Clu domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Translation initiation factor eIF3 subunit 135, putative

Species:

Leishmania major

UniProt:

Q4Q5C5_LEIMA

TriTrypDb:

LmjF.32.1560 , LMJLV39_320021800 , LMJSD75_320021800

Length:

918

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	3
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4Q5C5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5C5

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	11
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	11
GO:0071840	cellular component organization or biogenesis	2	11

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003743	translation initiation factor activity	4	2
GO:0005488	binding	1	2
GO:0008135	translation factor activity, RNA binding	3	2
GO:0045182	translation regulator activity	1	2
GO:0090079	translation regulator activity, nucleic acid binding	2	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	331	335	PF00656	0.538
CLV_C14_Caspase3-7	432	436	PF00656	0.529
CLV_C14_Caspase3-7	815	819	PF00656	0.555
CLV_NRD_NRD_1	327	329	PF00675	0.473
CLV_NRD_NRD_1	42	44	PF00675	0.691
CLV_NRD_NRD_1	456	458	PF00675	0.441
CLV_NRD_NRD_1	652	654	PF00675	0.449
CLV_NRD_NRD_1	78	80	PF00675	0.680
CLV_NRD_NRD_1	809	811	PF00675	0.772
CLV_NRD_NRD_1	882	884	PF00675	0.501
CLV_PCSK_FUR_1	454	458	PF00082	0.445
CLV_PCSK_KEX2_1	327	329	PF00082	0.463
CLV_PCSK_KEX2_1	41	43	PF00082	0.697
CLV_PCSK_KEX2_1	456	458	PF00082	0.384
CLV_PCSK_KEX2_1	77	79	PF00082	0.705
CLV_PCSK_KEX2_1	808	810	PF00082	0.766
CLV_PCSK_KEX2_1	881	883	PF00082	0.520
CLV_PCSK_PC1ET2_1	881	883	PF00082	0.520
CLV_PCSK_PC7_1	877	883	PF00082	0.401
CLV_PCSK_SKI1_1	118	122	PF00082	0.516
CLV_PCSK_SKI1_1	181	185	PF00082	0.590
CLV_PCSK_SKI1_1	297	301	PF00082	0.450
CLV_PCSK_SKI1_1	363	367	PF00082	0.363
CLV_PCSK_SKI1_1	422	426	PF00082	0.551
CLV_PCSK_SKI1_1	622	626	PF00082	0.519
CLV_PCSK_SKI1_1	704	708	PF00082	0.318
CLV_PCSK_SKI1_1	715	719	PF00082	0.318
CLV_PCSK_SKI1_1	886	890	PF00082	0.497
CLV_PCSK_SKI1_1	89	93	PF00082	0.401
CLV_Separin_Metazoa	428	432	PF03568	0.314
DEG_APCC_DBOX_1	885	893	PF00400	0.559
DEG_SCF_TRCP1_1	818	824	PF00400	0.557
DEG_SPOP_SBC_1	258	262	PF00917	0.539
DEG_SPOP_SBC_1	60	64	PF00917	0.707
DOC_AGCK_PIF_1	376	381	PF00069	0.468
DOC_CDC14_PxL_1	658	666	PF14671	0.511
DOC_CYCLIN_RxL_1	704	713	PF00134	0.558
DOC_CYCLIN_yClb1_LxF_4	598	604	PF00134	0.363
DOC_CYCLIN_yCln2_LP_2	366	372	PF00134	0.451
DOC_CYCLIN_yCln2_LP_2	466	469	PF00134	0.477
DOC_MAPK_DCC_7	465	473	PF00069	0.534
DOC_MAPK_gen_1	510	517	PF00069	0.569
DOC_MAPK_gen_1	653	661	PF00069	0.459
DOC_MAPK_gen_1	881	890	PF00069	0.547
DOC_MAPK_MEF2A_6	363	370	PF00069	0.477
DOC_MAPK_MEF2A_6	465	473	PF00069	0.540
DOC_MAPK_MEF2A_6	475	482	PF00069	0.662
DOC_MAPK_MEF2A_6	510	517	PF00069	0.510
DOC_MAPK_NFAT4_5	475	483	PF00069	0.476
DOC_PP1_RVXF_1	884	891	PF00149	0.536
DOC_PP2B_LxvP_1	366	369	PF13499	0.443
DOC_PP2B_LxvP_1	466	469	PF13499	0.477
DOC_PP2B_LxvP_1	659	662	PF13499	0.483
DOC_PP2B_LxvP_1	798	801	PF13499	0.566
DOC_PP2B_PxIxI_1	844	850	PF00149	0.424
DOC_PP4_FxxP_1	253	256	PF00568	0.531
DOC_PP4_FxxP_1	575	578	PF00568	0.515
DOC_PP4_FxxP_1	850	853	PF00568	0.609
DOC_PP4_MxPP_1	301	304	PF00568	0.531
DOC_SPAK_OSR1_1	602	606	PF12202	0.341
DOC_USP7_MATH_1	106	110	PF00917	0.535
DOC_USP7_MATH_1	12	16	PF00917	0.768
DOC_USP7_MATH_1	169	173	PF00917	0.629
DOC_USP7_MATH_1	183	187	PF00917	0.655
DOC_USP7_MATH_1	196	200	PF00917	0.488
DOC_USP7_MATH_1	259	263	PF00917	0.684
DOC_USP7_MATH_1	283	287	PF00917	0.498
DOC_USP7_MATH_1	388	392	PF00917	0.430
DOC_USP7_MATH_1	396	400	PF00917	0.569
DOC_USP7_MATH_1	424	428	PF00917	0.531
DOC_USP7_MATH_1	544	548	PF00917	0.561
DOC_USP7_MATH_1	549	553	PF00917	0.498
DOC_USP7_MATH_1	588	592	PF00917	0.314
DOC_USP7_MATH_1	753	757	PF00917	0.481
DOC_WW_Pin1_4	15	20	PF00397	0.719
DOC_WW_Pin1_4	164	169	PF00397	0.634
DOC_WW_Pin1_4	176	181	PF00397	0.596
DOC_WW_Pin1_4	34	39	PF00397	0.812
DOC_WW_Pin1_4	412	417	PF00397	0.683
DOC_WW_Pin1_4	481	486	PF00397	0.692
DOC_WW_Pin1_4	716	721	PF00397	0.563
DOC_WW_Pin1_4	78	83	PF00397	0.640
DOC_WW_Pin1_4	858	863	PF00397	0.771
DOC_WW_Pin1_4	870	875	PF00397	0.627
DOC_WW_Pin1_4	892	897	PF00397	0.538
LIG_14-3-3_CanoR_1	457	467	PF00244	0.549
LIG_14-3-3_CanoR_1	498	503	PF00244	0.536
LIG_14-3-3_CanoR_1	684	693	PF00244	0.533
LIG_14-3-3_CanoR_1	715	720	PF00244	0.507
LIG_14-3-3_CanoR_1	724	731	PF00244	0.495
LIG_BH_BH3_1	422	438	PF00452	0.469
LIG_BIR_III_2	31	35	PF00653	0.675
LIG_BIR_III_4	435	439	PF00653	0.433
LIG_BRCT_BRCA1_1	398	402	PF00533	0.580
LIG_BRCT_BRCA1_1	741	745	PF00533	0.539
LIG_BRCT_BRCA1_1	80	84	PF00533	0.556
LIG_Clathr_ClatBox_1	583	587	PF01394	0.528
LIG_deltaCOP1_diTrp_1	235	238	PF00928	0.469
LIG_deltaCOP1_diTrp_1	245	254	PF00928	0.518
LIG_DLG_GKlike_1	498	506	PF00625	0.483
LIG_eIF4E_1	389	395	PF01652	0.509
LIG_EVH1_1	850	854	PF00568	0.533
LIG_FHA_1	102	108	PF00498	0.532
LIG_FHA_1	258	264	PF00498	0.684
LIG_FHA_1	415	421	PF00498	0.672
LIG_FHA_1	461	467	PF00498	0.400
LIG_FHA_1	605	611	PF00498	0.517
LIG_FHA_1	619	625	PF00498	0.278
LIG_FHA_1	716	722	PF00498	0.513
LIG_FHA_1	730	736	PF00498	0.501
LIG_FHA_2	126	132	PF00498	0.537
LIG_FHA_2	145	151	PF00498	0.484
LIG_FHA_2	487	493	PF00498	0.672
LIG_FHA_2	529	535	PF00498	0.555
LIG_FHA_2	661	667	PF00498	0.474
LIG_FHA_2	717	723	PF00498	0.518
LIG_FHA_2	784	790	PF00498	0.560
LIG_FHA_2	809	815	PF00498	0.698
LIG_GBD_Chelix_1	425	433	PF00786	0.508
LIG_GBD_Chelix_1	569	577	PF00786	0.331
LIG_LIR_Apic_2	252	256	PF02991	0.526
LIG_LIR_Apic_2	572	578	PF02991	0.462
LIG_LIR_Gen_1	500	511	PF02991	0.531
LIG_LIR_Gen_1	657	664	PF02991	0.424
LIG_LIR_Gen_1	694	703	PF02991	0.520
LIG_LIR_Nem_3	115	120	PF02991	0.467
LIG_LIR_Nem_3	134	140	PF02991	0.248
LIG_LIR_Nem_3	217	222	PF02991	0.367
LIG_LIR_Nem_3	375	379	PF02991	0.385
LIG_LIR_Nem_3	447	451	PF02991	0.465
LIG_LIR_Nem_3	500	506	PF02991	0.537
LIG_LIR_Nem_3	657	661	PF02991	0.421
LIG_LIR_Nem_3	694	699	PF02991	0.520
LIG_NRBOX	730	736	PF00104	0.463
LIG_Pex14_1	158	162	PF04695	0.445
LIG_Pex14_1	236	240	PF04695	0.377
LIG_Pex14_2	121	125	PF04695	0.385
LIG_SH2_CRK	503	507	PF00017	0.541
LIG_SH2_CRK	620	624	PF00017	0.482
LIG_SH2_CRK	94	98	PF00017	0.427
LIG_SH2_STAP1	140	144	PF00017	0.517
LIG_SH2_STAP1	162	166	PF00017	0.601
LIG_SH2_STAP1	219	223	PF00017	0.483
LIG_SH2_STAP1	503	507	PF00017	0.513
LIG_SH2_STAP1	620	624	PF00017	0.379
LIG_SH2_STAT3	351	354	PF00017	0.491
LIG_SH2_STAT3	459	462	PF00017	0.485
LIG_SH2_STAT5	319	322	PF00017	0.485
LIG_SH2_STAT5	459	462	PF00017	0.348
LIG_SH2_STAT5	620	623	PF00017	0.409
LIG_SH2_STAT5	677	680	PF00017	0.506
LIG_SH2_STAT5	907	910	PF00017	0.497
LIG_SH3_1	848	854	PF00018	0.411
LIG_SH3_3	172	178	PF00018	0.740
LIG_SH3_3	20	26	PF00018	0.746
LIG_SH3_3	253	259	PF00018	0.610
LIG_SH3_3	309	315	PF00018	0.534
LIG_SH3_3	356	362	PF00018	0.474
LIG_SH3_3	413	419	PF00018	0.684
LIG_SH3_3	466	472	PF00018	0.473
LIG_SH3_3	479	485	PF00018	0.633
LIG_SH3_3	576	582	PF00018	0.411
LIG_SH3_3	798	804	PF00018	0.645
LIG_SH3_3	848	854	PF00018	0.593
LIG_SH3_3	857	863	PF00018	0.745
LIG_SUMO_SIM_anti_2	355	361	PF11976	0.499
LIG_SUMO_SIM_anti_2	479	484	PF11976	0.628
LIG_TRAF2_1	531	534	PF00917	0.547
LIG_WW_2	418	421	PF00397	0.563
LIG_WW_3	24	28	PF00397	0.765
MOD_CDC14_SPxK_1	18	21	PF00782	0.619
MOD_CDK_SPK_2	176	181	PF00069	0.651
MOD_CDK_SPxK_1	15	21	PF00069	0.622
MOD_CDK_SPxxK_3	34	41	PF00069	0.760
MOD_CDK_SPxxK_3	481	488	PF00069	0.644
MOD_CDK_SPxxK_3	870	877	PF00069	0.612
MOD_CK1_1	15	21	PF00069	0.776
MOD_CK1_1	262	268	PF00069	0.688
MOD_CK1_1	412	418	PF00069	0.689
MOD_CK1_1	484	490	PF00069	0.725
MOD_CK1_1	497	503	PF00069	0.271
MOD_CK1_1	532	538	PF00069	0.615
MOD_CK1_1	59	65	PF00069	0.618
MOD_CK1_1	716	722	PF00069	0.546
MOD_CK1_1	790	796	PF00069	0.431
MOD_CK1_1	799	805	PF00069	0.593
MOD_CK1_1	824	830	PF00069	0.600
MOD_CK2_1	144	150	PF00069	0.613
MOD_CK2_1	283	289	PF00069	0.527
MOD_CK2_1	486	492	PF00069	0.673
MOD_CK2_1	528	534	PF00069	0.543
MOD_CK2_1	660	666	PF00069	0.474
MOD_CK2_1	716	722	PF00069	0.495
MOD_CK2_1	783	789	PF00069	0.502
MOD_CK2_1	808	814	PF00069	0.749
MOD_GlcNHglycan	15	18	PF01048	0.806
MOD_GlcNHglycan	265	268	PF01048	0.614
MOD_GlcNHglycan	390	393	PF01048	0.480
MOD_GlcNHglycan	411	414	PF01048	0.754
MOD_GlcNHglycan	422	425	PF01048	0.574
MOD_GlcNHglycan	534	537	PF01048	0.585
MOD_GlcNHglycan	546	549	PF01048	0.409
MOD_GlcNHglycan	628	631	PF01048	0.659
MOD_GlcNHglycan	68	71	PF01048	0.696
MOD_GlcNHglycan	715	718	PF01048	0.320
MOD_GlcNHglycan	798	801	PF01048	0.570
MOD_GlcNHglycan	8	12	PF01048	0.782
MOD_GlcNHglycan	818	821	PF01048	0.461
MOD_GSK3_1	140	147	PF00069	0.557
MOD_GSK3_1	190	197	PF00069	0.496
MOD_GSK3_1	258	265	PF00069	0.610
MOD_GSK3_1	377	384	PF00069	0.389
MOD_GSK3_1	420	427	PF00069	0.557
MOD_GSK3_1	494	501	PF00069	0.624
MOD_GSK3_1	528	535	PF00069	0.560
MOD_GSK3_1	556	563	PF00069	0.529
MOD_GSK3_1	56	63	PF00069	0.710
MOD_GSK3_1	735	742	PF00069	0.647
MOD_GSK3_1	783	790	PF00069	0.510
MOD_GSK3_1	799	806	PF00069	0.459
MOD_GSK3_1	808	815	PF00069	0.661
MOD_GSK3_1	824	831	PF00069	0.755
MOD_GSK3_1	858	865	PF00069	0.788
MOD_N-GLC_1	12	17	PF02516	0.722
MOD_N-GLC_2	526	528	PF02516	0.514
MOD_N-GLC_2	590	592	PF02516	0.502
MOD_NEK2_1	112	117	PF00069	0.514
MOD_NEK2_1	203	208	PF00069	0.491
MOD_NEK2_1	381	386	PF00069	0.376
MOD_NEK2_1	429	434	PF00069	0.408
MOD_NEK2_1	458	463	PF00069	0.396
MOD_NEK2_1	502	507	PF00069	0.508
MOD_NEK2_1	730	735	PF00069	0.555
MOD_NEK2_1	745	750	PF00069	0.339
MOD_NEK2_1	765	770	PF00069	0.349
MOD_NEK2_1	787	792	PF00069	0.546
MOD_NEK2_1	908	913	PF00069	0.535
MOD_NEK2_2	222	227	PF00069	0.497
MOD_NEK2_2	588	593	PF00069	0.320
MOD_NMyristoyl	1	7	PF02799	0.617
MOD_PIKK_1	184	190	PF00454	0.549
MOD_PIKK_1	458	464	PF00454	0.489
MOD_PIKK_1	529	535	PF00454	0.530
MOD_PIKK_1	549	555	PF00454	0.469
MOD_PKA_1	42	48	PF00069	0.717
MOD_PKA_1	808	814	PF00069	0.744
MOD_PKA_2	26	32	PF00069	0.742
MOD_PKA_2	42	48	PF00069	0.560
MOD_PKA_2	497	503	PF00069	0.546
MOD_PKA_2	537	543	PF00069	0.589
MOD_PKA_2	723	729	PF00069	0.438
MOD_PKA_2	808	814	PF00069	0.744
MOD_PKB_1	808	816	PF00069	0.698
MOD_Plk_1	297	303	PF00069	0.573
MOD_Plk_1	407	413	PF00069	0.651
MOD_Plk_1	476	482	PF00069	0.679
MOD_Plk_4	106	112	PF00069	0.398
MOD_Plk_4	190	196	PF00069	0.616
MOD_Plk_4	259	265	PF00069	0.727
MOD_Plk_4	498	504	PF00069	0.547
MOD_Plk_4	556	562	PF00069	0.525
MOD_Plk_4	654	660	PF00069	0.399
MOD_Plk_4	730	736	PF00069	0.559
MOD_Plk_4	908	914	PF00069	0.544
MOD_ProDKin_1	15	21	PF00069	0.720
MOD_ProDKin_1	164	170	PF00069	0.641
MOD_ProDKin_1	176	182	PF00069	0.591
MOD_ProDKin_1	34	40	PF00069	0.812
MOD_ProDKin_1	412	418	PF00069	0.681
MOD_ProDKin_1	481	487	PF00069	0.693
MOD_ProDKin_1	716	722	PF00069	0.563
MOD_ProDKin_1	78	84	PF00069	0.629
MOD_ProDKin_1	858	864	PF00069	0.773
MOD_ProDKin_1	870	876	PF00069	0.624
MOD_ProDKin_1	892	898	PF00069	0.540
TRG_DiLeu_BaLyEn_6	462	467	PF01217	0.453
TRG_DiLeu_BaLyEn_6	579	584	PF01217	0.380
TRG_DiLeu_BaLyEn_6	842	847	PF01217	0.471
TRG_DiLeu_BaLyEn_6	883	888	PF01217	0.530
TRG_ENDOCYTIC_2	117	120	PF00928	0.514
TRG_ENDOCYTIC_2	503	506	PF00928	0.507
TRG_ENDOCYTIC_2	620	623	PF00928	0.488
TRG_ER_diArg_1	326	328	PF00400	0.470
TRG_ER_diArg_1	40	43	PF00400	0.703
TRG_ER_diArg_1	456	458	PF00400	0.441
TRG_ER_diArg_1	509	512	PF00400	0.447
TRG_ER_diArg_1	746	749	PF00400	0.543
TRG_ER_diArg_1	76	79	PF00400	0.718
TRG_ER_diArg_1	807	810	PF00400	0.708
TRG_Pf-PMV_PEXEL_1	247	252	PF00026	0.437
TRG_Pf-PMV_PEXEL_1	431	435	PF00026	0.316

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9B5	Leptomonas seymouri	46%	100%
A0A0S4IN68	Bodo saltans	28%	100%
A0A1X0NUD8	Trypanosomatidae	27%	100%
A0A3S7X5I2	Leishmania donovani	92%	100%
A0A422NLC9	Trypanosoma rangeli	29%	100%
A4HKE3	Leishmania braziliensis	70%	100%
A4I7X1	Leishmania infantum	92%	100%
E9B2T2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
V5BP08	Trypanosoma cruzi	29%	100%