Mannose-6-phosphate isomerase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphomannose isomerase

Species:

Leishmania major

UniProt:

Q4Q5C3_LEIMA

TriTrypDb:

LmjF.32.1580 , LMJLV39_320022000 , LMJSD75_320022000

Length:

421

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005829	cytosol	2	2
GO:0110165	cellular anatomical entity	1	2

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Expansion

Sequence features

Q4Q5C3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5C3

Function

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Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	11
GO:0005996	monosaccharide metabolic process	3	2
GO:0006013	mannose metabolic process	5	2
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0009225	nucleotide-sugar metabolic process	4	11
GO:0009226	nucleotide-sugar biosynthetic process	5	11

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004476	mannose-6-phosphate isomerase activity	5	11
GO:0005488	binding	1	11
GO:0008270	zinc ion binding	6	11
GO:0016853	isomerase activity	2	11
GO:0016860	intramolecular oxidoreductase activity	3	11
GO:0016861	intramolecular oxidoreductase activity, interconverting aldoses and ketoses	4	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	322	324	PF00675	0.463
CLV_PCSK_KEX2_1	158	160	PF00082	0.381
CLV_PCSK_PC1ET2_1	158	160	PF00082	0.381
CLV_PCSK_SKI1_1	100	104	PF00082	0.306
CLV_PCSK_SKI1_1	29	33	PF00082	0.367
DEG_APCC_DBOX_1	215	223	PF00400	0.531
DOC_CDC14_PxL_1	157	165	PF14671	0.392
DOC_MAPK_gen_1	35	45	PF00069	0.441
DOC_PP1_RVXF_1	405	412	PF00149	0.403
DOC_PP4_FxxP_1	392	395	PF00568	0.297

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I488	Leptomonas seymouri	77%	99%
A0A1X0NUN2	Trypanosomatidae	57%	100%
A0A3R7KE75	Trypanosoma rangeli	57%	100%
A2CIG5	Leishmania infantum	95%	100%
A2CIH3	Leishmania donovani	95%	100%
A5A6K3	Pan troglodytes	41%	100%
D0AA38	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
E9B2T4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
O43014	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	100%
P00946	Escherichia coli (strain K12)	32%	100%

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