0.438
CLV_PCSK_SKI1_1	346	350	PF00082	0.541
CLV_PCSK_SKI1_1	563	567	PF00082	0.491
CLV_PCSK_SKI1_1	587	591	PF00082	0.660
CLV_PCSK_SKI1_1	76	80	PF00082	0.505
CLV_PCSK_SKI1_1	781	785	PF00082	0.543
CLV_Separin_Metazoa	358	362	PF03568	0.502
DEG_APCC_DBOX_1	155	163	PF00400	0.594
DEG_APCC_DBOX_1	282	290	PF00400	0.386
DEG_APCC_DBOX_1	345	353	PF00400	0.539
DEG_COP1_1	417	424	PF00400	0.512
DEG_SCF_FBW7_1	643	649	PF00400	0.672
DEG_SPOP_SBC_1	415	419	PF00917	0.634
DEG_SPOP_SBC_1	646	650	PF00917	0.721
DEG_SPOP_SBC_1	749	753	PF00917	0.558
DOC_ANK_TNKS_1	726	733	PF00023	0.586
DOC_CKS1_1	643	648	PF01111	0.723
DOC_CYCLIN_RxL_1	320	328	PF00134	0.547
DOC_CYCLIN_RxL_1	560	571	PF00134	0.511
DOC_CYCLIN_RxL_1	709	723	PF00134	0.546
DOC_MAPK_gen_1	321	329	PF00069	0.430
DOC_MAPK_gen_1	361	367	PF00069	0.582
DOC_MAPK_MEF2A_6	321	329	PF00069	0.430
DOC_MAPK_NFAT4_5	322	330	PF00069	0.430
DOC_PP1_RVXF_1	232	238	PF00149	0.566
DOC_PP1_RVXF_1	362	368	PF00149	0.500
DOC_PP1_RVXF_1	689	695	PF00149	0.462
DOC_USP7_MATH_1	31	35	PF00917	0.565
DOC_USP7_MATH_1	415	419	PF00917	0.716
DOC_USP7_MATH_1	42	46	PF00917	0.524
DOC_USP7_MATH_1	420	424	PF00917	0.728
DOC_USP7_MATH_1	426	430	PF00917	0.722
DOC_USP7_MATH_1	442	446	PF00917	0.523
DOC_USP7_MATH_1	473	477	PF00917	0.749
DOC_USP7_MATH_1	499	503	PF00917	0.773
DOC_USP7_MATH_1	527	531	PF00917	0.552
DOC_USP7_MATH_1	646	650	PF00917	0.751
DOC_USP7_MATH_1	749	753	PF00917	0.650
DOC_USP7_MATH_2	527	533	PF00917	0.448
DOC_USP7_UBL2_3	185	189	PF12436	0.561
DOC_USP7_UBL2_3	679	683	PF12436	0.592
DOC_WW_Pin1_4	455	460	PF00397	0.731
DOC_WW_Pin1_4	462	467	PF00397	0.671
DOC_WW_Pin1_4	476	481	PF00397	0.696
DOC_WW_Pin1_4	569	574	PF00397	0.541
DOC_WW_Pin1_4	642	647	PF00397	0.665
DOC_WW_Pin1_4	735	740	PF00397	0.630
DOC_WW_Pin1_4	745	750	PF00397	0.712
LIG_14-3-3_CanoR_1	104	112	PF00244	0.468
LIG_14-3-3_CanoR_1	16	23	PF00244	0.603
LIG_14-3-3_CanoR_1	234	238	PF00244	0.464
LIG_14-3-3_CanoR_1	252	262	PF00244	0.350
LIG_14-3-3_CanoR_1	299	307	PF00244	0.420
LIG_14-3-3_CanoR_1	362	368	PF00244	0.472
LIG_14-3-3_CanoR_1	416	424	PF00244	0.635
LIG_14-3-3_CanoR_1	472	480	PF00244	0.679
LIG_14-3-3_CanoR_1	484	488	PF00244	0.732
LIG_14-3-3_CanoR_1	500	509	PF00244	0.595
LIG_14-3-3_CanoR_1	8	14	PF00244	0.658
LIG_Actin_WH2_2	330	345	PF00022	0.604
LIG_BRCT_BRCA1_1	113	117	PF00533	0.456
LIG_BRCT_BRCA1_1	464	468	PF00533	0.507
LIG_BRCT_BRCA1_1	636	640	PF00533	0.648
LIG_BRCT_BRCA1_1	99	103	PF00533	0.463
LIG_BRCT_BRCA1_2	636	642	PF00533	0.649
LIG_CaM_IQ_9	135	150	PF13499	0.544
LIG_CaM_IQ_9	671	687	PF13499	0.502
LIG_FHA_1	104	110	PF00498	0.482
LIG_FHA_1	354	360	PF00498	0.595
LIG_FHA_1	687	693	PF00498	0.538
LIG_FHA_1	91	97	PF00498	0.462
LIG_FHA_2	190	196	PF00498	0.450
LIG_FHA_2	205	211	PF00498	0.472
LIG_FHA_2	304	310	PF00498	0.505
LIG_FHA_2	371	377	PF00498	0.536
LIG_FHA_2	531	537	PF00498	0.528
LIG_FHA_2	627	633	PF00498	0.633
LIG_FHA_2	646	652	PF00498	0.695
LIG_LIR_Gen_1	215	225	PF02991	0.365
LIG_LIR_Gen_1	273	282	PF02991	0.534
LIG_LIR_Gen_1	290	300	PF02991	0.397
LIG_LIR_Gen_1	328	337	PF02991	0.535
LIG_LIR_Gen_1	45	54	PF02991	0.471
LIG_LIR_Gen_1	532	541	PF02991	0.452
LIG_LIR_Gen_1	635	643	PF02991	0.601
LIG_LIR_Gen_1	68	78	PF02991	0.538
LIG_LIR_Nem_3	114	120	PF02991	0.581
LIG_LIR_Nem_3	215	220	PF02991	0.352
LIG_LIR_Nem_3	273	278	PF02991	0.557
LIG_LIR_Nem_3	290	296	PF02991	0.387
LIG_LIR_Nem_3	328	332	PF02991	0.534
LIG_LIR_Nem_3	37	43	PF02991	0.508
LIG_LIR_Nem_3	376	381	PF02991	0.649
LIG_LIR_Nem_3	45	51	PF02991	0.443
LIG_LIR_Nem_3	532	537	PF02991	0.458
LIG_LIR_Nem_3	635	639	PF02991	0.638
LIG_LIR_Nem_3	68	73	PF02991	0.515
LIG_LIR_Nem_3	74	78	PF02991	0.465
LIG_MLH1_MIPbox_1	113	117	PF16413	0.572
LIG_NRBOX	108	114	PF00104	0.480
LIG_PDZ_Class_3	792	797	PF00595	0.618
LIG_Pex14_1	386	390	PF04695	0.602
LIG_Pex14_2	117	121	PF04695	0.465
LIG_Pex14_2	636	640	PF04695	0.600
LIG_SH2_CRK	217	221	PF00017	0.482
LIG_SH2_CRK	40	44	PF00017	0.581
LIG_SH2_CRK	48	52	PF00017	0.586
LIG_SH2_CRK	70	74	PF00017	0.515
LIG_SH2_GRB2like	48	51	PF00017	0.541
LIG_SH2_NCK_1	275	279	PF00017	0.526
LIG_SH2_NCK_1	390	394	PF00017	0.568
LIG_SH2_NCK_1	70	74	PF00017	0.479
LIG_SH2_SRC	171	174	PF00017	0.538
LIG_SH2_STAP1	48	52	PF00017	0.586
LIG_SH2_STAP1	699	703	PF00017	0.485
LIG_SH2_STAT3	335	338	PF00017	0.411
LIG_SH2_STAT5	390	393	PF00017	0.588
LIG_SH3_3	362	368	PF00018	0.496
LIG_SH3_3	475	481	PF00018	0.632
LIG_SH3_3	509	515	PF00018	0.729
LIG_SUMO_SIM_anti_2	532	540	PF11976	0.427
LIG_SUMO_SIM_anti_2	60	66	PF11976	0.531
LIG_SUMO_SIM_anti_2	93	100	PF11976	0.496
LIG_SUMO_SIM_par_1	563	568	PF11976	0.511
LIG_SUMO_SIM_par_1	93	100	PF11976	0.484
LIG_TRAF2_1	151	154	PF00917	0.446
LIG_TRAF2_1	310	313	PF00917	0.460
LIG_TRAF2_1	317	320	PF00917	0.437
LIG_UBA3_1	314	323	PF00899	0.447
LIG_WRC_WIRS_1	531	536	PF05994	0.530
LIG_WRC_WIRS_1	72	77	PF05994	0.471
MOD_CDK_SPK_2	569	574	PF00069	0.541
MOD_CDK_SPxxK_3	462	469	PF00069	0.700
MOD_CDK_SPxxK_3	735	742	PF00069	0.602
MOD_CDK_SPxxK_3	750	757	PF00069	0.761
MOD_CK1_1	476	482	PF00069	0.722
MOD_CK1_1	502	508	PF00069	0.682
MOD_CK1_1	513	519	PF00069	0.592
MOD_CK1_1	530	536	PF00069	0.458
MOD_CK1_1	568	574	PF00069	0.536
MOD_CK1_1	60	66	PF00069	0.558
MOD_CK1_1	617	623	PF00069	0.652
MOD_CK1_1	635	641	PF00069	0.477
MOD_CK1_1	647	653	PF00069	0.654
MOD_CK1_1	734	740	PF00069	0.788
MOD_CK1_1	748	754	PF00069	0.734
MOD_CK2_1	147	153	PF00069	0.545
MOD_CK2_1	16	22	PF00069	0.742
MOD_CK2_1	189	195	PF00069	0.419
MOD_CK2_1	204	210	PF00069	0.474
MOD_CK2_1	240	246	PF00069	0.541
MOD_CK2_1	303	309	PF00069	0.495
MOD_CK2_1	31	37	PF00069	0.648
MOD_CK2_1	620	626	PF00069	0.720
MOD_CK2_1	645	651	PF00069	0.748
MOD_Cter_Amidation	14	17	PF01082	0.680
MOD_Cter_Amidation	267	270	PF01082	0.561
MOD_Cter_Amidation	8	11	PF01082	0.711
MOD_GlcNHglycan	149	152	PF01048	0.498
MOD_GlcNHglycan	214	217	PF01048	0.518
MOD_GlcNHglycan	368	371	PF01048	0.564
MOD_GlcNHglycan	475	478	PF01048	0.574
MOD_GlcNHglycan	497	500	PF01048	0.647
MOD_GlcNHglycan	512	515	PF01048	0.599
MOD_GlcNHglycan	549	552	PF01048	0.644
MOD_GlcNHglycan	567	570	PF01048	0.591
MOD_GlcNHglycan	617	620	PF01048	0.692
MOD_GlcNHglycan	622	625	PF01048	0.644
MOD_GlcNHglycan	722	725	PF01048	0.616
MOD_GlcNHglycan	733	736	PF01048	0.697
MOD_GSK3_1	233	240	PF00069	0.497
MOD_GSK3_1	303	310	PF00069	0.524
MOD_GSK3_1	366	373	PF00069	0.566
MOD_GSK3_1	416	423	PF00069	0.668
MOD_GSK3_1	467	474	PF00069	0.776
MOD_GSK3_1	483	490	PF00069	0.606
MOD_GSK3_1	491	498	PF00069	0.637
MOD_GSK3_1	499	506	PF00069	0.550
MOD_GSK3_1	510	517	PF00069	0.496
MOD_GSK3_1	563	570	PF00069	0.506
MOD_GSK3_1	620	627	PF00069	0.694
MOD_GSK3_1	634	641	PF00069	0.537
MOD_GSK3_1	642	649	PF00069	0.620
MOD_GSK3_1	731	738	PF00069	0.688
MOD_GSK3_1	745	752	PF00069	0.651
MOD_GSK3_1	81	88	PF00069	0.544
MOD_N-GLC_1	354	359	PF02516	0.488
MOD_N-GLC_1	370	375	PF02516	0.528
MOD_N-GLC_1	398	403	PF02516	0.702
MOD_N-GLC_1	624	629	PF02516	0.630
MOD_N-GLC_1	659	664	PF02516	0.611
MOD_NEK2_1	1	6	PF00069	0.610
MOD_NEK2_1	179	184	PF00069	0.514
MOD_NEK2_1	248	253	PF00069	0.467
MOD_NEK2_1	263	268	PF00069	0.476
MOD_NEK2_1	325	330	PF00069	0.448
MOD_NEK2_1	435	440	PF00069	0.566
MOD_NEK2_1	471	476	PF00069	0.623
MOD_NEK2_1	483	488	PF00069	0.550
MOD_NEK2_1	565	570	PF00069	0.559
MOD_NEK2_1	57	62	PF00069	0.573
MOD_NEK2_1	96	101	PF00069	0.457
MOD_NEK2_2	233	238	PF00069	0.526
MOD_NEK2_2	467	472	PF00069	0.614
MOD_PIKK_1	16	22	PF00454	0.596
MOD_PIKK_1	263	269	PF00454	0.562
MOD_PIKK_1	380	386	PF00454	0.510
MOD_PIKK_1	435	441	PF00454	0.699
MOD_PKA_1	16	22	PF00069	0.526
MOD_PKA_1	188	194	PF00069	0.532
MOD_PKA_2	103	109	PF00069	0.471
MOD_PKA_2	16	22	PF00069	0.589
MOD_PKA_2	233	239	PF00069	0.480
MOD_PKA_2	248	254	PF00069	0.398
MOD_PKA_2	268	274	PF00069	0.378
MOD_PKA_2	298	304	PF00069	0.416
MOD_PKA_2	363	369	PF00069	0.565
MOD_PKA_2	415	421	PF00069	0.633
MOD_PKA_2	471	477	PF00069	0.768
MOD_PKA_2	483	489	PF00069	0.623
MOD_PKA_2	499	505	PF00069	0.582
MOD_PKA_2	708	714	PF00069	0.575
MOD_PKA_2	758	764	PF00069	0.524
MOD_PKA_2	767	773	PF00069	0.484
MOD_PKA_2	9	15	PF00069	0.615
MOD_Plk_1	25	31	PF00069	0.534
MOD_Plk_1	370	376	PF00069	0.574
MOD_Plk_1	624	630	PF00069	0.705
MOD_Plk_1	709	715	PF00069	0.564
MOD_Plk_2-3	71	77	PF00069	0.471
MOD_Plk_4	25	31	PF00069	0.650
MOD_Plk_4	303	309	PF00069	0.543
MOD_Plk_4	530	536	PF00069	0.444
MOD_Plk_4	60	66	PF00069	0.474
MOD_Plk_4	617	623	PF00069	0.613
MOD_Plk_4	635	641	PF00069	0.582
MOD_ProDKin_1	455	461	PF00069	0.730
MOD_ProDKin_1	462	468	PF00069	0.673
MOD_ProDKin_1	476	482	PF00069	0.697
MOD_ProDKin_1	569	575	PF00069	0.545
MOD_ProDKin_1	642	648	PF00069	0.666
MOD_ProDKin_1	735	741	PF00069	0.629
MOD_ProDKin_1	745	751	PF00069	0.709
TRG_DiLeu_BaEn_1	108	113	PF01217	0.514
TRG_DiLeu_BaEn_1	786	791	PF01217	0.540
TRG_DiLeu_BaEn_2	556	562	PF01217	0.459
TRG_DiLeu_BaEn_4	154	160	PF01217	0.523
TRG_DiLeu_BaLyEn_6	133	138	PF01217	0.508
TRG_DiLeu_LyEn_5	108	113	PF01217	0.514
TRG_ENDOCYTIC_2	217	220	PF00928	0.448
TRG_ENDOCYTIC_2	275	278	PF00928	0.575
TRG_ENDOCYTIC_2	40	43	PF00928	0.545
TRG_ENDOCYTIC_2	48	51	PF00928	0.511
TRG_ENDOCYTIC_2	70	73	PF00928	0.525
TRG_ER_diArg_1	103	105	PF00400	0.474
TRG_ER_diArg_1	156	158	PF00400	0.501
TRG_ER_diArg_1	16	18	PF00400	0.586
TRG_ER_diArg_1	360	362	PF00400	0.627
TRG_ER_diArg_1	8	11	PF00400	0.625
TRG_NES_CRM1_1	108	123	PF08389	0.520
TRG_NES_CRM1_1	53	68	PF08389	0.538
TRG_NES_CRM1_1	543	557	PF08389	0.565
TRG_NLS_MonoExtN_4	768	775	PF00514	0.537
TRG_Pf-PMV_PEXEL_1	136	141	PF00026	0.432
TRG_Pf-PMV_PEXEL_1	143	148	PF00026	0.422
TRG_Pf-PMV_PEXEL_1	157	161	PF00026	0.385
TRG_Pf-PMV_PEXEL_1	252	257	PF00026	0.397
TRG_Pf-PMV_PEXEL_1	778	782	PF00026	0.648

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ICL4	Leptomonas seymouri	62%	100%
A0A1X0NVY2	Trypanosomatidae	40%	100%
A0A3S5ISI8	Trypanosoma rangeli	40%	100%
A0A3S7X5E6	Leishmania donovani	93%	100%
A4HKA9	Leishmania braziliensis	76%	100%
A4I7T9	Leishmania infantum	93%	100%
D0A9Z9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9B2P7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%