LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
Q4Q5E4_LEIMA
TriTrypDb:
LmjF.32.1380
Length:
352

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q5E4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5E4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 258 262 PF00656 0.533
CLV_C14_Caspase3-7 87 91 PF00656 0.698
CLV_NRD_NRD_1 222 224 PF00675 0.717
CLV_NRD_NRD_1 243 245 PF00675 0.680
CLV_NRD_NRD_1 36 38 PF00675 0.534
CLV_NRD_NRD_1 6 8 PF00675 0.503
CLV_PCSK_KEX2_1 222 224 PF00082 0.717
CLV_PCSK_KEX2_1 243 245 PF00082 0.680
CLV_PCSK_KEX2_1 36 38 PF00082 0.622
CLV_PCSK_KEX2_1 6 8 PF00082 0.507
DEG_Nend_UBRbox_2 1 3 PF02207 0.604
DOC_CDC14_PxL_1 72 80 PF14671 0.545
DOC_CKS1_1 54 59 PF01111 0.635
DOC_CYCLIN_RxL_1 336 349 PF00134 0.441
DOC_CYCLIN_yClb1_LxF_4 69 75 PF00134 0.488
DOC_CYCLIN_yCln2_LP_2 162 168 PF00134 0.672
DOC_CYCLIN_yCln2_LP_2 282 288 PF00134 0.531
DOC_MAPK_DCC_7 159 168 PF00069 0.641
DOC_MAPK_gen_1 159 168 PF00069 0.641
DOC_MAPK_gen_1 243 250 PF00069 0.668
DOC_MAPK_gen_1 337 346 PF00069 0.436
DOC_MAPK_gen_1 6 12 PF00069 0.491
DOC_MAPK_MEF2A_6 161 170 PF00069 0.643
DOC_PP2B_LxvP_1 168 171 PF13499 0.773
DOC_USP7_MATH_1 127 131 PF00917 0.536
DOC_USP7_MATH_1 136 140 PF00917 0.597
DOC_USP7_MATH_1 146 150 PF00917 0.702
DOC_USP7_MATH_1 197 201 PF00917 0.814
DOC_USP7_MATH_1 319 323 PF00917 0.516
DOC_WW_Pin1_4 150 155 PF00397 0.723
DOC_WW_Pin1_4 161 166 PF00397 0.603
DOC_WW_Pin1_4 231 236 PF00397 0.789
DOC_WW_Pin1_4 289 294 PF00397 0.735
DOC_WW_Pin1_4 309 314 PF00397 0.606
DOC_WW_Pin1_4 53 58 PF00397 0.488
DOC_WW_Pin1_4 94 99 PF00397 0.807
LIG_14-3-3_CanoR_1 113 118 PF00244 0.668
LIG_14-3-3_CanoR_1 176 185 PF00244 0.684
LIG_14-3-3_CanoR_1 271 280 PF00244 0.665
LIG_APCC_ABBA_1 10 15 PF00400 0.505
LIG_BIR_III_2 305 309 PF00653 0.676
LIG_Clathr_ClatBox_1 22 26 PF01394 0.515
LIG_eIF4E_1 157 163 PF01652 0.678
LIG_FHA_1 188 194 PF00498 0.647
LIG_FHA_1 237 243 PF00498 0.577
LIG_FHA_1 53 59 PF00498 0.533
LIG_FHA_1 90 96 PF00498 0.718
LIG_LIR_Apic_2 155 160 PF02991 0.679
LIG_LIR_Apic_2 71 76 PF02991 0.424
LIG_LIR_Gen_1 28 38 PF02991 0.530
LIG_LIR_Gen_1 287 294 PF02991 0.661
LIG_LIR_Nem_3 28 34 PF02991 0.549
LIG_LIR_Nem_3 287 291 PF02991 0.639
LIG_MYND_1 107 111 PF01753 0.590
LIG_PDZ_Class_2 347 352 PF00595 0.622
LIG_SH2_CRK 157 161 PF00017 0.679
LIG_SH2_CRK 288 292 PF00017 0.682
LIG_SH2_NCK_1 288 292 PF00017 0.682
LIG_SH2_STAT5 120 123 PF00017 0.669
LIG_SH2_STAT5 13 16 PF00017 0.476
LIG_SH2_STAT5 345 348 PF00017 0.543
LIG_SH3_3 172 178 PF00018 0.786
LIG_SH3_3 179 185 PF00018 0.616
LIG_SH3_3 186 192 PF00018 0.623
LIG_SH3_3 227 233 PF00018 0.714
LIG_SH3_3 295 301 PF00018 0.628
LIG_SH3_3 73 79 PF00018 0.500
LIG_TRAF2_1 322 325 PF00917 0.585
LIG_TYR_ITIM 286 291 PF00017 0.630
LIG_UBA3_1 22 30 PF00899 0.516
MOD_CDK_SPxK_1 289 295 PF00069 0.690
MOD_CK1_1 149 155 PF00069 0.626
MOD_CK1_1 200 206 PF00069 0.628
MOD_CK2_1 314 320 PF00069 0.672
MOD_DYRK1A_RPxSP_1 231 235 PF00069 0.709
MOD_GlcNHglycan 130 133 PF01048 0.690
MOD_GlcNHglycan 146 149 PF01048 0.519
MOD_GlcNHglycan 172 175 PF01048 0.619
MOD_GlcNHglycan 185 188 PF01048 0.776
MOD_GlcNHglycan 2 6 PF01048 0.593
MOD_GSK3_1 146 153 PF00069 0.706
MOD_GSK3_1 166 173 PF00069 0.454
MOD_GSK3_1 183 190 PF00069 0.620
MOD_GSK3_1 231 238 PF00069 0.700
MOD_GSK3_1 84 91 PF00069 0.683
MOD_NEK2_1 1 6 PF00069 0.579
MOD_PIKK_1 177 183 PF00454 0.761
MOD_PKA_2 112 118 PF00069 0.784
MOD_PKA_2 136 142 PF00069 0.712
MOD_PKA_2 200 206 PF00069 0.614
MOD_Plk_4 136 142 PF00069 0.702
MOD_Plk_4 152 158 PF00069 0.542
MOD_Plk_4 68 74 PF00069 0.419
MOD_ProDKin_1 150 156 PF00069 0.724
MOD_ProDKin_1 161 167 PF00069 0.602
MOD_ProDKin_1 231 237 PF00069 0.791
MOD_ProDKin_1 289 295 PF00069 0.737
MOD_ProDKin_1 309 315 PF00069 0.608
MOD_ProDKin_1 53 59 PF00069 0.496
MOD_ProDKin_1 94 100 PF00069 0.809
TRG_DiLeu_BaLyEn_6 158 163 PF01217 0.664
TRG_DiLeu_BaLyEn_6 18 23 PF01217 0.636
TRG_ENDOCYTIC_2 288 291 PF00928 0.642
TRG_ER_diArg_1 159 162 PF00400 0.661
TRG_ER_diArg_1 221 223 PF00400 0.714
TRG_ER_diArg_1 242 244 PF00400 0.779
TRG_ER_diArg_1 280 283 PF00400 0.652
TRG_ER_diArg_1 35 37 PF00400 0.534
TRG_Pf-PMV_PEXEL_1 21 26 PF00026 0.519
TRG_Pf-PMV_PEXEL_1 271 276 PF00026 0.569

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IMP1 Leptomonas seymouri 36% 85%
A0A3S7X5H0 Leishmania donovani 82% 100%
A4HKC6 Leishmania braziliensis 56% 100%
A4I7V1 Leishmania infantum 82% 100%
E9B2R3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 84% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS