PPPDE domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PPPDE putative peptidase domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q5E9_LEIMA

TriTrypDb:

LmjF.32.1330 , LMJLV39_320019400 , LMJSD75_320019400

Length:

629

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

Q4Q5E9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5E9

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0019538	protein metabolic process	3	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0044238	primary metabolic process	2	2
GO:0070646	protein modification by small protein removal	5	2
GO:0070647	protein modification by small protein conjugation or removal	5	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0008233	peptidase activity	3	12
GO:0016787	hydrolase activity	2	12
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	282	286	PF00656	0.325
CLV_C14_Caspase3-7	394	398	PF00656	0.400
CLV_NRD_NRD_1	116	118	PF00675	0.765
CLV_NRD_NRD_1	122	124	PF00675	0.788
CLV_NRD_NRD_1	373	375	PF00675	0.626
CLV_NRD_NRD_1	43	45	PF00675	0.784
CLV_NRD_NRD_1	536	538	PF00675	0.403
CLV_PCSK_KEX2_1	122	124	PF00082	0.789
CLV_PCSK_KEX2_1	173	175	PF00082	0.576
CLV_PCSK_KEX2_1	358	360	PF00082	0.566
CLV_PCSK_KEX2_1	373	375	PF00082	0.650
CLV_PCSK_KEX2_1	536	538	PF00082	0.428
CLV_PCSK_PC1ET2_1	173	175	PF00082	0.525
CLV_PCSK_PC1ET2_1	358	360	PF00082	0.601
CLV_PCSK_PC1ET2_1	373	375	PF00082	0.607
CLV_PCSK_SKI1_1	267	271	PF00082	0.564
CLV_PCSK_SKI1_1	359	363	PF00082	0.514
CLV_PCSK_SKI1_1	375	379	PF00082	0.574
CLV_PCSK_SKI1_1	468	472	PF00082	0.288
CLV_PCSK_SKI1_1	537	541	PF00082	0.431
CLV_PCSK_SKI1_1	550	554	PF00082	0.351
CLV_PCSK_SKI1_1	562	566	PF00082	0.351
DEG_SCF_FBW7_1	86	92	PF00400	0.516
DOC_ANK_TNKS_1	461	468	PF00023	0.606
DOC_CKS1_1	39	44	PF01111	0.579
DOC_CKS1_1	86	91	PF01111	0.519
DOC_CYCLIN_RxL_1	263	273	PF00134	0.332
DOC_CYCLIN_RxL_1	355	365	PF00134	0.360
DOC_MAPK_gen_1	218	226	PF00069	0.288
DOC_MAPK_gen_1	358	364	PF00069	0.371
DOC_MAPK_gen_1	373	384	PF00069	0.370
DOC_MAPK_gen_1	492	500	PF00069	0.362
DOC_MAPK_gen_1	560	567	PF00069	0.607
DOC_MAPK_JIP1_4	350	356	PF00069	0.405
DOC_MAPK_JIP1_4	378	384	PF00069	0.407
DOC_MAPK_MEF2A_6	156	164	PF00069	0.317
DOC_MAPK_RevD_3	360	375	PF00069	0.364
DOC_MAPK_RevD_3	523	537	PF00069	0.461
DOC_PP1_RVXF_1	466	472	PF00149	0.547
DOC_PP2B_LxvP_1	127	130	PF13499	0.478
DOC_PP2B_LxvP_1	182	185	PF13499	0.325
DOC_PP2B_LxvP_1	565	568	PF13499	0.462
DOC_PP4_MxPP_1	69	72	PF00568	0.439
DOC_USP7_MATH_1	28	32	PF00917	0.567
DOC_USP7_MATH_1	496	500	PF00917	0.333
DOC_USP7_MATH_1	568	572	PF00917	0.590
DOC_USP7_MATH_1	89	93	PF00917	0.568
DOC_USP7_UBL2_3	369	373	PF12436	0.375
DOC_USP7_UBL2_3	57	61	PF12436	0.520
DOC_WW_Pin1_4	362	367	PF00397	0.381
DOC_WW_Pin1_4	38	43	PF00397	0.578
DOC_WW_Pin1_4	415	420	PF00397	0.355
DOC_WW_Pin1_4	6	11	PF00397	0.587
DOC_WW_Pin1_4	85	90	PF00397	0.574
LIG_14-3-3_CanoR_1	110	116	PF00244	0.483
LIG_14-3-3_CanoR_1	316	321	PF00244	0.385
LIG_14-3-3_CanoR_1	44	51	PF00244	0.562
LIG_14-3-3_CanoR_1	550	555	PF00244	0.597
LIG_14-3-3_CanoR_1	560	568	PF00244	0.586
LIG_14-3-3_CanoR_1	581	590	PF00244	0.570
LIG_14-3-3_CanoR_1	74	82	PF00244	0.567
LIG_14-3-3_CanoR_1	93	98	PF00244	0.327
LIG_Actin_WH2_2	108	124	PF00022	0.448
LIG_Actin_WH2_2	457	475	PF00022	0.608
LIG_APCC_ABBA_1	197	202	PF00400	0.362
LIG_APCC_ABBA_1	485	490	PF00400	0.353
LIG_BRCT_BRCA1_1	231	235	PF00533	0.325
LIG_BRCT_BRCA1_1	594	598	PF00533	0.630
LIG_Clathr_ClatBox_1	179	183	PF01394	0.362
LIG_EVH1_2	71	75	PF00568	0.440
LIG_FHA_1	2	8	PF00498	0.567
LIG_FHA_1	219	225	PF00498	0.306
LIG_FHA_1	342	348	PF00498	0.368
LIG_FHA_1	394	400	PF00498	0.406
LIG_FHA_1	410	416	PF00498	0.333
LIG_FHA_1	528	534	PF00498	0.478
LIG_FHA_1	551	557	PF00498	0.518
LIG_FHA_1	585	591	PF00498	0.587
LIG_FHA_1	75	81	PF00498	0.589
LIG_FHA_2	152	158	PF00498	0.447
LIG_FHA_2	381	387	PF00498	0.405
LIG_FHA_2	586	592	PF00498	0.565
LIG_FHA_2	621	627	PF00498	0.590
LIG_FHA_2	74	80	PF00498	0.610
LIG_GBD_Chelix_1	356	364	PF00786	0.609
LIG_GBD_Chelix_1	551	559	PF00786	0.353
LIG_LIR_Gen_1	495	505	PF02991	0.328
LIG_LIR_Gen_1	569	580	PF02991	0.579
LIG_LIR_Nem_3	221	226	PF02991	0.309
LIG_LIR_Nem_3	232	238	PF02991	0.365
LIG_LIR_Nem_3	250	254	PF02991	0.322
LIG_LIR_Nem_3	422	426	PF02991	0.303
LIG_LIR_Nem_3	459	463	PF02991	0.559
LIG_LIR_Nem_3	495	500	PF02991	0.343
LIG_LIR_Nem_3	569	575	PF02991	0.589
LIG_MAD2	63	71	PF02301	0.448
LIG_MLH1_MIPbox_1	231	235	PF16413	0.325
LIG_MYND_1	461	465	PF01753	0.597
LIG_NRBOX	550	556	PF00104	0.599
LIG_NRBOX	616	622	PF00104	0.600
LIG_PCNA_yPIPBox_3	573	581	PF02747	0.567
LIG_Pex14_1	423	427	PF04695	0.375
LIG_PTB_Apo_2	439	446	PF02174	0.475
LIG_REV1ctd_RIR_1	232	240	PF16727	0.381
LIG_SH2_CRK	251	255	PF00017	0.337
LIG_SH2_CRK	483	487	PF00017	0.359
LIG_SH2_PTP2	407	410	PF00017	0.335
LIG_SH2_SRC	407	410	PF00017	0.317
LIG_SH2_STAP1	175	179	PF00017	0.214
LIG_SH2_STAP1	547	551	PF00017	0.605
LIG_SH2_STAP1	602	606	PF00017	0.568
LIG_SH2_STAT5	200	203	PF00017	0.358
LIG_SH2_STAT5	223	226	PF00017	0.298
LIG_SH2_STAT5	279	282	PF00017	0.311
LIG_SH2_STAT5	367	370	PF00017	0.339
LIG_SH2_STAT5	407	410	PF00017	0.340
LIG_SH2_STAT5	514	517	PF00017	0.344
LIG_SH2_STAT5	592	595	PF00017	0.590
LIG_SH3_3	113	119	PF00018	0.553
LIG_SH3_3	22	28	PF00018	0.502
LIG_SH3_3	29	35	PF00018	0.551
LIG_SH3_3	36	42	PF00018	0.524
LIG_SH3_3	4	10	PF00018	0.536
LIG_SH3_3	591	597	PF00018	0.571
LIG_SH3_3	83	89	PF00018	0.556
LIG_SUMO_SIM_par_1	360	365	PF11976	0.388
LIG_TYR_ITIM	405	410	PF00017	0.329
LIG_TYR_ITSM	219	226	PF00017	0.242
MOD_CDK_SPK_2	6	11	PF00069	0.532
MOD_CDK_SPK_2	85	90	PF00069	0.591
MOD_CDK_SPxK_1	38	44	PF00069	0.525
MOD_CDK_SPxxK_3	362	369	PF00069	0.388
MOD_CDK_SPxxK_3	38	45	PF00069	0.526
MOD_CK1_1	331	337	PF00069	0.400
MOD_CK1_1	46	52	PF00069	0.566
MOD_CK1_1	508	514	PF00069	0.242
MOD_CK1_1	584	590	PF00069	0.556
MOD_CK1_1	611	617	PF00069	0.606
MOD_CK1_1	9	15	PF00069	0.556
MOD_CK2_1	292	298	PF00069	0.342
MOD_CK2_1	380	386	PF00069	0.408
MOD_CK2_1	585	591	PF00069	0.505
MOD_CK2_1	73	79	PF00069	0.612
MOD_GlcNHglycan	189	192	PF01048	0.494
MOD_GlcNHglycan	272	275	PF01048	0.505
MOD_GlcNHglycan	330	333	PF01048	0.552
MOD_GlcNHglycan	562	565	PF01048	0.411
MOD_GSK3_1	2	9	PF00069	0.610
MOD_GSK3_1	337	344	PF00069	0.378
MOD_GSK3_1	411	418	PF00069	0.384
MOD_GSK3_1	444	451	PF00069	0.449
MOD_GSK3_1	508	515	PF00069	0.242
MOD_GSK3_1	580	587	PF00069	0.512
MOD_GSK3_1	81	88	PF00069	0.566
MOD_GSK3_1	89	96	PF00069	0.510
MOD_LATS_1	446	452	PF00433	0.428
MOD_N-GLC_1	585	590	PF02516	0.403
MOD_N-GLC_1	611	616	PF02516	0.341
MOD_NEK2_1	224	229	PF00069	0.288
MOD_NEK2_1	270	275	PF00069	0.302
MOD_NEK2_1	300	305	PF00069	0.455
MOD_NEK2_1	307	312	PF00069	0.402
MOD_NEK2_1	328	333	PF00069	0.394
MOD_NEK2_1	505	510	PF00069	0.384
MOD_NEK2_1	582	587	PF00069	0.487
MOD_NEK2_1	73	78	PF00069	0.483
MOD_NEK2_1	95	100	PF00069	0.509
MOD_PIKK_1	537	543	PF00454	0.636
MOD_PK_1	322	328	PF00069	0.423
MOD_PK_1	93	99	PF00069	0.504
MOD_PKA_2	349	355	PF00069	0.404
MOD_PKA_2	43	49	PF00069	0.586
MOD_PKA_2	580	586	PF00069	0.425
MOD_PKA_2	73	79	PF00069	0.449
MOD_PKA_2	89	95	PF00069	0.519
MOD_Plk_1	131	137	PF00069	0.413
MOD_Plk_1	46	52	PF00069	0.518
MOD_Plk_1	585	591	PF00069	0.609
MOD_Plk_4	142	148	PF00069	0.381
MOD_Plk_4	28	34	PF00069	0.594
MOD_Plk_4	380	386	PF00069	0.304
MOD_Plk_4	411	417	PF00069	0.344
MOD_Plk_4	448	454	PF00069	0.418
MOD_Plk_4	496	502	PF00069	0.321
MOD_Plk_4	508	514	PF00069	0.321
MOD_Plk_4	550	556	PF00069	0.501
MOD_ProDKin_1	362	368	PF00069	0.377
MOD_ProDKin_1	38	44	PF00069	0.579
MOD_ProDKin_1	415	421	PF00069	0.356
MOD_ProDKin_1	6	12	PF00069	0.587
MOD_ProDKin_1	85	91	PF00069	0.571
MOD_SUMO_for_1	288	291	PF00179	0.381
TRG_DiLeu_BaEn_1	613	618	PF01217	0.534
TRG_DiLeu_BaEn_2	263	269	PF01217	0.381
TRG_DiLeu_BaLyEn_6	459	464	PF01217	0.586
TRG_ENDOCYTIC_2	17	20	PF00928	0.594
TRG_ENDOCYTIC_2	223	226	PF00928	0.260
TRG_ENDOCYTIC_2	251	254	PF00928	0.313
TRG_ENDOCYTIC_2	407	410	PF00928	0.320
TRG_ENDOCYTIC_2	483	486	PF00928	0.458
TRG_ENDOCYTIC_2	602	605	PF00928	0.542
TRG_ER_diArg_1	121	123	PF00400	0.589
TRG_ER_diArg_1	212	215	PF00400	0.312
TRG_ER_diArg_1	315	318	PF00400	0.451
TRG_ER_diArg_1	535	537	PF00400	0.597
TRG_ER_diArg_1	559	562	PF00400	0.618
TRG_NLS_Bipartite_1	358	377	PF00514	0.340
TRG_Pf-PMV_PEXEL_1	267	272	PF00026	0.525
TRG_Pf-PMV_PEXEL_1	318	323	PF00026	0.615
TRG_Pf-PMV_PEXEL_1	462	466	PF00026	0.415

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ICK7	Leptomonas seymouri	63%	100%
A0A0S4J986	Bodo saltans	28%	100%
A0A1X0NUY4	Trypanosomatidae	39%	100%
A0A3Q8IFV8	Leishmania donovani	91%	100%
A0A3R7KQA7	Trypanosoma rangeli	33%	100%
A4HKC1	Leishmania braziliensis	75%	100%
A4I7V0	Leishmania infantum	91%	100%
D0AA08	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9B2Q8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
V5BQT4	Trypanosoma cruzi	39%	100%