Arf-GAP domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Putative GTPase activating protein for Arf, putative

Species:

Leishmania major

UniProt:

Q4Q5C4_LEIMA

TriTrypDb:

LmjF.32.1570 , LMJLV39_320021900 , LMJSD75_320021900

Length:

731

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q5C4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5C4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005096	GTPase activator activity	4	6
GO:0008047	enzyme activator activity	3	6
GO:0030234	enzyme regulator activity	2	6
GO:0030695	GTPase regulator activity	4	6
GO:0060589	nucleoside-triphosphatase regulator activity	3	6
GO:0098772	molecular function regulator activity	1	6
GO:0140677	molecular function activator activity	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	127	129	PF00675	0.496
CLV_NRD_NRD_1	314	316	PF00675	0.688
CLV_NRD_NRD_1	321	323	PF00675	0.622
CLV_NRD_NRD_1	397	399	PF00675	0.712
CLV_NRD_NRD_1	467	469	PF00675	0.674
CLV_NRD_NRD_1	616	618	PF00675	0.738
CLV_NRD_NRD_1	711	713	PF00675	0.514
CLV_PCSK_FUR_1	394	398	PF00082	0.704
CLV_PCSK_FUR_1	91	95	PF00082	0.412
CLV_PCSK_KEX2_1	127	129	PF00082	0.496
CLV_PCSK_KEX2_1	153	155	PF00082	0.565
CLV_PCSK_KEX2_1	313	315	PF00082	0.687
CLV_PCSK_KEX2_1	318	320	PF00082	0.645
CLV_PCSK_KEX2_1	396	398	PF00082	0.708
CLV_PCSK_KEX2_1	401	403	PF00082	0.672
CLV_PCSK_KEX2_1	616	618	PF00082	0.738
CLV_PCSK_KEX2_1	711	713	PF00082	0.514
CLV_PCSK_KEX2_1	93	95	PF00082	0.408
CLV_PCSK_PC1ET2_1	153	155	PF00082	0.565
CLV_PCSK_PC1ET2_1	318	320	PF00082	0.690
CLV_PCSK_PC1ET2_1	401	403	PF00082	0.714
CLV_PCSK_PC1ET2_1	93	95	PF00082	0.408
CLV_PCSK_PC7_1	314	320	PF00082	0.688
CLV_PCSK_PC7_1	397	403	PF00082	0.692
CLV_PCSK_SKI1_1	115	119	PF00082	0.377
CLV_PCSK_SKI1_1	208	212	PF00082	0.659
CLV_PCSK_SKI1_1	229	233	PF00082	0.597
CLV_PCSK_SKI1_1	315	319	PF00082	0.703
CLV_PCSK_SKI1_1	357	361	PF00082	0.648
CLV_PCSK_SKI1_1	372	376	PF00082	0.543
CLV_PCSK_SKI1_1	443	447	PF00082	0.667
CLV_PCSK_SKI1_1	484	488	PF00082	0.659
CLV_PCSK_SKI1_1	616	620	PF00082	0.590
CLV_PCSK_SKI1_1	718	722	PF00082	0.649
DEG_APCC_DBOX_1	401	409	PF00400	0.659
DEG_ODPH_VHL_1	413	425	PF01847	0.540
DEG_SCF_FBW7_1	169	175	PF00400	0.645
DEG_SCF_FBW7_1	434	441	PF00400	0.559
DEG_SPOP_SBC_1	520	524	PF00917	0.709
DEG_SPOP_SBC_1	661	665	PF00917	0.560
DOC_CKS1_1	169	174	PF01111	0.646
DOC_CKS1_1	508	513	PF01111	0.553
DOC_CKS1_1	685	690	PF01111	0.651
DOC_CYCLIN_yCln2_LP_2	23	29	PF00134	0.262
DOC_MAPK_gen_1	15	22	PF00069	0.380
DOC_MAPK_gen_1	67	75	PF00069	0.412
DOC_MAPK_gen_1	711	719	PF00069	0.494
DOC_MAPK_MEF2A_6	229	237	PF00069	0.613
DOC_MAPK_MEF2A_6	323	332	PF00069	0.656
DOC_MAPK_MEF2A_6	427	436	PF00069	0.660
DOC_PP1_RVXF_1	615	622	PF00149	0.546
DOC_PP2B_LxvP_1	133	136	PF13499	0.480
DOC_PP2B_LxvP_1	413	416	PF13499	0.524
DOC_PP2B_LxvP_1	529	532	PF13499	0.558
DOC_PP2B_LxvP_1	620	623	PF13499	0.622
DOC_PP2B_PxIxI_1	264	270	PF00149	0.537
DOC_PP4_FxxP_1	581	584	PF00568	0.774
DOC_USP7_MATH_1	137	141	PF00917	0.721
DOC_USP7_MATH_1	172	176	PF00917	0.674
DOC_USP7_MATH_1	194	198	PF00917	0.693
DOC_USP7_MATH_1	273	277	PF00917	0.721
DOC_USP7_MATH_1	304	308	PF00917	0.727
DOC_USP7_MATH_1	376	380	PF00917	0.616
DOC_USP7_MATH_1	449	453	PF00917	0.712
DOC_USP7_MATH_1	456	460	PF00917	0.655
DOC_USP7_MATH_1	461	465	PF00917	0.615
DOC_USP7_MATH_1	589	593	PF00917	0.704
DOC_USP7_MATH_1	659	663	PF00917	0.682
DOC_USP7_MATH_1	82	86	PF00917	0.379
DOC_WW_Pin1_4	168	173	PF00397	0.836
DOC_WW_Pin1_4	203	208	PF00397	0.755
DOC_WW_Pin1_4	229	234	PF00397	0.595
DOC_WW_Pin1_4	253	258	PF00397	0.668
DOC_WW_Pin1_4	261	266	PF00397	0.692
DOC_WW_Pin1_4	271	276	PF00397	0.772
DOC_WW_Pin1_4	297	302	PF00397	0.622
DOC_WW_Pin1_4	357	362	PF00397	0.742
DOC_WW_Pin1_4	428	433	PF00397	0.684
DOC_WW_Pin1_4	434	439	PF00397	0.705
DOC_WW_Pin1_4	450	455	PF00397	0.610
DOC_WW_Pin1_4	478	483	PF00397	0.688
DOC_WW_Pin1_4	507	512	PF00397	0.612
DOC_WW_Pin1_4	570	575	PF00397	0.652
DOC_WW_Pin1_4	657	662	PF00397	0.655
DOC_WW_Pin1_4	672	677	PF00397	0.564
DOC_WW_Pin1_4	684	689	PF00397	0.550
LIG_14-3-3_CanoR_1	322	328	PF00244	0.652
LIG_14-3-3_CanoR_1	355	363	PF00244	0.646
LIG_14-3-3_CanoR_1	427	432	PF00244	0.551
LIG_14-3-3_CanoR_1	450	454	PF00244	0.577
LIG_14-3-3_CanoR_1	462	466	PF00244	0.654
LIG_14-3-3_CanoR_1	484	492	PF00244	0.649
LIG_14-3-3_CanoR_1	521	529	PF00244	0.627
LIG_14-3-3_CanoR_1	565	569	PF00244	0.636
LIG_14-3-3_CanoR_1	668	674	PF00244	0.677
LIG_14-3-3_CanoR_1	686	695	PF00244	0.504
LIG_14-3-3_CanoR_1	725	730	PF00244	0.660
LIG_BIR_II_1	1	5	PF00653	0.606
LIG_BRCT_BRCA1_1	662	666	PF00533	0.530
LIG_BRCT_BRCA1_1	688	692	PF00533	0.655
LIG_CaM_IQ_9	1	17	PF13499	0.530
LIG_CSL_BTD_1	620	623	PF09270	0.522
LIG_CtBP_PxDLS_1	415	419	PF00389	0.523
LIG_deltaCOP1_diTrp_1	74	83	PF00928	0.412
LIG_FHA_1	171	177	PF00498	0.700
LIG_FHA_1	230	236	PF00498	0.668
LIG_FHA_1	264	270	PF00498	0.659
LIG_FHA_1	278	284	PF00498	0.679
LIG_FHA_1	298	304	PF00498	0.547
LIG_FHA_1	358	364	PF00498	0.700
LIG_FHA_1	373	379	PF00498	0.561
LIG_FHA_1	404	410	PF00498	0.657
LIG_FHA_1	442	448	PF00498	0.722
LIG_FHA_1	485	491	PF00498	0.693
LIG_FHA_1	508	514	PF00498	0.643
LIG_FHA_1	585	591	PF00498	0.587
LIG_FHA_1	6	12	PF00498	0.534
LIG_FHA_1	698	704	PF00498	0.625
LIG_FHA_1	70	76	PF00498	0.412
LIG_FHA_2	531	537	PF00498	0.668
LIG_FHA_2	676	682	PF00498	0.541
LIG_LIR_Apic_2	103	107	PF02991	0.408
LIG_LIR_Gen_1	40	49	PF02991	0.412
LIG_LIR_Gen_1	663	674	PF02991	0.607
LIG_LIR_Nem_3	40	44	PF02991	0.412
LIG_LIR_Nem_3	417	423	PF02991	0.643
LIG_LIR_Nem_3	663	669	PF02991	0.603
LIG_LIR_Nem_3	689	695	PF02991	0.601
LIG_NRBOX	18	24	PF00104	0.412
LIG_PCNA_yPIPBox_3	9	23	PF02747	0.484
LIG_SH2_CRK	130	134	PF00017	0.541
LIG_SH2_PTP2	104	107	PF00017	0.412
LIG_SH2_STAP1	96	100	PF00017	0.337
LIG_SH2_STAT3	630	633	PF00017	0.573
LIG_SH2_STAT5	104	107	PF00017	0.412
LIG_SH2_STAT5	124	127	PF00017	0.284
LIG_SH2_STAT5	215	218	PF00017	0.587
LIG_SH2_STAT5	630	633	PF00017	0.647
LIG_SH3_1	129	135	PF00018	0.491
LIG_SH3_1	166	172	PF00018	0.656
LIG_SH3_2	479	484	PF14604	0.588
LIG_SH3_3	129	135	PF00018	0.506
LIG_SH3_3	166	172	PF00018	0.688
LIG_SH3_3	244	250	PF00018	0.814
LIG_SH3_3	259	265	PF00018	0.523
LIG_SH3_3	269	275	PF00018	0.615
LIG_SH3_3	340	346	PF00018	0.565
LIG_SH3_3	476	482	PF00018	0.728
LIG_SH3_3	505	511	PF00018	0.589
LIG_SH3_3	574	580	PF00018	0.663
LIG_SH3_3	646	652	PF00018	0.574
LIG_SUMO_SIM_anti_2	276	283	PF11976	0.655
LIG_SUMO_SIM_par_1	263	271	PF11976	0.635
LIG_SUMO_SIM_par_1	276	286	PF11976	0.684
LIG_SUMO_SIM_par_1	328	334	PF11976	0.556
LIG_SUMO_SIM_par_1	375	383	PF11976	0.582
LIG_SUMO_SIM_par_1	443	448	PF11976	0.667
LIG_TRAF2_1	385	388	PF00917	0.658
LIG_WW_3	490	494	PF00397	0.686
MOD_CDC14_SPxK_1	481	484	PF00782	0.664
MOD_CDK_SPK_2	203	208	PF00069	0.644
MOD_CDK_SPK_2	450	455	PF00069	0.561
MOD_CDK_SPxK_1	478	484	PF00069	0.664
MOD_CDK_SPxK_1	572	578	PF00069	0.580
MOD_CDK_SPxxK_3	428	435	PF00069	0.580
MOD_CDK_SPxxK_3	436	443	PF00069	0.556
MOD_CK1_1	214	220	PF00069	0.583
MOD_CK1_1	263	269	PF00069	0.623
MOD_CK1_1	274	280	PF00069	0.684
MOD_CK1_1	389	395	PF00069	0.677
MOD_CK1_1	426	432	PF00069	0.665
MOD_CK1_1	524	530	PF00069	0.644
MOD_CK1_1	553	559	PF00069	0.648
MOD_CK1_1	566	572	PF00069	0.621
MOD_CK1_1	611	617	PF00069	0.575
MOD_CK1_1	639	645	PF00069	0.688
MOD_CK1_1	660	666	PF00069	0.694
MOD_CK1_1	672	678	PF00069	0.666
MOD_CK2_1	137	143	PF00069	0.587
MOD_CK2_1	376	382	PF00069	0.631
MOD_CK2_1	530	536	PF00069	0.676
MOD_GlcNHglycan	111	115	PF01048	0.362
MOD_GlcNHglycan	243	246	PF01048	0.710
MOD_GlcNHglycan	305	309	PF01048	0.712
MOD_GlcNHglycan	33	37	PF01048	0.337
MOD_GlcNHglycan	390	394	PF01048	0.634
MOD_GlcNHglycan	524	527	PF01048	0.670
MOD_GlcNHglycan	54	57	PF01048	0.412
MOD_GlcNHglycan	552	555	PF01048	0.696
MOD_GlcNHglycan	560	563	PF01048	0.641
MOD_GlcNHglycan	638	641	PF01048	0.584
MOD_GSK3_1	168	175	PF00069	0.698
MOD_GSK3_1	249	256	PF00069	0.630
MOD_GSK3_1	271	278	PF00069	0.693
MOD_GSK3_1	304	311	PF00069	0.759
MOD_GSK3_1	372	379	PF00069	0.644
MOD_GSK3_1	423	430	PF00069	0.753
MOD_GSK3_1	434	441	PF00069	0.592
MOD_GSK3_1	520	527	PF00069	0.656
MOD_GSK3_1	546	553	PF00069	0.758
MOD_GSK3_1	566	573	PF00069	0.551
MOD_GSK3_1	607	614	PF00069	0.538
MOD_GSK3_1	63	70	PF00069	0.412
MOD_GSK3_1	635	642	PF00069	0.738
MOD_GSK3_1	655	662	PF00069	0.583
MOD_GSK3_1	664	671	PF00069	0.623
MOD_GSK3_1	675	682	PF00069	0.521
MOD_GSK3_1	693	700	PF00069	0.591
MOD_GSK3_1	96	103	PF00069	0.503
MOD_N-GLC_1	203	208	PF02516	0.649
MOD_N-GLC_1	241	246	PF02516	0.641
MOD_N-GLC_1	309	314	PF02516	0.575
MOD_N-GLC_1	557	562	PF02516	0.650
MOD_NEK2_1	211	216	PF00069	0.669
MOD_NEK2_1	241	246	PF00069	0.666
MOD_NEK2_1	32	37	PF00069	0.337
MOD_NEK2_1	423	428	PF00069	0.657
MOD_NEK2_1	550	555	PF00069	0.750
MOD_NEK2_1	557	562	PF00069	0.701
MOD_NEK2_1	563	568	PF00069	0.618
MOD_NEK2_1	612	617	PF00069	0.686
MOD_NEK2_1	655	660	PF00069	0.594
MOD_NEK2_1	669	674	PF00069	0.560
MOD_NEK2_2	172	177	PF00069	0.641
MOD_PIKK_1	170	176	PF00454	0.609
MOD_PIKK_1	484	490	PF00454	0.735
MOD_PIKK_1	687	693	PF00454	0.650
MOD_PKA_1	313	319	PF00069	0.689
MOD_PKA_1	322	328	PF00069	0.591
MOD_PKA_2	176	182	PF00069	0.662
MOD_PKA_2	313	319	PF00069	0.756
MOD_PKA_2	321	327	PF00069	0.680
MOD_PKA_2	426	432	PF00069	0.650
MOD_PKA_2	449	455	PF00069	0.578
MOD_PKA_2	461	467	PF00069	0.675
MOD_PKA_2	5	11	PF00069	0.567
MOD_PKA_2	52	58	PF00069	0.412
MOD_PKA_2	520	526	PF00069	0.603
MOD_PKA_2	564	570	PF00069	0.634
MOD_PKA_2	582	588	PF00069	0.728
MOD_PKA_2	636	642	PF00069	0.708
MOD_PKA_2	655	661	PF00069	0.531
MOD_PKA_2	669	675	PF00069	0.670
MOD_PKB_1	353	361	PF00069	0.637
MOD_PKB_1	723	731	PF00069	0.575
MOD_Plk_1	211	217	PF00069	0.580
MOD_Plk_1	416	422	PF00069	0.613
MOD_Plk_1	546	552	PF00069	0.649
MOD_Plk_1	679	685	PF00069	0.629
MOD_Plk_1	96	102	PF00069	0.412
MOD_Plk_4	100	106	PF00069	0.412
MOD_Plk_4	211	217	PF00069	0.608
MOD_Plk_4	263	269	PF00069	0.569
MOD_Plk_4	277	283	PF00069	0.675
MOD_Plk_4	650	656	PF00069	0.542
MOD_Plk_4	669	675	PF00069	0.635
MOD_ProDKin_1	168	174	PF00069	0.835
MOD_ProDKin_1	203	209	PF00069	0.753
MOD_ProDKin_1	229	235	PF00069	0.601
MOD_ProDKin_1	253	259	PF00069	0.665
MOD_ProDKin_1	261	267	PF00069	0.694
MOD_ProDKin_1	271	277	PF00069	0.775
MOD_ProDKin_1	297	303	PF00069	0.623
MOD_ProDKin_1	357	363	PF00069	0.746
MOD_ProDKin_1	428	434	PF00069	0.687
MOD_ProDKin_1	436	442	PF00069	0.696
MOD_ProDKin_1	450	456	PF00069	0.616
MOD_ProDKin_1	478	484	PF00069	0.689
MOD_ProDKin_1	507	513	PF00069	0.617
MOD_ProDKin_1	570	576	PF00069	0.648
MOD_ProDKin_1	657	663	PF00069	0.653
MOD_ProDKin_1	672	678	PF00069	0.564
MOD_ProDKin_1	684	690	PF00069	0.553
MOD_SUMO_rev_2	147	155	PF00179	0.632
MOD_SUMO_rev_2	366	374	PF00179	0.658
MOD_SUMO_rev_2	626	631	PF00179	0.602
TRG_DiLeu_BaEn_2	78	84	PF01217	0.412
TRG_DiLeu_BaLyEn_6	178	183	PF01217	0.559
TRG_DiLeu_LyEn_5	509	514	PF01217	0.639
TRG_ENDOCYTIC_2	130	133	PF00928	0.509
TRG_ER_diArg_1	127	129	PF00400	0.459
TRG_ER_diArg_1	313	315	PF00400	0.684
TRG_ER_diArg_1	394	397	PF00400	0.704
TRG_ER_diArg_1	399	402	PF00400	0.682
TRG_ER_diArg_1	590	593	PF00400	0.645
TRG_ER_diArg_1	711	713	PF00400	0.592
TRG_NES_CRM1_1	708	722	PF08389	0.501
TRG_NLS_MonoExtC_3	399	404	PF00514	0.660
TRG_NLS_MonoExtN_4	397	404	PF00514	0.710
TRG_Pf-PMV_PEXEL_1	17	21	PF00026	0.362
TRG_Pf-PMV_PEXEL_1	711	715	PF00026	0.651
TRG_Pf-PMV_PEXEL_1	718	722	PF00026	0.553

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X5J1	Leishmania donovani	80%	100%
A4HKE4	Leishmania braziliensis	49%	99%
A4I7X2	Leishmania infantum	80%	100%
E9B2T3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%