MIP-T3 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Microtubule-binding protein MIP-T3, putative

Species:

Leishmania major

UniProt:

Q4Q5D5_LEIMA

TriTrypDb:

LmjF.32.1470 , LMJLV39_320020700 , LMJSD75_320020700

Length:

279

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005813	centrosome	3	2
GO:0005815	microtubule organizing center	2	2
GO:0005930	axoneme	2	2
GO:0030992	intraciliary transport particle B	2	2
GO:0032991	protein-containing complex	1	2
GO:0036064	ciliary basal body	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q5D5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5D5

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0006996	organelle organization	4	2
GO:0007017	microtubule-based process	2	2
GO:0007018	microtubule-based movement	3	2
GO:0009987	cellular process	1	2
GO:0010970	transport along microtubule	4	2
GO:0016043	cellular component organization	3	2
GO:0022607	cellular component assembly	4	2
GO:0030030	cell projection organization	4	2
GO:0030031	cell projection assembly	5	2
GO:0030705	cytoskeleton-dependent intracellular transport	4	2
GO:0031503	protein-containing complex localization	2	2
GO:0032886	regulation of microtubule-based process	4	2
GO:0033043	regulation of organelle organization	5	2
GO:0042073	intraciliary transport	3	2
GO:0044782	cilium organization	5	2
GO:0046907	intracellular transport	3	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051128	regulation of cellular component organization	4	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051493	regulation of cytoskeleton organization	6	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0060271	cilium assembly	6	2
GO:0065007	biological regulation	1	2
GO:0070507	regulation of microtubule cytoskeleton organization	5	2
GO:0070925	organelle assembly	5	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0099111	microtubule-based transport	4	2
GO:0120031	plasma membrane bounded cell projection assembly	6	2
GO:0120036	plasma membrane bounded cell projection organization	5	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0005515	protein binding	2	11
GO:0008017	microtubule binding	5	11
GO:0008092	cytoskeletal protein binding	3	11
GO:0015631	tubulin binding	4	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	59	63	PF00656	0.426
CLV_NRD_NRD_1	170	172	PF00675	0.549
CLV_NRD_NRD_1	183	185	PF00675	0.516
CLV_NRD_NRD_1	197	199	PF00675	0.552
CLV_PCSK_KEX2_1	182	184	PF00082	0.543
CLV_PCSK_KEX2_1	251	253	PF00082	0.504
CLV_PCSK_KEX2_1	31	33	PF00082	0.254
CLV_PCSK_PC1ET2_1	251	253	PF00082	0.504
CLV_PCSK_PC1ET2_1	31	33	PF00082	0.254
CLV_PCSK_SKI1_1	28	32	PF00082	0.269
CLV_PCSK_SKI1_1	85	89	PF00082	0.387
DOC_CKS1_1	128	133	PF01111	0.671
DOC_CYCLIN_yCln2_LP_2	141	147	PF00134	0.501
DOC_MAPK_gen_1	182	189	PF00069	0.453
DOC_MAPK_gen_1	85	93	PF00069	0.501
DOC_MAPK_MEF2A_6	85	93	PF00069	0.523
DOC_USP7_MATH_1	148	152	PF00917	0.657
DOC_USP7_UBL2_3	195	199	PF12436	0.524
DOC_WW_Pin1_4	127	132	PF00397	0.526
DOC_WW_Pin1_4	140	145	PF00397	0.697
DOC_WW_Pin1_4	19	24	PF00397	0.460
LIG_14-3-3_CanoR_1	171	179	PF00244	0.608
LIG_14-3-3_CanoR_1	182	190	PF00244	0.570
LIG_APCC_ABBA_1	187	192	PF00400	0.350
LIG_BIR_II_1	1	5	PF00653	0.527
LIG_EVH1_2	33	37	PF00568	0.436
LIG_FHA_1	24	30	PF00498	0.414
LIG_FHA_1	75	81	PF00498	0.436
LIG_FHA_2	19	25	PF00498	0.408
LIG_LIR_Nem_3	107	113	PF02991	0.555
LIG_LIR_Nem_3	46	52	PF02991	0.494
LIG_MYND_1	23	27	PF01753	0.450
LIG_PDZ_Class_2	274	279	PF00595	0.367
LIG_SH2_CRK	15	19	PF00017	0.483
LIG_SH2_GRB2like	82	85	PF00017	0.531
LIG_SH2_SRC	52	55	PF00017	0.449
LIG_SH2_STAP1	203	207	PF00017	0.669
LIG_SH2_STAP1	52	56	PF00017	0.449
LIG_SH2_STAT3	120	123	PF00017	0.355
LIG_SH2_STAT5	113	116	PF00017	0.555
LIG_SH2_STAT5	75	78	PF00017	0.436
LIG_SH2_STAT5	82	85	PF00017	0.436
LIG_SH3_3	141	147	PF00018	0.565
LIG_UBA3_1	79	88	PF00899	0.483
MOD_CDK_SPK_2	23	28	PF00069	0.421
MOD_CK1_1	137	143	PF00069	0.630
MOD_CK1_1	151	157	PF00069	0.601
MOD_CK1_1	164	170	PF00069	0.558
MOD_CK1_1	185	191	PF00069	0.507
MOD_CK1_1	201	207	PF00069	0.633
MOD_CK2_1	18	24	PF00069	0.484
MOD_CK2_1	97	103	PF00069	0.436
MOD_GlcNHglycan	1	4	PF01048	0.584
MOD_GlcNHglycan	136	139	PF01048	0.643
MOD_GlcNHglycan	166	169	PF01048	0.617
MOD_GlcNHglycan	200	203	PF01048	0.491
MOD_GlcNHglycan	62	65	PF01048	0.330
MOD_GlcNHglycan	8	11	PF01048	0.308
MOD_GlcNHglycan	99	102	PF01048	0.236
MOD_GSK3_1	19	26	PF00069	0.498
MOD_GSK3_1	214	221	PF00069	0.644
MOD_N-GLC_1	159	164	PF02516	0.733
MOD_NEK2_1	161	166	PF00069	0.594
MOD_NEK2_1	18	23	PF00069	0.537
MOD_NEK2_1	60	65	PF00069	0.452
MOD_PKA_1	171	177	PF00069	0.560
MOD_PKA_1	182	188	PF00069	0.513
MOD_PKA_1	198	204	PF00069	0.419
MOD_PKA_2	182	188	PF00069	0.612
MOD_PKA_2	60	66	PF00069	0.483
MOD_Plk_1	159	165	PF00069	0.599
MOD_Plk_2-3	262	268	PF00069	0.469
MOD_Plk_4	185	191	PF00069	0.427
MOD_Plk_4	218	224	PF00069	0.472
MOD_Plk_4	75	81	PF00069	0.436
MOD_ProDKin_1	127	133	PF00069	0.535
MOD_ProDKin_1	140	146	PF00069	0.696
MOD_ProDKin_1	19	25	PF00069	0.460
MOD_SUMO_for_1	87	90	PF00179	0.483
MOD_SUMO_rev_2	67	73	PF00179	0.439
TRG_ENDOCYTIC_2	15	18	PF00928	0.531
TRG_ENDOCYTIC_2	52	55	PF00928	0.436
TRG_ER_diArg_1	182	184	PF00400	0.566
TRG_NES_CRM1_1	81	92	PF08389	0.483
TRG_Pf-PMV_PEXEL_1	36	40	PF00026	0.248

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAU9	Leptomonas seymouri	63%	100%
A0A1X0NUE7	Trypanosomatidae	49%	98%
A0A3S7X5H3	Leishmania donovani	92%	100%
A0A422NIC4	Trypanosoma rangeli	46%	100%
A4HKD4	Leishmania braziliensis	76%	100%
A4I7W4	Leishmania infantum	92%	100%
D0AA27	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
E9B2S2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5AZG9	Trypanosoma cruzi	52%	92%