Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q5C9_LEIMA

TriTrypDb:

LmjF.32.1520 , LMJLV39_320021400 , LMJSD75_320021400

Length:

524

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

Q4Q5C9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5C9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	10	12	PF00675	0.484
CLV_NRD_NRD_1	142	144	PF00675	0.663
CLV_NRD_NRD_1	193	195	PF00675	0.759
CLV_NRD_NRD_1	377	379	PF00675	0.685
CLV_NRD_NRD_1	441	443	PF00675	0.536
CLV_PCSK_FUR_1	191	195	PF00082	0.662
CLV_PCSK_FUR_1	8	12	PF00082	0.494
CLV_PCSK_KEX2_1	10	12	PF00082	0.484
CLV_PCSK_KEX2_1	193	195	PF00082	0.764
CLV_PCSK_KEX2_1	210	212	PF00082	0.659
CLV_PCSK_KEX2_1	377	379	PF00082	0.677
CLV_PCSK_KEX2_1	47	49	PF00082	0.698
CLV_PCSK_PC1ET2_1	210	212	PF00082	0.674
CLV_PCSK_PC1ET2_1	47	49	PF00082	0.698
CLV_PCSK_SKI1_1	108	112	PF00082	0.627
CLV_PCSK_SKI1_1	194	198	PF00082	0.659
CLV_PCSK_SKI1_1	217	221	PF00082	0.633
CLV_PCSK_SKI1_1	340	344	PF00082	0.619
CLV_PCSK_SKI1_1	377	381	PF00082	0.651
CLV_PCSK_SKI1_1	433	437	PF00082	0.502
CLV_PCSK_SKI1_1	48	52	PF00082	0.700
CLV_PCSK_SKI1_1	500	504	PF00082	0.681
DEG_APCC_DBOX_1	72	80	PF00400	0.432
DEG_COP1_1	59	68	PF00400	0.408
DEG_Nend_UBRbox_2	1	3	PF02207	0.643
DEG_SCF_FBW7_2	86	93	PF00400	0.371
DOC_CDC14_PxL_1	351	359	PF14671	0.412
DOC_CKS1_1	283	288	PF01111	0.422
DOC_CKS1_1	87	92	PF01111	0.361
DOC_CYCLIN_RxL_1	374	384	PF00134	0.450
DOC_CYCLIN_RxL_1	430	439	PF00134	0.311
DOC_MAPK_gen_1	143	149	PF00069	0.426
DOC_MAPK_gen_1	442	453	PF00069	0.417
DOC_MAPK_gen_1	47	55	PF00069	0.428
DOC_MAPK_gen_1	75	85	PF00069	0.473
DOC_MAPK_MEF2A_6	446	455	PF00069	0.421
DOC_MAPK_MEF2A_6	47	55	PF00069	0.428
DOC_PP2B_LxvP_1	292	295	PF13499	0.475
DOC_PP2B_LxvP_1	41	44	PF13499	0.507
DOC_PP4_FxxP_1	63	66	PF00568	0.417
DOC_USP7_MATH_1	129	133	PF00917	0.447
DOC_USP7_MATH_1	235	239	PF00917	0.482
DOC_USP7_MATH_1	259	263	PF00917	0.463
DOC_USP7_MATH_1	42	46	PF00917	0.462
DOC_USP7_MATH_1	422	426	PF00917	0.396
DOC_USP7_MATH_1	486	490	PF00917	0.493
DOC_WW_Pin1_4	282	287	PF00397	0.477
DOC_WW_Pin1_4	395	400	PF00397	0.398
DOC_WW_Pin1_4	406	411	PF00397	0.332
DOC_WW_Pin1_4	478	483	PF00397	0.516
DOC_WW_Pin1_4	86	91	PF00397	0.370
LIG_14-3-3_CanoR_1	296	300	PF00244	0.450
LIG_14-3-3_CanoR_1	313	317	PF00244	0.308
LIG_14-3-3_CanoR_1	327	337	PF00244	0.369
LIG_14-3-3_CanoR_1	405	410	PF00244	0.333
LIG_14-3-3_CanoR_1	454	460	PF00244	0.456
LIG_Actin_WH2_2	311	329	PF00022	0.432
LIG_BRCT_BRCA1_1	331	335	PF00533	0.389
LIG_Clathr_ClatBox_1	435	439	PF01394	0.355
LIG_deltaCOP1_diTrp_1	389	397	PF00928	0.375
LIG_FHA_1	116	122	PF00498	0.395
LIG_FHA_1	156	162	PF00498	0.438
LIG_FHA_1	165	171	PF00498	0.389
LIG_FHA_1	218	224	PF00498	0.384
LIG_FHA_1	455	461	PF00498	0.505
LIG_FHA_2	128	134	PF00498	0.433
LIG_FHA_2	329	335	PF00498	0.434
LIG_FHA_2	367	373	PF00498	0.444
LIG_LIR_Apic_2	61	66	PF02991	0.415
LIG_LIR_Apic_2	84	90	PF02991	0.415
LIG_LIR_Gen_1	16	26	PF02991	0.512
LIG_LIR_Gen_1	168	179	PF02991	0.476
LIG_LIR_Gen_1	301	312	PF02991	0.510
LIG_LIR_Gen_1	315	324	PF02991	0.316
LIG_LIR_Gen_1	350	357	PF02991	0.397
LIG_LIR_Gen_1	516	524	PF02991	0.500
LIG_LIR_Nem_3	16	21	PF02991	0.616
LIG_LIR_Nem_3	168	174	PF02991	0.456
LIG_LIR_Nem_3	267	272	PF02991	0.474
LIG_LIR_Nem_3	315	319	PF02991	0.337
LIG_LIR_Nem_3	350	354	PF02991	0.389
LIG_LIR_Nem_3	389	395	PF02991	0.426
LIG_LIR_Nem_3	516	521	PF02991	0.504
LIG_MAD2	221	229	PF02301	0.386
LIG_MYND_1	86	90	PF01753	0.480
LIG_NRBOX	338	344	PF00104	0.418
LIG_PALB2_WD40_1	424	432	PF16756	0.335
LIG_PCNA_yPIPBox_3	340	352	PF02747	0.415
LIG_Pex14_1	103	107	PF04695	0.407
LIG_Pex14_1	391	395	PF04695	0.384
LIG_SH2_CRK	107	111	PF00017	0.420
LIG_SH2_CRK	18	22	PF00017	0.492
LIG_SH2_CRK	316	320	PF00017	0.368
LIG_SH2_CRK	9	13	PF00017	0.619
LIG_SH2_STAP1	18	22	PF00017	0.512
LIG_SH2_STAP1	214	218	PF00017	0.452
LIG_SH2_STAP1	304	308	PF00017	0.467
LIG_SH2_STAP1	388	392	PF00017	0.376
LIG_SH2_STAT5	104	107	PF00017	0.284
LIG_SH2_STAT5	156	159	PF00017	0.445
LIG_SH2_STAT5	169	172	PF00017	0.361
LIG_SH2_STAT5	291	294	PF00017	0.451
LIG_SH2_STAT5	87	90	PF00017	0.471
LIG_SH3_3	184	190	PF00018	0.489
LIG_SH3_3	281	287	PF00018	0.489
LIG_SH3_3	50	56	PF00018	0.426
LIG_SUMO_SIM_par_1	145	152	PF11976	0.453
LIG_SUMO_SIM_par_1	456	462	PF11976	0.490
LIG_SUMO_SIM_par_1	49	54	PF11976	0.441
LIG_TRAF2_1	308	311	PF00917	0.452
LIG_TYR_ITIM	105	110	PF00017	0.411
LIG_TYR_ITIM	314	319	PF00017	0.416
LIG_UBA3_1	420	426	PF00899	0.386
LIG_WRC_WIRS_1	348	353	PF05994	0.398
MOD_CK1_1	136	142	PF00069	0.488
MOD_CK1_1	298	304	PF00069	0.454
MOD_CK2_1	127	133	PF00069	0.424
MOD_CK2_1	328	334	PF00069	0.454
MOD_CK2_1	366	372	PF00069	0.451
MOD_CK2_1	510	516	PF00069	0.493
MOD_GlcNHglycan	135	138	PF01048	0.713
MOD_GlcNHglycan	175	178	PF01048	0.697
MOD_GlcNHglycan	262	265	PF01048	0.686
MOD_GlcNHglycan	331	334	PF01048	0.691
MOD_GlcNHglycan	359	362	PF01048	0.649
MOD_GlcNHglycan	366	369	PF01048	0.666
MOD_GlcNHglycan	44	47	PF01048	0.672
MOD_GlcNHglycan	445	449	PF01048	0.615
MOD_GlcNHglycan	463	466	PF01048	0.698
MOD_GlcNHglycan	475	479	PF01048	0.667
MOD_GlcNHglycan	69	72	PF01048	0.579
MOD_GSK3_1	123	130	PF00069	0.500
MOD_GSK3_1	165	172	PF00069	0.455
MOD_GSK3_1	249	256	PF00069	0.547
MOD_GSK3_1	295	302	PF00069	0.451
MOD_GSK3_1	362	369	PF00069	0.467
MOD_GSK3_1	474	481	PF00069	0.512
MOD_GSK3_1	482	489	PF00069	0.465
MOD_GSK3_1	77	84	PF00069	0.420
MOD_N-GLC_1	122	127	PF02516	0.659
MOD_N-GLC_1	299	304	PF02516	0.694
MOD_NEK2_1	106	111	PF00069	0.417
MOD_NEK2_1	121	126	PF00069	0.368
MOD_NEK2_1	299	304	PF00069	0.494
MOD_NEK2_1	312	317	PF00069	0.341
MOD_NEK2_1	357	362	PF00069	0.373
MOD_NEK2_1	51	56	PF00069	0.461
MOD_PIKK_1	235	241	PF00454	0.509
MOD_PIKK_1	279	285	PF00454	0.481
MOD_PIKK_1	397	403	PF00454	0.306
MOD_PIKK_1	78	84	PF00454	0.396
MOD_PKA_2	295	301	PF00069	0.452
MOD_PKA_2	312	318	PF00069	0.303
MOD_PKA_2	329	335	PF00069	0.322
MOD_PKA_2	453	459	PF00069	0.448
MOD_Plk_1	122	128	PF00069	0.390
MOD_Plk_1	299	305	PF00069	0.564
MOD_Plk_1	51	57	PF00069	0.423
MOD_Plk_2-3	201	207	PF00069	0.418
MOD_Plk_4	165	171	PF00069	0.455
MOD_Plk_4	299	305	PF00069	0.529
MOD_Plk_4	347	353	PF00069	0.407
MOD_Plk_4	416	422	PF00069	0.368
MOD_Plk_4	486	492	PF00069	0.431
MOD_ProDKin_1	282	288	PF00069	0.469
MOD_ProDKin_1	395	401	PF00069	0.400
MOD_ProDKin_1	406	412	PF00069	0.329
MOD_ProDKin_1	478	484	PF00069	0.516
MOD_ProDKin_1	86	92	PF00069	0.369
MOD_SUMO_for_1	13	16	PF00179	0.665
TRG_DiLeu_BaLyEn_6	375	380	PF01217	0.444
TRG_ENDOCYTIC_2	107	110	PF00928	0.416
TRG_ENDOCYTIC_2	18	21	PF00928	0.607
TRG_ENDOCYTIC_2	291	294	PF00928	0.451
TRG_ENDOCYTIC_2	304	307	PF00928	0.445
TRG_ENDOCYTIC_2	316	319	PF00928	0.320
TRG_ER_diArg_1	192	194	PF00400	0.563
TRG_ER_diArg_1	377	379	PF00400	0.462
TRG_ER_diArg_1	73	76	PF00400	0.429
TRG_ER_diArg_1	9	11	PF00400	0.689
TRG_Pf-PMV_PEXEL_1	108	113	PF00026	0.625
TRG_Pf-PMV_PEXEL_1	340	345	PF00026	0.621
TRG_Pf-PMV_PEXEL_1	377	382	PF00026	0.645
TRG_Pf-PMV_PEXEL_1	383	387	PF00026	0.564

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X5J8	Leishmania donovani	82%	100%
A4HKE0	Leishmania braziliensis	52%	100%
A4I7W8	Leishmania infantum	82%	89%
E9B2S8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%