LicD_family_-_putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

LicD family, putative

Species:

Leishmania major

UniProt:

Q4Q5E7_LEIMA

TriTrypDb:

LmjF.32.1350 , LMJLV39_320019600 , LMJSD75_320019600

Length:

449

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q5E7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5E7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	112	116	PF00656	0.698
CLV_C14_Caspase3-7	181	185	PF00656	0.694
CLV_C14_Caspase3-7	27	31	PF00656	0.754
CLV_C14_Caspase3-7	79	83	PF00656	0.654
CLV_NRD_NRD_1	171	173	PF00675	0.680
CLV_NRD_NRD_1	198	200	PF00675	0.613
CLV_NRD_NRD_1	242	244	PF00675	0.546
CLV_NRD_NRD_1	378	380	PF00675	0.451
CLV_NRD_NRD_1	46	48	PF00675	0.552
CLV_PCSK_KEX2_1	197	199	PF00082	0.626
CLV_PCSK_KEX2_1	242	244	PF00082	0.546
CLV_PCSK_KEX2_1	46	48	PF00082	0.552
CLV_PCSK_SKI1_1	172	176	PF00082	0.686
CLV_PCSK_SKI1_1	230	234	PF00082	0.569
CLV_PCSK_SKI1_1	409	413	PF00082	0.506
CLV_PCSK_SKI1_1	444	448	PF00082	0.457
CLV_PCSK_SKI1_1	47	51	PF00082	0.601
CLV_PCSK_SKI1_1	92	96	PF00082	0.477
DEG_COP1_1	268	278	PF00400	0.486
DEG_SCF_FBW7_2	69	75	PF00400	0.590
DOC_CKS1_1	427	432	PF01111	0.514
DOC_CKS1_1	69	74	PF01111	0.592
DOC_CYCLIN_RxL_1	206	215	PF00134	0.519
DOC_CYCLIN_yCln2_LP_2	412	415	PF00134	0.549
DOC_PP1_RVXF_1	107	114	PF00149	0.690
DOC_PP1_RVXF_1	207	214	PF00149	0.459
DOC_PP1_RVXF_1	226	232	PF00149	0.330
DOC_PP2B_LxvP_1	158	161	PF13499	0.588
DOC_PP2B_LxvP_1	412	415	PF13499	0.549
DOC_PP4_FxxP_1	133	136	PF00568	0.567
DOC_PP4_FxxP_1	411	414	PF00568	0.445
DOC_USP7_MATH_1	121	125	PF00917	0.671
DOC_USP7_MATH_1	136	140	PF00917	0.678
DOC_USP7_MATH_1	166	170	PF00917	0.657
DOC_USP7_MATH_1	17	21	PF00917	0.721
DOC_USP7_MATH_1	23	27	PF00917	0.679
DOC_USP7_MATH_1	301	305	PF00917	0.473
DOC_USP7_MATH_2	78	84	PF00917	0.659
DOC_USP7_UBL2_3	444	448	PF12436	0.598
DOC_WW_Pin1_4	125	130	PF00397	0.751
DOC_WW_Pin1_4	19	24	PF00397	0.728
DOC_WW_Pin1_4	426	431	PF00397	0.508
DOC_WW_Pin1_4	68	73	PF00397	0.591
LIG_14-3-3_CanoR_1	172	179	PF00244	0.669
LIG_14-3-3_CanoR_1	56	64	PF00244	0.573
LIG_APCC_ABBA_1	247	252	PF00400	0.346
LIG_BRCT_BRCA1_1	39	43	PF00533	0.648
LIG_deltaCOP1_diTrp_1	271	280	PF00928	0.498
LIG_deltaCOP1_diTrp_1	52	57	PF00928	0.728
LIG_FHA_1	106	112	PF00498	0.690
LIG_FHA_1	206	212	PF00498	0.495
LIG_FHA_1	402	408	PF00498	0.677
LIG_FHA_1	434	440	PF00498	0.506
LIG_FHA_2	166	172	PF00498	0.664
LIG_FHA_2	25	31	PF00498	0.749
LIG_FHA_2	266	272	PF00498	0.618
LIG_FHA_2	391	397	PF00498	0.469
LIG_FHA_2	99	105	PF00498	0.710
LIG_LIR_Apic_2	130	136	PF02991	0.565
LIG_LIR_Apic_2	271	276	PF02991	0.482
LIG_LIR_Apic_2	425	430	PF02991	0.516
LIG_LIR_Gen_1	104	114	PF02991	0.693
LIG_LIR_Gen_1	289	298	PF02991	0.512
LIG_LIR_Gen_1	305	316	PF02991	0.493
LIG_LIR_Nem_3	104	110	PF02991	0.618
LIG_LIR_Nem_3	146	152	PF02991	0.725
LIG_LIR_Nem_3	244	250	PF02991	0.406
LIG_LIR_Nem_3	305	311	PF02991	0.494
LIG_LIR_Nem_3	442	446	PF02991	0.487
LIG_LIR_Nem_3	88	94	PF02991	0.579
LIG_LYPXL_yS_3	340	343	PF13949	0.479
LIG_PCNA_yPIPBox_3	292	306	PF02747	0.527
LIG_Pex14_1	368	372	PF04695	0.450
LIG_Pex14_1	53	57	PF04695	0.628
LIG_SH2_CRK	296	300	PF00017	0.595
LIG_SH2_NCK_1	260	264	PF00017	0.351
LIG_SH2_NCK_1	373	377	PF00017	0.503
LIG_SH2_SRC	260	263	PF00017	0.336
LIG_SH2_STAP1	250	254	PF00017	0.340
LIG_SH2_STAP1	260	264	PF00017	0.372
LIG_SH2_STAT5	290	293	PF00017	0.476
LIG_SH2_STAT5	418	421	PF00017	0.458
LIG_SH2_STAT5	435	438	PF00017	0.512
LIG_SH3_3	66	72	PF00018	0.716
LIG_SUMO_SIM_par_1	215	222	PF11976	0.422
LIG_TRAF2_1	101	104	PF00917	0.711
LIG_TRAF2_1	212	215	PF00917	0.422
LIG_TRAF2_1	219	222	PF00917	0.460
LIG_TYR_ITIM	258	263	PF00017	0.346
LIG_TYR_ITIM	338	343	PF00017	0.462
MOD_CDK_SPK_2	426	431	PF00069	0.508
MOD_CK1_1	125	131	PF00069	0.743
MOD_CK1_1	15	21	PF00069	0.661
MOD_CK1_1	279	285	PF00069	0.678
MOD_CK1_1	3	9	PF00069	0.641
MOD_CK2_1	165	171	PF00069	0.577
MOD_CK2_1	368	374	PF00069	0.466
MOD_CK2_1	38	44	PF00069	0.740
MOD_CK2_1	390	396	PF00069	0.467
MOD_CK2_1	431	437	PF00069	0.526
MOD_CK2_1	55	61	PF00069	0.563
MOD_CK2_1	64	70	PF00069	0.635
MOD_CK2_1	98	104	PF00069	0.719
MOD_GlcNHglycan	124	127	PF01048	0.735
MOD_GlcNHglycan	130	133	PF01048	0.682
MOD_GlcNHglycan	138	141	PF01048	0.576
MOD_GlcNHglycan	15	18	PF01048	0.813
MOD_GlcNHglycan	330	333	PF01048	0.470
MOD_GlcNHglycan	66	69	PF01048	0.692
MOD_GSK3_1	121	128	PF00069	0.759
MOD_GSK3_1	13	20	PF00069	0.702
MOD_GSK3_1	276	283	PF00069	0.554
MOD_GSK3_1	64	71	PF00069	0.703
MOD_NEK2_1	1	6	PF00069	0.530
MOD_NEK2_1	302	307	PF00069	0.593
MOD_NEK2_1	328	333	PF00069	0.506
MOD_NEK2_1	343	348	PF00069	0.582
MOD_NEK2_2	368	373	PF00069	0.457
MOD_PIKK_1	17	23	PF00454	0.750
MOD_PK_1	403	409	PF00069	0.613
MOD_PKA_1	172	178	PF00069	0.688
MOD_PKA_2	360	366	PF00069	0.374
MOD_PKA_2	55	61	PF00069	0.606
MOD_Plk_1	276	282	PF00069	0.726
MOD_Plk_1	29	35	PF00069	0.818
MOD_Plk_1	81	87	PF00069	0.672
MOD_Plk_4	286	292	PF00069	0.462
MOD_Plk_4	29	35	PF00069	0.760
MOD_Plk_4	3	9	PF00069	0.786
MOD_Plk_4	368	374	PF00069	0.453
MOD_Plk_4	38	44	PF00069	0.569
MOD_ProDKin_1	125	131	PF00069	0.752
MOD_ProDKin_1	19	25	PF00069	0.727
MOD_ProDKin_1	426	432	PF00069	0.514
MOD_ProDKin_1	68	74	PF00069	0.590
MOD_SUMO_rev_2	169	175	PF00179	0.681
MOD_SUMO_rev_2	437	446	PF00179	0.437
MOD_SUMO_rev_2	70	78	PF00179	0.705
TRG_DiLeu_BaEn_2	361	367	PF01217	0.600
TRG_DiLeu_BaLyEn_6	294	299	PF01217	0.577
TRG_ENDOCYTIC_2	260	263	PF00928	0.326
TRG_ENDOCYTIC_2	290	293	PF00928	0.542
TRG_ENDOCYTIC_2	296	299	PF00928	0.437
TRG_ENDOCYTIC_2	340	343	PF00928	0.479
TRG_ENDOCYTIC_2	91	94	PF00928	0.496
TRG_ER_diArg_1	196	199	PF00400	0.606
TRG_ER_diArg_1	45	47	PF00400	0.607
TRG_Pf-PMV_PEXEL_1	417	421	PF00026	0.461

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMW8	Leptomonas seymouri	48%	93%
A0A3S7X5H6	Leishmania donovani	89%	91%
A4HKC3	Leishmania braziliensis	69%	92%
A4I7V4	Leishmania infantum	90%	91%
E9B2R0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	91%