Cauli_VI domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q5D2_LEIMA

TriTrypDb:

LmjF.32.1495 , LMJLV39_320021000 , LMJSD75_320021000

Length:

375

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q5D2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5D2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	122	126	PF00656	0.690
CLV_C14_Caspase3-7	181	185	PF00656	0.701
CLV_NRD_NRD_1	148	150	PF00675	0.634
CLV_NRD_NRD_1	257	259	PF00675	0.553
CLV_NRD_NRD_1	351	353	PF00675	0.439
CLV_PCSK_KEX2_1	148	150	PF00082	0.637
CLV_PCSK_KEX2_1	257	259	PF00082	0.553
CLV_PCSK_SKI1_1	127	131	PF00082	0.628
CLV_PCSK_SKI1_1	137	141	PF00082	0.598
DEG_APCC_DBOX_1	136	144	PF00400	0.682
DEG_APCC_DBOX_1	20	28	PF00400	0.488
DEG_Kelch_Keap1_1	98	103	PF01344	0.580
DEG_Nend_UBRbox_2	1	3	PF02207	0.689
DOC_ANK_TNKS_1	69	76	PF00023	0.564
DOC_CKS1_1	322	327	PF01111	0.398
DOC_CYCLIN_RxL_1	48	57	PF00134	0.463
DOC_MAPK_gen_1	286	295	PF00069	0.497
DOC_PP1_RVXF_1	255	262	PF00149	0.608
DOC_PP2B_LxvP_1	164	167	PF13499	0.660
DOC_PP4_FxxP_1	144	147	PF00568	0.620
DOC_PP4_FxxP_1	322	325	PF00568	0.506
DOC_USP7_MATH_1	155	159	PF00917	0.760
DOC_USP7_MATH_1	82	86	PF00917	0.726
DOC_WW_Pin1_4	162	167	PF00397	0.760
DOC_WW_Pin1_4	200	205	PF00397	0.597
DOC_WW_Pin1_4	235	240	PF00397	0.678
DOC_WW_Pin1_4	321	326	PF00397	0.394
DOC_WW_Pin1_4	78	83	PF00397	0.626
LIG_14-3-3_CanoR_1	260	268	PF00244	0.577
LIG_14-3-3_CanoR_1	352	357	PF00244	0.518
LIG_14-3-3_CanoR_1	7	15	PF00244	0.556
LIG_14-3-3_CanoR_1	70	74	PF00244	0.562
LIG_Actin_WH2_2	5	23	PF00022	0.724
LIG_APCC_ABBA_1	130	135	PF00400	0.639
LIG_BRCT_BRCA1_1	318	322	PF00533	0.542
LIG_FHA_1	126	132	PF00498	0.605
LIG_FHA_1	151	157	PF00498	0.635
LIG_FHA_1	188	194	PF00498	0.702
LIG_FHA_1	289	295	PF00498	0.405
LIG_FHA_1	356	362	PF00498	0.395
LIG_FHA_1	90	96	PF00498	0.713
LIG_FHA_2	117	123	PF00498	0.693
LIG_HCF-1_HBM_1	339	342	PF13415	0.455
LIG_LIR_Apic_2	319	325	PF02991	0.520
LIG_LIR_Gen_1	270	279	PF02991	0.398
LIG_LIR_Gen_1	339	350	PF02991	0.403
LIG_LIR_Nem_3	270	275	PF02991	0.396
LIG_LIR_Nem_3	339	345	PF02991	0.371
LIG_NRBOX	359	365	PF00104	0.392
LIG_SH2_NCK_1	188	192	PF00017	0.573
LIG_SH2_NCK_1	262	266	PF00017	0.501
LIG_SH2_STAP1	188	192	PF00017	0.573
LIG_SH2_STAT3	351	354	PF00017	0.429
LIG_SH2_STAT5	301	304	PF00017	0.495
LIG_SH2_STAT5	323	326	PF00017	0.415
LIG_SH2_STAT5	342	345	PF00017	0.355
LIG_SH2_STAT5	365	368	PF00017	0.493
LIG_SH3_3	10	16	PF00018	0.580
LIG_SH3_3	128	134	PF00018	0.602
LIG_SH3_3	149	155	PF00018	0.707
LIG_SH3_3	164	170	PF00018	0.727
LIG_SH3_4	316	323	PF00018	0.389
LIG_SUMO_SIM_par_1	206	211	PF11976	0.670
LIG_SUMO_SIM_par_1	51	57	PF11976	0.478
LIG_TRFH_1	342	346	PF08558	0.363
LIG_UBA3_1	139	146	PF00899	0.691
LIG_ULM_U2AF65_1	257	262	PF00076	0.613
LIG_WRC_WIRS_1	117	122	PF05994	0.553
MOD_CDK_SPxxK_3	162	169	PF00069	0.592
MOD_CK1_1	165	171	PF00069	0.701
MOD_CK1_1	241	247	PF00069	0.513
MOD_CK1_1	263	269	PF00069	0.625
MOD_CK1_1	282	288	PF00069	0.549
MOD_CK1_1	34	40	PF00069	0.620
MOD_CK1_1	355	361	PF00069	0.429
MOD_CK1_1	81	87	PF00069	0.652
MOD_CK1_1	98	104	PF00069	0.531
MOD_CK2_1	116	122	PF00069	0.693
MOD_CK2_1	34	40	PF00069	0.542
MOD_CK2_1	97	103	PF00069	0.604
MOD_GlcNHglycan	100	103	PF01048	0.616
MOD_GlcNHglycan	157	160	PF01048	0.559
MOD_GlcNHglycan	2	6	PF01048	0.771
MOD_GlcNHglycan	249	252	PF01048	0.678
MOD_GlcNHglycan	281	284	PF01048	0.573
MOD_GlcNHglycan	33	36	PF01048	0.645
MOD_GSK3_1	11	18	PF00069	0.523
MOD_GSK3_1	263	270	PF00069	0.617
MOD_GSK3_1	78	85	PF00069	0.679
MOD_N-GLC_1	182	187	PF02516	0.710
MOD_N-GLC_1	310	315	PF02516	0.348
MOD_NEK2_1	1	6	PF00069	0.776
MOD_NEK2_1	116	121	PF00069	0.676
MOD_NEK2_1	95	100	PF00069	0.750
MOD_PIKK_1	208	214	PF00454	0.528
MOD_PIKK_1	238	244	PF00454	0.555
MOD_PIKK_1	316	322	PF00454	0.423
MOD_PK_1	352	358	PF00069	0.454
MOD_PKA_1	352	358	PF00069	0.507
MOD_PKA_2	168	174	PF00069	0.610
MOD_PKA_2	20	26	PF00069	0.504
MOD_PKA_2	6	12	PF00069	0.563
MOD_PKA_2	69	75	PF00069	0.731
MOD_PKB_1	258	266	PF00069	0.610
MOD_PKB_1	286	294	PF00069	0.504
MOD_Plk_1	182	188	PF00069	0.678
MOD_Plk_4	75	81	PF00069	0.777
MOD_ProDKin_1	162	168	PF00069	0.759
MOD_ProDKin_1	200	206	PF00069	0.597
MOD_ProDKin_1	235	241	PF00069	0.668
MOD_ProDKin_1	321	327	PF00069	0.395
MOD_ProDKin_1	78	84	PF00069	0.626
TRG_DiLeu_BaEn_1	339	344	PF01217	0.373
TRG_DiLeu_BaEn_4	40	46	PF01217	0.635
TRG_ENDOCYTIC_2	299	302	PF00928	0.418
TRG_ENDOCYTIC_2	342	345	PF00928	0.359
TRG_ER_diArg_1	147	149	PF00400	0.636
TRG_ER_diArg_1	231	234	PF00400	0.680
TRG_ER_diArg_1	257	260	PF00400	0.563
TRG_ER_diArg_1	295	298	PF00400	0.537
TRG_ER_diArg_1	49	52	PF00400	0.490
TRG_Pf-PMV_PEXEL_1	215	220	PF00026	0.654
TRG_Pf-PMV_PEXEL_1	331	335	PF00026	0.495
TRG_Pf-PMV_PEXEL_1	43	48	PF00026	0.501

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PGP1	Leptomonas seymouri	33%	100%
A0A3S7X5J3	Leishmania donovani	84%	100%
A4HKD7	Leishmania braziliensis	59%	100%
A4I808	Leishmania infantum	84%	100%
E9B2S5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	99%