Mannose-6-phosphate isomerase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphomannose isomerase

Species:

Leishmania major

UniProt:

Q4Q5C3_LEIMA

TriTrypDb:

LmjF.32.1580 , LMJLV39_320022000 , LMJSD75_320022000

Length:

421

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005829	cytosol	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q5C3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5C3

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	11
GO:0005996	monosaccharide metabolic process	3	2
GO:0006013	mannose metabolic process	5	2
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0009225	nucleotide-sugar metabolic process	4	11
GO:0009226	nucleotide-sugar biosynthetic process	5	11
GO:0009298	GDP-mannose biosynthetic process	6	11
GO:0009987	cellular process	1	11
GO:0016051	carbohydrate biosynthetic process	4	2
GO:0018130	heterocycle biosynthetic process	4	11
GO:0019307	mannose biosynthetic process	6	2
GO:0019318	hexose metabolic process	4	2
GO:0019319	hexose biosynthetic process	5	2
GO:0019438	aromatic compound biosynthetic process	4	11
GO:0019673	GDP-mannose metabolic process	5	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034654	nucleobase-containing compound biosynthetic process	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044249	cellular biosynthetic process	3	11
GO:0044271	cellular nitrogen compound biosynthetic process	4	11
GO:0044281	small molecule metabolic process	2	11
GO:0044283	small molecule biosynthetic process	3	2
GO:0046364	monosaccharide biosynthetic process	4	2
GO:0046483	heterocycle metabolic process	3	11
GO:0055086	nucleobase-containing small molecule metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:1901135	carbohydrate derivative metabolic process	3	11
GO:1901137	carbohydrate derivative biosynthetic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11
GO:1901362	organic cyclic compound biosynthetic process	4	11
GO:1901576	organic substance biosynthetic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004476	mannose-6-phosphate isomerase activity	5	11
GO:0005488	binding	1	11
GO:0008270	zinc ion binding	6	11
GO:0016853	isomerase activity	2	11
GO:0016860	intramolecular oxidoreductase activity	3	11
GO:0016861	intramolecular oxidoreductase activity, interconverting aldoses and ketoses	4	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0046914	transition metal ion binding	5	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	322	324	PF00675	0.463
CLV_PCSK_KEX2_1	158	160	PF00082	0.381
CLV_PCSK_PC1ET2_1	158	160	PF00082	0.381
CLV_PCSK_SKI1_1	100	104	PF00082	0.306
CLV_PCSK_SKI1_1	29	33	PF00082	0.367
DEG_APCC_DBOX_1	215	223	PF00400	0.531
DOC_CDC14_PxL_1	157	165	PF14671	0.392
DOC_MAPK_gen_1	35	45	PF00069	0.441
DOC_PP1_RVXF_1	405	412	PF00149	0.403
DOC_PP4_FxxP_1	392	395	PF00568	0.297
DOC_USP7_MATH_1	137	141	PF00917	0.388
DOC_USP7_MATH_1	186	190	PF00917	0.347
DOC_USP7_MATH_1	20	24	PF00917	0.435
DOC_USP7_MATH_1	317	321	PF00917	0.502
DOC_USP7_UBL2_3	193	197	PF12436	0.516
DOC_WW_Pin1_4	293	298	PF00397	0.332
LIG_BIR_II_1	1	5	PF00653	0.557
LIG_Clathr_ClatBox_1	4	8	PF01394	0.466
LIG_EVH1_2	339	343	PF00568	0.337
LIG_FHA_1	212	218	PF00498	0.487
LIG_FHA_1	311	317	PF00498	0.343
LIG_FHA_1	359	365	PF00498	0.441
LIG_FHA_1	366	372	PF00498	0.338
LIG_FHA_1	413	419	PF00498	0.418
LIG_FHA_2	137	143	PF00498	0.435
LIG_GBD_Chelix_1	211	219	PF00786	0.188
LIG_LIR_Apic_2	123	128	PF02991	0.448
LIG_LIR_Apic_2	390	395	PF02991	0.304
LIG_LIR_Gen_1	139	149	PF02991	0.435
LIG_LIR_Gen_1	232	243	PF02991	0.456
LIG_LIR_Nem_3	139	144	PF02991	0.435
LIG_LIR_Nem_3	232	238	PF02991	0.466
LIG_LIR_Nem_3	296	302	PF02991	0.366
LIG_LIR_Nem_3	345	349	PF02991	0.349
LIG_Pex14_1	249	253	PF04695	0.435
LIG_Pex14_1	332	336	PF04695	0.513
LIG_Pex14_2	40	44	PF04695	0.516
LIG_SH2_CRK	337	341	PF00017	0.338
LIG_SH2_CRK	396	400	PF00017	0.416
LIG_SH2_NCK_1	353	357	PF00017	0.394
LIG_SH2_SRC	353	356	PF00017	0.569
LIG_SH2_STAT3	349	352	PF00017	0.436
LIG_SH2_STAT5	156	159	PF00017	0.375
LIG_SH2_STAT5	252	255	PF00017	0.461
LIG_SH2_STAT5	256	259	PF00017	0.341
LIG_SH2_STAT5	275	278	PF00017	0.480
LIG_SH2_STAT5	76	79	PF00017	0.523
LIG_SH2_STAT5	92	95	PF00017	0.420
LIG_SH3_2	49	54	PF14604	0.483
LIG_SH3_3	361	367	PF00018	0.488
LIG_SH3_3	46	52	PF00018	0.441
LIG_Sin3_3	406	413	PF02671	0.337
LIG_SUMO_SIM_anti_2	279	285	PF11976	0.301
LIG_SUMO_SIM_par_1	95	101	PF11976	0.435
LIG_TRAF2_1	189	192	PF00917	0.516
LIG_TRAF2_2	340	345	PF00917	0.464
LIG_TYR_ITIM	394	399	PF00017	0.368
LIG_UBA3_1	153	158	PF00899	0.345
LIG_UBA3_1	305	310	PF00899	0.376
LIG_WRC_WIRS_1	138	143	PF05994	0.388
MOD_CDK_SPK_2	293	298	PF00069	0.332
MOD_CDK_SPxxK_3	293	300	PF00069	0.337
MOD_CK1_1	98	104	PF00069	0.435
MOD_CK2_1	136	142	PF00069	0.435
MOD_CK2_1	186	192	PF00069	0.372
MOD_CK2_1	265	271	PF00069	0.358
MOD_GlcNHglycan	181	184	PF01048	0.435
MOD_GlcNHglycan	276	279	PF01048	0.445
MOD_GlcNHglycan	317	320	PF01048	0.529
MOD_GlcNHglycan	34	38	PF01048	0.335
MOD_GlcNHglycan	356	359	PF01048	0.493
MOD_GlcNHglycan	376	380	PF01048	0.218
MOD_GSK3_1	29	36	PF00069	0.517
MOD_GSK3_1	311	318	PF00069	0.493
MOD_GSK3_1	354	361	PF00069	0.424
MOD_GSK3_1	412	419	PF00069	0.409
MOD_N-GLC_1	358	363	PF02516	0.367
MOD_N-GLC_1	381	386	PF02516	0.405
MOD_NEK2_1	375	380	PF00069	0.437
MOD_NEK2_1	411	416	PF00069	0.308
MOD_NEK2_1	86	91	PF00069	0.466
MOD_NEK2_2	344	349	PF00069	0.322
MOD_PK_1	95	101	PF00069	0.435
MOD_PKA_2	322	328	PF00069	0.399
MOD_PKA_2	86	92	PF00069	0.466
MOD_Plk_1	344	350	PF00069	0.289
MOD_Plk_4	20	26	PF00069	0.464
MOD_Plk_4	301	307	PF00069	0.327
MOD_Plk_4	72	78	PF00069	0.536
MOD_Plk_4	81	87	PF00069	0.536
MOD_ProDKin_1	293	299	PF00069	0.335
MOD_SUMO_for_1	5	8	PF00179	0.434
MOD_SUMO_rev_2	188	195	PF00179	0.449
MOD_SUMO_rev_2	318	325	PF00179	0.437
MOD_SUMO_rev_2	65	75	PF00179	0.388
TRG_DiLeu_BaEn_1	162	167	PF01217	0.358
TRG_DiLeu_BaEn_4	191	197	PF01217	0.516
TRG_ENDOCYTIC_2	256	259	PF00928	0.335
TRG_ENDOCYTIC_2	396	399	PF00928	0.356
TRG_Pf-PMV_PEXEL_1	111	115	PF00026	0.241

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I488	Leptomonas seymouri	77%	99%
A0A1X0NUN2	Trypanosomatidae	57%	100%
A0A3R7KE75	Trypanosoma rangeli	57%	100%
A2CIG5	Leishmania infantum	95%	100%
A2CIH3	Leishmania donovani	95%	100%
A5A6K3	Pan troglodytes	41%	100%
D0AA38	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
E9B2T4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
O43014	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	100%
P00946	Escherichia coli (strain K12)	32%	100%
P25081	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	33%	100%
P29951	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	39%	91%
P29952	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	36%	98%
P34650	Caenorhabditis elegans	36%	100%
P34948	Candida albicans (strain SC5314 / ATCC MYA-2876)	36%	95%
P34949	Homo sapiens	41%	100%
Q2V6T4	Leishmania braziliensis	84%	98%
Q3SZI0	Bos taurus	40%	100%
Q54PA0	Dictyostelium discoideum	37%	93%
Q66WM4	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	36%	92%
Q68FX1	Rattus norvegicus	40%	100%
Q75AB5	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	34%	98%
Q76IQ2	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	37%	98%
Q83KZ1	Shigella flexneri	32%	100%
Q870Y1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	36%	92%
Q8HXX2	Macaca fascicularis	41%	100%
Q8J093	Ogataea parapolymorpha (strain ATCC 26012 / BCRC 20466 / JCM 22074 / NRRL Y-7560 / DL-1)	33%	99%
Q924M7	Mus musculus	39%	100%
Q9FZH5	Arabidopsis thaliana	35%	95%
Q9GP38	Echinococcus multilocularis	36%	97%
Q9HFU4	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	36%	97%
Q9M884	Arabidopsis thaliana	35%	97%
V5DFU6	Trypanosoma cruzi	55%	100%