Putative ATP-dependent zinc metallopeptidase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Metalloprotease M41 FtsH, putative

Species:

Leishmania major

UniProt:

Q4Q5D1_LEIMA

TriTrypDb:

LmjF.32.1500 , LMJLV39_320021100 , LMJSD75_320021100

Length:

718

Annotations

LeishMANIAdb annotations

Homologous to bacterial FtsH and Eukaryotic AFG3 proteins. Probably involved in mitochondrial protein processing.. Localization: Mitochondrial (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 30
NetGPI	no	yes: 0, no: 30

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0005745	m-AAA complex	4	4
GO:0032991	protein-containing complex	1	4
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0098796	membrane protein complex	2	4
GO:0098798	mitochondrial protein-containing complex	2	4
GO:0098800	inner mitochondrial membrane protein complex	3	4
GO:0110165	cellular anatomical entity	1	24
GO:1902494	catalytic complex	2	4
GO:1905368	peptidase complex	3	4
GO:0016020	membrane	2	22

Expansion

Sequence features

Q4Q5D1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5D1

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	31
GO:0006807	nitrogen compound metabolic process	2	31
GO:0008152	metabolic process	1	31
GO:0009987	cellular process	1	4
GO:0016043	cellular component organization	3	4
GO:0016485	protein processing	5	4
GO:0019538	protein metabolic process	3	31
GO:0022607	cellular component assembly	4	4
GO:0034982	mitochondrial protein processing	6	4
GO:0043170	macromolecule metabolic process	3	31
GO:0043933	protein-containing complex organization	4	4
GO:0044238	primary metabolic process	2	31
GO:0051604	protein maturation	4	4
GO:0065003	protein-containing complex assembly	5	4
GO:0071704	organic substance metabolic process	2	31
GO:0071840	cellular component organization or biogenesis	2	4
GO:1901564	organonitrogen compound metabolic process	3	31

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	31
GO:0003824	catalytic activity	1	31
GO:0004175	endopeptidase activity	4	31
GO:0004176	ATP-dependent peptidase activity	2	31
GO:0004222	metalloendopeptidase activity	5	31
GO:0005488	binding	1	31
GO:0005524	ATP binding	5	31
GO:0008233	peptidase activity	3	31
GO:0008237	metallopeptidase activity	4	31
GO:0016462	pyrophosphatase activity	5	31
GO:0016787	hydrolase activity	2	31
GO:0016817	hydrolase activity, acting on acid anhydrides	3	31
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	31
GO:0016887	ATP hydrolysis activity	7	31
GO:0017076	purine nucleotide binding	4	31
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	31
GO:0030554	adenyl nucleotide binding	5	31
GO:0032553	ribonucleotide binding	3	31
GO:0032555	purine ribonucleotide binding	4	31
GO:0032559	adenyl ribonucleotide binding	5	31
GO:0035639	purine ribonucleoside triphosphate binding	4	31
GO:0036094	small molecule binding	2	31
GO:0043167	ion binding	2	31
GO:0043168	anion binding	3	31
GO:0097159	organic cyclic compound binding	2	31
GO:0097367	carbohydrate derivative binding	2	31
GO:0140096	catalytic activity, acting on a protein	2	31
GO:0140657	ATP-dependent activity	1	31
GO:1901265	nucleoside phosphate binding	3	31
GO:1901363	heterocyclic compound binding	2	31

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	310	314	PF00656	0.444
CLV_C14_Caspase3-7	50	54	PF00656	0.409
CLV_C14_Caspase3-7	644	648	PF00656	0.496
CLV_NRD_NRD_1	156	158	PF00675	0.337
CLV_NRD_NRD_1	376	378	PF00675	0.244
CLV_PCSK_KEX2_1	156	158	PF00082	0.337
CLV_PCSK_KEX2_1	290	292	PF00082	0.244
CLV_PCSK_PC1ET2_1	290	292	PF00082	0.239
CLV_PCSK_SKI1_1	257	261	PF00082	0.244
CLV_PCSK_SKI1_1	293	297	PF00082	0.244
CLV_PCSK_SKI1_1	367	371	PF00082	0.243
CLV_PCSK_SKI1_1	377	381	PF00082	0.244
CLV_PCSK_SKI1_1	399	403	PF00082	0.306
CLV_PCSK_SKI1_1	441	445	PF00082	0.393
CLV_PCSK_SKI1_1	625	629	PF00082	0.281
CLV_PCSK_SKI1_1	679	683	PF00082	0.264
CLV_PCSK_SKI1_1	713	717	PF00082	0.351
DEG_Nend_UBRbox_3	1	3	PF02207	0.504
DOC_CKS1_1	41	46	PF01111	0.377
DOC_CYCLIN_RxL_1	290	298	PF00134	0.457
DOC_CYCLIN_RxL_1	676	686	PF00134	0.505
DOC_MAPK_gen_1	300	308	PF00069	0.497
DOC_MAPK_gen_1	371	381	PF00069	0.444
DOC_MAPK_gen_1	687	696	PF00069	0.440
DOC_MAPK_MEF2A_6	300	308	PF00069	0.443
DOC_MAPK_MEF2A_6	374	383	PF00069	0.444
DOC_MAPK_MEF2A_6	502	509	PF00069	0.604
DOC_MAPK_MEF2A_6	553	560	PF00069	0.396
DOC_MAPK_NFAT4_5	553	561	PF00069	0.526
DOC_PP2B_LxvP_1	38	41	PF13499	0.425
DOC_PP4_FxxP_1	148	151	PF00568	0.250
DOC_PP4_MxPP_1	26	29	PF00568	0.390
DOC_USP7_MATH_1	162	166	PF00917	0.661
DOC_USP7_MATH_1	170	174	PF00917	0.719
DOC_USP7_MATH_1	179	183	PF00917	0.537
DOC_USP7_MATH_1	314	318	PF00917	0.452
DOC_USP7_MATH_1	422	426	PF00917	0.710
DOC_USP7_MATH_1	430	434	PF00917	0.711
DOC_USP7_MATH_1	46	50	PF00917	0.599
DOC_USP7_MATH_1	463	467	PF00917	0.538
DOC_USP7_MATH_1	8	12	PF00917	0.392
DOC_USP7_UBL2_3	220	224	PF12436	0.520
DOC_USP7_UBL2_3	231	235	PF12436	0.542
DOC_USP7_UBL2_3	553	557	PF12436	0.413
DOC_USP7_UBL2_3	641	645	PF12436	0.473
DOC_USP7_UBL2_3	699	703	PF12436	0.428
DOC_WW_Pin1_4	267	272	PF00397	0.491
DOC_WW_Pin1_4	4	9	PF00397	0.419
DOC_WW_Pin1_4	40	45	PF00397	0.505
DOC_WW_Pin1_4	428	433	PF00397	0.736
DOC_WW_Pin1_4	475	480	PF00397	0.509
LIG_14-3-3_CanoR_1	649	655	PF00244	0.480
LIG_BIR_III_2	453	457	PF00653	0.702
LIG_BIR_III_4	313	317	PF00653	0.444
LIG_BRCT_BRCA1_1	268	272	PF00533	0.472
LIG_CaM_IQ_9	612	627	PF13499	0.442
LIG_FHA_1	444	450	PF00498	0.732
LIG_FHA_1	476	482	PF00498	0.510
LIG_FHA_1	546	552	PF00498	0.509
LIG_FHA_1	568	574	PF00498	0.421
LIG_FHA_2	207	213	PF00498	0.516
LIG_FHA_2	346	352	PF00498	0.475
LIG_FHA_2	414	420	PF00498	0.628
LIG_FHA_2	651	657	PF00498	0.483
LIG_GSK3_LRP6_1	40	45	PF00069	0.378
LIG_IBAR_NPY_1	58	60	PF08397	0.396
LIG_LIR_Apic_2	136	140	PF02991	0.322
LIG_LIR_Gen_1	11	19	PF02991	0.439
LIG_LIR_Gen_1	234	244	PF02991	0.507
LIG_LIR_Gen_1	279	284	PF02991	0.445
LIG_LIR_Gen_1	469	474	PF02991	0.626
LIG_LIR_Gen_1	535	545	PF02991	0.456
LIG_LIR_Gen_1	584	594	PF02991	0.475
LIG_LIR_Nem_3	113	119	PF02991	0.412
LIG_LIR_Nem_3	208	213	PF02991	0.517
LIG_LIR_Nem_3	234	239	PF02991	0.503
LIG_LIR_Nem_3	279	283	PF02991	0.445
LIG_LIR_Nem_3	391	396	PF02991	0.496
LIG_LIR_Nem_3	469	473	PF02991	0.630
LIG_LIR_Nem_3	535	540	PF02991	0.449
LIG_LIR_Nem_3	584	590	PF02991	0.470
LIG_LIR_Nem_3	72	77	PF02991	0.384
LIG_NRBOX	690	696	PF00104	0.445
LIG_PCNA_yPIPBox_3	511	524	PF02747	0.530
LIG_PDZ_Class_2	713	718	PF00595	0.637
LIG_Pex14_2	280	284	PF04695	0.442
LIG_PTB_Apo_2	141	148	PF02174	0.409
LIG_PTB_Apo_2	464	471	PF02174	0.534
LIG_PTB_Phospho_1	464	470	PF10480	0.539
LIG_SH2_CRK	106	110	PF00017	0.475
LIG_SH2_CRK	470	474	PF00017	0.461
LIG_SH2_CRK	60	64	PF00017	0.532
LIG_SH2_GRB2like	396	399	PF00017	0.518
LIG_SH2_SRC	106	109	PF00017	0.475
LIG_SH2_STAP1	470	474	PF00017	0.522
LIG_SH2_STAP1	569	573	PF00017	0.457
LIG_SH2_STAP1	89	93	PF00017	0.411
LIG_SH2_STAT3	17	20	PF00017	0.432
LIG_SH2_STAT3	32	35	PF00017	0.362
LIG_SH2_STAT3	569	572	PF00017	0.442
LIG_SH2_STAT3	77	80	PF00017	0.497
LIG_SH2_STAT3	91	94	PF00017	0.546
LIG_SH2_STAT5	154	157	PF00017	0.346
LIG_SH2_STAT5	226	229	PF00017	0.495
LIG_SH2_STAT5	396	399	PF00017	0.499
LIG_SH2_STAT5	569	572	PF00017	0.450
LIG_SH2_STAT5	60	63	PF00017	0.524
LIG_SH2_STAT5	674	677	PF00017	0.460
LIG_SH2_STAT5	74	77	PF00017	0.557
LIG_SH3_3	102	108	PF00018	0.551
LIG_SH3_3	120	126	PF00018	0.350
LIG_SH3_3	192	198	PF00018	0.629
LIG_SH3_3	376	382	PF00018	0.439
LIG_SH3_3	38	44	PF00018	0.522
LIG_SH3_4	408	415	PF00018	0.604
LIG_SH3_4	641	648	PF00018	0.526
LIG_Sin3_3	666	673	PF02671	0.394
LIG_SUMO_SIM_anti_2	351	357	PF11976	0.451
LIG_SxIP_EBH_1	557	567	PF03271	0.432
LIG_TRAF2_1	219	222	PF00917	0.477
LIG_TRAF2_1	330	333	PF00917	0.458
LIG_TRAF2_2	109	114	PF00917	0.449
LIG_TYR_ITSM	533	540	PF00017	0.310
LIG_UBA3_1	189	197	PF00899	0.516
LIG_WW_1	103	106	PF00397	0.657
MOD_CK1_1	133	139	PF00069	0.409
MOD_CK1_1	234	240	PF00069	0.560
MOD_CK1_1	431	437	PF00069	0.551
MOD_CK1_1	475	481	PF00069	0.424
MOD_CK1_1	528	534	PF00069	0.308
MOD_CK1_1	72	78	PF00069	0.437
MOD_CK2_1	327	333	PF00069	0.313
MOD_CK2_1	345	351	PF00069	0.259
MOD_CK2_1	413	419	PF00069	0.556
MOD_CK2_1	463	469	PF00069	0.448
MOD_CK2_1	650	656	PF00069	0.339
MOD_CMANNOS	651	654	PF00535	0.409
MOD_Cter_Amidation	519	522	PF01082	0.438
MOD_Cter_Amidation	696	699	PF01082	0.448
MOD_GlcNHglycan	126	129	PF01048	0.501
MOD_GlcNHglycan	132	135	PF01048	0.473
MOD_GlcNHglycan	164	167	PF01048	0.578
MOD_GlcNHglycan	168	171	PF01048	0.635
MOD_GlcNHglycan	17	20	PF01048	0.648
MOD_GlcNHglycan	172	175	PF01048	0.674
MOD_GlcNHglycan	186	189	PF01048	0.633
MOD_GlcNHglycan	275	278	PF01048	0.274
MOD_GlcNHglycan	286	289	PF01048	0.313
MOD_GlcNHglycan	424	427	PF01048	0.724
MOD_GlcNHglycan	671	674	PF01048	0.334
MOD_GSK3_1	162	169	PF00069	0.582
MOD_GSK3_1	180	187	PF00069	0.633
MOD_GSK3_1	267	274	PF00069	0.282
MOD_GSK3_1	4	11	PF00069	0.505
MOD_GSK3_1	428	435	PF00069	0.606
MOD_GSK3_1	475	482	PF00069	0.381
MOD_GSK3_1	528	535	PF00069	0.301
MOD_N-GLC_1	333	338	PF02516	0.299
MOD_N-GLC_1	528	533	PF02516	0.205
MOD_NEK2_1	273	278	PF00069	0.214
MOD_NEK2_1	284	289	PF00069	0.229
MOD_NEK2_1	532	537	PF00069	0.279
MOD_NEK2_1	545	550	PF00069	0.325
MOD_NEK2_1	585	590	PF00069	0.284
MOD_NEK2_1	631	636	PF00069	0.313
MOD_NEK2_1	669	674	PF00069	0.265
MOD_NEK2_2	8	13	PF00069	0.644
MOD_PIKK_1	47	53	PF00454	0.726
MOD_PIKK_1	567	573	PF00454	0.294
MOD_PIKK_1	585	591	PF00454	0.294
MOD_PK_1	455	461	PF00069	0.417
MOD_PK_1	605	611	PF00069	0.409
MOD_PKA_1	377	383	PF00069	0.205
MOD_PKA_2	124	130	PF00069	0.520
MOD_PKA_2	525	531	PF00069	0.313
MOD_PKA_2	616	622	PF00069	0.298
MOD_Plk_1	333	339	PF00069	0.294
MOD_Plk_1	528	534	PF00069	0.293
MOD_Plk_1	605	611	PF00069	0.315
MOD_Plk_1	677	683	PF00069	0.409
MOD_Plk_2-3	579	585	PF00069	0.409
MOD_Plk_4	133	139	PF00069	0.296
MOD_Plk_4	255	261	PF00069	0.294
MOD_Plk_4	485	491	PF00069	0.370
MOD_Plk_4	556	562	PF00069	0.303
MOD_Plk_4	677	683	PF00069	0.317
MOD_Plk_4	69	75	PF00069	0.715
MOD_Plk_4	8	14	PF00069	0.588
MOD_ProDKin_1	267	273	PF00069	0.359
MOD_ProDKin_1	4	10	PF00069	0.532
MOD_ProDKin_1	40	46	PF00069	0.657
MOD_ProDKin_1	428	434	PF00069	0.702
MOD_ProDKin_1	475	481	PF00069	0.382
MOD_SUMO_for_1	219	222	PF00179	0.445
MOD_SUMO_for_1	454	457	PF00179	0.645
MOD_SUMO_for_1	660	663	PF00179	0.334
MOD_SUMO_rev_2	294	302	PF00179	0.409
MOD_SUMO_rev_2	372	380	PF00179	0.294
MOD_SUMO_rev_2	439	449	PF00179	0.726
MOD_SUMO_rev_2	452	456	PF00179	0.503
TRG_DiLeu_BaEn_1	445	450	PF01217	0.707
TRG_DiLeu_BaEn_1	665	670	PF01217	0.300
TRG_ENDOCYTIC_2	116	119	PF00928	0.479
TRG_ENDOCYTIC_2	226	229	PF00928	0.366
TRG_ENDOCYTIC_2	470	473	PF00928	0.547
TRG_ENDOCYTIC_2	537	540	PF00928	0.310
TRG_ER_diArg_1	155	157	PF00400	0.428
TRG_ER_diArg_1	524	527	PF00400	0.476
TRG_ER_diArg_1	562	565	PF00400	0.291
TRG_Pf-PMV_PEXEL_1	293	297	PF00026	0.295
TRG_Pf-PMV_PEXEL_1	335	339	PF00026	0.321
TRG_Pf-PMV_PEXEL_1	667	671	PF00026	0.359

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8A5	Leptomonas seymouri	47%	100%
A0A0N1HUW7	Leptomonas seymouri	32%	100%
A0A0N1I6C1	Leptomonas seymouri	35%	92%
A0A0N1IMN9	Leptomonas seymouri	80%	100%
A0A0N1PBB9	Leptomonas seymouri	48%	100%
A0A0N1PGD9	Leptomonas seymouri	33%	72%
A0A0S4J3N2	Bodo saltans	71%	100%
A0A0S4J9Q2	Bodo saltans	34%	100%
A0A0S4JAH0	Bodo saltans	50%	100%
A0A0S4JGG9	Bodo saltans	50%	100%
A0A0S4JTL4	Bodo saltans	33%	85%
A0A1X0NKD8	Trypanosomatidae	32%	100%
A0A1X0P749	Trypanosomatidae	51%	100%
A0A1X0P7E6	Trypanosomatidae	51%	100%
A0A1X0P9F5	Trypanosomatidae	34%	100%
A0A3Q8IFG3	Leishmania donovani	97%	100%
A0A3Q8IHD0	Leishmania donovani	35%	100%
A0A3Q8IJP7	Leishmania donovani	48%	100%
A0A3R7KKD0	Trypanosoma rangeli	47%	100%
A0A3R7L0P7	Trypanosoma rangeli	75%	100%
A0A3R7REN1	Trypanosoma rangeli	34%	100%
A0A3S5H775	Leishmania donovani	48%	100%
A0A3S5H828	Leishmania donovani	34%	100%
A0A422N673	Trypanosoma rangeli	35%	100%
A0A422NJ44	Trypanosoma rangeli	49%	100%
A0L4S0	Magnetococcus marinus (strain ATCC BAA-1437 / JCM 17883 / MC-1)	36%	100%
A0LR74	Acidothermus cellulolyticus (strain ATCC 43068 / DSM 8971 / 11B)	34%	100%
A0PXM8	Clostridium novyi (strain NT)	39%	100%
A1AT11	Pelobacter propionicus (strain DSM 2379 / NBRC 103807 / OttBd1)	32%	100%
A1URA3	Bartonella bacilliformis (strain ATCC 35685 / NCTC 12138 / KC583)	36%	94%
A2ZVG7	Oryza sativa subsp. japonica	35%	92%
A4H9H1	Leishmania braziliensis	49%	100%
A4HAA8	Leishmania braziliensis	47%	100%
A4HAL9	Leishmania braziliensis	35%	91%
A4HJ48	Leishmania braziliensis	31%	70%
A4HKD8	Leishmania braziliensis	86%	100%
A4HPD5	Leishmania braziliensis	32%	100%
A4HXT7	Leishmania infantum	48%	100%
A4HYI8	Leishmania infantum	48%	100%
A4I809	Leishmania infantum	97%	100%
A4I9Q6	Leishmania infantum	35%	100%
A4ICH8	Leishmania infantum	34%	100%
A5U8T5	Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra)	34%	94%
A5W382	Pseudomonas putida (strain ATCC 700007 / DSM 6899 / BCRC 17059 / F1)	35%	100%
A6LD25	Parabacteroides distasonis (strain ATCC 8503 / DSM 20701 / CIP 104284 / JCM 5825 / NCTC 11152)	32%	100%
A6QBN8	Sulfurovum sp. (strain NBC37-1)	34%	100%
A6TWP7	Alkaliphilus metalliredigens (strain QYMF)	38%	100%
A8F7F7	Pseudothermotoga lettingae (strain ATCC BAA-301 / DSM 14385 / NBRC 107922 / TMO)	38%	100%
A8ZNZ4	Acaryochloris marina (strain MBIC 11017)	32%	100%
A9BFL9	Petrotoga mobilis (strain DSM 10674 / SJ95)	32%	100%
A9BHD3	Petrotoga mobilis (strain DSM 10674 / SJ95)	32%	100%
A9NE17	Acholeplasma laidlawii (strain PG-8A)	36%	100%
B0B970	Chlamydia trachomatis serovar L2 (strain 434/Bu / ATCC VR-902B)	36%	79%
B0K5A3	Thermoanaerobacter sp. (strain X514)	37%	100%
B0K657	Thermoanaerobacter sp. (strain X514)	34%	100%
B1AI94	Ureaplasma parvum serovar 3 (strain ATCC 27815 / 27 / NCTC 11736)	32%	100%
B1ZMG6	Opitutus terrae (strain DSM 11246 / JCM 15787 / PB90-1)	33%	100%
B2JVU2	Paraburkholderia phymatum (strain DSM 17167 / CIP 108236 / LMG 21445 / STM815)	36%	100%
B2UE66	Ralstonia pickettii (strain 12J)	37%	100%
B2UMY1	Akkermansia muciniphila (strain ATCC BAA-835 / DSM 22959 / JCM 33894 / BCRC 81048 / CCUG 64013 / CIP 107961 / Muc)	34%	88%
B3DY14	Methylacidiphilum infernorum (isolate V4)	35%	100%
B3PNH3	Metamycoplasma arthritidis (strain 158L3-1)	34%	97%
B3QZS3	Phytoplasma mali (strain AT)	32%	100%
B3R057	Phytoplasma mali (strain AT)	35%	100%
B3R0R7	Phytoplasma mali (strain AT)	34%	100%
B4SCV5	Pelodictyon phaeoclathratiforme (strain DSM 5477 / BU-1)	36%	100%
B4U7U4	Hydrogenobaculum sp. (strain Y04AAS1)	33%	100%
B7J0N5	Borreliella burgdorferi (strain ZS7)	34%	100%
B7T1V0	Vaucheria litorea	33%	100%
B8D065	Halothermothrix orenii (strain H 168 / OCM 544 / DSM 9562)	35%	100%
B8G4Q6	Chloroflexus aggregans (strain MD-66 / DSM 9485)	35%	100%
B8H444	Caulobacter vibrioides (strain NA1000 / CB15N)	34%	100%
B8I4B9	Ruminiclostridium cellulolyticum (strain ATCC 35319 / DSM 5812 / JCM 6584 / H10)	35%	100%
B8J992	Anaeromyxobacter dehalogenans (strain 2CP-1 / ATCC BAA-258)	34%	100%
B9L3S8	Thermomicrobium roseum (strain ATCC 27502 / DSM 5159 / P-2)	37%	100%
B9MPK5	Caldicellulosiruptor bescii (strain ATCC BAA-1888 / DSM 6725 / Z-1320)	38%	100%
C0ZPK5	Rhodococcus erythropolis (strain PR4 / NBRC 100887)	35%	84%
C1F8X6	Acidobacterium capsulatum (strain ATCC 51196 / DSM 11244 / BCRC 80197 / JCM 7670 / NBRC 15755 / NCIMB 13165 / 161)	37%	100%
C5CES8	Kosmotoga olearia (strain ATCC BAA-1733 / DSM 21960 / TBF 19.5.1)	34%	100%
C5J6A7	Mesomycoplasma conjunctivae (strain ATCC 25834 / NCTC 10147 / HRC/581)	33%	95%
C6V4R9	Neorickettsia risticii (strain Illinois)	34%	100%
C6VKW6	Lactiplantibacillus plantarum (strain JDM1)	38%	96%
C7M0M0	Acidimicrobium ferrooxidans (strain DSM 10331 / JCM 15462 / NBRC 103882 / ICP)	36%	100%
C7N1I1	Slackia heliotrinireducens (strain ATCC 29202 / DSM 20476 / NCTC 11029 / RHS 1)	34%	92%
C7N914	Leptotrichia buccalis (strain ATCC 14201 / DSM 1135 / JCM 12969 / NCTC 10249 / C-1013-b)	35%	93%
C8W731	Lancefieldella parvula (strain ATCC 33793 / DSM 20469 / CCUG 32760 / JCM 10300 / KCTC 3663 / VPI 0546 / 1246)	33%	100%
C8WEG0	Zymomonas mobilis subsp. mobilis (strain NCIMB 11163 / B70)	37%	100%
C9ZMX6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
C9ZZX3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
D0A3J7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
D0AA32	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	67%	100%
D0LWB8	Haliangium ochraceum (strain DSM 14365 / JCM 11303 / SMP-2)	39%	100%
D0MGU8	Rhodothermus marinus (strain ATCC 43812 / DSM 4252 / R-10)	36%	100%
D1AXT4	Streptobacillus moniliformis (strain ATCC 14647 / DSM 12112 / NCTC 10651 / 9901)	36%	100%
D1BLD0	Veillonella parvula (strain ATCC 10790 / DSM 2008 / CCUG 5123 / JCM 12972 / NCTC 11810 / Te3)	35%	100%
D1C2C6	Sphaerobacter thermophilus (strain DSM 20745 / S 6022)	37%	100%
D1C8C0	Sphaerobacter thermophilus (strain DSM 20745 / S 6022)	34%	100%
D1CDT8	Thermobaculum terrenum (strain ATCC BAA-798 / YNP1)	37%	100%
D2NQQ7	Rothia mucilaginosa (strain DY-18)	36%	95%
D2QZ34	Pirellula staleyi (strain ATCC 27377 / DSM 6068 / ICPB 4128)	35%	100%
D3EZK2	Conexibacter woesei (strain DSM 14684 / CIP 108061 / JCM 11494 / NBRC 100937 / ID131577)	38%	96%
D3FFN2	Mycoplasma gallisepticum (strain R(high / passage 156))	33%	94%
D4HA34	Cutibacterium acnes (strain SK137)	37%	100%
D5D8E3	Sulcia muelleri (strain DMIN)	34%	100%
D5H7Z5	Salinibacter ruber (strain M8)	35%	100%
D5HA94	Salinibacter ruber (strain M8)	33%	100%
E9ARJ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	100%
E9ASB2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E9AT49	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E9B1M1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	81%
E9B2S6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
E9B4S8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
O19922	Cyanidium caldarium	34%	100%
O32617	Helicobacter felis (strain ATCC 49179 / NCTC 12436 / CS1)	34%	100%
O69076	Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)	37%	100%
O78516	Guillardia theta	35%	100%
O80983	Arabidopsis thaliana	36%	100%
O82150	Nicotiana tabacum	37%	100%
P0A4V9	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	34%	94%
P0AAI3	Escherichia coli (strain K12)	33%	100%
P0AAI4	Shigella flexneri	33%	100%
P32795	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	34%	96%
P39925	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	94%
P40341	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	33%	87%
P46469	Lactococcus lactis subsp. lactis (strain IL1403)	36%	100%
P47695	Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37)	34%	100%
P49825	Trieres chinensis	31%	100%
P51327	Porphyra purpurea	34%	100%
P57462	Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS)	33%	100%
P59652	Streptococcus pneumoniae (strain ATCC BAA-255 / R6)	36%	100%
P63343	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	33%	100%
P63344	Salmonella typhi	33%	100%
P71377	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	33%	100%
P71408	Helicobacter pylori (strain ATCC 700392 / 26695)	33%	100%
P73179	Synechocystis sp. (strain PCC 6803 / Kazusa)	35%	100%
P73437	Synechocystis sp. (strain PCC 6803 / Kazusa)	34%	100%
P75120	Mycoplasma pneumoniae (strain ATCC 29342 / M129 / Subtype 1)	33%	100%
P9WQN2	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	35%	94%
P9WQN3	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	34%	94%
Q04Q03	Leptospira borgpetersenii serovar Hardjo-bovis (strain JB197)	35%	100%
Q0DHL4	Oryza sativa subsp. japonica	38%	87%
Q0TTK8	Clostridium perfringens (strain ATCC 13124 / DSM 756 / JCM 1290 / NCIMB 6125 / NCTC 8237 / Type A)	33%	100%
Q10ZF7	Trichodesmium erythraeum (strain IMS101)	37%	100%
Q1AV13	Rubrobacter xylanophilus (strain DSM 9941 / NBRC 16129 / PRD-1)	36%	100%
Q1D491	Myxococcus xanthus (strain DK1622)	37%	100%
Q1LLA9	Cupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507 / CH34)	32%	100%
Q1RGP0	Rickettsia bellii (strain RML369-C)	31%	100%
Q1XDF9	Neopyropia yezoensis	35%	100%
Q2JNP0	Synechococcus sp. (strain JA-2-3B'a(2-13))	37%	100%
Q2KJI7	Bos taurus	35%	89%
Q2NIN5	Aster yellows witches'-broom phytoplasma (strain AYWB)	36%	100%
Q2SF13	Hahella chejuensis (strain KCTC 2396)	31%	100%
Q39102	Arabidopsis thaliana	36%	100%
Q39444	Capsicum annuum	37%	100%
Q3B6R3	Chlorobium luteolum (strain DSM 273 / BCRC 81028 / 2530)	36%	100%
Q3ULF4	Mus musculus	36%	92%
Q4A5F0	Mycoplasmopsis synoviae (strain 53)	34%	100%
Q4L3G8	Staphylococcus haemolyticus (strain JCSC1435)	34%	99%
Q4Q1E9	Leishmania major	34%	100%
Q4Q399	Leishmania major	34%	100%
Q4QD50	Leishmania major	47%	100%
Q4QDY0	Leishmania major	48%	100%
Q55700	Synechocystis sp. (strain PCC 6803 / Kazusa)	34%	100%
Q5SI82	Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)	36%	100%
Q5Z974	Oryza sativa subsp. japonica	36%	100%
Q60AK1	Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)	33%	100%
Q655S1	Oryza sativa subsp. japonica	35%	100%
Q67JH0	Symbiobacterium thermophilum (strain T / IAM 14863)	39%	100%
Q67LC0	Symbiobacterium thermophilum (strain T / IAM 14863)	35%	100%
Q67T82	Symbiobacterium thermophilum (strain T / IAM 14863)	37%	100%
Q67WJ2	Oryza sativa subsp. japonica	35%	100%
Q6KHA4	Mycoplasma mobile (strain ATCC 43663 / 163K / NCTC 11711)	33%	100%
Q6LUJ8	Photobacterium profundum (strain SS9)	35%	100%
Q6M2F0	Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025)	34%	84%
Q6MDI5	Protochlamydia amoebophila (strain UWE25)	38%	78%
Q6MJV1	Bdellovibrio bacteriovorus (strain ATCC 15356 / DSM 50701 / NCIMB 9529 / HD100)	35%	100%
Q6MLS7	Bdellovibrio bacteriovorus (strain ATCC 15356 / DSM 50701 / NCIMB 9529 / HD100)	34%	100%
Q7TT47	Rattus norvegicus	36%	92%
Q7UUZ7	Rhodopirellula baltica (strain DSM 10527 / NCIMB 13988 / SH1)	36%	100%
Q83FV7	Tropheryma whipplei (strain Twist)	34%	100%
Q83XX3	Oenococcus oeni	34%	100%
Q84WU8	Arabidopsis thaliana	39%	89%
Q88Z31	Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)	38%	96%
Q89AF2	Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)	33%	100%
Q8EUA6	Malacoplasma penetrans (strain HF-2)	33%	87%
Q8JZQ2	Mus musculus	35%	90%
Q8K9G8	Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)	32%	100%
Q8LQJ8	Oryza sativa subsp. japonica	36%	100%
Q8LQJ9	Oryza sativa subsp. japonica	37%	100%
Q8S2A7	Oryza sativa subsp. japonica	37%	90%
Q8VZI8	Arabidopsis thaliana	37%	88%
Q8W585	Arabidopsis thaliana	34%	100%
Q8X9L0	Escherichia coli O157:H7	33%	100%
Q8YMZ8	Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)	37%	100%
Q920A7	Mus musculus	37%	91%
Q98PE4	Mycoplasmopsis pulmonis (strain UAB CTIP)	32%	99%
Q9BAE0	Medicago sativa	36%	100%
Q9FH02	Arabidopsis thaliana	38%	100%
Q9HGM3	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	38%	93%
Q9N3T5	Caenorhabditis elegans	37%	92%
Q9TJ83	Cyanidioschyzon merolae (strain NIES-3377 / 10D)	34%	100%
Q9UQ90	Homo sapiens	36%	90%
Q9WZ49	Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)	36%	100%
Q9Y4W6	Homo sapiens	35%	90%
Q9ZM66	Helicobacter pylori (strain J99 / ATCC 700824)	33%	100%
V5B092	Trypanosoma cruzi	35%	100%
V5B4C8	Trypanosoma cruzi	48%	100%
V5BEV9	Trypanosoma cruzi	34%	100%
V5BP04	Trypanosoma cruzi	73%	100%