Lipase_3 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q5D4_LEIMA

TriTrypDb:

LmjF.32.1480 , LMJLV39_320020800 , LMJSD75_320020800

Length:

472

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q5D4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5D4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	412	418	PF00089	0.609
CLV_NRD_NRD_1	188	190	PF00675	0.358
CLV_NRD_NRD_1	212	214	PF00675	0.461
CLV_NRD_NRD_1	410	412	PF00675	0.534
CLV_NRD_NRD_1	428	430	PF00675	0.601
CLV_NRD_NRD_1	51	53	PF00675	0.522
CLV_PCSK_KEX2_1	190	192	PF00082	0.552
CLV_PCSK_KEX2_1	410	412	PF00082	0.556
CLV_PCSK_KEX2_1	51	53	PF00082	0.522
CLV_PCSK_PC1ET2_1	190	192	PF00082	0.543
CLV_PCSK_SKI1_1	184	188	PF00082	0.516
CLV_PCSK_SKI1_1	278	282	PF00082	0.444
CLV_PCSK_SKI1_1	291	295	PF00082	0.563
CLV_PCSK_SKI1_1	429	433	PF00082	0.519
CLV_PCSK_SKI1_1	435	439	PF00082	0.470
CLV_PCSK_SKI1_1	83	87	PF00082	0.519
CLV_PCSK_SKI1_1	9	13	PF00082	0.798
CLV_PCSK_SKI1_1	95	99	PF00082	0.516
DEG_APCC_DBOX_1	414	422	PF00400	0.604
DEG_APCC_KENBOX_2	354	358	PF00400	0.589
DEG_SPOP_SBC_1	446	450	PF00917	0.632
DOC_CYCLIN_yCln2_LP_2	390	396	PF00134	0.532
DOC_MAPK_gen_1	189	200	PF00069	0.420
DOC_MAPK_gen_1	294	303	PF00069	0.511
DOC_MAPK_MEF2A_6	193	202	PF00069	0.403
DOC_PP1_RVXF_1	136	143	PF00149	0.442
DOC_PP1_RVXF_1	170	177	PF00149	0.364
DOC_PP1_RVXF_1	182	189	PF00149	0.340
DOC_PP1_RVXF_1	44	51	PF00149	0.663
DOC_PP1_RVXF_1	81	87	PF00149	0.511
DOC_PP1_RVXF_1	93	100	PF00149	0.515
DOC_PP2B_LxvP_1	390	393	PF13499	0.516
DOC_PP2B_LxvP_1	422	425	PF13499	0.508
DOC_PP4_FxxP_1	202	205	PF00568	0.460
DOC_PP4_FxxP_1	248	251	PF00568	0.474
DOC_PP4_FxxP_1	283	286	PF00568	0.439
DOC_USP7_MATH_1	447	451	PF00917	0.756
DOC_USP7_UBL2_3	210	214	PF12436	0.467
DOC_USP7_UBL2_3	91	95	PF12436	0.639
DOC_WW_Pin1_4	319	324	PF00397	0.496
DOC_WW_Pin1_4	456	461	PF00397	0.770
DOC_WW_Pin1_4	467	472	PF00397	0.724
DOC_WW_Pin1_4	90	95	PF00397	0.549
LIG_14-3-3_CanoR_1	191	200	PF00244	0.450
LIG_14-3-3_CanoR_1	415	419	PF00244	0.624
LIG_APCC_ABBA_1	71	76	PF00400	0.522
LIG_BRCT_BRCA1_1	150	154	PF00533	0.414
LIG_BRCT_BRCA1_1	387	391	PF00533	0.510
LIG_deltaCOP1_diTrp_1	329	338	PF00928	0.453
LIG_deltaCOP1_diTrp_1	76	86	PF00928	0.500
LIG_eIF4E_1	284	290	PF01652	0.478
LIG_FHA_1	135	141	PF00498	0.455
LIG_FHA_1	153	159	PF00498	0.293
LIG_FHA_1	181	187	PF00498	0.341
LIG_FHA_1	193	199	PF00498	0.429
LIG_FHA_1	252	258	PF00498	0.436
LIG_FHA_1	290	296	PF00498	0.547
LIG_FHA_1	302	308	PF00498	0.511
LIG_FHA_1	387	393	PF00498	0.556
LIG_FHA_1	426	432	PF00498	0.498
LIG_FHA_1	452	458	PF00498	0.688
LIG_FHA_2	295	301	PF00498	0.547
LIG_FHA_2	320	326	PF00498	0.472
LIG_FHA_2	436	442	PF00498	0.512
LIG_FHA_2	63	69	PF00498	0.527
LIG_FHA_2	96	102	PF00498	0.557
LIG_LIR_Apic_2	245	251	PF02991	0.480
LIG_LIR_Apic_2	282	286	PF02991	0.437
LIG_LIR_Gen_1	121	130	PF02991	0.413
LIG_LIR_Gen_1	151	161	PF02991	0.407
LIG_LIR_Gen_1	196	205	PF02991	0.493
LIG_LIR_Gen_1	206	215	PF02991	0.481
LIG_LIR_Gen_1	240	251	PF02991	0.494
LIG_LIR_Gen_1	265	272	PF02991	0.404
LIG_LIR_Gen_1	362	370	PF02991	0.510
LIG_LIR_Nem_3	121	127	PF02991	0.501
LIG_LIR_Nem_3	151	157	PF02991	0.424
LIG_LIR_Nem_3	196	202	PF02991	0.417
LIG_LIR_Nem_3	206	211	PF02991	0.407
LIG_LIR_Nem_3	240	246	PF02991	0.516
LIG_LIR_Nem_3	25	29	PF02991	0.574
LIG_LIR_Nem_3	265	269	PF02991	0.410
LIG_LIR_Nem_3	315	321	PF02991	0.492
LIG_LIR_Nem_3	362	366	PF02991	0.512
LIG_LIR_Nem_3	388	394	PF02991	0.547
LIG_LIR_Nem_3	433	437	PF02991	0.501
LIG_LIR_Nem_3	47	53	PF02991	0.525
LIG_PCNA_yPIPBox_3	397	411	PF02747	0.540
LIG_Pex14_2	124	128	PF04695	0.330
LIG_Pex14_2	86	90	PF04695	0.521
LIG_PTB_Apo_2	354	361	PF02174	0.480
LIG_SH2_CRK	26	30	PF00017	0.561
LIG_SH2_NCK_1	321	325	PF00017	0.482
LIG_SH2_STAP1	194	198	PF00017	0.424
LIG_SH2_STAP1	220	224	PF00017	0.449
LIG_SH2_STAP1	255	259	PF00017	0.413
LIG_SH2_STAT5	129	132	PF00017	0.402
LIG_SH2_STAT5	194	197	PF00017	0.440
LIG_SH2_STAT5	199	202	PF00017	0.360
LIG_SH2_STAT5	321	324	PF00017	0.481
LIG_SH2_STAT5	352	355	PF00017	0.466
LIG_SH3_3	18	24	PF00018	0.568
LIG_SUMO_SIM_par_1	110	117	PF11976	0.464
LIG_TRAF2_1	36	39	PF00917	0.564
LIG_TRAF2_1	75	78	PF00917	0.532
MOD_CDK_SPK_2	90	95	PF00069	0.549
MOD_CK1_1	192	198	PF00069	0.438
MOD_CK1_1	362	368	PF00069	0.511
MOD_CK1_1	414	420	PF00069	0.543
MOD_CK1_1	44	50	PF00069	0.661
MOD_CK2_1	146	152	PF00069	0.401
MOD_CK2_1	294	300	PF00069	0.672
MOD_CK2_1	319	325	PF00069	0.495
MOD_CK2_1	33	39	PF00069	0.678
MOD_CK2_1	447	453	PF00069	0.565
MOD_CK2_1	62	68	PF00069	0.582
MOD_CK2_1	95	101	PF00069	0.536
MOD_GlcNHglycan	142	145	PF01048	0.430
MOD_GlcNHglycan	259	262	PF01048	0.419
MOD_GSK3_1	128	135	PF00069	0.417
MOD_GSK3_1	148	155	PF00069	0.296
MOD_GSK3_1	180	187	PF00069	0.380
MOD_GSK3_1	189	196	PF00069	0.413
MOD_GSK3_1	29	36	PF00069	0.651
MOD_GSK3_1	392	399	PF00069	0.554
MOD_GSK3_1	441	448	PF00069	0.619
MOD_GSK3_1	463	470	PF00069	0.754
MOD_N-GLC_1	396	401	PF02516	0.557
MOD_NEK2_1	140	145	PF00069	0.510
MOD_NEK2_1	289	294	PF00069	0.516
MOD_NEK2_1	29	34	PF00069	0.623
MOD_NEK2_1	41	46	PF00069	0.597
MOD_NEK2_2	386	391	PF00069	0.523
MOD_PIKK_1	284	290	PF00454	0.463
MOD_PKA_1	189	195	PF00069	0.419
MOD_PKA_2	192	198	PF00069	0.456
MOD_PKA_2	284	290	PF00069	0.475
MOD_PKA_2	29	35	PF00069	0.555
MOD_PKA_2	414	420	PF00069	0.621
MOD_PKA_2	441	447	PF00069	0.549
MOD_PKA_2	451	457	PF00069	0.635
MOD_PKB_1	191	199	PF00069	0.572
MOD_Plk_1	146	152	PF00069	0.480
MOD_Plk_1	184	190	PF00069	0.366
MOD_Plk_1	220	226	PF00069	0.529
MOD_Plk_1	396	402	PF00069	0.532
MOD_Plk_1	463	469	PF00069	0.789
MOD_Plk_4	234	240	PF00069	0.490
MOD_Plk_4	359	365	PF00069	0.574
MOD_Plk_4	386	392	PF00069	0.529
MOD_ProDKin_1	319	325	PF00069	0.495
MOD_ProDKin_1	456	462	PF00069	0.760
MOD_ProDKin_1	90	96	PF00069	0.549
MOD_SUMO_for_1	353	356	PF00179	0.566
MOD_SUMO_rev_2	242	251	PF00179	0.620
MOD_SUMO_rev_2	38	47	PF00179	0.573
MOD_SUMO_rev_2	427	437	PF00179	0.533
TRG_DiLeu_BaLyEn_6	271	276	PF01217	0.380
TRG_DiLeu_BaLyEn_6	399	404	PF01217	0.506
TRG_ENDOCYTIC_2	199	202	PF00928	0.474
TRG_ENDOCYTIC_2	208	211	PF00928	0.518
TRG_ENDOCYTIC_2	26	29	PF00928	0.564
TRG_ENDOCYTIC_2	321	324	PF00928	0.453
TRG_ER_diArg_1	188	191	PF00400	0.521
TRG_ER_diArg_1	410	412	PF00400	0.534
TRG_ER_diArg_1	50	52	PF00400	0.529
TRG_NLS_MonoExtC_3	188	193	PF00514	0.486
TRG_NLS_MonoExtN_4	189	194	PF00514	0.511
TRG_Pf-PMV_PEXEL_1	429	433	PF00026	0.500
TRG_Pf-PMV_PEXEL_1	51	55	PF00026	0.519

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ICK2	Leptomonas seymouri	85%	71%
A0A0S4J6R5	Bodo saltans	68%	82%
A0A1X0NV16	Trypanosomatidae	76%	86%
A0A3S7X5I1	Leishmania donovani	96%	100%
A0A422NID9	Trypanosoma rangeli	73%	100%
A4HKD5	Leishmania braziliensis	91%	100%
A4I7W5	Leishmania infantum	96%	100%
D0AA28	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	70%	86%
E9B2S3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	72%
V5DFT8	Trypanosoma cruzi	74%	90%