WLM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WLM domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q5F1_LEIMA

TriTrypDb:

LmjF.32.1310 , LMJLV39_320019200 , LMJSD75_320019200

Length:

382

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q5F1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5F1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	14	16	PF00675	0.448
CLV_NRD_NRD_1	146	148	PF00675	0.522
CLV_NRD_NRD_1	200	202	PF00675	0.355
CLV_NRD_NRD_1	224	226	PF00675	0.454
CLV_NRD_NRD_1	233	235	PF00675	0.361
CLV_NRD_NRD_1	326	328	PF00675	0.723
CLV_PCSK_KEX2_1	14	16	PF00082	0.448
CLV_PCSK_KEX2_1	146	148	PF00082	0.522
CLV_PCSK_KEX2_1	200	202	PF00082	0.402
CLV_PCSK_KEX2_1	224	226	PF00082	0.393
CLV_PCSK_KEX2_1	233	235	PF00082	0.308
CLV_PCSK_KEX2_1	328	330	PF00082	0.761
CLV_PCSK_PC1ET2_1	328	330	PF00082	0.761
CLV_PCSK_PC7_1	142	148	PF00082	0.436
CLV_PCSK_PC7_1	220	226	PF00082	0.513
CLV_PCSK_SKI1_1	220	224	PF00082	0.429
CLV_PCSK_SKI1_1	28	32	PF00082	0.411
CLV_PCSK_SKI1_1	9	13	PF00082	0.369
DEG_APCC_DBOX_1	219	227	PF00400	0.513
DEG_Nend_UBRbox_2	1	3	PF02207	0.530
DEG_SPOP_SBC_1	110	114	PF00917	0.464
DEG_SPOP_SBC_1	181	185	PF00917	0.417
DOC_ANK_TNKS_1	45	52	PF00023	0.411
DOC_CKS1_1	339	344	PF01111	0.736
DOC_MAPK_gen_1	14	21	PF00069	0.448
DOC_MAPK_gen_1	52	59	PF00069	0.411
DOC_MAPK_MEF2A_6	28	37	PF00069	0.411
DOC_MAPK_MEF2A_6	91	100	PF00069	0.411
DOC_PP2B_PxIxI_1	341	347	PF00149	0.576
DOC_PP4_FxxP_1	47	50	PF00568	0.411
DOC_SPAK_OSR1_1	46	50	PF12202	0.411
DOC_USP7_MATH_1	110	114	PF00917	0.461
DOC_USP7_MATH_1	136	140	PF00917	0.381
DOC_USP7_MATH_1	181	185	PF00917	0.511
DOC_USP7_MATH_1	349	353	PF00917	0.694
DOC_WW_Pin1_4	111	116	PF00397	0.446
DOC_WW_Pin1_4	185	190	PF00397	0.427
DOC_WW_Pin1_4	214	219	PF00397	0.379
DOC_WW_Pin1_4	235	240	PF00397	0.588
DOC_WW_Pin1_4	334	339	PF00397	0.730
LIG_14-3-3_CanoR_1	180	190	PF00244	0.381
LIG_14-3-3_CanoR_1	28	33	PF00244	0.389
LIG_APCC_ABBA_1	56	61	PF00400	0.411
LIG_BRCT_BRCA1_1	191	195	PF00533	0.513
LIG_BRCT_BRCA1_1	308	312	PF00533	0.665
LIG_FHA_1	236	242	PF00498	0.672
LIG_FHA_1	339	345	PF00498	0.749
LIG_FHA_1	355	361	PF00498	0.541
LIG_FHA_1	69	75	PF00498	0.436
LIG_FHA_2	366	372	PF00498	0.675
LIG_LIR_Gen_1	370	380	PF02991	0.675
LIG_LIR_Nem_3	370	376	PF02991	0.665
LIG_LIR_Nem_3	55	59	PF02991	0.342
LIG_LIR_Nem_3	79	85	PF02991	0.436
LIG_LYPXL_S_1	107	111	PF13949	0.513
LIG_LYPXL_yS_3	108	111	PF13949	0.513
LIG_Pex14_1	83	87	PF04695	0.411
LIG_PTB_Apo_2	255	262	PF02174	0.580
LIG_PTB_Apo_2	81	88	PF02174	0.411
LIG_PTB_Phospho_1	81	87	PF10480	0.411
LIG_SH2_CRK	210	214	PF00017	0.389
LIG_SH2_CRK	87	91	PF00017	0.411
LIG_SH2_PTP2	373	376	PF00017	0.637
LIG_SH2_STAT5	373	376	PF00017	0.637
LIG_SH3_3	7	13	PF00018	0.411
LIG_SUMO_SIM_par_1	243	249	PF11976	0.690
LIG_SUMO_SIM_par_1	250	255	PF11976	0.657
LIG_SUMO_SIM_par_1	340	347	PF11976	0.694
LIG_TRAF2_1	368	371	PF00917	0.709
LIG_TYR_ITIM	85	90	PF00017	0.411
MOD_CDK_SPxK_1	214	220	PF00069	0.436
MOD_CK1_1	123	129	PF00069	0.407
MOD_CK1_1	165	171	PF00069	0.388
MOD_CK1_1	183	189	PF00069	0.292
MOD_CK1_1	334	340	PF00069	0.776
MOD_CK1_1	347	353	PF00069	0.721
MOD_CK2_1	125	131	PF00069	0.436
MOD_CK2_1	282	288	PF00069	0.686
MOD_CK2_1	334	340	PF00069	0.746
MOD_CK2_1	365	371	PF00069	0.721
MOD_Cter_Amidation	144	147	PF01082	0.395
MOD_Cter_Amidation	198	201	PF01082	0.411
MOD_Cter_Amidation	50	53	PF01082	0.411
MOD_GlcNHglycan	127	130	PF01048	0.378
MOD_GlcNHglycan	139	142	PF01048	0.409
MOD_GlcNHglycan	191	194	PF01048	0.498
MOD_GlcNHglycan	284	287	PF01048	0.712
MOD_GSK3_1	110	117	PF00069	0.428
MOD_GSK3_1	180	187	PF00069	0.352
MOD_GSK3_1	252	259	PF00069	0.794
MOD_GSK3_1	334	341	PF00069	0.773
MOD_GSK3_1	347	354	PF00069	0.647
MOD_N-GLC_1	257	262	PF02516	0.661
MOD_NEK2_1	116	121	PF00069	0.474
MOD_NEK2_1	241	246	PF00069	0.666
MOD_NEK2_1	252	257	PF00069	0.737
MOD_NEK2_1	96	101	PF00069	0.513
MOD_PIKK_1	120	126	PF00454	0.513
MOD_PIKK_1	354	360	PF00454	0.667
MOD_PKB_1	329	337	PF00069	0.708
MOD_Plk_1	257	263	PF00069	0.663
MOD_Plk_1	322	328	PF00069	0.635
MOD_Plk_1	96	102	PF00069	0.513
MOD_Plk_2-3	266	272	PF00069	0.602
MOD_Plk_4	171	177	PF00069	0.397
MOD_Plk_4	28	34	PF00069	0.411
MOD_Plk_4	340	346	PF00069	0.581
MOD_ProDKin_1	111	117	PF00069	0.446
MOD_ProDKin_1	185	191	PF00069	0.427
MOD_ProDKin_1	214	220	PF00069	0.379
MOD_ProDKin_1	235	241	PF00069	0.595
MOD_ProDKin_1	334	340	PF00069	0.731
TRG_ENDOCYTIC_2	108	111	PF00928	0.513
TRG_ENDOCYTIC_2	373	376	PF00928	0.637
TRG_ENDOCYTIC_2	86	89	PF00928	0.355
TRG_ER_diArg_1	13	15	PF00400	0.423
TRG_ER_diArg_1	146	148	PF00400	0.436
TRG_ER_diArg_1	200	202	PF00400	0.411
TRG_ER_diArg_1	223	225	PF00400	0.459
TRG_ER_diArg_1	233	235	PF00400	0.353
TRG_ER_diArg_1	326	329	PF00400	0.726
TRG_ER_diArg_1	7	10	PF00400	0.420
TRG_NLS_MonoCore_2	327	332	PF00514	0.760
TRG_NLS_MonoExtC_3	326	331	PF00514	0.759
TRG_NLS_MonoExtN_4	327	332	PF00514	0.721

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAV8	Leptomonas seymouri	46%	89%
A0A3Q8IFF9	Leishmania donovani	90%	100%
A4HKB9	Leishmania braziliensis	66%	100%
A4I7U8	Leishmania infantum	90%	100%
E9B2Q6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	99%