PSP1 C-terminal domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PSP1 C-terminal conserved region, putative

Species:

Leishmania major

UniProt:

Q4Q5C6_LEIMA

TriTrypDb:

LmjF.32.1550 , LMJLV39_320021700 , LMJSD75_320021700

Length:

401

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q5C6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5C6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	72	76	PF00656	0.470
CLV_NRD_NRD_1	199	201	PF00675	0.566
CLV_NRD_NRD_1	221	223	PF00675	0.398
CLV_NRD_NRD_1	385	387	PF00675	0.651
CLV_NRD_NRD_1	69	71	PF00675	0.621
CLV_NRD_NRD_1	88	90	PF00675	0.509
CLV_PCSK_FUR_1	219	223	PF00082	0.404
CLV_PCSK_KEX2_1	131	133	PF00082	0.674
CLV_PCSK_KEX2_1	198	200	PF00082	0.574
CLV_PCSK_KEX2_1	216	218	PF00082	0.422
CLV_PCSK_KEX2_1	221	223	PF00082	0.398
CLV_PCSK_KEX2_1	385	387	PF00082	0.660
CLV_PCSK_KEX2_1	69	71	PF00082	0.619
CLV_PCSK_KEX2_1	88	90	PF00082	0.509
CLV_PCSK_PC1ET2_1	131	133	PF00082	0.674
CLV_PCSK_PC1ET2_1	216	218	PF00082	0.422
CLV_PCSK_PC7_1	217	223	PF00082	0.413
CLV_PCSK_SKI1_1	160	164	PF00082	0.662
CLV_PCSK_SKI1_1	221	225	PF00082	0.387
CLV_PCSK_SKI1_1	287	291	PF00082	0.412
CLV_PCSK_SKI1_1	306	310	PF00082	0.183
CLV_PCSK_SKI1_1	354	358	PF00082	0.395
CLV_PCSK_SKI1_1	74	78	PF00082	0.598
DEG_APCC_DBOX_1	146	154	PF00400	0.612
DEG_APCC_DBOX_1	220	228	PF00400	0.487
DEG_SCF_FBW7_1	56	62	PF00400	0.509
DOC_ANK_TNKS_1	271	278	PF00023	0.439
DOC_CKS1_1	56	61	PF01111	0.511
DOC_MAPK_DCC_7	219	229	PF00069	0.485
DOC_MAPK_gen_1	219	229	PF00069	0.459
DOC_MAPK_gen_1	382	392	PF00069	0.599
DOC_MAPK_GRA24_9	213	229	PF00069	0.479
DOC_PP1_RVXF_1	334	340	PF00149	0.315
DOC_PP1_RVXF_1	387	393	PF00149	0.609
DOC_PP4_FxxP_1	127	130	PF00568	0.510
DOC_PP4_FxxP_1	223	226	PF00568	0.468
DOC_USP7_MATH_1	130	134	PF00917	0.735
DOC_USP7_MATH_1	146	150	PF00917	0.544
DOC_USP7_MATH_1	180	184	PF00917	0.745
DOC_USP7_MATH_1	47	51	PF00917	0.755
DOC_USP7_MATH_2	3	9	PF00917	0.526
DOC_WW_Pin1_4	122	127	PF00397	0.653
DOC_WW_Pin1_4	154	159	PF00397	0.658
DOC_WW_Pin1_4	175	180	PF00397	0.680
DOC_WW_Pin1_4	222	227	PF00397	0.488
DOC_WW_Pin1_4	28	33	PF00397	0.507
DOC_WW_Pin1_4	38	43	PF00397	0.609
DOC_WW_Pin1_4	55	60	PF00397	0.547
LIG_14-3-3_CanoR_1	147	151	PF00244	0.721
LIG_14-3-3_CanoR_1	177	187	PF00244	0.658
LIG_14-3-3_CanoR_1	287	294	PF00244	0.315
LIG_14-3-3_CanoR_1	306	315	PF00244	0.183
LIG_14-3-3_CanoR_1	318	324	PF00244	0.268
LIG_14-3-3_CanoR_1	69	78	PF00244	0.497
LIG_BRCT_BRCA1_1	337	341	PF00533	0.315
LIG_CtBP_PxDLS_1	164	168	PF00389	0.530
LIG_FHA_1	85	91	PF00498	0.506
LIG_FHA_2	209	215	PF00498	0.442
LIG_FHA_2	288	294	PF00498	0.366
LIG_FHA_2	309	315	PF00498	0.294
LIG_FHA_2	80	86	PF00498	0.425
LIG_GBD_Chelix_1	315	323	PF00786	0.294
LIG_HP1_1	146	150	PF01393	0.608
LIG_LIR_Apic_2	124	130	PF02991	0.537
LIG_LIR_LC3C_4	244	249	PF02991	0.432
LIG_LIR_Nem_3	348	352	PF02991	0.343
LIG_LIR_Nem_3	355	360	PF02991	0.434
LIG_LIR_Nem_3	75	80	PF02991	0.437
LIG_MLH1_MIPbox_1	337	341	PF16413	0.315
LIG_PCNA_PIPBox_1	10	19	PF02747	0.379
LIG_PCNA_yPIPBox_3	350	360	PF02747	0.294
LIG_PCNA_yPIPBox_3	88	102	PF02747	0.486
LIG_SH2_PTP2	234	237	PF00017	0.432
LIG_SH2_SRC	234	237	PF00017	0.432
LIG_SH2_STAT3	78	81	PF00017	0.541
LIG_SH2_STAT5	16	19	PF00017	0.457
LIG_SH2_STAT5	234	237	PF00017	0.432
LIG_SH2_STAT5	25	28	PF00017	0.416
LIG_SH2_STAT5	78	81	PF00017	0.530
LIG_SH3_1	53	59	PF00018	0.539
LIG_SH3_3	158	164	PF00018	0.528
LIG_SH3_3	232	238	PF00018	0.440
LIG_SH3_3	270	276	PF00018	0.631
LIG_SH3_3	53	59	PF00018	0.651
LIG_SUMO_SIM_par_1	2	9	PF11976	0.500
LIG_TRAF2_1	290	293	PF00917	0.345
MOD_CDC14_SPxK_1	157	160	PF00782	0.677
MOD_CDK_SPxK_1	154	160	PF00069	0.681
MOD_CK1_1	103	109	PF00069	0.517
MOD_CK1_1	225	231	PF00069	0.489
MOD_CK1_1	33	39	PF00069	0.634
MOD_CK2_1	118	124	PF00069	0.684
MOD_CK2_1	208	214	PF00069	0.447
MOD_CK2_1	287	293	PF00069	0.346
MOD_CK2_1	43	49	PF00069	0.544
MOD_CK2_1	79	85	PF00069	0.439
MOD_GlcNHglycan	108	111	PF01048	0.633
MOD_GlcNHglycan	112	115	PF01048	0.648
MOD_GlcNHglycan	180	183	PF01048	0.656
MOD_GlcNHglycan	32	35	PF01048	0.649
MOD_GlcNHglycan	342	345	PF01048	0.345
MOD_GlcNHglycan	398	401	PF01048	0.573
MOD_GlcNHglycan	45	48	PF01048	0.596
MOD_GlcNHglycan	49	52	PF01048	0.610
MOD_GSK3_1	105	112	PF00069	0.567
MOD_GSK3_1	114	121	PF00069	0.688
MOD_GSK3_1	163	170	PF00069	0.665
MOD_GSK3_1	178	185	PF00069	0.534
MOD_GSK3_1	36	43	PF00069	0.653
MOD_GSK3_1	55	62	PF00069	0.530
MOD_NEK2_1	307	312	PF00069	0.395
MOD_NEK2_1	366	371	PF00069	0.504
MOD_NEK2_1	394	399	PF00069	0.669
MOD_NEK2_1	79	84	PF00069	0.586
MOD_NEK2_2	308	313	PF00069	0.294
MOD_PIKK_1	182	188	PF00454	0.662
MOD_PIKK_1	91	97	PF00454	0.505
MOD_PKA_1	69	75	PF00069	0.515
MOD_PKA_2	103	109	PF00069	0.508
MOD_PKA_2	146	152	PF00069	0.637
MOD_PKA_2	172	178	PF00069	0.685
MOD_PKA_2	187	193	PF00069	0.558
MOD_PKA_2	381	387	PF00069	0.517
MOD_PKA_2	69	75	PF00069	0.547
MOD_Plk_2-3	300	306	PF00069	0.294
MOD_Plk_4	146	152	PF00069	0.637
MOD_Plk_4	79	85	PF00069	0.579
MOD_ProDKin_1	122	128	PF00069	0.653
MOD_ProDKin_1	154	160	PF00069	0.660
MOD_ProDKin_1	175	181	PF00069	0.678
MOD_ProDKin_1	222	228	PF00069	0.492
MOD_ProDKin_1	28	34	PF00069	0.517
MOD_ProDKin_1	38	44	PF00069	0.609
MOD_ProDKin_1	55	61	PF00069	0.548
TRG_DiLeu_BaEn_4	292	298	PF01217	0.345
TRG_ENDOCYTIC_2	16	19	PF00928	0.457
TRG_ENDOCYTIC_2	234	237	PF00928	0.352
TRG_ER_diArg_1	197	200	PF00400	0.510
TRG_ER_diArg_1	217	220	PF00400	0.425
TRG_ER_diArg_1	221	223	PF00400	0.398
TRG_ER_diArg_1	389	392	PF00400	0.715
TRG_ER_diArg_1	68	70	PF00400	0.640
TRG_ER_diArg_1	88	90	PF00400	0.509
TRG_NES_CRM1_1	314	329	PF08389	0.345
TRG_NES_CRM1_1	9	22	PF08389	0.432
TRG_NLS_Bipartite_1	198	220	PF00514	0.515
TRG_Pf-PMV_PEXEL_1	313	317	PF00026	0.395
TRG_Pf-PMV_PEXEL_1	350	355	PF00026	0.316
TRG_Pf-PMV_PEXEL_1	88	93	PF00026	0.419

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P982	Leptomonas seymouri	48%	93%
A0A3S7X5G4	Leishmania donovani	93%	100%
A4HKE2	Leishmania braziliensis	70%	99%
A4I7X0	Leishmania infantum	93%	100%
E9B2T1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%