CRAL-TRIO domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CRAL/TRIO domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q5F6_LEIMA

TriTrypDb:

LmjF.32.1260 , LMJLV39_320018600 , LMJSD75_320018600

Length:

478

Annotations

LeishMANIAdb annotations

Carries a conserved CRAL-TRIO domain. Its didtant homologs are cytoplasmic and are involved in antiviral response.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 29
NetGPI	no	yes: 0, no: 29

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q5F6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5F6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	433	437	PF00656	0.507
CLV_NRD_NRD_1	149	151	PF00675	0.388
CLV_NRD_NRD_1	168	170	PF00675	0.388
CLV_NRD_NRD_1	221	223	PF00675	0.258
CLV_PCSK_KEX2_1	149	151	PF00082	0.388
CLV_PCSK_KEX2_1	221	223	PF00082	0.266
CLV_PCSK_KEX2_1	417	419	PF00082	0.552
CLV_PCSK_PC1ET2_1	417	419	PF00082	0.587
CLV_PCSK_SKI1_1	165	169	PF00082	0.295
CLV_PCSK_SKI1_1	241	245	PF00082	0.326
CLV_PCSK_SKI1_1	279	283	PF00082	0.381
CLV_PCSK_SKI1_1	35	39	PF00082	0.447
CLV_PCSK_SKI1_1	77	81	PF00082	0.418
DEG_APCC_DBOX_1	148	156	PF00400	0.420
DEG_APCC_DBOX_1	164	172	PF00400	0.239
DOC_CKS1_1	53	58	PF01111	0.415
DOC_CYCLIN_yCln2_LP_2	11	17	PF00134	0.325
DOC_MAPK_gen_1	169	177	PF00069	0.388
DOC_MAPK_gen_1	221	229	PF00069	0.281
DOC_MAPK_gen_1	404	412	PF00069	0.559
DOC_MAPK_gen_1	80	89	PF00069	0.271
DOC_MAPK_MEF2A_6	169	177	PF00069	0.233
DOC_MAPK_MEF2A_6	404	412	PF00069	0.559
DOC_PP1_RVXF_1	290	296	PF00149	0.292
DOC_PP4_FxxP_1	295	298	PF00568	0.345
DOC_SPAK_OSR1_1	387	391	PF12202	0.443
DOC_USP7_MATH_1	304	308	PF00917	0.373
DOC_WW_Pin1_4	124	129	PF00397	0.550
DOC_WW_Pin1_4	134	139	PF00397	0.399
DOC_WW_Pin1_4	294	299	PF00397	0.422
DOC_WW_Pin1_4	472	477	PF00397	0.482
DOC_WW_Pin1_4	52	57	PF00397	0.469
LIG_14-3-3_CanoR_1	131	137	PF00244	0.437
LIG_14-3-3_CanoR_1	22	30	PF00244	0.465
LIG_14-3-3_CanoR_1	222	228	PF00244	0.367
LIG_14-3-3_CanoR_1	279	289	PF00244	0.378
LIG_14-3-3_CanoR_1	387	391	PF00244	0.383
LIG_14-3-3_CanoR_1	418	426	PF00244	0.503
LIG_14-3-3_CanoR_1	465	473	PF00244	0.466
LIG_BIR_II_1	1	5	PF00653	0.491
LIG_BRCT_BRCA1_1	388	392	PF00533	0.406
LIG_deltaCOP1_diTrp_1	372	378	PF00928	0.316
LIG_deltaCOP1_diTrp_1	97	104	PF00928	0.426
LIG_FHA_1	1	7	PF00498	0.519
LIG_FHA_1	135	141	PF00498	0.362
LIG_FHA_1	162	168	PF00498	0.282
LIG_FHA_1	22	28	PF00498	0.421
LIG_FHA_1	224	230	PF00498	0.308
LIG_FHA_1	300	306	PF00498	0.382
LIG_FHA_1	338	344	PF00498	0.627
LIG_FHA_1	349	355	PF00498	0.418
LIG_FHA_1	48	54	PF00498	0.501
LIG_FHA_2	177	183	PF00498	0.299
LIG_FHA_2	337	343	PF00498	0.698
LIG_FHA_2	417	423	PF00498	0.582
LIG_GBD_Chelix_1	154	162	PF00786	0.203
LIG_LIR_Apic_2	294	298	PF02991	0.360
LIG_LIR_Apic_2	436	441	PF02991	0.500
LIG_LIR_Apic_2	97	101	PF02991	0.287
LIG_LIR_Gen_1	182	193	PF02991	0.388
LIG_LIR_Gen_1	385	394	PF02991	0.450
LIG_LIR_Nem_3	182	188	PF02991	0.290
LIG_LIR_Nem_3	235	239	PF02991	0.354
LIG_LIR_Nem_3	36	41	PF02991	0.467
LIG_LIR_Nem_3	385	391	PF02991	0.379
LIG_Pex14_2	184	188	PF04695	0.233
LIG_Pex14_2	38	42	PF04695	0.272
LIG_Pex14_2	388	392	PF04695	0.340
LIG_Pex14_2	88	92	PF04695	0.367
LIG_REV1ctd_RIR_1	86	95	PF16727	0.260
LIG_SH2_CRK	278	282	PF00017	0.344
LIG_SH2_CRK	65	69	PF00017	0.319
LIG_SH2_NCK_1	109	113	PF00017	0.297
LIG_SH2_SRC	202	205	PF00017	0.258
LIG_SH2_STAP1	65	69	PF00017	0.412
LIG_SH2_STAT3	393	396	PF00017	0.458
LIG_SH3_1	170	176	PF00018	0.213
LIG_SH3_3	170	176	PF00018	0.442
LIG_SH3_3	265	271	PF00018	0.377
LIG_SUMO_SIM_par_1	225	230	PF11976	0.359
LIG_TRAF2_1	180	183	PF00917	0.213
LIG_TRAF2_1	339	342	PF00917	0.609
LIG_TRFH_1	4	8	PF08558	0.309
LIG_TYR_ITIM	154	159	PF00017	0.405
LIG_TYR_ITIM	234	239	PF00017	0.386
LIG_TYR_ITIM	63	68	PF00017	0.225
LIG_WRC_WIRS_1	1	6	PF05994	0.352
MOD_CDK_SPxxK_3	124	131	PF00069	0.334
MOD_CK1_1	102	108	PF00069	0.459
MOD_CK1_1	455	461	PF00069	0.476
MOD_CK2_1	176	182	PF00069	0.353
MOD_CK2_1	336	342	PF00069	0.526
MOD_CK2_1	416	422	PF00069	0.563
MOD_CK2_1	472	478	PF00069	0.513
MOD_Cter_Amidation	358	361	PF01082	0.463
MOD_GlcNHglycan	101	104	PF01048	0.457
MOD_GlcNHglycan	282	285	PF01048	0.361
MOD_GlcNHglycan	35	38	PF01048	0.323
MOD_GSK3_1	294	301	PF00069	0.352
MOD_GSK3_1	348	355	PF00069	0.455
MOD_GSK3_1	377	384	PF00069	0.397
MOD_GSK3_1	412	419	PF00069	0.537
MOD_N-GLC_1	299	304	PF02516	0.372
MOD_N-GLC_1	352	357	PF02516	0.306
MOD_N-GLC_2	223	225	PF02516	0.388
MOD_NEK2_1	122	127	PF00069	0.440
MOD_NEK2_1	244	249	PF00069	0.339
MOD_NEK2_1	280	285	PF00069	0.318
MOD_NEK2_1	378	383	PF00069	0.337
MOD_PIKK_1	21	27	PF00454	0.437
MOD_PKA_1	417	423	PF00069	0.548
MOD_PKA_2	21	27	PF00069	0.471
MOD_PKA_2	386	392	PF00069	0.423
MOD_PKA_2	417	423	PF00069	0.514
MOD_PKA_2	47	53	PF00069	0.410
MOD_PKB_1	409	417	PF00069	0.338
MOD_Plk_1	352	358	PF00069	0.465
MOD_Plk_1	412	418	PF00069	0.388
MOD_Plk_4	223	229	PF00069	0.366
MOD_Plk_4	304	310	PF00069	0.384
MOD_Plk_4	434	440	PF00069	0.412
MOD_Plk_4	452	458	PF00069	0.342
MOD_ProDKin_1	124	130	PF00069	0.546
MOD_ProDKin_1	134	140	PF00069	0.396
MOD_ProDKin_1	294	300	PF00069	0.422
MOD_ProDKin_1	472	478	PF00069	0.489
MOD_ProDKin_1	52	58	PF00069	0.458
MOD_SUMO_for_1	426	429	PF00179	0.420
TRG_DiLeu_BaLyEn_6	276	281	PF01217	0.417
TRG_DiLeu_BaLyEn_6	36	41	PF01217	0.503
TRG_DiLeu_BaLyEn_6	58	63	PF01217	0.314
TRG_ENDOCYTIC_2	130	133	PF00928	0.415
TRG_ENDOCYTIC_2	156	159	PF00928	0.374
TRG_ENDOCYTIC_2	236	239	PF00928	0.355
TRG_ENDOCYTIC_2	278	281	PF00928	0.360
TRG_ENDOCYTIC_2	65	68	PF00928	0.324
TRG_ER_diArg_1	220	222	PF00400	0.254
TRG_ER_diArg_1	408	411	PF00400	0.548
TRG_NLS_MonoExtC_3	168	173	PF00514	0.233
TRG_Pf-PMV_PEXEL_1	241	245	PF00026	0.392

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6D4	Leptomonas seymouri	27%	91%
A0A0N0P991	Leptomonas seymouri	66%	100%
A0A0N0P9K9	Leptomonas seymouri	29%	100%
A0A0N1I2J8	Leptomonas seymouri	32%	100%
A0A0N1PCS4	Leptomonas seymouri	31%	100%
A0A0S4J7N0	Bodo saltans	25%	100%
A0A0S4KJL3	Bodo saltans	33%	100%
A0A1X0NUH5	Trypanosomatidae	25%	82%
A0A1X0NUJ5	Trypanosomatidae	30%	100%
A0A3Q8ICN0	Leishmania donovani	30%	96%
A0A3Q8IGQ2	Leishmania donovani	94%	100%
A0A3R7MUL5	Trypanosoma rangeli	24%	87%
A0A3S7X4P4	Leishmania donovani	28%	92%
A0A3S7X4R1	Leishmania donovani	33%	97%
A0A422P1E3	Trypanosoma rangeli	28%	100%
A4HJI7	Leishmania braziliensis	30%	94%
A4HJI8	Leishmania braziliensis	32%	100%
A4HJI9	Leishmania braziliensis	30%	100%
A4HKB3	Leishmania braziliensis	82%	100%
A4HKB4	Leishmania braziliensis	25%	97%
A4I6Y2	Leishmania infantum	28%	92%
A4I6Y3	Leishmania infantum	33%	97%
A4I6Y4	Leishmania infantum	31%	100%
A4I7U3	Leishmania infantum	94%	100%
A8Y5H7	Mus musculus	23%	67%
E9B204	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	92%
E9B205	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	97%
E9B206	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9B2Q1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
O43304	Homo sapiens	26%	69%
Q0V9N0	Xenopus tropicalis	25%	68%
Q16KN5	Aedes aegypti	22%	74%
Q29JQ0	Drosophila pseudoobscura pseudoobscura	22%	71%
Q4Q655	Leishmania major	30%	99%
Q4Q656	Leishmania major	33%	97%
Q4Q657	Leishmania major	27%	92%
Q7PWB1	Anopheles gambiae	22%	70%
Q92503	Homo sapiens	23%	67%
Q99J08	Mus musculus	22%	100%
Q99MS0	Rattus norvegicus	22%	100%
Q9VMD6	Drosophila melanogaster	23%	73%
V5BL84	Trypanosoma cruzi	26%	100%
V5BQT0	Trypanosoma cruzi	25%	86%