G5-interacting protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

G5-interacting protein, putative

Species:

Leishmania major

UniProt:

Q4Q5E5_LEIMA

TriTrypDb:

LmjF.32.1370 , LMJLV39_320019800 , LMJSD75_320019800

Length:

790

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q5E5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5E5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	673	677	PF00656	0.579
CLV_C14_Caspase3-7	775	779	PF00656	0.532
CLV_NRD_NRD_1	748	750	PF00675	0.465
CLV_PCSK_KEX2_1	277	279	PF00082	0.567
CLV_PCSK_KEX2_1	467	469	PF00082	0.643
CLV_PCSK_KEX2_1	748	750	PF00082	0.465
CLV_PCSK_PC1ET2_1	277	279	PF00082	0.562
CLV_PCSK_PC1ET2_1	467	469	PF00082	0.643
CLV_PCSK_PC7_1	463	469	PF00082	0.596
CLV_PCSK_SKI1_1	321	325	PF00082	0.528
CLV_PCSK_SKI1_1	543	547	PF00082	0.486
CLV_PCSK_SKI1_1	730	734	PF00082	0.675
DOC_CKS1_1	499	504	PF01111	0.378
DOC_CYCLIN_yClb5_NLxxxL_5	522	531	PF00134	0.505
DOC_MAPK_FxFP_2	655	658	PF00069	0.457
DOC_MAPK_gen_1	662	669	PF00069	0.409
DOC_MAPK_gen_1	738	746	PF00069	0.573
DOC_MAPK_MEF2A_6	662	669	PF00069	0.409
DOC_PP1_RVXF_1	374	381	PF00149	0.565
DOC_PP2B_LxvP_1	238	241	PF13499	0.789
DOC_PP4_FxxP_1	639	642	PF00568	0.405
DOC_PP4_FxxP_1	655	658	PF00568	0.457
DOC_PP4_FxxP_1	765	768	PF00568	0.534
DOC_USP7_MATH_1	193	197	PF00917	0.758
DOC_USP7_MATH_1	245	249	PF00917	0.569
DOC_USP7_MATH_1	422	426	PF00917	0.497
DOC_USP7_MATH_1	461	465	PF00917	0.459
DOC_USP7_MATH_1	549	553	PF00917	0.539
DOC_USP7_MATH_1	607	611	PF00917	0.586
DOC_USP7_UBL2_3	264	268	PF12436	0.547
DOC_USP7_UBL2_3	327	331	PF12436	0.600
DOC_USP7_UBL2_3	382	386	PF12436	0.595
DOC_USP7_UBL2_3	730	734	PF12436	0.643
DOC_USP7_UBL2_3	736	740	PF12436	0.623
DOC_WW_Pin1_4	251	256	PF00397	0.563
DOC_WW_Pin1_4	309	314	PF00397	0.543
DOC_WW_Pin1_4	498	503	PF00397	0.365
DOC_WW_Pin1_4	752	757	PF00397	0.538
LIG_14-3-3_CanoR_1	236	241	PF00244	0.793
LIG_14-3-3_CanoR_1	376	381	PF00244	0.561
LIG_BIR_II_1	1	5	PF00653	0.743
LIG_BRCT_BRCA1_1	599	603	PF00533	0.536
LIG_BRCT_BRCA1_2	599	605	PF00533	0.551
LIG_Clathr_ClatBox_1	562	566	PF01394	0.507
LIG_deltaCOP1_diTrp_1	676	681	PF00928	0.451
LIG_eIF4E_1	348	354	PF01652	0.488
LIG_FHA_1	212	218	PF00498	0.826
LIG_FHA_1	499	505	PF00498	0.436
LIG_FHA_1	662	668	PF00498	0.446
LIG_FHA_1	713	719	PF00498	0.491
LIG_FHA_2	448	454	PF00498	0.486
LIG_FHA_2	473	479	PF00498	0.599
LIG_FHA_2	623	629	PF00498	0.356
LIG_LIR_Apic_2	438	444	PF02991	0.556
LIG_LIR_Apic_2	473	479	PF02991	0.475
LIG_LIR_Gen_1	108	117	PF02991	0.816
LIG_LIR_Gen_1	279	286	PF02991	0.519
LIG_LIR_Gen_1	484	493	PF02991	0.438
LIG_LIR_Gen_1	516	527	PF02991	0.431
LIG_LIR_Nem_3	108	113	PF02991	0.787
LIG_LIR_Nem_3	279	284	PF02991	0.484
LIG_LIR_Nem_3	484	488	PF02991	0.414
LIG_LIR_Nem_3	516	522	PF02991	0.402
LIG_LIR_Nem_3	523	528	PF02991	0.390
LIG_LIR_Nem_3	600	606	PF02991	0.514
LIG_LIR_Nem_3	628	633	PF02991	0.531
LIG_LIR_Nem_3	646	650	PF02991	0.532
LIG_LIR_Nem_3	680	684	PF02991	0.397
LIG_PCNA_PIPBox_1	754	763	PF02747	0.313
LIG_PTB_Apo_2	39	46	PF02174	0.765
LIG_PTB_Apo_2	50	57	PF02174	0.767
LIG_PTB_Apo_2	651	658	PF02174	0.499
LIG_PTB_Phospho_1	39	45	PF10480	0.767
LIG_PTB_Phospho_1	50	56	PF10480	0.767
LIG_PTB_Phospho_1	651	657	PF10480	0.518
LIG_Rb_LxCxE_1	559	578	PF01857	0.517
LIG_SH2_CRK	110	114	PF00017	0.789
LIG_SH2_CRK	141	145	PF00017	0.790
LIG_SH2_CRK	525	529	PF00017	0.390
LIG_SH2_GRB2like	110	113	PF00017	0.790
LIG_SH2_GRB2like	51	54	PF00017	0.757
LIG_SH2_NCK_1	476	480	PF00017	0.507
LIG_SH2_PTP2	283	286	PF00017	0.421
LIG_SH2_PTP2	519	522	PF00017	0.395
LIG_SH2_SRC	51	54	PF00017	0.790
LIG_SH2_STAP1	472	476	PF00017	0.578
LIG_SH2_STAP1	514	518	PF00017	0.485
LIG_SH2_STAP1	688	692	PF00017	0.577
LIG_SH2_STAT3	153	156	PF00017	0.735
LIG_SH2_STAT5	134	137	PF00017	0.777
LIG_SH2_STAT5	249	252	PF00017	0.704
LIG_SH2_STAT5	283	286	PF00017	0.421
LIG_SH2_STAT5	348	351	PF00017	0.389
LIG_SH2_STAT5	352	355	PF00017	0.408
LIG_SH2_STAT5	441	444	PF00017	0.526
LIG_SH2_STAT5	472	475	PF00017	0.569
LIG_SH2_STAT5	481	484	PF00017	0.416
LIG_SH2_STAT5	485	488	PF00017	0.392
LIG_SH2_STAT5	498	501	PF00017	0.438
LIG_SH2_STAT5	519	522	PF00017	0.371
LIG_SH2_STAT5	575	578	PF00017	0.404
LIG_SH2_STAT5	684	687	PF00017	0.448
LIG_SH3_1	441	447	PF00018	0.532
LIG_SH3_3	100	106	PF00018	0.729
LIG_SH3_3	154	160	PF00018	0.812
LIG_SH3_3	163	169	PF00018	0.773
LIG_SH3_3	231	237	PF00018	0.717
LIG_SH3_3	3	9	PF00018	0.777
LIG_SH3_3	441	447	PF00018	0.418
LIG_SH3_3	463	469	PF00018	0.604
LIG_SH3_3	88	94	PF00018	0.722
LIG_SH3_CIN85_PxpxPR_1	231	236	PF14604	0.690
LIG_SUMO_SIM_anti_2	402	410	PF11976	0.476
LIG_SUMO_SIM_anti_2	507	513	PF11976	0.359
LIG_SUMO_SIM_par_1	402	410	PF11976	0.351
LIG_SUMO_SIM_par_1	704	710	PF11976	0.521
LIG_TRAF2_1	306	309	PF00917	0.650
LIG_UBA3_1	541	546	PF00899	0.530
LIG_UBA3_1	579	584	PF00899	0.424
LIG_ULM_U2AF65_1	748	753	PF00076	0.506
LIG_WRC_WIRS_1	678	683	PF05994	0.500
LIG_WRC_WIRS_1	743	748	PF05994	0.547
MOD_CDK_SPK_2	251	256	PF00069	0.611
MOD_CDK_SPxxK_3	309	316	PF00069	0.605
MOD_CK1_1	248	254	PF00069	0.635
MOD_CK1_1	608	614	PF00069	0.528
MOD_CK1_1	696	702	PF00069	0.572
MOD_CK1_1	772	778	PF00069	0.539
MOD_CK2_1	309	315	PF00069	0.568
MOD_CK2_1	369	375	PF00069	0.573
MOD_CK2_1	447	453	PF00069	0.519
MOD_CK2_1	472	478	PF00069	0.573
MOD_CK2_1	544	550	PF00069	0.583
MOD_CK2_1	622	628	PF00069	0.351
MOD_GlcNHglycan	119	122	PF01048	0.709
MOD_GlcNHglycan	220	223	PF01048	0.791
MOD_GlcNHglycan	292	295	PF01048	0.641
MOD_GlcNHglycan	327	330	PF01048	0.529
MOD_GlcNHglycan	33	36	PF01048	0.742
MOD_GlcNHglycan	423	427	PF01048	0.474
MOD_GlcNHglycan	490	493	PF01048	0.525
MOD_GlcNHglycan	550	554	PF01048	0.627
MOD_GlcNHglycan	739	743	PF01048	0.509
MOD_GlcNHglycan	91	94	PF01048	0.796
MOD_GSK3_1	263	270	PF00069	0.541
MOD_GSK3_1	286	293	PF00069	0.531
MOD_GSK3_1	376	383	PF00069	0.600
MOD_GSK3_1	470	477	PF00069	0.528
MOD_GSK3_1	692	699	PF00069	0.528
MOD_GSK3_1	7	14	PF00069	0.805
MOD_GSK3_1	730	737	PF00069	0.696
MOD_GSK3_1	738	745	PF00069	0.484
MOD_GSK3_1	778	785	PF00069	0.553
MOD_N-GLC_1	18	23	PF02516	0.817
MOD_N-GLC_1	608	613	PF02516	0.527
MOD_N-GLC_2	133	135	PF02516	0.782
MOD_NEK2_1	179	184	PF00069	0.783
MOD_NEK2_1	286	291	PF00069	0.502
MOD_NEK2_1	380	385	PF00069	0.598
MOD_NEK2_1	488	493	PF00069	0.526
MOD_NEK2_1	599	604	PF00069	0.519
MOD_NEK2_1	693	698	PF00069	0.541
MOD_NEK2_1	728	733	PF00069	0.650
MOD_NEK2_2	514	519	PF00069	0.479
MOD_OFUCOSY	621	626	PF10250	0.346
MOD_PIKK_1	105	111	PF00454	0.820
MOD_PIKK_1	556	562	PF00454	0.574
MOD_PIKK_1	755	761	PF00454	0.513
MOD_PK_1	236	242	PF00069	0.792
MOD_PKA_2	696	702	PF00069	0.576
MOD_Plk_1	422	428	PF00069	0.462
MOD_Plk_1	461	467	PF00069	0.518
MOD_Plk_1	514	520	PF00069	0.474
MOD_Plk_1	565	571	PF00069	0.392
MOD_Plk_1	608	614	PF00069	0.517
MOD_Plk_1	738	744	PF00069	0.579
MOD_Plk_2-3	369	375	PF00069	0.573
MOD_Plk_4	126	132	PF00069	0.550
MOD_Plk_4	245	251	PF00069	0.752
MOD_Plk_4	369	375	PF00069	0.541
MOD_Plk_4	507	513	PF00069	0.402
MOD_Plk_4	514	520	PF00069	0.418
MOD_Plk_4	565	571	PF00069	0.424
MOD_Plk_4	772	778	PF00069	0.511
MOD_ProDKin_1	251	257	PF00069	0.547
MOD_ProDKin_1	309	315	PF00069	0.542
MOD_ProDKin_1	498	504	PF00069	0.365
MOD_ProDKin_1	752	758	PF00069	0.539
MOD_SUMO_for_1	276	279	PF00179	0.572
MOD_SUMO_for_1	411	414	PF00179	0.589
MOD_SUMO_for_1	435	438	PF00179	0.493
MOD_SUMO_for_1	545	548	PF00179	0.542
MOD_SUMO_rev_2	408	413	PF00179	0.596
MOD_SUMO_rev_2	616	625	PF00179	0.502
MOD_SUMO_rev_2	659	664	PF00179	0.575
TRG_DiLeu_BaEn_1	369	374	PF01217	0.565
TRG_DiLeu_BaEn_1	423	428	PF01217	0.461
TRG_DiLeu_BaEn_2	437	443	PF01217	0.550
TRG_DiLeu_BaLyEn_6	610	615	PF01217	0.501
TRG_ENDOCYTIC_2	110	113	PF00928	0.823
TRG_ENDOCYTIC_2	134	137	PF00928	0.777
TRG_ENDOCYTIC_2	141	144	PF00928	0.669
TRG_ENDOCYTIC_2	283	286	PF00928	0.513
TRG_ENDOCYTIC_2	485	488	PF00928	0.414
TRG_ENDOCYTIC_2	519	522	PF00928	0.357
TRG_ENDOCYTIC_2	525	528	PF00928	0.369
TRG_ENDOCYTIC_2	630	633	PF00928	0.516
TRG_ER_diArg_1	665	668	PF00400	0.464
TRG_NLS_MonoExtC_3	542	548	PF00514	0.540

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P989	Leptomonas seymouri	58%	99%
A0A0S4IM67	Bodo saltans	23%	100%
A0A1X0NUG5	Trypanosomatidae	36%	100%
A0A3S7X5G1	Leishmania donovani	94%	100%
A0A422NI97	Trypanosoma rangeli	34%	100%
A4HKC5	Leishmania braziliensis	84%	100%
A4I7V2	Leishmania infantum	95%	100%
D0AA13	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9B2R2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	99%