Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q5C1_LEIMA

TriTrypDb:

LmjF.32.1600 , LMJLV39_320022200 , LMJSD75_320022200

Length:

667

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q5C1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5C1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	100	104	PF00656	0.619
CLV_C14_Caspase3-7	185	189	PF00656	0.754
CLV_C14_Caspase3-7	329	333	PF00656	0.596
CLV_NRD_NRD_1	100	102	PF00675	0.740
CLV_NRD_NRD_1	215	217	PF00675	0.690
CLV_NRD_NRD_1	34	36	PF00675	0.721
CLV_NRD_NRD_1	485	487	PF00675	0.797
CLV_NRD_NRD_1	519	521	PF00675	0.779
CLV_NRD_NRD_1	549	551	PF00675	0.720
CLV_PCSK_KEX2_1	215	217	PF00082	0.682
CLV_PCSK_KEX2_1	34	36	PF00082	0.721
CLV_PCSK_KEX2_1	485	487	PF00082	0.743
CLV_PCSK_KEX2_1	519	521	PF00082	0.779
CLV_PCSK_SKI1_1	123	127	PF00082	0.692
CLV_PCSK_SKI1_1	320	324	PF00082	0.766
CLV_PCSK_SKI1_1	404	408	PF00082	0.723
CLV_PCSK_SKI1_1	448	452	PF00082	0.794
CLV_PCSK_SKI1_1	58	62	PF00082	0.631
CLV_PCSK_SKI1_1	617	621	PF00082	0.632
CLV_PCSK_SKI1_1	74	78	PF00082	0.670
DEG_APCC_DBOX_1	12	20	PF00400	0.569
DEG_APCC_DBOX_1	622	630	PF00400	0.678
DEG_SPOP_SBC_1	526	530	PF00917	0.729
DEG_SPOP_SBC_1	59	63	PF00917	0.743
DOC_CKS1_1	239	244	PF01111	0.715
DOC_CKS1_1	370	375	PF01111	0.612
DOC_MAPK_DCC_7	555	565	PF00069	0.723
DOC_MAPK_gen_1	276	284	PF00069	0.580
DOC_MAPK_gen_1	559	567	PF00069	0.684
DOC_MAPK_JIP1_4	561	567	PF00069	0.678
DOC_MAPK_MEF2A_6	559	567	PF00069	0.684
DOC_PP4_FxxP_1	655	658	PF00568	0.698
DOC_SPAK_OSR1_1	643	647	PF12202	0.530
DOC_USP7_MATH_1	115	119	PF00917	0.620
DOC_USP7_MATH_1	142	146	PF00917	0.675
DOC_USP7_MATH_1	217	221	PF00917	0.634
DOC_USP7_MATH_1	47	51	PF00917	0.649
DOC_USP7_MATH_1	518	522	PF00917	0.798
DOC_USP7_MATH_1	546	550	PF00917	0.728
DOC_USP7_MATH_1	59	63	PF00917	0.700
DOC_USP7_MATH_1	7	11	PF00917	0.523
DOC_USP7_MATH_1	75	79	PF00917	0.548
DOC_USP7_UBL2_3	551	555	PF12436	0.708
DOC_WW_Pin1_4	111	116	PF00397	0.694
DOC_WW_Pin1_4	161	166	PF00397	0.781
DOC_WW_Pin1_4	187	192	PF00397	0.728
DOC_WW_Pin1_4	210	215	PF00397	0.696
DOC_WW_Pin1_4	238	243	PF00397	0.735
DOC_WW_Pin1_4	285	290	PF00397	0.683
DOC_WW_Pin1_4	332	337	PF00397	0.713
DOC_WW_Pin1_4	347	352	PF00397	0.742
DOC_WW_Pin1_4	369	374	PF00397	0.700
DOC_WW_Pin1_4	484	489	PF00397	0.751
DOC_WW_Pin1_4	50	55	PF00397	0.720
DOC_WW_Pin1_4	62	67	PF00397	0.712
LIG_14-3-3_CanoR_1	216	222	PF00244	0.742
LIG_14-3-3_CanoR_1	236	242	PF00244	0.602
LIG_14-3-3_CanoR_1	320	328	PF00244	0.721
LIG_14-3-3_CanoR_1	34	38	PF00244	0.570
LIG_14-3-3_CanoR_1	404	411	PF00244	0.740
LIG_14-3-3_CanoR_1	462	472	PF00244	0.758
LIG_14-3-3_CanoR_1	502	510	PF00244	0.794
LIG_14-3-3_CanoR_1	548	554	PF00244	0.829
LIG_14-3-3_CanoR_1	623	627	PF00244	0.671
LIG_14-3-3_CanoR_1	643	647	PF00244	0.433
LIG_14-3-3_CanoR_1	74	83	PF00244	0.823
LIG_14-3-3_CanoR_1	8	16	PF00244	0.553
LIG_BIR_II_1	1	5	PF00653	0.630
LIG_BRCT_BRCA1_1	1	5	PF00533	0.630
LIG_BRCT_BRCA1_1	203	207	PF00533	0.790
LIG_deltaCOP1_diTrp_1	428	431	PF00928	0.742
LIG_EVH1_2	174	178	PF00568	0.580
LIG_FHA_1	150	156	PF00498	0.790
LIG_FHA_1	216	222	PF00498	0.742
LIG_FHA_1	223	229	PF00498	0.655
LIG_FHA_1	251	257	PF00498	0.658
LIG_FHA_1	363	369	PF00498	0.762
LIG_FHA_1	420	426	PF00498	0.737
LIG_FHA_1	441	447	PF00498	0.638
LIG_FHA_1	505	511	PF00498	0.792
LIG_FHA_1	55	61	PF00498	0.752
LIG_FHA_1	83	89	PF00498	0.746
LIG_FHA_2	180	186	PF00498	0.733
LIG_FHA_2	20	26	PF00498	0.576
LIG_FHA_2	239	245	PF00498	0.717
LIG_FHA_2	247	253	PF00498	0.814
LIG_FHA_2	263	269	PF00498	0.643
LIG_FHA_2	342	348	PF00498	0.839
LIG_FHA_2	380	386	PF00498	0.649
LIG_FHA_2	391	397	PF00498	0.599
LIG_FHA_2	574	580	PF00498	0.501
LIG_FHA_2	610	616	PF00498	0.520
LIG_HCF-1_HBM_1	38	41	PF13415	0.673
LIG_LIR_Apic_2	596	602	PF02991	0.638
LIG_LIR_Apic_2	654	658	PF02991	0.706
LIG_LIR_Gen_1	265	273	PF02991	0.609
LIG_LIR_Gen_1	381	391	PF02991	0.608
LIG_LIR_Gen_1	579	589	PF02991	0.525
LIG_LIR_Gen_1	640	648	PF02991	0.759
LIG_LIR_Nem_3	265	270	PF02991	0.568
LIG_LIR_Nem_3	381	386	PF02991	0.604
LIG_LIR_Nem_3	579	584	PF02991	0.500
LIG_LIR_Nem_3	640	644	PF02991	0.760
LIG_NRBOX	579	585	PF00104	0.507
LIG_Pex14_2	106	110	PF04695	0.739
LIG_RPA_C_Fungi	3	15	PF08784	0.430
LIG_SH2_CRK	599	603	PF00017	0.635
LIG_SH2_SRC	375	378	PF00017	0.648
LIG_SH2_STAT5	41	44	PF00017	0.753
LIG_SH2_STAT5	610	613	PF00017	0.525
LIG_SH3_3	164	170	PF00018	0.794
LIG_SH3_3	190	196	PF00018	0.726
LIG_SH3_3	211	217	PF00018	0.677
LIG_SH3_3	335	341	PF00018	0.723
LIG_SH3_3	447	453	PF00018	0.684
LIG_SH3_3	654	660	PF00018	0.638
LIG_SUMO_SIM_anti_2	384	390	PF11976	0.833
LIG_SUMO_SIM_par_1	224	230	PF11976	0.591
LIG_TRAF2_1	22	25	PF00917	0.594
LIG_TRAF2_1	242	245	PF00917	0.791
LIG_TRAF2_1	313	316	PF00917	0.724
LIG_TRAF2_1	612	615	PF00917	0.612
LIG_TRFH_1	599	603	PF08558	0.635
LIG_TYR_ITIM	662	667	PF00017	0.561
MOD_CDC14_SPxK_1	213	216	PF00782	0.683
MOD_CDC14_SPxK_1	354	357	PF00782	0.607
MOD_CDK_SPK_2	210	215	PF00069	0.696
MOD_CDK_SPK_2	238	243	PF00069	0.754
MOD_CDK_SPK_2	334	339	PF00069	0.830
MOD_CDK_SPK_2	369	374	PF00069	0.606
MOD_CDK_SPxK_1	210	216	PF00069	0.676
MOD_CDK_SPxK_1	347	353	PF00069	0.745
MOD_CDK_SPxxK_3	161	168	PF00069	0.779
MOD_CDK_SPxxK_3	332	339	PF00069	0.727
MOD_CK1_1	113	119	PF00069	0.641
MOD_CK1_1	238	244	PF00069	0.600
MOD_CK1_1	246	252	PF00069	0.709
MOD_CK1_1	288	294	PF00069	0.725
MOD_CK1_1	334	340	PF00069	0.825
MOD_CK1_1	362	368	PF00069	0.789
MOD_CK1_1	50	56	PF00069	0.672
MOD_CK1_1	503	509	PF00069	0.787
MOD_CK1_1	528	534	PF00069	0.735
MOD_CK1_1	542	548	PF00069	0.621
MOD_CK1_1	549	555	PF00069	0.690
MOD_CK1_1	62	68	PF00069	0.758
MOD_CK1_1	625	631	PF00069	0.695
MOD_CK1_1	647	653	PF00069	0.682
MOD_CK2_1	142	148	PF00069	0.724
MOD_CK2_1	19	25	PF00069	0.588
MOD_CK2_1	238	244	PF00069	0.717
MOD_CK2_1	341	347	PF00069	0.744
MOD_CK2_1	358	364	PF00069	0.562
MOD_CK2_1	381	387	PF00069	0.641
MOD_CK2_1	415	421	PF00069	0.593
MOD_CK2_1	573	579	PF00069	0.497
MOD_CK2_1	609	615	PF00069	0.524
MOD_GlcNHglycan	115	118	PF01048	0.671
MOD_GlcNHglycan	128	131	PF01048	0.578
MOD_GlcNHglycan	142	145	PF01048	0.569
MOD_GlcNHglycan	417	420	PF01048	0.698
MOD_GlcNHglycan	49	52	PF01048	0.659
MOD_GlcNHglycan	502	505	PF01048	0.721
MOD_GlcNHglycan	515	518	PF01048	0.719
MOD_GlcNHglycan	520	523	PF01048	0.671
MOD_GlcNHglycan	530	533	PF01048	0.485
MOD_GlcNHglycan	535	538	PF01048	0.600
MOD_GlcNHglycan	551	554	PF01048	0.739
MOD_GlcNHglycan	646	649	PF01048	0.761
MOD_GlcNHglycan	68	71	PF01048	0.595
MOD_GlcNHglycan	9	12	PF01048	0.562
MOD_GlcNHglycan	97	100	PF01048	0.684
MOD_GSK3_1	109	116	PF00069	0.607
MOD_GSK3_1	140	147	PF00069	0.716
MOD_GSK3_1	15	22	PF00069	0.566
MOD_GSK3_1	156	163	PF00069	0.594
MOD_GSK3_1	179	186	PF00069	0.707
MOD_GSK3_1	234	241	PF00069	0.769
MOD_GSK3_1	246	253	PF00069	0.678
MOD_GSK3_1	284	291	PF00069	0.623
MOD_GSK3_1	304	311	PF00069	0.577
MOD_GSK3_1	322	329	PF00069	0.535
MOD_GSK3_1	341	348	PF00069	0.682
MOD_GSK3_1	358	365	PF00069	0.649
MOD_GSK3_1	390	397	PF00069	0.761
MOD_GSK3_1	407	414	PF00069	0.672
MOD_GSK3_1	415	422	PF00069	0.706
MOD_GSK3_1	436	443	PF00069	0.611
MOD_GSK3_1	458	465	PF00069	0.774
MOD_GSK3_1	50	57	PF00069	0.686
MOD_GSK3_1	500	507	PF00069	0.828
MOD_GSK3_1	535	542	PF00069	0.779
MOD_GSK3_1	58	65	PF00069	0.734
MOD_GSK3_1	589	596	PF00069	0.709
MOD_GSK3_1	66	73	PF00069	0.752
MOD_GSK3_1	82	89	PF00069	0.720
MOD_N-GLC_1	398	403	PF02516	0.808
MOD_NEK2_1	110	115	PF00069	0.766
MOD_NEK2_1	282	287	PF00069	0.635
MOD_NEK2_1	322	327	PF00069	0.769
MOD_NEK2_1	411	416	PF00069	0.789
MOD_NEK2_1	622	627	PF00069	0.563
MOD_NEK2_1	644	649	PF00069	0.529
MOD_PIKK_1	235	241	PF00454	0.606
MOD_PIKK_1	77	83	PF00454	0.821
MOD_PK_1	539	545	PF00069	0.581
MOD_PKA_1	215	221	PF00069	0.742
MOD_PKA_2	14	20	PF00069	0.575
MOD_PKA_2	156	162	PF00069	0.583
MOD_PKA_2	215	221	PF00069	0.701
MOD_PKA_2	235	241	PF00069	0.736
MOD_PKA_2	33	39	PF00069	0.625
MOD_PKA_2	458	464	PF00069	0.726
MOD_PKA_2	504	510	PF00069	0.759
MOD_PKA_2	518	524	PF00069	0.632
MOD_PKA_2	533	539	PF00069	0.630
MOD_PKA_2	549	555	PF00069	0.654
MOD_PKA_2	622	628	PF00069	0.567
MOD_PKA_2	642	648	PF00069	0.430
MOD_PKA_2	7	13	PF00069	0.549
MOD_PKB_1	13	21	PF00069	0.599
MOD_Plk_1	243	249	PF00069	0.811
MOD_Plk_1	251	257	PF00069	0.709
MOD_Plk_1	262	268	PF00069	0.673
MOD_Plk_1	420	426	PF00069	0.698
MOD_Plk_1	567	573	PF00069	0.551
MOD_Plk_2-3	263	269	PF00069	0.738
MOD_Plk_2-3	381	387	PF00069	0.605
MOD_Plk_2-3	86	92	PF00069	0.715
MOD_Plk_4	251	257	PF00069	0.715
MOD_Plk_4	288	294	PF00069	0.696
MOD_Plk_4	411	417	PF00069	0.614
MOD_Plk_4	567	573	PF00069	0.551
MOD_Plk_4	625	631	PF00069	0.617
MOD_ProDKin_1	111	117	PF00069	0.697
MOD_ProDKin_1	161	167	PF00069	0.775
MOD_ProDKin_1	187	193	PF00069	0.726
MOD_ProDKin_1	210	216	PF00069	0.698
MOD_ProDKin_1	238	244	PF00069	0.737
MOD_ProDKin_1	285	291	PF00069	0.691
MOD_ProDKin_1	332	338	PF00069	0.714
MOD_ProDKin_1	347	353	PF00069	0.745
MOD_ProDKin_1	369	375	PF00069	0.703
MOD_ProDKin_1	484	490	PF00069	0.749
MOD_ProDKin_1	50	56	PF00069	0.725
MOD_ProDKin_1	62	68	PF00069	0.714
TRG_DiLeu_BaEn_1	579	584	PF01217	0.500
TRG_DiLeu_BaEn_2	37	43	PF01217	0.670
TRG_DiLeu_BaEn_4	614	620	PF01217	0.622
TRG_ENDOCYTIC_2	641	644	PF00928	0.767
TRG_ENDOCYTIC_2	664	667	PF00928	0.643
TRG_ER_diArg_1	12	15	PF00400	0.558
TRG_ER_diArg_1	214	216	PF00400	0.688
TRG_ER_diArg_1	484	486	PF00400	0.804
TRG_ER_diArg_1	518	520	PF00400	0.753
TRG_ER_diArg_1	584	587	PF00400	0.542
TRG_Pf-PMV_PEXEL_1	587	591	PF00026	0.569

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ICJ5	Leptomonas seymouri	37%	100%
A0A3Q8IJ88	Leishmania donovani	85%	100%
A4HKE7	Leishmania braziliensis	59%	100%
A4I7X5	Leishmania infantum	85%	100%
E9B2T6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%