Putative NUDIX hydrolase dihydroneopterin triphosphate pyrophosphohydrolase/hydrolase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NUDIX hydrolase dihydroneopterin triphosphate pyrophosphohydrolase/hydrolase, putative

Species:

Leishmania major

UniProt:

Q4Q5C8_LEIMA

TriTrypDb:

LmjF.32.1530 , LMJLV39_320021500 , LMJSD75_320021500

Length:

215

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	3
GO:0110165	cellular anatomical entity	1	3
GO:0005777	peroxisome	6	1
GO:0020015	glycosome	7	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

Q4Q5C8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5C8

Function

Biological processes
Term	Name	Level	Count
GO:0000290	deadenylation-dependent decapping of nuclear-transcribed mRNA	8	3
GO:0000956	nuclear-transcribed mRNA catabolic process	7	3
GO:0006139	nucleobase-containing compound metabolic process	3	3
GO:0006401	RNA catabolic process	5	3
GO:0006402	mRNA catabolic process	6	3
GO:0006725	cellular aromatic compound metabolic process	3	3
GO:0006807	nitrogen compound metabolic process	2	3
GO:0008152	metabolic process	1	3
GO:0009056	catabolic process	2	3
GO:0009057	macromolecule catabolic process	4	3
GO:0009892	negative regulation of metabolic process	4	3
GO:0009987	cellular process	1	3
GO:0010468	regulation of gene expression	5	3
GO:0010605	negative regulation of macromolecule metabolic process	5	3
GO:0010629	negative regulation of gene expression	6	3
GO:0016070	RNA metabolic process	5	3
GO:0016071	mRNA metabolic process	6	3
GO:0019222	regulation of metabolic process	3	3
GO:0019439	aromatic compound catabolic process	4	3
GO:0034641	cellular nitrogen compound metabolic process	3	3
GO:0034655	nucleobase-containing compound catabolic process	4	3
GO:0043170	macromolecule metabolic process	3	3
GO:0044237	cellular metabolic process	2	3
GO:0044238	primary metabolic process	2	3
GO:0044248	cellular catabolic process	3	3
GO:0044260	obsolete cellular macromolecule metabolic process	3	3
GO:0044265	obsolete cellular macromolecule catabolic process	4	3
GO:0044270	cellular nitrogen compound catabolic process	4	3
GO:0046483	heterocycle metabolic process	3	3
GO:0046700	heterocycle catabolic process	4	3
GO:0048519	negative regulation of biological process	3	3
GO:0050789	regulation of biological process	2	3
GO:0060255	regulation of macromolecule metabolic process	4	3
GO:0065007	biological regulation	1	3
GO:0071704	organic substance metabolic process	2	3
GO:0090304	nucleic acid metabolic process	4	3
GO:0110154	RNA decapping	6	3
GO:0110156	methylguanosine-cap decapping	7	3
GO:1901360	organic cyclic compound metabolic process	3	3
GO:1901361	organic cyclic compound catabolic process	4	3
GO:1901575	organic substance catabolic process	3	3

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	16
GO:0016462	pyrophosphatase activity	5	11
GO:0016787	hydrolase activity	2	16
GO:0016817	hydrolase activity, acting on acid anhydrides	3	11
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	11
GO:0050072	obsolete m7G(5')pppN diphosphatase activity	6	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	107	109	PF00675	0.459
CLV_NRD_NRD_1	118	120	PF00675	0.424
CLV_NRD_NRD_1	13	15	PF00675	0.282
CLV_NRD_NRD_1	173	175	PF00675	0.325
CLV_PCSK_KEX2_1	107	109	PF00082	0.538
CLV_PCSK_KEX2_1	13	15	PF00082	0.294
CLV_PCSK_KEX2_1	149	151	PF00082	0.422
CLV_PCSK_KEX2_1	175	177	PF00082	0.414
CLV_PCSK_PC1ET2_1	149	151	PF00082	0.417
CLV_PCSK_PC1ET2_1	175	177	PF00082	0.412
CLV_PCSK_SKI1_1	72	76	PF00082	0.403
DOC_MAPK_gen_1	114	123	PF00069	0.470
DOC_MAPK_gen_1	13	20	PF00069	0.283
DOC_MAPK_MEF2A_6	13	20	PF00069	0.339
DOC_USP7_MATH_1	160	164	PF00917	0.452
DOC_USP7_MATH_1	33	37	PF00917	0.199
DOC_USP7_MATH_1	84	88	PF00917	0.295
DOC_USP7_UBL2_3	116	120	PF12436	0.399
DOC_WW_Pin1_4	50	55	PF00397	0.360
LIG_14-3-3_CanoR_1	13	17	PF00244	0.279
LIG_14-3-3_CanoR_1	150	159	PF00244	0.543
LIG_14-3-3_CanoR_1	41	45	PF00244	0.437
LIG_Actin_WH2_2	127	143	PF00022	0.244
LIG_deltaCOP1_diTrp_1	155	161	PF00928	0.260
LIG_eIF4E_1	129	135	PF01652	0.225
LIG_FHA_1	203	209	PF00498	0.425
LIG_FHA_1	33	39	PF00498	0.194
LIG_FHA_2	60	66	PF00498	0.389
LIG_LIR_Gen_1	61	70	PF02991	0.309
LIG_LIR_Nem_3	115	121	PF02991	0.390
LIG_LIR_Nem_3	127	132	PF02991	0.326
LIG_LIR_Nem_3	154	159	PF02991	0.400
LIG_LIR_Nem_3	61	66	PF02991	0.309
LIG_LYPXL_S_1	128	132	PF13949	0.317
LIG_LYPXL_yS_3	129	132	PF13949	0.318
LIG_MYND_3	191	195	PF01753	0.281
LIG_PDZ_Class_1	210	215	PF00595	0.711
LIG_SH2_STAT5	133	136	PF00017	0.355
LIG_TRAF2_1	124	127	PF00917	0.338
LIG_TRAF2_1	62	65	PF00917	0.427
LIG_UBA3_1	131	139	PF00899	0.285
LIG_WW_3	171	175	PF00397	0.287
MOD_CDC14_SPxK_1	53	56	PF00782	0.190
MOD_CDK_SPxK_1	50	56	PF00069	0.190
MOD_CK1_1	202	208	PF00069	0.565
MOD_CK2_1	121	127	PF00069	0.433
MOD_CK2_1	59	65	PF00069	0.348
MOD_GlcNHglycan	123	126	PF01048	0.505
MOD_GlcNHglycan	201	204	PF01048	0.457
MOD_GlcNHglycan	82	85	PF01048	0.327
MOD_GlcNHglycan	86	89	PF01048	0.335
MOD_GSK3_1	151	158	PF00069	0.414
MOD_GSK3_1	198	205	PF00069	0.365
MOD_GSK3_1	206	213	PF00069	0.421
MOD_GSK3_1	50	57	PF00069	0.297
MOD_GSK3_1	80	87	PF00069	0.368
MOD_NEK2_1	121	126	PF00069	0.445
MOD_NEK2_1	40	45	PF00069	0.380
MOD_PKA_2	12	18	PF00069	0.290
MOD_PKA_2	40	46	PF00069	0.376
MOD_PKA_2	59	65	PF00069	0.190
MOD_Plk_1	72	78	PF00069	0.460
MOD_Plk_4	72	78	PF00069	0.459
MOD_ProDKin_1	50	56	PF00069	0.360
MOD_SUMO_for_1	135	138	PF00179	0.538
TRG_DiLeu_BaEn_2	22	28	PF01217	0.392
TRG_DiLeu_BaLyEn_6	189	194	PF01217	0.381
TRG_DiLeu_LyEn_5	127	132	PF01217	0.251
TRG_ENDOCYTIC_2	129	132	PF00928	0.318
TRG_ER_diArg_1	12	14	PF00400	0.309
TRG_ER_diArg_1	173	176	PF00400	0.308
TRG_NLS_MonoExtN_4	172	178	PF00514	0.297

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P9K0	Leptomonas seymouri	50%	91%
A0A1X0P292	Trypanosomatidae	37%	71%
A0A3Q8IFW7	Leishmania donovani	50%	88%
A0A3Q8IL17	Leishmania donovani	84%	82%
A0A422P4Y4	Trypanosoma rangeli	39%	90%
A4HKE1	Leishmania braziliensis	70%	93%
A4I7W9	Leishmania infantum	50%	88%
C9ZPX0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
C9ZQT5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	71%
E9B2T0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	88%
Q4Q5C7	Leishmania major	48%	100%
Q4QJJ4	Leishmania major	30%	100%
V5BU70	Trypanosoma cruzi	42%	84%
V5DQQ5	Trypanosoma cruzi	42%	84%