Putative ADP-ribosylation factor GTPase activating protein 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ADP-ribosylation factor GTPase activating protein 1, putative

Species:

Leishmania major

UniProt:

Q4Q5F9_LEIMA

TriTrypDb:

LmjF.32.1230 , LMJLV39_320018300 , LMJSD75_320018300

Length:

402

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000139	Golgi membrane	5	2
GO:0016020	membrane	2	2
GO:0031090	organelle membrane	3	2
GO:0098588	bounding membrane of organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q5F9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5F9

Function

Biological processes
Term	Name	Level	Count
GO:0006901	vesicle coating	6	2
GO:0006996	organelle organization	4	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0016050	vesicle organization	5	2
GO:0048200	Golgi transport vesicle coating	7	2
GO:0048205	COPI coating of Golgi vesicle	8	2
GO:0071840	cellular component organization or biogenesis	2	2

Molecular functions
Term	Name	Level	Count
GO:0005096	GTPase activator activity	4	12
GO:0008047	enzyme activator activity	3	12
GO:0030234	enzyme regulator activity	2	12
GO:0030695	GTPase regulator activity	4	12
GO:0060589	nucleoside-triphosphatase regulator activity	3	12
GO:0098772	molecular function regulator activity	1	12
GO:0140677	molecular function activator activity	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	276	280	PF00656	0.732
CLV_C14_Caspase3-7	68	72	PF00656	0.329
CLV_NRD_NRD_1	90	92	PF00675	0.295
CLV_PCSK_KEX2_1	90	92	PF00082	0.310
DEG_SPOP_SBC_1	315	319	PF00917	0.710
DEG_SPOP_SBC_1	65	69	PF00917	0.329
DOC_ANK_TNKS_1	294	301	PF00023	0.533
DOC_CDC14_PxL_1	110	118	PF14671	0.498
DOC_CKS1_1	102	107	PF01111	0.364
DOC_MAPK_gen_1	10	18	PF00069	0.308
DOC_MAPK_gen_1	77	86	PF00069	0.294
DOC_MAPK_gen_1	90	96	PF00069	0.294
DOC_MAPK_MEF2A_6	56	64	PF00069	0.310
DOC_PP1_RVXF_1	91	97	PF00149	0.379
DOC_USP7_MATH_1	147	151	PF00917	0.582
DOC_USP7_MATH_1	156	160	PF00917	0.717
DOC_USP7_MATH_1	2	6	PF00917	0.601
DOC_USP7_MATH_1	23	27	PF00917	0.323
DOC_USP7_MATH_1	233	237	PF00917	0.600
DOC_USP7_MATH_1	315	319	PF00917	0.711
DOC_USP7_MATH_1	330	334	PF00917	0.727
DOC_USP7_MATH_1	335	339	PF00917	0.722
DOC_USP7_MATH_1	341	345	PF00917	0.706
DOC_USP7_MATH_1	353	357	PF00917	0.648
DOC_USP7_MATH_1	364	368	PF00917	0.607
DOC_USP7_MATH_1	386	390	PF00917	0.657
DOC_WW_Pin1_4	101	106	PF00397	0.367
DOC_WW_Pin1_4	311	316	PF00397	0.731
DOC_WW_Pin1_4	32	37	PF00397	0.383
DOC_WW_Pin1_4	331	336	PF00397	0.609
DOC_WW_Pin1_4	346	351	PF00397	0.620
DOC_WW_Pin1_4	380	385	PF00397	0.734
DOC_WW_Pin1_4	5	10	PF00397	0.567
LIG_14-3-3_CanoR_1	225	229	PF00244	0.687
LIG_14-3-3_CanoR_1	327	335	PF00244	0.631
LIG_14-3-3_CanoR_1	66	71	PF00244	0.329
LIG_APCC_ABBAyCdc20_2	91	97	PF00400	0.379
LIG_BIR_II_1	1	5	PF00653	0.537
LIG_BIR_III_4	376	380	PF00653	0.552
LIG_BRCT_BRCA1_1	25	29	PF00533	0.325
LIG_CaM_NSCaTE_8	141	148	PF13499	0.558
LIG_deltaCOP1_diTrp_1	133	141	PF00928	0.406
LIG_deltaCOP1_diTrp_1	393	402	PF00928	0.663
LIG_deltaCOP1_diTrp_1	71	76	PF00928	0.294
LIG_FHA_1	203	209	PF00498	0.544
LIG_FHA_1	211	217	PF00498	0.575
LIG_FHA_1	334	340	PF00498	0.762
LIG_FHA_2	388	394	PF00498	0.685
LIG_LIR_Apic_2	133	139	PF02991	0.395
LIG_LIR_Apic_2	344	350	PF02991	0.749
LIG_LIR_Apic_2	5	9	PF02991	0.508
LIG_LIR_Gen_1	12	23	PF02991	0.353
LIG_LIR_Gen_1	189	195	PF02991	0.524
LIG_LIR_Gen_1	196	206	PF02991	0.478
LIG_LIR_Gen_1	35	46	PF02991	0.415
LIG_LIR_Nem_3	12	18	PF02991	0.453
LIG_LIR_Nem_3	189	194	PF02991	0.507
LIG_LIR_Nem_3	196	201	PF02991	0.460
LIG_LIR_Nem_3	231	235	PF02991	0.427
LIG_LIR_Nem_3	286	291	PF02991	0.704
LIG_LIR_Nem_3	35	41	PF02991	0.407
LIG_LIR_Nem_3	45	49	PF02991	0.294
LIG_PDZ_Class_3	397	402	PF00595	0.708
LIG_SH2_CRK	142	146	PF00017	0.495
LIG_SH2_CRK	191	195	PF00017	0.569
LIG_SH2_PTP2	6	9	PF00017	0.525
LIG_SH2_STAP1	118	122	PF00017	0.379
LIG_SH2_STAP1	191	195	PF00017	0.659
LIG_SH2_STAP1	242	246	PF00017	0.550
LIG_SH2_STAT5	142	145	PF00017	0.513
LIG_SH2_STAT5	6	9	PF00017	0.525
LIG_SH2_STAT5	95	98	PF00017	0.310
LIG_SH3_2	102	107	PF14604	0.351
LIG_SH3_3	366	372	PF00018	0.765
LIG_SH3_3	99	105	PF00018	0.283
LIG_TYR_ITSM	284	291	PF00017	0.658
MOD_CDC14_SPxK_1	349	352	PF00782	0.748
MOD_CDK_SPK_2	5	10	PF00069	0.334
MOD_CDK_SPxK_1	101	107	PF00069	0.403
MOD_CDK_SPxK_1	346	352	PF00069	0.774
MOD_CK1_1	132	138	PF00069	0.372
MOD_CK1_1	181	187	PF00069	0.583
MOD_CK1_1	196	202	PF00069	0.547
MOD_CK1_1	314	320	PF00069	0.750
MOD_CK1_1	331	337	PF00069	0.563
MOD_CK1_1	342	348	PF00069	0.713
MOD_CK1_1	351	357	PF00069	0.724
MOD_CK1_1	387	393	PF00069	0.665
MOD_CK1_1	5	11	PF00069	0.472
MOD_CK2_1	326	332	PF00069	0.772
MOD_CMANNOS	73	76	PF00535	0.294
MOD_GlcNHglycan	191	194	PF01048	0.469
MOD_GlcNHglycan	195	198	PF01048	0.544
MOD_GlcNHglycan	235	238	PF01048	0.537
MOD_GlcNHglycan	239	242	PF01048	0.536
MOD_GlcNHglycan	328	331	PF01048	0.730
MOD_GlcNHglycan	341	344	PF01048	0.690
MOD_GlcNHglycan	355	358	PF01048	0.536
MOD_GlcNHglycan	51	54	PF01048	0.298
MOD_GSK3_1	156	163	PF00069	0.621
MOD_GSK3_1	189	196	PF00069	0.497
MOD_GSK3_1	224	231	PF00069	0.512
MOD_GSK3_1	233	240	PF00069	0.524
MOD_GSK3_1	311	318	PF00069	0.695
MOD_GSK3_1	326	333	PF00069	0.610
MOD_GSK3_1	335	342	PF00069	0.746
MOD_GSK3_1	359	366	PF00069	0.745
MOD_GSK3_1	380	387	PF00069	0.716
MOD_GSK3_1	60	67	PF00069	0.294
MOD_N-GLC_1	49	54	PF02516	0.415
MOD_NEK2_1	224	229	PF00069	0.633
MOD_NEK2_1	326	331	PF00069	0.702
MOD_NEK2_1	42	47	PF00069	0.324
MOD_NEK2_1	49	54	PF00069	0.262
MOD_NEK2_1	64	69	PF00069	0.294
MOD_PIKK_1	199	205	PF00454	0.564
MOD_PIKK_1	23	29	PF00454	0.208
MOD_PIKK_1	359	365	PF00454	0.727
MOD_PIKK_1	384	390	PF00454	0.691
MOD_PKA_2	224	230	PF00069	0.688
MOD_PKA_2	326	332	PF00069	0.689
MOD_PKA_2	65	71	PF00069	0.329
MOD_Plk_1	132	138	PF00069	0.403
MOD_Plk_1	274	280	PF00069	0.736
MOD_Plk_1	315	321	PF00069	0.705
MOD_Plk_1	393	399	PF00069	0.572
MOD_Plk_2-3	393	399	PF00069	0.572
MOD_Plk_4	316	322	PF00069	0.647
MOD_Plk_4	42	48	PF00069	0.396
MOD_Plk_4	60	66	PF00069	0.151
MOD_ProDKin_1	101	107	PF00069	0.367
MOD_ProDKin_1	311	317	PF00069	0.731
MOD_ProDKin_1	32	38	PF00069	0.383
MOD_ProDKin_1	331	337	PF00069	0.611
MOD_ProDKin_1	346	352	PF00069	0.623
MOD_ProDKin_1	380	386	PF00069	0.734
MOD_ProDKin_1	5	11	PF00069	0.559
MOD_SUMO_for_1	9	12	PF00179	0.454
MOD_SUMO_rev_2	71	78	PF00179	0.208
MOD_SUMO_rev_2	97	102	PF00179	0.208
TRG_ENDOCYTIC_2	110	113	PF00928	0.364
TRG_ENDOCYTIC_2	118	121	PF00928	0.363
TRG_ENDOCYTIC_2	142	145	PF00928	0.420
TRG_ENDOCYTIC_2	191	194	PF00928	0.565
TRG_ENDOCYTIC_2	288	291	PF00928	0.752
TRG_ER_diArg_1	90	93	PF00400	0.307
TRG_Pf-PMV_PEXEL_1	324	328	PF00026	0.750

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMX1	Leptomonas seymouri	57%	100%
A0A0S4KJM8	Bodo saltans	40%	72%
A0A1X0NUZ4	Trypanosomatidae	50%	100%
A0A3Q8IGX3	Leishmania donovani	89%	100%
A0A422P1B3	Trypanosoma rangeli	52%	100%
A4HKB0	Leishmania braziliensis	71%	99%
A4I7U0	Leishmania infantum	89%	100%
D0AA00	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9B2P8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q62848	Rattus norvegicus	34%	97%
Q8N6T3	Homo sapiens	34%	99%
Q9EPJ9	Mus musculus	35%	97%
V5BGP1	Trypanosoma cruzi	49%	100%