Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q5D7_LEIMA

TriTrypDb:

LmjF.32.1450 , LMJLV39_320020500 , LMJSD75_320020500

Length:

161

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

Q4Q5D7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5D7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	142	146	PF00656	0.598
CLV_NRD_NRD_1	9	11	PF00675	0.653
CLV_PCSK_FUR_1	10	14	PF00082	0.703
CLV_PCSK_KEX2_1	12	14	PF00082	0.676
CLV_PCSK_KEX2_1	9	11	PF00082	0.644
CLV_PCSK_PC1ET2_1	12	14	PF00082	0.727
CLV_PCSK_SKI1_1	29	33	PF00082	0.608
DEG_COP1_1	109	120	PF00400	0.648
DEG_Nend_UBRbox_1	1	4	PF02207	0.415
DOC_USP7_MATH_1	151	155	PF00917	0.647
DOC_WW_Pin1_4	11	16	PF00397	0.427
DOC_WW_Pin1_4	112	117	PF00397	0.648
LIG_AP2alpha_1	65	69	PF02296	0.431
LIG_APCC_ABBA_1	89	94	PF00400	0.255
LIG_BRCT_BRCA1_1	82	86	PF00533	0.424
LIG_deltaCOP1_diTrp_1	74	80	PF00928	0.279
LIG_FHA_1	109	115	PF00498	0.651
LIG_FHA_2	125	131	PF00498	0.575
LIG_IRF3_LxIS_1	144	150	PF10401	0.607
LIG_LIR_Gen_1	133	144	PF02991	0.618
LIG_LIR_Gen_1	74	85	PF02991	0.269
LIG_LIR_Nem_3	133	139	PF02991	0.629
LIG_LIR_Nem_3	74	80	PF02991	0.296
LIG_LIR_Nem_3	83	89	PF02991	0.413
LIG_MLH1_MIPbox_1	83	87	PF16413	0.370
LIG_Pex14_2	65	69	PF04695	0.375
LIG_SH2_PTP2	138	141	PF00017	0.560
LIG_SH2_STAT5	138	141	PF00017	0.560
LIG_SH2_STAT5	21	24	PF00017	0.467
LIG_SH3_1	12	18	PF00018	0.449
LIG_SH3_3	12	18	PF00018	0.431
LIG_SH3_3	44	50	PF00018	0.409
LIG_SH3_4	49	56	PF00018	0.412
LIG_SH3_5	116	120	PF00018	0.659
LIG_TRAF2_1	126	129	PF00917	0.558
MOD_CK1_1	110	116	PF00069	0.610
MOD_CK1_1	150	156	PF00069	0.660
MOD_CK2_1	124	130	PF00069	0.474
MOD_CK2_1	150	156	PF00069	0.652
MOD_GlcNHglycan	149	152	PF01048	0.586
MOD_GlcNHglycan	38	41	PF01048	0.439
MOD_GSK3_1	106	113	PF00069	0.537
MOD_GSK3_1	147	154	PF00069	0.650
MOD_NEK2_1	106	111	PF00069	0.529
MOD_NEK2_1	147	152	PF00069	0.630
MOD_NEK2_1	80	85	PF00069	0.304
MOD_NEK2_2	75	80	PF00069	0.285
MOD_Plk_1	73	79	PF00069	0.290
MOD_Plk_2-3	124	130	PF00069	0.475
MOD_Plk_4	81	87	PF00069	0.400
MOD_ProDKin_1	11	17	PF00069	0.538
MOD_ProDKin_1	112	118	PF00069	0.563
MOD_SUMO_rev_2	119	127	PF00179	0.506
TRG_ENDOCYTIC_2	138	141	PF00928	0.443
TRG_ENDOCYTIC_2	92	95	PF00928	0.399
TRG_ER_diArg_1	8	10	PF00400	0.637
TRG_NLS_MonoCore_2	9	14	PF00514	0.571
TRG_NLS_MonoExtC_3	10	15	PF00514	0.583
TRG_NLS_MonoExtN_4	9	15	PF00514	0.574

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P9K3	Leptomonas seymouri	74%	100%
A0A0S4J7V8	Bodo saltans	51%	90%
A0A1X0NUF1	Trypanosomatidae	65%	98%
A0A3Q8IGR1	Leishmania donovani	93%	100%
A0A422NIA9	Trypanosoma rangeli	62%	100%
A4HKD2	Leishmania braziliensis	80%	100%
A4I7W2	Leishmania infantum	93%	100%
D0AA25	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	99%
E9B2S0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%