Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q5D8_LEIMA

TriTrypDb:

LmjF.32.1440 , LMJLV39_320020400 , LMJSD75_320020400

Length:

147

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q5D8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5D8

PDB structure(s): 7aih_BC , 7ane_BC

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	51	53	PF00675	0.434
CLV_NRD_NRD_1	7	9	PF00675	0.347
CLV_PCSK_KEX2_1	51	53	PF00082	0.409
CLV_PCSK_KEX2_1	7	9	PF00082	0.402
CLV_PCSK_PC7_1	47	53	PF00082	0.407
CLV_Separin_Metazoa	44	48	PF03568	0.482
DEG_Nend_UBRbox_3	1	3	PF02207	0.415
DOC_MAPK_gen_1	33	40	PF00069	0.505
DOC_MAPK_gen_1	51	58	PF00069	0.291
DOC_MAPK_MEF2A_6	33	40	PF00069	0.505
DOC_MAPK_MEF2A_6	51	58	PF00069	0.291
DOC_MAPK_NFAT4_5	33	41	PF00069	0.501
DOC_MAPK_NFAT4_5	51	59	PF00069	0.292
DOC_MAPK_RevD_3	36	52	PF00069	0.493
DOC_USP7_MATH_1	10	14	PF00917	0.334
DOC_USP7_MATH_1	115	119	PF00917	0.544
DOC_WW_Pin1_4	90	95	PF00397	0.414
LIG_14-3-3_CanoR_1	8	18	PF00244	0.452
LIG_FHA_1	115	121	PF00498	0.500
LIG_FHA_1	94	100	PF00498	0.479
LIG_Integrin_isoDGR_2	49	51	PF01839	0.427
LIG_LIR_Gen_1	12	19	PF02991	0.417
LIG_LIR_Gen_1	68	79	PF02991	0.420
LIG_LIR_Nem_3	12	18	PF02991	0.414
LIG_LIR_Nem_3	68	74	PF02991	0.441
LIG_SH2_STAP1	5	9	PF00017	0.390
MOD_CK1_1	21	27	PF00069	0.515
MOD_CK2_1	130	136	PF00069	0.453
MOD_Cter_Amidation	49	52	PF01082	0.413
MOD_GlcNHglycan	82	85	PF01048	0.422
MOD_GSK3_1	107	114	PF00069	0.486
MOD_N-GLC_1	66	71	PF02516	0.532
MOD_NEK2_1	105	110	PF00069	0.440
MOD_NEK2_1	18	23	PF00069	0.522
MOD_NEK2_1	66	71	PF00069	0.427
MOD_NEK2_1	9	14	PF00069	0.498
MOD_NEK2_2	10	15	PF00069	0.389
MOD_PIKK_1	107	113	PF00454	0.457
MOD_PIKK_1	115	121	PF00454	0.527
MOD_PIKK_1	26	32	PF00454	0.392
MOD_PIKK_1	93	99	PF00454	0.428
MOD_Plk_1	66	72	PF00069	0.526
MOD_Plk_2-3	130	136	PF00069	0.571
MOD_Plk_4	10	16	PF00069	0.392
MOD_Plk_4	21	27	PF00069	0.399
MOD_ProDKin_1	90	96	PF00069	0.417
MOD_SUMO_for_1	41	44	PF00179	0.519
TRG_DiLeu_BaEn_2	135	141	PF01217	0.406
TRG_DiLeu_BaLyEn_6	52	57	PF01217	0.411
TRG_ER_diArg_1	7	9	PF00400	0.347
TRG_Pf-PMV_PEXEL_1	7	11	PF00026	0.335

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I494	Leptomonas seymouri	83%	100%
A0A0S4J787	Bodo saltans	66%	100%
A0A1X0NUE5	Trypanosomatidae	77%	100%
A0A3Q8IGY2	Leishmania donovani	91%	100%
A0A3S5IR91	Trypanosoma rangeli	74%	100%
A4HKD1	Leishmania braziliensis	88%	100%
A4I7W1	Leishmania infantum	92%	100%
D0AA24	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	72%	100%
E9B2R9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%