Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q5E3_LEIMA

TriTrypDb:

LmjF.32.1390 , LMJLV39_320019900 , LMJSD75_320019900

Length:

752

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q5E3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5E3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	738	742	PF00656	0.710
CLV_NRD_NRD_1	160	162	PF00675	0.554
CLV_NRD_NRD_1	382	384	PF00675	0.389
CLV_NRD_NRD_1	52	54	PF00675	0.696
CLV_NRD_NRD_1	676	678	PF00675	0.752
CLV_PCSK_KEX2_1	160	162	PF00082	0.554
CLV_PCSK_KEX2_1	314	316	PF00082	0.403
CLV_PCSK_KEX2_1	52	54	PF00082	0.697
CLV_PCSK_KEX2_1	676	678	PF00082	0.752
CLV_PCSK_KEX2_1	8	10	PF00082	0.684
CLV_PCSK_PC1ET2_1	314	316	PF00082	0.403
CLV_PCSK_PC1ET2_1	8	10	PF00082	0.620
CLV_PCSK_SKI1_1	210	214	PF00082	0.392
CLV_PCSK_SKI1_1	272	276	PF00082	0.502
CLV_PCSK_SKI1_1	310	314	PF00082	0.429
CLV_PCSK_SKI1_1	351	355	PF00082	0.563
CLV_PCSK_SKI1_1	400	404	PF00082	0.480
CLV_PCSK_SKI1_1	508	512	PF00082	0.420
CLV_PCSK_SKI1_1	666	670	PF00082	0.517
CLV_PCSK_SKI1_1	9	13	PF00082	0.686
DEG_APCC_DBOX_1	159	167	PF00400	0.528
DEG_MDM2_SWIB_1	276	283	PF02201	0.444
DEG_Nend_Nbox_1	1	3	PF02207	0.655
DEG_ODPH_VHL_1	419	431	PF01847	0.414
DEG_SPOP_SBC_1	267	271	PF00917	0.431
DOC_ANK_TNKS_1	51	58	PF00023	0.719
DOC_CKS1_1	354	359	PF01111	0.567
DOC_CKS1_1	401	406	PF01111	0.424
DOC_CYCLIN_RxL_1	204	217	PF00134	0.396
DOC_CYCLIN_RxL_1	381	392	PF00134	0.465
DOC_MAPK_gen_1	666	675	PF00069	0.715
DOC_MAPK_gen_1	683	693	PF00069	0.475
DOC_MAPK_MEF2A_6	686	695	PF00069	0.587
DOC_PP1_RVXF_1	280	286	PF00149	0.485
DOC_PP2B_LxvP_1	386	389	PF13499	0.476
DOC_PP2B_LxvP_1	418	421	PF13499	0.542
DOC_PP4_FxxP_1	646	649	PF00568	0.728
DOC_USP7_MATH_1	101	105	PF00917	0.690
DOC_USP7_MATH_1	108	112	PF00917	0.625
DOC_USP7_MATH_1	11	15	PF00917	0.548
DOC_USP7_MATH_1	122	126	PF00917	0.500
DOC_USP7_MATH_1	244	248	PF00917	0.410
DOC_USP7_MATH_1	332	336	PF00917	0.438
DOC_USP7_MATH_1	389	393	PF00917	0.579
DOC_USP7_MATH_1	549	553	PF00917	0.492
DOC_USP7_MATH_1	564	568	PF00917	0.482
DOC_USP7_MATH_1	668	672	PF00917	0.671
DOC_USP7_MATH_1	712	716	PF00917	0.765
DOC_USP7_MATH_1	743	747	PF00917	0.769
DOC_USP7_UBL2_3	268	272	PF12436	0.547
DOC_USP7_UBL2_3	310	314	PF12436	0.369
DOC_WW_Pin1_4	115	120	PF00397	0.818
DOC_WW_Pin1_4	18	23	PF00397	0.599
DOC_WW_Pin1_4	353	358	PF00397	0.583
DOC_WW_Pin1_4	360	365	PF00397	0.561
DOC_WW_Pin1_4	400	405	PF00397	0.461
DOC_WW_Pin1_4	436	441	PF00397	0.685
DOC_WW_Pin1_4	707	712	PF00397	0.667
DOC_WW_Pin1_4	741	746	PF00397	0.694
LIG_14-3-3_CanoR_1	315	324	PF00244	0.397
LIG_14-3-3_CanoR_1	383	387	PF00244	0.480
LIG_14-3-3_CanoR_1	414	421	PF00244	0.469
LIG_14-3-3_CanoR_1	441	448	PF00244	0.515
LIG_14-3-3_CanoR_1	516	520	PF00244	0.466
LIG_14-3-3_CanoR_1	676	684	PF00244	0.809
LIG_14-3-3_CanoR_1	9	18	PF00244	0.584
LIG_Actin_WH2_2	660	678	PF00022	0.531
LIG_BIR_III_2	437	441	PF00653	0.594
LIG_BRCT_BRCA1_1	438	442	PF00533	0.499
LIG_BRCT_BRCA1_1	482	486	PF00533	0.429
LIG_CtBP_PxDLS_1	364	368	PF00389	0.488
LIG_EH1_1	205	213	PF00400	0.444
LIG_eIF4E_1	307	313	PF01652	0.415
LIG_FHA_1	10	16	PF00498	0.553
LIG_FHA_1	124	130	PF00498	0.712
LIG_FHA_1	165	171	PF00498	0.364
LIG_FHA_1	203	209	PF00498	0.572
LIG_FHA_1	222	228	PF00498	0.268
LIG_FHA_1	414	420	PF00498	0.418
LIG_FHA_1	540	546	PF00498	0.470
LIG_FHA_1	636	642	PF00498	0.658
LIG_FHA_2	116	122	PF00498	0.710
LIG_FHA_2	420	426	PF00498	0.536
LIG_FHA_2	733	739	PF00498	0.763
LIG_GBD_Chelix_1	502	510	PF00786	0.285
LIG_LIR_Apic_2	644	649	PF02991	0.726
LIG_LIR_Gen_1	277	286	PF02991	0.452
LIG_LIR_Gen_1	463	473	PF02991	0.350
LIG_LIR_Gen_1	671	679	PF02991	0.669
LIG_LIR_Gen_1	721	731	PF02991	0.642
LIG_LIR_Gen_1	85	95	PF02991	0.464
LIG_LIR_Nem_3	111	115	PF02991	0.689
LIG_LIR_Nem_3	277	283	PF02991	0.461
LIG_LIR_Nem_3	463	468	PF02991	0.344
LIG_LIR_Nem_3	483	489	PF02991	0.416
LIG_LIR_Nem_3	531	537	PF02991	0.424
LIG_LIR_Nem_3	671	675	PF02991	0.673
LIG_LIR_Nem_3	715	719	PF02991	0.647
LIG_LIR_Nem_3	721	727	PF02991	0.649
LIG_LIR_Nem_3	85	91	PF02991	0.474
LIG_MLH1_MIPbox_1	482	486	PF16413	0.425
LIG_NRBOX	165	171	PF00104	0.424
LIG_NRBOX	86	92	PF00104	0.453
LIG_PCNA_APIM_2	533	539	PF02747	0.420
LIG_Pex14_2	216	220	PF04695	0.479
LIG_Pex14_2	276	280	PF04695	0.382
LIG_Rb_LxCxE_1	339	358	PF01857	0.504
LIG_REV1ctd_RIR_1	306	314	PF16727	0.361
LIG_SH2_PTP2	401	404	PF00017	0.458
LIG_SH2_PTP2	672	675	PF00017	0.670
LIG_SH2_SRC	292	295	PF00017	0.404
LIG_SH2_SRC	337	340	PF00017	0.320
LIG_SH2_SRC	38	41	PF00017	0.494
LIG_SH2_STAP1	317	321	PF00017	0.472
LIG_SH2_STAP1	395	399	PF00017	0.315
LIG_SH2_STAT5	292	295	PF00017	0.405
LIG_SH2_STAT5	305	308	PF00017	0.382
LIG_SH2_STAT5	337	340	PF00017	0.424
LIG_SH2_STAT5	38	41	PF00017	0.480
LIG_SH2_STAT5	401	404	PF00017	0.468
LIG_SH2_STAT5	536	539	PF00017	0.427
LIG_SH2_STAT5	672	675	PF00017	0.610
LIG_SH2_STAT5	79	82	PF00017	0.457
LIG_SH3_3	428	434	PF00018	0.525
LIG_SH3_3	681	687	PF00018	0.746
LIG_Sin3_3	147	154	PF02671	0.608
LIG_SUMO_SIM_anti_2	403	409	PF11976	0.447
LIG_SUMO_SIM_par_1	293	299	PF11976	0.411
LIG_SUMO_SIM_par_1	691	696	PF11976	0.620
LIG_TRAF2_1	154	157	PF00917	0.523
LIG_TRAF2_1	422	425	PF00917	0.605
LIG_TRAF2_1	605	608	PF00917	0.542
LIG_TRAF2_1	746	749	PF00917	0.584
LIG_TRFH_1	452	456	PF08558	0.556
LIG_UBA3_1	378	384	PF00899	0.424
LIG_UBA3_1	87	94	PF00899	0.462
LIG_WRC_WIRS_1	169	174	PF05994	0.370
MOD_CDK_SPK_2	436	441	PF00069	0.562
MOD_CK1_1	111	117	PF00069	0.760
MOD_CK1_1	202	208	PF00069	0.394
MOD_CK1_1	21	27	PF00069	0.586
MOD_CK1_1	259	265	PF00069	0.507
MOD_CK1_1	41	47	PF00069	0.565
MOD_CK1_1	567	573	PF00069	0.373
MOD_CK1_1	655	661	PF00069	0.669
MOD_CK2_1	11	17	PF00069	0.565
MOD_CK2_1	115	121	PF00069	0.659
MOD_CK2_1	340	346	PF00069	0.393
MOD_CK2_1	419	425	PF00069	0.527
MOD_CK2_1	726	732	PF00069	0.614
MOD_CK2_1	743	749	PF00069	0.751
MOD_GlcNHglycan	145	148	PF01048	0.725
MOD_GlcNHglycan	258	261	PF01048	0.476
MOD_GlcNHglycan	319	322	PF01048	0.398
MOD_GlcNHglycan	351	354	PF01048	0.562
MOD_GlcNHglycan	434	437	PF01048	0.692
MOD_GlcNHglycan	443	446	PF01048	0.648
MOD_GlcNHglycan	482	485	PF01048	0.493
MOD_GlcNHglycan	524	527	PF01048	0.509
MOD_GlcNHglycan	586	589	PF01048	0.627
MOD_GlcNHglycan	660	663	PF01048	0.689
MOD_GlcNHglycan	677	680	PF01048	0.597
MOD_GlcNHglycan	70	73	PF01048	0.550
MOD_GlcNHglycan	729	732	PF01048	0.743
MOD_GSK3_1	111	118	PF00069	0.724
MOD_GSK3_1	164	171	PF00069	0.433
MOD_GSK3_1	174	181	PF00069	0.447
MOD_GSK3_1	192	199	PF00069	0.424
MOD_GSK3_1	227	234	PF00069	0.546
MOD_GSK3_1	266	273	PF00069	0.494
MOD_GSK3_1	349	356	PF00069	0.572
MOD_GSK3_1	432	439	PF00069	0.611
MOD_GSK3_1	472	479	PF00069	0.483
MOD_GSK3_1	563	570	PF00069	0.441
MOD_GSK3_1	574	581	PF00069	0.432
MOD_GSK3_1	658	665	PF00069	0.676
MOD_N-GLC_1	164	169	PF02516	0.378
MOD_N-GLC_1	564	569	PF02516	0.459
MOD_N-GLC_1	577	582	PF02516	0.289
MOD_N-GLC_1	717	722	PF02516	0.552
MOD_NEK2_1	172	177	PF00069	0.445
MOD_NEK2_1	220	225	PF00069	0.480
MOD_NEK2_1	231	236	PF00069	0.490
MOD_NEK2_1	256	261	PF00069	0.490
MOD_NEK2_1	266	271	PF00069	0.502
MOD_NEK2_1	275	280	PF00069	0.268
MOD_NEK2_1	374	379	PF00069	0.276
MOD_NEK2_1	394	399	PF00069	0.443
MOD_NEK2_1	480	485	PF00069	0.426
MOD_NEK2_1	584	589	PF00069	0.510
MOD_NEK2_1	726	731	PF00069	0.628
MOD_NEK2_2	509	514	PF00069	0.464
MOD_PIKK_1	174	180	PF00454	0.474
MOD_PIKK_1	199	205	PF00454	0.442
MOD_PIKK_1	221	227	PF00454	0.462
MOD_PIKK_1	275	281	PF00454	0.511
MOD_PKA_2	382	388	PF00069	0.412
MOD_PKA_2	413	419	PF00069	0.456
MOD_PKA_2	515	521	PF00069	0.478
MOD_PKA_2	624	630	PF00069	0.655
MOD_PKA_2	635	641	PF00069	0.527
MOD_PKA_2	655	661	PF00069	0.677
MOD_PKA_2	675	681	PF00069	0.674
MOD_Plk_1	389	395	PF00069	0.474
MOD_Plk_1	466	472	PF00069	0.405
MOD_Plk_1	476	482	PF00069	0.427
MOD_Plk_1	564	570	PF00069	0.581
MOD_Plk_1	577	583	PF00069	0.339
MOD_Plk_2-3	732	738	PF00069	0.698
MOD_Plk_4	244	250	PF00069	0.345
MOD_Plk_4	374	380	PF00069	0.347
MOD_Plk_4	382	388	PF00069	0.412
MOD_Plk_4	389	395	PF00069	0.403
MOD_Plk_4	476	482	PF00069	0.514
MOD_Plk_4	509	515	PF00069	0.408
MOD_Plk_4	539	545	PF00069	0.570
MOD_Plk_4	549	555	PF00069	0.392
MOD_Plk_4	668	674	PF00069	0.650
MOD_Plk_4	83	89	PF00069	0.472
MOD_ProDKin_1	115	121	PF00069	0.818
MOD_ProDKin_1	18	24	PF00069	0.593
MOD_ProDKin_1	353	359	PF00069	0.581
MOD_ProDKin_1	360	366	PF00069	0.546
MOD_ProDKin_1	400	406	PF00069	0.459
MOD_ProDKin_1	436	442	PF00069	0.686
MOD_ProDKin_1	707	713	PF00069	0.670
MOD_ProDKin_1	741	747	PF00069	0.694
MOD_SUMO_for_1	698	701	PF00179	0.618
TRG_DiLeu_BaEn_4	700	706	PF01217	0.623
TRG_DiLeu_BaLyEn_6	207	212	PF01217	0.373
TRG_ENDOCYTIC_2	292	295	PF00928	0.390
TRG_ENDOCYTIC_2	303	306	PF00928	0.346
TRG_ENDOCYTIC_2	672	675	PF00928	0.670
TRG_ENDOCYTIC_2	716	719	PF00928	0.585
TRG_ER_diArg_1	675	677	PF00400	0.750
TRG_NES_CRM1_1	463	477	PF08389	0.377
TRG_NES_CRM1_1	574	586	PF08389	0.496
TRG_NES_CRM1_1	85	98	PF08389	0.371
TRG_Pf-PMV_PEXEL_1	210	214	PF00026	0.452

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2J2	Leptomonas seymouri	58%	99%
A0A1X0NUI7	Trypanosomatidae	30%	100%
A0A3S7X5F7	Leishmania donovani	93%	100%
A4HKC7	Leishmania braziliensis	74%	97%
A4I7V6	Leishmania infantum	93%	100%
E9B2R4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%