Peptide deformylase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Peptide deformylase

Gene product:

polypeptide deformylase-like protein, putative

Species:

Leishmania major

UniProt:

Q4Q5F2_LEIMA

TriTrypDb:

LmjF.32.1300 , LMJLV39_320019100 , LMJSD75_320019100

Length:

271

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q5F2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5F2

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	12
GO:0006518	peptide metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009058	biosynthetic process	2	12
GO:0009059	macromolecule biosynthetic process	4	12
GO:0009987	cellular process	1	12
GO:0018193	peptidyl-amino acid modification	5	2
GO:0018206	peptidyl-methionine modification	6	2
GO:0019538	protein metabolic process	3	12
GO:0031365	N-terminal protein amino acid modification	5	2
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	12
GO:0036211	protein modification process	4	2
GO:0043043	peptide biosynthetic process	5	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	2
GO:0043603	amide metabolic process	3	12
GO:0043604	amide biosynthetic process	4	12
GO:0043686	co-translational protein modification	5	2
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0044271	cellular nitrogen compound biosynthetic process	4	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901566	organonitrogen compound biosynthetic process	4	12
GO:1901576	organic substance biosynthetic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0016787	hydrolase activity	2	12
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	3	12
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	4	12
GO:0042586	peptide deformylase activity	5	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	2	4	PF00675	0.589
CLV_NRD_NRD_1	51	53	PF00675	0.274
CLV_NRD_NRD_1	8	10	PF00675	0.598
CLV_PCSK_KEX2_1	2	4	PF00082	0.587
CLV_PCSK_KEX2_1	51	53	PF00082	0.274
CLV_PCSK_KEX2_1	8	10	PF00082	0.585
CLV_PCSK_SKI1_1	197	201	PF00082	0.306
CLV_PCSK_SKI1_1	59	63	PF00082	0.253
DEG_Nend_UBRbox_1	1	4	PF02207	0.565
DEG_SPOP_SBC_1	28	32	PF00917	0.583
DOC_CKS1_1	232	237	PF01111	0.349
DOC_PP4_FxxP_1	97	100	PF00568	0.262
DOC_USP7_MATH_1	28	32	PF00917	0.502
DOC_USP7_MATH_1	57	61	PF00917	0.324
DOC_WW_Pin1_4	231	236	PF00397	0.420
DOC_WW_Pin1_4	29	34	PF00397	0.473
DOC_WW_Pin1_4	72	77	PF00397	0.281
LIG_14-3-3_CanoR_1	162	168	PF00244	0.347
LIG_Actin_WH2_2	36	53	PF00022	0.398
LIG_BIR_III_4	23	27	PF00653	0.433
LIG_BRCT_BRCA1_1	31	35	PF00533	0.501
LIG_BRCT_BRCA1_1	74	78	PF00533	0.351
LIG_FHA_1	13	19	PF00498	0.589
LIG_FHA_1	152	158	PF00498	0.340
LIG_FHA_1	60	66	PF00498	0.340
LIG_FHA_1	68	74	PF00498	0.340
LIG_FHA_2	116	122	PF00498	0.359
LIG_LIR_Apic_2	121	126	PF02991	0.247
LIG_LIR_Apic_2	96	100	PF02991	0.262
LIG_Pex14_1	221	225	PF04695	0.339
LIG_SH2_SRC	168	171	PF00017	0.274
LIG_SH2_STAP1	120	124	PF00017	0.334
LIG_SH2_STAP1	256	260	PF00017	0.419
LIG_SH2_STAT5	219	222	PF00017	0.266
LIG_SH2_STAT5	231	234	PF00017	0.367
LIG_SH2_STAT5	241	244	PF00017	0.377
LIG_SH3_3	123	129	PF00018	0.262
LIG_SH3_3	154	160	PF00018	0.247
LIG_SH3_3	229	235	PF00018	0.394
LIG_SH3_3	244	250	PF00018	0.286
LIG_SH3_3	61	67	PF00018	0.308
LIG_SUMO_SIM_par_1	107	113	PF11976	0.295
LIG_TRAF2_2	235	240	PF00917	0.307
MOD_CDK_SPxxK_3	29	36	PF00069	0.465
MOD_CK1_1	149	155	PF00069	0.323
MOD_CK1_1	31	37	PF00069	0.561
MOD_CK2_1	115	121	PF00069	0.376
MOD_CK2_1	31	37	PF00069	0.532
MOD_GlcNHglycan	165	168	PF01048	0.250
MOD_GlcNHglycan	226	229	PF01048	0.327
MOD_GlcNHglycan	97	100	PF01048	0.262
MOD_GSK3_1	27	34	PF00069	0.592
MOD_GSK3_1	68	75	PF00069	0.320
MOD_N-GLC_1	243	248	PF02516	0.434
MOD_NEK2_1	110	115	PF00069	0.295
MOD_NEK2_1	195	200	PF00069	0.325
MOD_NEK2_1	208	213	PF00069	0.249
MOD_NEK2_1	78	83	PF00069	0.276
MOD_NEK2_1	95	100	PF00069	0.338
MOD_PIKK_1	68	74	PF00454	0.317
MOD_PKA_2	161	167	PF00069	0.390
MOD_Plk_1	243	249	PF00069	0.427
MOD_Plk_4	13	19	PF00069	0.568
MOD_Plk_4	195	201	PF00069	0.247
MOD_Plk_4	243	249	PF00069	0.424
MOD_Plk_4	78	84	PF00069	0.360
MOD_ProDKin_1	231	237	PF00069	0.418
MOD_ProDKin_1	29	35	PF00069	0.470
MOD_ProDKin_1	72	78	PF00069	0.281
MOD_SUMO_rev_2	34	43	PF00179	0.544
TRG_DiLeu_BaEn_1	190	195	PF01217	0.378
TRG_ER_diArg_1	1	3	PF00400	0.634
TRG_ER_diArg_1	182	185	PF00400	0.260
TRG_ER_diArg_1	50	52	PF00400	0.274
TRG_ER_diArg_1	7	9	PF00400	0.634
TRG_Pf-PMV_PEXEL_1	185	190	PF00026	0.262

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4A0	Leptomonas seymouri	73%	99%
A0A0S4KJX6	Bodo saltans	55%	98%
A0A1X0NUS7	Trypanosomatidae	65%	100%
A0A3R7P233	Trypanosoma rangeli	62%	100%
A0A3S7X5G9	Leishmania donovani	96%	100%
A4HKB8	Leishmania braziliensis	84%	100%
A4I7U7	Leishmania infantum	96%	100%
D0AA05	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	65%	100%
E9B2Q5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q9HBH1	Homo sapiens	28%	100%
V5B173	Trypanosoma cruzi	64%	100%