LeishMANIAdb
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CRAL-TRIO domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
CRAL-TRIO domain-containing protein
Gene product:
CRAL/TRIO domain containing protein, putative
Species:
Leishmania major
UniProt:
Q4Q5F5_LEIMA
TriTrypDb:
LmjF.32.1270 , LMJLV39_320018700 * , LMJSD75_320018700 *
Length:
767

Annotations

LeishMANIAdb annotations

Carries a conserved CRAL-TRIO domain. Its didtant homologs are cytoplasmic and are involved in antiviral response.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q5F5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5F5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 15 19 PF00656 0.513
CLV_C14_Caspase3-7 24 28 PF00656 0.397
CLV_C14_Caspase3-7 54 58 PF00656 0.537
CLV_C14_Caspase3-7 625 629 PF00656 0.531
CLV_NRD_NRD_1 105 107 PF00675 0.414
CLV_NRD_NRD_1 118 120 PF00675 0.479
CLV_NRD_NRD_1 263 265 PF00675 0.773
CLV_NRD_NRD_1 313 315 PF00675 0.682
CLV_NRD_NRD_1 455 457 PF00675 0.379
CLV_NRD_NRD_1 495 497 PF00675 0.357
CLV_NRD_NRD_1 514 516 PF00675 0.240
CLV_NRD_NRD_1 673 675 PF00675 0.467
CLV_NRD_NRD_1 720 722 PF00675 0.466
CLV_PCSK_KEX2_1 105 107 PF00082 0.418
CLV_PCSK_KEX2_1 117 119 PF00082 0.481
CLV_PCSK_KEX2_1 263 265 PF00082 0.720
CLV_PCSK_KEX2_1 270 272 PF00082 0.622
CLV_PCSK_KEX2_1 313 315 PF00082 0.656
CLV_PCSK_KEX2_1 455 457 PF00082 0.375
CLV_PCSK_KEX2_1 494 496 PF00082 0.345
CLV_PCSK_KEX2_1 51 53 PF00082 0.537
CLV_PCSK_KEX2_1 514 516 PF00082 0.274
CLV_PCSK_KEX2_1 719 721 PF00082 0.486
CLV_PCSK_PC1ET2_1 270 272 PF00082 0.558
CLV_PCSK_PC1ET2_1 51 53 PF00082 0.537
CLV_PCSK_PC7_1 113 119 PF00082 0.511
CLV_PCSK_PC7_1 451 457 PF00082 0.375
CLV_PCSK_SKI1_1 105 109 PF00082 0.390
CLV_PCSK_SKI1_1 519 523 PF00082 0.397
CLV_PCSK_SKI1_1 560 564 PF00082 0.390
CLV_PCSK_SKI1_1 665 669 PF00082 0.437
CLV_PCSK_SKI1_1 95 99 PF00082 0.412
DEG_APCC_DBOX_1 104 112 PF00400 0.359
DEG_APCC_DBOX_1 518 526 PF00400 0.274
DEG_Nend_UBRbox_3 1 3 PF02207 0.671
DEG_SPOP_SBC_1 220 224 PF00917 0.669
DEG_SPOP_SBC_1 485 489 PF00917 0.310
DEG_SPOP_SBC_1 617 621 PF00917 0.516
DOC_CDC14_PxL_1 280 288 PF14671 0.583
DOC_CKS1_1 340 345 PF01111 0.633
DOC_CKS1_1 60 65 PF01111 0.537
DOC_CYCLIN_RxL_1 514 527 PF00134 0.332
DOC_CYCLIN_yCln2_LP_2 378 384 PF00134 0.406
DOC_CYCLIN_yCln2_LP_2 517 523 PF00134 0.370
DOC_MAPK_gen_1 275 282 PF00069 0.594
DOC_MAPK_gen_1 565 573 PF00069 0.375
DOC_MAPK_gen_1 669 678 PF00069 0.527
DOC_MAPK_gen_1 750 757 PF00069 0.399
DOC_MAPK_gen_1 95 104 PF00069 0.441
DOC_MAPK_JIP1_4 519 525 PF00069 0.310
DOC_MAPK_MEF2A_6 377 385 PF00069 0.358
DOC_MAPK_MEF2A_6 515 524 PF00069 0.406
DOC_MAPK_MEF2A_6 750 757 PF00069 0.423
DOC_MAPK_NFAT4_5 750 758 PF00069 0.428
DOC_PP1_RVXF_1 568 574 PF00149 0.410
DOC_PP1_RVXF_1 672 679 PF00149 0.455
DOC_PP2B_LxvP_1 147 150 PF13499 0.479
DOC_PP4_FxxP_1 655 658 PF00568 0.560
DOC_USP7_MATH_1 185 189 PF00917 0.580
DOC_USP7_MATH_1 195 199 PF00917 0.591
DOC_USP7_MATH_1 203 207 PF00917 0.549
DOC_USP7_MATH_1 213 217 PF00917 0.608
DOC_USP7_MATH_1 25 29 PF00917 0.461
DOC_USP7_MATH_1 297 301 PF00917 0.694
DOC_USP7_MATH_1 363 367 PF00917 0.560
DOC_USP7_MATH_1 485 489 PF00917 0.420
DOC_USP7_MATH_1 67 71 PF00917 0.589
DOC_USP7_MATH_1 670 674 PF00917 0.464
DOC_USP7_UBL2_3 346 350 PF12436 0.535
DOC_WW_Pin1_4 199 204 PF00397 0.667
DOC_WW_Pin1_4 221 226 PF00397 0.671
DOC_WW_Pin1_4 255 260 PF00397 0.683
DOC_WW_Pin1_4 290 295 PF00397 0.667
DOC_WW_Pin1_4 3 8 PF00397 0.617
DOC_WW_Pin1_4 339 344 PF00397 0.656
DOC_WW_Pin1_4 361 366 PF00397 0.659
DOC_WW_Pin1_4 422 427 PF00397 0.370
DOC_WW_Pin1_4 56 61 PF00397 0.537
DOC_WW_Pin1_4 605 610 PF00397 0.422
DOC_WW_Pin1_4 728 733 PF00397 0.331
DOC_WW_Pin1_4 82 87 PF00397 0.443
LIG_14-3-3_CanoR_1 11 17 PF00244 0.486
LIG_14-3-3_CanoR_1 254 258 PF00244 0.669
LIG_14-3-3_CanoR_1 275 280 PF00244 0.619
LIG_14-3-3_CanoR_1 303 309 PF00244 0.675
LIG_14-3-3_CanoR_1 52 56 PF00244 0.536
LIG_14-3-3_CanoR_1 618 623 PF00244 0.678
LIG_14-3-3_CanoR_1 674 679 PF00244 0.569
LIG_14-3-3_CanoR_1 750 756 PF00244 0.425
LIG_14-3-3_CterR_2 762 767 PF00244 0.472
LIG_Actin_WH2_2 36 53 PF00022 0.501
LIG_Actin_WH2_2 547 562 PF00022 0.266
LIG_BIR_III_2 428 432 PF00653 0.375
LIG_BIR_III_2 611 615 PF00653 0.579
LIG_BRCT_BRCA1_1 700 704 PF00533 0.401
LIG_Clathr_ClatBox_1 443 447 PF01394 0.375
LIG_deltaCOP1_diTrp_1 685 690 PF00928 0.433
LIG_deltaCOP1_diTrp_1 740 748 PF00928 0.449
LIG_DLG_GKlike_1 275 282 PF00625 0.594
LIG_eIF4E_1 16 22 PF01652 0.524
LIG_eIF4E_1 516 522 PF01652 0.370
LIG_eIF4E_1 661 667 PF01652 0.396
LIG_FHA_1 224 230 PF00498 0.614
LIG_FHA_1 24 30 PF00498 0.508
LIG_FHA_1 38 44 PF00498 0.472
LIG_FHA_1 438 444 PF00498 0.475
LIG_FHA_1 547 553 PF00498 0.375
LIG_FHA_1 640 646 PF00498 0.614
LIG_FHA_2 423 429 PF00498 0.375
LIG_FHA_2 52 58 PF00498 0.556
LIG_FHA_2 580 586 PF00498 0.406
LIG_FHA_2 60 66 PF00498 0.602
LIG_FHA_2 611 617 PF00498 0.581
LIG_FHA_2 638 644 PF00498 0.617
LIG_FHA_2 83 89 PF00498 0.412
LIG_LIR_Apic_2 337 343 PF02991 0.634
LIG_LIR_Apic_2 652 658 PF02991 0.573
LIG_LIR_Gen_1 183 194 PF02991 0.656
LIG_LIR_Gen_1 278 286 PF02991 0.636
LIG_LIR_Gen_1 439 449 PF02991 0.468
LIG_LIR_Gen_1 553 563 PF02991 0.369
LIG_LIR_Gen_1 697 707 PF02991 0.529
LIG_LIR_Nem_3 183 189 PF02991 0.684
LIG_LIR_Nem_3 274 279 PF02991 0.627
LIG_LIR_Nem_3 439 444 PF02991 0.369
LIG_LIR_Nem_3 535 539 PF02991 0.518
LIG_LIR_Nem_3 553 559 PF02991 0.216
LIG_LIR_Nem_3 653 659 PF02991 0.542
LIG_LIR_Nem_3 697 703 PF02991 0.523
LIG_LIR_Nem_3 88 94 PF02991 0.416
LIG_NRBOX 45 51 PF00104 0.470
LIG_Pex14_2 655 659 PF04695 0.461
LIG_Pex14_2 700 704 PF04695 0.449
LIG_PTB_Apo_2 176 183 PF02174 0.568
LIG_PTB_Phospho_1 176 182 PF10480 0.566
LIG_REV1ctd_RIR_1 745 754 PF16727 0.448
LIG_SH2_CRK 186 190 PF00017 0.604
LIG_SH2_CRK 406 410 PF00017 0.397
LIG_SH2_CRK 441 445 PF00017 0.455
LIG_SH2_CRK 518 522 PF00017 0.370
LIG_SH2_CRK 94 98 PF00017 0.420
LIG_SH2_NCK_1 182 186 PF00017 0.606
LIG_SH2_NCK_1 340 344 PF00017 0.634
LIG_SH2_PTP2 729 732 PF00017 0.432
LIG_SH2_SRC 182 185 PF00017 0.607
LIG_SH2_STAP1 145 149 PF00017 0.368
LIG_SH2_STAP1 186 190 PF00017 0.650
LIG_SH2_STAP1 369 373 PF00017 0.574
LIG_SH2_STAP1 441 445 PF00017 0.375
LIG_SH2_STAT5 186 189 PF00017 0.588
LIG_SH2_STAT5 406 409 PF00017 0.320
LIG_SH2_STAT5 452 455 PF00017 0.310
LIG_SH2_STAT5 516 519 PF00017 0.370
LIG_SH2_STAT5 544 547 PF00017 0.370
LIG_SH2_STAT5 556 559 PF00017 0.370
LIG_SH2_STAT5 661 664 PF00017 0.515
LIG_SH2_STAT5 729 732 PF00017 0.407
LIG_SH2_STAT5 76 79 PF00017 0.472
LIG_SH2_STAT5 91 94 PF00017 0.464
LIG_SH3_3 197 203 PF00018 0.569
LIG_SH3_3 222 228 PF00018 0.688
LIG_SH3_3 354 360 PF00018 0.637
LIG_SH3_3 57 63 PF00018 0.583
LIG_SUMO_SIM_anti_2 501 507 PF11976 0.315
LIG_SUMO_SIM_par_1 381 387 PF11976 0.426
LIG_SUMO_SIM_par_1 442 447 PF11976 0.510
LIG_SUMO_SIM_par_1 501 507 PF11976 0.315
LIG_SUMO_SIM_par_1 521 527 PF11976 0.189
LIG_SUMO_SIM_par_1 549 555 PF11976 0.244
LIG_SxIP_EBH_1 275 289 PF03271 0.628
LIG_TRFH_1 422 426 PF08558 0.370
LIG_TRFH_1 82 86 PF08558 0.453
LIG_TYR_ITIM 404 409 PF00017 0.474
LIG_TYR_ITIM 554 559 PF00017 0.459
LIG_TYR_ITIM 92 97 PF00017 0.418
MOD_CDK_SPK_2 255 260 PF00069 0.641
MOD_CDK_SPxxK_3 339 346 PF00069 0.568
MOD_CK1_1 153 159 PF00069 0.536
MOD_CK1_1 188 194 PF00069 0.723
MOD_CK1_1 223 229 PF00069 0.815
MOD_CK1_1 23 29 PF00069 0.511
MOD_CK1_1 255 261 PF00069 0.669
MOD_CK1_1 278 284 PF00069 0.618
MOD_CK1_1 295 301 PF00069 0.523
MOD_CK1_1 306 312 PF00069 0.662
MOD_CK1_1 320 326 PF00069 0.540
MOD_CK1_1 631 637 PF00069 0.692
MOD_CK1_1 733 739 PF00069 0.379
MOD_CK2_1 255 261 PF00069 0.633
MOD_CK2_1 579 585 PF00069 0.359
MOD_CK2_1 637 643 PF00069 0.599
MOD_CK2_1 82 88 PF00069 0.519
MOD_DYRK1A_RPxSP_1 199 203 PF00069 0.567
MOD_GlcNHglycan 113 116 PF01048 0.465
MOD_GlcNHglycan 156 159 PF01048 0.569
MOD_GlcNHglycan 215 218 PF01048 0.750
MOD_GlcNHglycan 23 26 PF01048 0.474
MOD_GlcNHglycan 297 300 PF01048 0.662
MOD_GlcNHglycan 325 328 PF01048 0.621
MOD_GlcNHglycan 332 335 PF01048 0.594
MOD_GlcNHglycan 69 72 PF01048 0.530
MOD_GlcNHglycan 700 703 PF01048 0.433
MOD_GlcNHglycan 705 708 PF01048 0.500
MOD_GSK3_1 12 19 PF00069 0.581
MOD_GSK3_1 150 157 PF00069 0.499
MOD_GSK3_1 184 191 PF00069 0.722
MOD_GSK3_1 195 202 PF00069 0.696
MOD_GSK3_1 203 210 PF00069 0.668
MOD_GSK3_1 21 28 PF00069 0.431
MOD_GSK3_1 219 226 PF00069 0.649
MOD_GSK3_1 271 278 PF00069 0.661
MOD_GSK3_1 288 295 PF00069 0.579
MOD_GSK3_1 303 310 PF00069 0.676
MOD_GSK3_1 317 324 PF00069 0.556
MOD_GSK3_1 359 366 PF00069 0.602
MOD_GSK3_1 480 487 PF00069 0.328
MOD_GSK3_1 546 553 PF00069 0.382
MOD_GSK3_1 572 579 PF00069 0.412
MOD_GSK3_1 616 623 PF00069 0.701
MOD_GSK3_1 628 635 PF00069 0.635
MOD_GSK3_1 639 646 PF00069 0.701
MOD_GSK3_1 670 677 PF00069 0.481
MOD_GSK3_1 760 767 PF00069 0.446
MOD_GSK3_1 78 85 PF00069 0.533
MOD_LATS_1 301 307 PF00433 0.665
MOD_N-GLC_1 1 6 PF02516 0.649
MOD_N-GLC_1 153 158 PF02516 0.553
MOD_N-GLC_1 295 300 PF02516 0.707
MOD_N-GLC_1 303 308 PF02516 0.681
MOD_N-GLC_1 546 551 PF02516 0.375
MOD_N-GLC_2 532 534 PF02516 0.244
MOD_NEK2_1 1 6 PF00069 0.692
MOD_NEK2_1 12 17 PF00069 0.505
MOD_NEK2_1 189 194 PF00069 0.564
MOD_NEK2_1 21 26 PF00069 0.322
MOD_NEK2_1 252 257 PF00069 0.574
MOD_NEK2_1 436 441 PF00069 0.369
MOD_NEK2_1 498 503 PF00069 0.310
MOD_NEK2_1 50 55 PF00069 0.508
MOD_NEK2_1 524 529 PF00069 0.370
MOD_NEK2_1 622 627 PF00069 0.657
MOD_NEK2_1 97 102 PF00069 0.351
MOD_NEK2_2 751 756 PF00069 0.417
MOD_PIKK_1 1 7 PF00454 0.646
MOD_PIKK_1 208 214 PF00454 0.550
MOD_PIKK_1 632 638 PF00454 0.647
MOD_PIKK_1 643 649 PF00454 0.548
MOD_PKA_1 263 269 PF00069 0.733
MOD_PKA_1 51 57 PF00069 0.603
MOD_PKA_1 674 680 PF00069 0.453
MOD_PKA_2 253 259 PF00069 0.660
MOD_PKA_2 263 269 PF00069 0.606
MOD_PKA_2 472 478 PF00069 0.339
MOD_PKA_2 51 57 PF00069 0.537
MOD_PKA_2 617 623 PF00069 0.714
MOD_PKA_2 670 676 PF00069 0.466
MOD_PKA_2 751 757 PF00069 0.465
MOD_Plk_1 303 309 PF00069 0.800
MOD_Plk_1 760 766 PF00069 0.457
MOD_Plk_1 78 84 PF00069 0.526
MOD_Plk_4 185 191 PF00069 0.580
MOD_Plk_4 278 284 PF00069 0.654
MOD_Plk_4 317 323 PF00069 0.673
MOD_Plk_4 364 370 PF00069 0.525
MOD_Plk_4 552 558 PF00069 0.433
MOD_Plk_4 712 718 PF00069 0.497
MOD_Plk_4 733 739 PF00069 0.336
MOD_ProDKin_1 199 205 PF00069 0.668
MOD_ProDKin_1 221 227 PF00069 0.671
MOD_ProDKin_1 255 261 PF00069 0.683
MOD_ProDKin_1 290 296 PF00069 0.669
MOD_ProDKin_1 3 9 PF00069 0.616
MOD_ProDKin_1 339 345 PF00069 0.655
MOD_ProDKin_1 361 367 PF00069 0.654
MOD_ProDKin_1 422 428 PF00069 0.370
MOD_ProDKin_1 56 62 PF00069 0.535
MOD_ProDKin_1 605 611 PF00069 0.437
MOD_ProDKin_1 728 734 PF00069 0.332
MOD_ProDKin_1 82 88 PF00069 0.435
MOD_SUMO_for_1 345 348 PF00179 0.556
MOD_SUMO_for_1 692 695 PF00179 0.366
MOD_SUMO_rev_2 347 352 PF00179 0.577
TRG_DiLeu_BaEn_4 347 353 PF01217 0.591
TRG_DiLeu_BaLyEn_6 374 379 PF01217 0.350
TRG_DiLeu_BaLyEn_6 517 522 PF01217 0.346
TRG_ENDOCYTIC_2 186 189 PF00928 0.686
TRG_ENDOCYTIC_2 396 399 PF00928 0.451
TRG_ENDOCYTIC_2 406 409 PF00928 0.390
TRG_ENDOCYTIC_2 441 444 PF00928 0.455
TRG_ENDOCYTIC_2 518 521 PF00928 0.370
TRG_ENDOCYTIC_2 556 559 PF00928 0.503
TRG_ENDOCYTIC_2 94 97 PF00928 0.409
TRG_ER_diArg_1 104 106 PF00400 0.392
TRG_ER_diArg_1 117 119 PF00400 0.412
TRG_ER_diArg_1 167 170 PF00400 0.617
TRG_ER_diArg_1 313 316 PF00400 0.586
TRG_ER_diArg_1 455 458 PF00400 0.413
TRG_ER_diArg_1 493 496 PF00400 0.332
TRG_ER_diArg_1 513 515 PF00400 0.233
TRG_ER_diArg_1 718 721 PF00400 0.488
TRG_ER_diArg_1 750 753 PF00400 0.436
TRG_Pf-PMV_PEXEL_1 106 110 PF00026 0.445
TRG_Pf-PMV_PEXEL_1 199 204 PF00026 0.584

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P992 Leptomonas seymouri 43% 100%
A0A3S5H7R8 Leishmania donovani 86% 100%
A0A3S7X4P4 Leishmania donovani 24% 100%
A4HKB5 Leishmania braziliensis 62% 100%
A4I6Y2 Leishmania infantum 24% 100%
A4I7U4 Leishmania infantum 86% 100%
E9B204 Leishmania mexicana (strain MHOM/GT/2001/U1103) 24% 100%
E9B2Q2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 80% 100%
Q4Q657 Leishmania major 23% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS