Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q5F0_LEIMA

TriTrypDb:

LmjF.32.1320 , LMJLV39_320019300 , LMJSD75_320019300

Length:

543

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4Q5F0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5F0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	135	137	PF00675	0.647
CLV_NRD_NRD_1	203	205	PF00675	0.642
CLV_NRD_NRD_1	291	293	PF00675	0.522
CLV_NRD_NRD_1	338	340	PF00675	0.596
CLV_NRD_NRD_1	513	515	PF00675	0.445
CLV_NRD_NRD_1	94	96	PF00675	0.427
CLV_PCSK_FUR_1	336	340	PF00082	0.544
CLV_PCSK_KEX2_1	203	205	PF00082	0.667
CLV_PCSK_KEX2_1	222	224	PF00082	0.656
CLV_PCSK_KEX2_1	291	293	PF00082	0.522
CLV_PCSK_KEX2_1	338	340	PF00082	0.479
CLV_PCSK_KEX2_1	495	497	PF00082	0.476
CLV_PCSK_KEX2_1	513	515	PF00082	0.445
CLV_PCSK_KEX2_1	93	95	PF00082	0.400
CLV_PCSK_PC1ET2_1	222	224	PF00082	0.656
CLV_PCSK_PC1ET2_1	495	497	PF00082	0.476
CLV_PCSK_SKI1_1	323	327	PF00082	0.506
CLV_PCSK_SKI1_1	408	412	PF00082	0.470
CLV_PCSK_SKI1_1	41	45	PF00082	0.578
CLV_PCSK_SKI1_1	456	460	PF00082	0.488
CLV_PCSK_SKI1_1	484	488	PF00082	0.499
CLV_PCSK_SKI1_1	496	500	PF00082	0.352
CLV_PCSK_SKI1_1	71	75	PF00082	0.452
CLV_Separin_Metazoa	242	246	PF03568	0.557
DEG_APCC_DBOX_1	337	345	PF00400	0.486
DEG_Nend_UBRbox_3	1	3	PF02207	0.594
DEG_SPOP_SBC_1	315	319	PF00917	0.640
DOC_CYCLIN_RxL_1	66	78	PF00134	0.508
DOC_PP2B_LxvP_1	187	190	PF13499	0.643
DOC_PP2B_LxvP_1	241	244	PF13499	0.620
DOC_PP2B_LxvP_1	37	40	PF13499	0.467
DOC_USP7_MATH_1	307	311	PF00917	0.652
DOC_USP7_MATH_1	315	319	PF00917	0.609
DOC_WW_Pin1_4	166	171	PF00397	0.644
DOC_WW_Pin1_4	173	178	PF00397	0.685
DOC_WW_Pin1_4	316	321	PF00397	0.621
LIG_14-3-3_CanoR_1	105	111	PF00244	0.507
LIG_14-3-3_CanoR_1	223	229	PF00244	0.669
LIG_14-3-3_CanoR_1	309	314	PF00244	0.684
LIG_14-3-3_CanoR_1	456	464	PF00244	0.455
LIG_14-3-3_CanoR_1	58	62	PF00244	0.550
LIG_BIR_III_4	197	201	PF00653	0.653
LIG_BRCT_BRCA1_1	525	529	PF00533	0.506
LIG_EVH1_1	142	146	PF00568	0.612
LIG_EVH1_1	187	191	PF00568	0.646
LIG_FHA_1	223	229	PF00498	0.656
LIG_FHA_1	324	330	PF00498	0.548
LIG_FHA_1	442	448	PF00498	0.525
LIG_FHA_1	452	458	PF00498	0.396
LIG_FHA_2	118	124	PF00498	0.612
LIG_FHA_2	162	168	PF00498	0.731
LIG_FHA_2	231	237	PF00498	0.551
LIG_FHA_2	45	51	PF00498	0.635
LIG_FHA_2	517	523	PF00498	0.470
LIG_FHA_2	58	64	PF00498	0.436
LIG_LIR_Gen_1	233	243	PF02991	0.642
LIG_LIR_Gen_1	8	17	PF02991	0.566
LIG_LIR_Nem_3	231	235	PF02991	0.727
LIG_LIR_Nem_3	27	32	PF02991	0.580
LIG_LIR_Nem_3	459	464	PF02991	0.459
LIG_LIR_Nem_3	69	73	PF02991	0.637
LIG_LIR_Nem_3	8	14	PF02991	0.592
LIG_MYND_1	140	144	PF01753	0.613
LIG_PDZ_Class_2	538	543	PF00595	0.626
LIG_Pex14_1	420	424	PF04695	0.502
LIG_PTAP_UEV_1	303	308	PF05743	0.633
LIG_SH2_CRK	235	239	PF00017	0.633
LIG_SH2_CRK	29	33	PF00017	0.622
LIG_SH2_GRB2like	11	14	PF00017	0.443
LIG_SH2_NCK_1	235	239	PF00017	0.546
LIG_SH2_STAT3	505	508	PF00017	0.471
LIG_SH2_STAT5	11	14	PF00017	0.508
LIG_SH2_STAT5	260	263	PF00017	0.612
LIG_SH2_STAT5	38	41	PF00017	0.578
LIG_SH2_STAT5	491	494	PF00017	0.454
LIG_SH2_STAT5	59	62	PF00017	0.525
LIG_SH3_1	137	143	PF00018	0.672
LIG_SH3_2	304	309	PF14604	0.671
LIG_SH3_3	135	141	PF00018	0.699
LIG_SH3_3	144	150	PF00018	0.604
LIG_SH3_3	183	189	PF00018	0.663
LIG_SH3_3	251	257	PF00018	0.539
LIG_SH3_3	301	307	PF00018	0.803
LIG_SUMO_SIM_anti_2	49	58	PF11976	0.568
LIG_TRAF2_1	124	127	PF00917	0.624
LIG_TRAF2_1	269	272	PF00917	0.410
LIG_TRAF2_1	425	428	PF00917	0.474
LIG_TYR_ITSM	231	238	PF00017	0.549
LIG_UBA3_1	264	273	PF00899	0.516
LIG_UBA3_1	36	42	PF00899	0.492
LIG_WW_2	140	143	PF00397	0.612
MOD_CDK_SPxxK_3	173	180	PF00069	0.676
MOD_CDK_SPxxK_3	316	323	PF00069	0.543
MOD_CK1_1	206	212	PF00069	0.659
MOD_CK1_1	283	289	PF00069	0.674
MOD_CK2_1	117	123	PF00069	0.661
MOD_CK2_1	266	272	PF00069	0.419
MOD_CK2_1	361	367	PF00069	0.539
MOD_CK2_1	415	421	PF00069	0.476
MOD_CK2_1	44	50	PF00069	0.629
MOD_CK2_1	57	63	PF00069	0.427
MOD_GlcNHglycan	205	208	PF01048	0.810
MOD_GlcNHglycan	288	291	PF01048	0.489
MOD_GlcNHglycan	303	307	PF01048	0.669
MOD_GlcNHglycan	480	483	PF01048	0.504
MOD_GlcNHglycan	529	532	PF01048	0.664
MOD_GSK3_1	117	124	PF00069	0.609
MOD_GSK3_1	189	196	PF00069	0.716
MOD_GSK3_1	199	206	PF00069	0.810
MOD_GSK3_1	248	255	PF00069	0.560
MOD_GSK3_1	298	305	PF00069	0.780
MOD_GSK3_1	44	51	PF00069	0.604
MOD_GSK3_1	523	530	PF00069	0.501
MOD_GSK3_1	62	69	PF00069	0.550
MOD_LATS_1	351	357	PF00433	0.455
MOD_NEK2_1	264	269	PF00069	0.632
MOD_NEK2_1	478	483	PF00069	0.501
MOD_NEK2_1	516	521	PF00069	0.494
MOD_NEK2_1	523	528	PF00069	0.485
MOD_PIKK_1	189	195	PF00454	0.813
MOD_PIKK_1	222	228	PF00454	0.696
MOD_PIKK_1	230	236	PF00454	0.595
MOD_PIKK_1	248	254	PF00454	0.616
MOD_PIKK_1	451	457	PF00454	0.470
MOD_PKA_1	203	209	PF00069	0.624
MOD_PKA_1	222	228	PF00069	0.653
MOD_PKA_1	527	533	PF00069	0.536
MOD_PKA_2	104	110	PF00069	0.555
MOD_PKA_2	203	209	PF00069	0.665
MOD_PKA_2	222	228	PF00069	0.632
MOD_PKA_2	283	289	PF00069	0.553
MOD_PKA_2	308	314	PF00069	0.751
MOD_PKA_2	415	421	PF00069	0.591
MOD_PKA_2	516	522	PF00069	0.460
MOD_PKA_2	57	63	PF00069	0.494
MOD_PKB_1	439	447	PF00069	0.481
MOD_PKB_1	64	72	PF00069	0.535
MOD_Plk_1	230	236	PF00069	0.595
MOD_Plk_1	280	286	PF00069	0.510
MOD_Plk_2-3	119	125	PF00069	0.615
MOD_Plk_2-3	266	272	PF00069	0.419
MOD_ProDKin_1	166	172	PF00069	0.642
MOD_ProDKin_1	173	179	PF00069	0.687
MOD_ProDKin_1	316	322	PF00069	0.619
MOD_SUMO_rev_2	266	275	PF00179	0.506
MOD_SUMO_rev_2	360	369	PF00179	0.523
MOD_SUMO_rev_2	421	430	PF00179	0.499
MOD_SUMO_rev_2	489	497	PF00179	0.504
MOD_SUMO_rev_2	78	86	PF00179	0.485
TRG_DiLeu_BaEn_1	52	57	PF01217	0.553
TRG_DiLeu_BaLyEn_6	260	265	PF01217	0.562
TRG_DiLeu_BaLyEn_6	453	458	PF01217	0.489
TRG_ENDOCYTIC_2	11	14	PF00928	0.479
TRG_ENDOCYTIC_2	235	238	PF00928	0.677
TRG_ENDOCYTIC_2	29	32	PF00928	0.562
TRG_ER_diArg_1	291	294	PF00400	0.537
TRG_ER_diArg_1	335	338	PF00400	0.632
TRG_ER_diArg_1	93	95	PF00400	0.424
TRG_Pf-PMV_PEXEL_1	109	113	PF00026	0.519
TRG_Pf-PMV_PEXEL_1	353	357	PF00026	0.500
TRG_Pf-PMV_PEXEL_1	363	367	PF00026	0.496
TRG_Pf-PMV_PEXEL_1	456	460	PF00026	0.444
TRG_Pf-PMV_PEXEL_1	514	518	PF00026	0.423

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IKZ7	Leishmania donovani	92%	100%
A4HKC0	Leishmania braziliensis	68%	98%
A4I7U9	Leishmania infantum	92%	100%
E9B2Q7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
V5BL88	Trypanosoma cruzi	26%	87%