Kynurenine formamidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Putative cyclase, putative

Species:

Leishmania major

UniProt:

Q4Q5E1_LEIMA

TriTrypDb:

LmjF.32.1410 , LMJLV39_320020100 , LMJSD75_320020100

Length:

410

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

Q4Q5E1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5E1

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	10
GO:0006520	amino acid metabolic process	3	10
GO:0006568	tryptophan metabolic process	5	10
GO:0006569	tryptophan catabolic process	5	10
GO:0006576	biogenic amine metabolic process	5	10
GO:0006586	indolalkylamine metabolic process	5	10
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0009056	catabolic process	2	10
GO:0009063	amino acid catabolic process	4	10
GO:0009072	aromatic amino acid metabolic process	4	10
GO:0009074	aromatic amino acid family catabolic process	5	10
GO:0009308	amine metabolic process	4	10
GO:0009987	cellular process	1	10
GO:0016054	organic acid catabolic process	4	10
GO:0019439	aromatic compound catabolic process	4	10
GO:0019441	tryptophan catabolic process to kynurenine	5	10
GO:0019752	carboxylic acid metabolic process	5	10
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0042180	cellular ketone metabolic process	3	10
GO:0042430	indole-containing compound metabolic process	4	10
GO:0042436	indole-containing compound catabolic process	5	10
GO:0042537	benzene-containing compound metabolic process	4	10
GO:0043436	oxoacid metabolic process	4	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0044248	cellular catabolic process	3	10
GO:0044270	cellular nitrogen compound catabolic process	4	10
GO:0044281	small molecule metabolic process	2	10
GO:0044282	small molecule catabolic process	3	10
GO:0046395	carboxylic acid catabolic process	5	10
GO:0046483	heterocycle metabolic process	3	10
GO:0046700	heterocycle catabolic process	4	10
GO:0070189	kynurenine metabolic process	4	10
GO:0071704	organic substance metabolic process	2	10
GO:1901360	organic cyclic compound metabolic process	3	10
GO:1901361	organic cyclic compound catabolic process	4	10
GO:1901564	organonitrogen compound metabolic process	3	10
GO:1901565	organonitrogen compound catabolic process	4	10
GO:1901575	organic substance catabolic process	3	10
GO:1901605	alpha-amino acid metabolic process	4	10
GO:1901606	alpha-amino acid catabolic process	5	10

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0004061	arylformamidase activity	5	10
GO:0016787	hydrolase activity	2	10
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	3	10
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	4	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	146	150	PF00656	0.229
CLV_C14_Caspase3-7	168	172	PF00656	0.361
CLV_NRD_NRD_1	105	107	PF00675	0.475
CLV_NRD_NRD_1	12	14	PF00675	0.564
CLV_PCSK_KEX2_1	105	107	PF00082	0.469
CLV_PCSK_KEX2_1	19	21	PF00082	0.607
CLV_PCSK_PC1ET2_1	19	21	PF00082	0.621
CLV_PCSK_SKI1_1	157	161	PF00082	0.546
CLV_PCSK_SKI1_1	20	24	PF00082	0.657
CLV_PCSK_SKI1_1	243	247	PF00082	0.490
CLV_PCSK_SKI1_1	270	274	PF00082	0.594
CLV_PCSK_SKI1_1	321	325	PF00082	0.550
DEG_APCC_DBOX_1	320	328	PF00400	0.350
DEG_MDM2_SWIB_1	103	111	PF02201	0.595
DOC_CYCLIN_RxL_1	239	248	PF00134	0.294
DOC_MAPK_FxFP_2	306	309	PF00069	0.350
DOC_MAPK_gen_1	19	30	PF00069	0.482
DOC_MAPK_MEF2A_6	317	324	PF00069	0.316
DOC_PP1_RVXF_1	268	274	PF00149	0.258
DOC_PP4_FxxP_1	306	309	PF00568	0.343
DOC_USP7_MATH_1	118	122	PF00917	0.501
DOC_USP7_MATH_1	212	216	PF00917	0.229
DOC_USP7_MATH_1	22	26	PF00917	0.490
DOC_USP7_MATH_1	297	301	PF00917	0.341
DOC_USP7_MATH_1	75	79	PF00917	0.443
DOC_USP7_MATH_1	90	94	PF00917	0.672
DOC_USP7_UBL2_3	19	23	PF12436	0.466
DOC_USP7_UBL2_3	225	229	PF12436	0.390
DOC_WW_Pin1_4	144	149	PF00397	0.463
DOC_WW_Pin1_4	252	257	PF00397	0.333
DOC_WW_Pin1_4	276	281	PF00397	0.258
DOC_WW_Pin1_4	326	331	PF00397	0.327
DOC_WW_Pin1_4	362	367	PF00397	0.407
DOC_WW_Pin1_4	48	53	PF00397	0.466
DOC_WW_Pin1_4	93	98	PF00397	0.683
LIG_14-3-3_CanoR_1	105	114	PF00244	0.679
LIG_14-3-3_CanoR_1	137	144	PF00244	0.514
LIG_14-3-3_CanoR_1	157	162	PF00244	0.308
LIG_14-3-3_CanoR_1	178	185	PF00244	0.334
LIG_14-3-3_CanoR_1	249	256	PF00244	0.301
LIG_14-3-3_CanoR_1	398	403	PF00244	0.402
LIG_14-3-3_CanoR_1	57	65	PF00244	0.498
LIG_Actin_WH2_2	346	362	PF00022	0.424
LIG_BIR_III_4	396	400	PF00653	0.401
LIG_BRCT_BRCA1_1	120	124	PF00533	0.484
LIG_BRCT_BRCA1_1	400	404	PF00533	0.375
LIG_BRCT_BRCA1_1	77	81	PF00533	0.400
LIG_Clathr_ClatBox_1	324	328	PF01394	0.361
LIG_CtBP_PxDLS_1	27	31	PF00389	0.519
LIG_EVH1_2	268	272	PF00568	0.363
LIG_FHA_1	106	112	PF00498	0.609
LIG_FHA_1	217	223	PF00498	0.290
LIG_FHA_1	260	266	PF00498	0.375
LIG_FHA_1	283	289	PF00498	0.261
LIG_FHA_1	35	41	PF00498	0.452
LIG_FHA_1	56	62	PF00498	0.420
LIG_FHA_1	84	90	PF00498	0.369
LIG_FHA_2	144	150	PF00498	0.229
LIG_FHA_2	166	172	PF00498	0.308
LIG_FHA_2	293	299	PF00498	0.317
LIG_FHA_2	4	10	PF00498	0.461
LIG_GBD_Chelix_1	195	203	PF00786	0.550
LIG_GBD_Chelix_1	30	38	PF00786	0.604
LIG_LIR_Gen_1	121	132	PF02991	0.443
LIG_LIR_Gen_1	139	148	PF02991	0.337
LIG_LIR_Gen_1	2	11	PF02991	0.496
LIG_LIR_Gen_1	301	312	PF02991	0.333
LIG_LIR_Gen_1	51	61	PF02991	0.446
LIG_LIR_Nem_3	121	127	PF02991	0.403
LIG_LIR_Nem_3	139	144	PF02991	0.453
LIG_LIR_Nem_3	2	8	PF02991	0.478
LIG_LIR_Nem_3	301	307	PF02991	0.327
LIG_LIR_Nem_3	51	56	PF02991	0.421
LIG_LIR_Nem_3	78	84	PF02991	0.382
LIG_LIR_Nem_3	93	98	PF02991	0.593
LIG_LYPXL_yS_3	132	135	PF13949	0.468
LIG_MAD2	44	52	PF02301	0.357
LIG_MYND_1	48	52	PF01753	0.463
LIG_NRBOX	83	89	PF00104	0.428
LIG_PDZ_Class_3	405	410	PF00595	0.453
LIG_Pex14_2	103	107	PF04695	0.644
LIG_PTB_Apo_2	355	362	PF02174	0.358
LIG_PTB_Phospho_1	355	361	PF10480	0.412
LIG_SH2_CRK	304	308	PF00017	0.331
LIG_SH2_CRK	361	365	PF00017	0.448
LIG_SH2_GRB2like	141	144	PF00017	0.469
LIG_SH2_SRC	185	188	PF00017	0.361
LIG_SH2_SRC	394	397	PF00017	0.386
LIG_SH2_STAP1	304	308	PF00017	0.331
LIG_SH2_STAT5	314	317	PF00017	0.287
LIG_SH2_STAT5	361	364	PF00017	0.437
LIG_SH3_3	145	151	PF00018	0.307
LIG_SH3_3	225	231	PF00018	0.366
LIG_SH3_3	268	274	PF00018	0.391
LIG_SH3_3	329	335	PF00018	0.330
LIG_SH3_3	43	49	PF00018	0.442
LIG_SH3_3	63	69	PF00018	0.420
LIG_SUMO_SIM_anti_2	219	224	PF11976	0.339
LIG_SUMO_SIM_par_1	195	202	PF11976	0.274
LIG_SUMO_SIM_par_1	218	224	PF11976	0.355
LIG_SUMO_SIM_par_1	243	248	PF11976	0.308
LIG_SUMO_SIM_par_1	273	279	PF11976	0.273
LIG_SUMO_SIM_par_1	85	91	PF11976	0.422
LIG_TYR_ITIM	359	364	PF00017	0.438
LIG_WW_3	267	271	PF00397	0.252
MOD_CK1_1	251	257	PF00069	0.383
MOD_CK1_1	383	389	PF00069	0.386
MOD_CK1_1	70	76	PF00069	0.359
MOD_CK1_1	93	99	PF00069	0.687
MOD_CK2_1	136	142	PF00069	0.509
MOD_CK2_1	257	263	PF00069	0.348
MOD_CK2_1	292	298	PF00069	0.317
MOD_GlcNHglycan	190	193	PF01048	0.533
MOD_GlcNHglycan	24	27	PF01048	0.643
MOD_GlcNHglycan	257	260	PF01048	0.555
MOD_GlcNHglycan	380	383	PF01048	0.588
MOD_GlcNHglycan	77	80	PF01048	0.443
MOD_GSK3_1	114	121	PF00069	0.487
MOD_GSK3_1	157	164	PF00069	0.309
MOD_GSK3_1	212	219	PF00069	0.301
MOD_GSK3_1	22	29	PF00069	0.469
MOD_GSK3_1	245	252	PF00069	0.342
MOD_GSK3_1	255	262	PF00069	0.292
MOD_GSK3_1	278	285	PF00069	0.359
MOD_GSK3_1	56	63	PF00069	0.438
MOD_GSK3_1	67	74	PF00069	0.258
MOD_N-GLC_1	142	147	PF02516	0.661
MOD_N-GLC_1	388	393	PF02516	0.653
MOD_NEK2_1	159	164	PF00069	0.323
MOD_NEK2_1	176	181	PF00069	0.290
MOD_NEK2_1	245	250	PF00069	0.284
MOD_NEK2_1	359	364	PF00069	0.383
MOD_NEK2_1	388	393	PF00069	0.410
MOD_NEK2_1	88	93	PF00069	0.557
MOD_PIKK_1	136	142	PF00454	0.497
MOD_PIKK_1	161	167	PF00454	0.334
MOD_PIKK_1	278	284	PF00454	0.258
MOD_PIKK_1	388	394	PF00454	0.383
MOD_PIKK_1	60	66	PF00454	0.455
MOD_PK_1	398	404	PF00069	0.404
MOD_PKA_1	105	111	PF00069	0.677
MOD_PKA_2	105	111	PF00069	0.661
MOD_PKA_2	136	142	PF00069	0.525
MOD_PKA_2	248	254	PF00069	0.328
MOD_PKA_2	359	365	PF00069	0.387
MOD_PKA_2	56	62	PF00069	0.495
MOD_PKB_1	129	137	PF00069	0.499
MOD_Plk_1	212	218	PF00069	0.229
MOD_Plk_1	34	40	PF00069	0.337
MOD_Plk_2-3	328	334	PF00069	0.308
MOD_Plk_4	118	124	PF00069	0.449
MOD_Plk_4	380	386	PF00069	0.351
MOD_Plk_4	398	404	PF00069	0.343
MOD_Plk_4	83	89	PF00069	0.380
MOD_ProDKin_1	144	150	PF00069	0.330
MOD_ProDKin_1	252	258	PF00069	0.333
MOD_ProDKin_1	276	282	PF00069	0.258
MOD_ProDKin_1	326	332	PF00069	0.327
MOD_ProDKin_1	362	368	PF00069	0.403
MOD_ProDKin_1	48	54	PF00069	0.464
MOD_ProDKin_1	93	99	PF00069	0.683
MOD_SUMO_rev_2	17	25	PF00179	0.450
TRG_DiLeu_BaLyEn_6	107	112	PF01217	0.670
TRG_DiLeu_BaLyEn_6	240	245	PF01217	0.308
TRG_DiLeu_BaLyEn_6	363	368	PF01217	0.402
TRG_ENDOCYTIC_2	132	135	PF00928	0.432
TRG_ENDOCYTIC_2	141	144	PF00928	0.486
TRG_ENDOCYTIC_2	304	307	PF00928	0.363
TRG_ENDOCYTIC_2	361	364	PF00928	0.446
TRG_ER_diArg_1	104	106	PF00400	0.691
TRG_ER_diArg_1	128	131	PF00400	0.372
TRG_Pf-PMV_PEXEL_1	126	130	PF00026	0.559

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9C3	Leptomonas seymouri	53%	100%
A0A0S4J7K0	Bodo saltans	29%	100%
A0A1X0NW41	Trypanosomatidae	37%	100%
A0A3S7X5K2	Leishmania donovani	90%	100%
A0A422NIA6	Trypanosoma rangeli	31%	100%
A4HKC9	Leishmania braziliensis	73%	100%
A4I7V8	Leishmania infantum	90%	100%
E9B2R6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%