Putative ubiquitin hydrolase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ubiquitin hydrolase, putative

Species:

Leishmania major

UniProt:

Q4Q5F7_LEIMA

TriTrypDb:

LmjF.32.1250 , LMJLV39_320018500 , LMJSD75_320018500

Length:

409

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q5F7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5F7

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	12
GO:0006511	ubiquitin-dependent protein catabolic process	7	10
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009056	catabolic process	2	10
GO:0009057	macromolecule catabolic process	4	10
GO:0009987	cellular process	1	10
GO:0016579	protein deubiquitination	6	12
GO:0019538	protein metabolic process	3	12
GO:0019941	modification-dependent protein catabolic process	6	10
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0043632	modification-dependent macromolecule catabolic process	5	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	12
GO:0044248	cellular catabolic process	3	10
GO:0044260	obsolete cellular macromolecule metabolic process	3	10
GO:0044265	obsolete cellular macromolecule catabolic process	4	10
GO:0051603	proteolysis involved in protein catabolic process	5	10
GO:0070646	protein modification by small protein removal	5	12
GO:0070647	protein modification by small protein conjugation or removal	5	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901575	organic substance catabolic process	3	10

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004843	cysteine-type deubiquitinase activity	5	12
GO:0008233	peptidase activity	3	12
GO:0008234	cysteine-type peptidase activity	4	12
GO:0016787	hydrolase activity	2	12
GO:0019783	ubiquitin-like protein peptidase activity	4	12
GO:0101005	deubiquitinase activity	5	12
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	281	283	PF00675	0.297
CLV_PCSK_KEX2_1	281	283	PF00082	0.270
CLV_PCSK_SKI1_1	261	265	PF00082	0.252
CLV_PCSK_SKI1_1	302	306	PF00082	0.316
DEG_Nend_UBRbox_3	1	3	PF02207	0.243
DEG_SPOP_SBC_1	163	167	PF00917	0.206
DOC_CYCLIN_RxL_1	299	309	PF00134	0.279
DOC_CYCLIN_yClb5_NLxxxL_5	261	267	PF00134	0.347
DOC_MAPK_DCC_7	268	277	PF00069	0.260
DOC_MAPK_gen_1	177	184	PF00069	0.279
DOC_MAPK_gen_1	212	221	PF00069	0.279
DOC_MAPK_gen_1	261	269	PF00069	0.273
DOC_MAPK_MEF2A_6	214	223	PF00069	0.364
DOC_MAPK_MEF2A_6	225	233	PF00069	0.306
DOC_MAPK_MEF2A_6	268	277	PF00069	0.260
DOC_MAPK_RevD_3	267	282	PF00069	0.339
DOC_PP2B_LxvP_1	304	307	PF13499	0.245
DOC_USP7_MATH_1	128	132	PF00917	0.306
DOC_USP7_MATH_1	134	138	PF00917	0.277
DOC_USP7_MATH_1	146	150	PF00917	0.206
DOC_USP7_MATH_1	163	167	PF00917	0.375
DOC_USP7_MATH_1	75	79	PF00917	0.306
DOC_USP7_UBL2_3	177	181	PF12436	0.305
DOC_USP7_UBL2_3	261	265	PF12436	0.249
DOC_USP7_UBL2_3	393	397	PF12436	0.391
DOC_WW_Pin1_4	348	353	PF00397	0.341
DOC_WW_Pin1_4	369	374	PF00397	0.305
LIG_14-3-3_CanoR_1	216	222	PF00244	0.362
LIG_14-3-3_CanoR_1	247	255	PF00244	0.340
LIG_14-3-3_CanoR_1	299	305	PF00244	0.338
LIG_14-3-3_CanoR_1	324	329	PF00244	0.390
LIG_BRCT_BRCA1_1	197	201	PF00533	0.369
LIG_BRCT_BRCA1_1	273	277	PF00533	0.280
LIG_Clathr_ClatBox_1	118	122	PF01394	0.389
LIG_Clathr_ClatBox_1	291	295	PF01394	0.279
LIG_FHA_1	24	30	PF00498	0.400
LIG_FHA_1	249	255	PF00498	0.292
LIG_FHA_1	264	270	PF00498	0.176
LIG_FHA_1	299	305	PF00498	0.237
LIG_FHA_1	365	371	PF00498	0.437
LIG_FHA_1	376	382	PF00498	0.378
LIG_FHA_2	133	139	PF00498	0.280
LIG_Integrin_RGD_1	332	334	PF01839	0.389
LIG_LIR_Apic_2	224	230	PF02991	0.389
LIG_LIR_Apic_2	49	55	PF02991	0.296
LIG_LIR_Gen_1	21	29	PF02991	0.387
LIG_LIR_Gen_1	274	285	PF02991	0.434
LIG_LIR_Gen_1	4	13	PF02991	0.221
LIG_LIR_Nem_3	21	25	PF02991	0.387
LIG_LIR_Nem_3	224	229	PF02991	0.251
LIG_LIR_Nem_3	274	280	PF02991	0.434
LIG_LIR_Nem_3	320	326	PF02991	0.269
LIG_LIR_Nem_3	398	404	PF02991	0.245
LIG_MYND_1	65	69	PF01753	0.318
LIG_NRBOX	106	112	PF00104	0.305
LIG_Pex14_1	48	52	PF04695	0.260
LIG_Pex14_1	53	57	PF04695	0.260
LIG_Pex14_2	18	22	PF04695	0.318
LIG_SH2_CRK	227	231	PF00017	0.437
LIG_SH2_CRK	323	327	PF00017	0.305
LIG_SH2_STAT5	227	230	PF00017	0.392
LIG_SH2_STAT5	341	344	PF00017	0.286
LIG_SH2_STAT5	401	404	PF00017	0.245
LIG_SH3_3	66	72	PF00018	0.409
LIG_SUMO_SIM_par_1	25	30	PF11976	0.255
LIG_TRAF2_1	98	101	PF00917	0.279
LIG_TYR_ITSM	397	404	PF00017	0.389
LIG_WRC_WIRS_1	19	24	PF05994	0.293
MOD_CK1_1	149	155	PF00069	0.235
MOD_CK2_1	132	138	PF00069	0.338
MOD_CK2_1	254	260	PF00069	0.335
MOD_CK2_1	95	101	PF00069	0.289
MOD_GlcNHglycan	151	154	PF01048	0.444
MOD_GlcNHglycan	79	82	PF01048	0.356
MOD_GlcNHglycan	84	87	PF01048	0.363
MOD_GSK3_1	128	135	PF00069	0.291
MOD_GSK3_1	187	194	PF00069	0.304
MOD_GSK3_1	23	30	PF00069	0.376
MOD_GSK3_1	312	319	PF00069	0.294
MOD_N-GLC_1	1	6	PF02516	0.229
MOD_N-GLC_1	385	390	PF02516	0.398
MOD_N-GLC_1	75	80	PF02516	0.388
MOD_N-GLC_2	5	7	PF02516	0.260
MOD_NEK2_1	1	6	PF00069	0.306
MOD_NEK2_1	196	201	PF00069	0.350
MOD_NEK2_1	245	250	PF00069	0.246
MOD_NEK2_1	25	30	PF00069	0.260
MOD_NEK2_1	263	268	PF00069	0.260
MOD_NEK2_1	8	13	PF00069	0.299
MOD_NEK2_1	95	100	PF00069	0.269
MOD_PIKK_1	88	94	PF00454	0.333
MOD_PK_1	324	330	PF00069	0.318
MOD_PKA_2	217	223	PF00069	0.318
MOD_PKA_2	298	304	PF00069	0.199
MOD_Plk_1	237	243	PF00069	0.259
MOD_Plk_1	245	251	PF00069	0.160
MOD_Plk_1	312	318	PF00069	0.252
MOD_Plk_1	385	391	PF00069	0.389
MOD_Plk_2-3	132	138	PF00069	0.412
MOD_Plk_4	196	202	PF00069	0.358
MOD_Plk_4	217	223	PF00069	0.275
MOD_Plk_4	271	277	PF00069	0.322
MOD_Plk_4	324	330	PF00069	0.315
MOD_Plk_4	340	346	PF00069	0.293
MOD_Plk_4	375	381	PF00069	0.403
MOD_Plk_4	38	44	PF00069	0.233
MOD_Plk_4	396	402	PF00069	0.389
MOD_Plk_4	63	69	PF00069	0.397
MOD_Plk_4	8	14	PF00069	0.389
MOD_ProDKin_1	348	354	PF00069	0.341
MOD_ProDKin_1	369	375	PF00069	0.305
TRG_DiLeu_BaEn_2	397	403	PF01217	0.339
TRG_DiLeu_BaEn_4	116	122	PF01217	0.318
TRG_DiLeu_BaLyEn_6	321	326	PF01217	0.389
TRG_ENDOCYTIC_2	226	229	PF00928	0.415
TRG_ENDOCYTIC_2	323	326	PF00928	0.260
TRG_ENDOCYTIC_2	401	404	PF00928	0.245
TRG_ER_diArg_1	216	219	PF00400	0.206
TRG_ER_diArg_1	280	282	PF00400	0.292

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMP3	Leptomonas seymouri	64%	80%
A0A0S4IXL6	Bodo saltans	33%	75%
A0A1X0NUI1	Trypanosomatidae	45%	92%
A0A3S7X5G6	Leishmania donovani	91%	97%
A0A422P1B8	Trypanosoma rangeli	43%	93%
A4HKB2	Leishmania braziliensis	78%	100%
A4I7U2	Leishmania infantum	92%	76%
D0AA02	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	93%
E9B2Q0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
O94269	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	80%
Q9FPS3	Arabidopsis thaliana	27%	74%
V5DHM6	Trypanosoma cruzi	43%	100%