DNA helicase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

DNA helicase

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q5C0_LEIMA

TriTrypDb:

LmjF.32.1610 , LMJLV39_320022300 , LMJSD75_320022300

Length:

291

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q5C0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5C0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	56	60	PF00656	0.641
CLV_NRD_NRD_1	231	233	PF00675	0.445
CLV_NRD_NRD_1	239	241	PF00675	0.553
CLV_PCSK_FUR_1	229	233	PF00082	0.555
CLV_PCSK_KEX2_1	173	175	PF00082	0.426
CLV_PCSK_KEX2_1	231	233	PF00082	0.442
CLV_PCSK_KEX2_1	239	241	PF00082	0.539
CLV_PCSK_KEX2_1	260	262	PF00082	0.406
CLV_PCSK_PC1ET2_1	173	175	PF00082	0.494
CLV_PCSK_PC1ET2_1	260	262	PF00082	0.401
CLV_PCSK_SKI1_1	231	235	PF00082	0.517
DEG_APCC_DBOX_1	273	281	PF00400	0.422
DEG_Nend_Nbox_1	1	3	PF02207	0.540
DOC_CKS1_1	187	192	PF01111	0.499
DOC_CYCLIN_RxL_1	228	238	PF00134	0.475
DOC_MAPK_DCC_7	95	105	PF00069	0.462
DOC_MAPK_gen_1	173	181	PF00069	0.439
DOC_MAPK_gen_1	182	188	PF00069	0.452
DOC_PP1_RVXF_1	1	8	PF00149	0.583
DOC_PP4_FxxP_1	187	190	PF00568	0.483
DOC_USP7_MATH_1	148	152	PF00917	0.506
DOC_USP7_MATH_1	71	75	PF00917	0.613
DOC_WW_Pin1_4	186	191	PF00397	0.349
LIG_14-3-3_CanoR_1	162	167	PF00244	0.578
LIG_14-3-3_CanoR_1	90	98	PF00244	0.371
LIG_APCC_ABBA_1	120	125	PF00400	0.502
LIG_Clathr_ClatBox_1	106	110	PF01394	0.306
LIG_EH1_1	100	108	PF00400	0.315
LIG_eIF4E_1	123	129	PF01652	0.392
LIG_eIF4E_1	228	234	PF01652	0.500
LIG_FHA_1	212	218	PF00498	0.472
LIG_FHA_1	82	88	PF00498	0.393
LIG_FHA_2	152	158	PF00498	0.558
LIG_FHA_2	274	280	PF00498	0.422
LIG_LIR_Gen_1	175	181	PF02991	0.373
LIG_LIR_Gen_1	4	15	PF02991	0.654
LIG_LIR_Gen_1	45	54	PF02991	0.453
LIG_LIR_Gen_1	89	98	PF02991	0.494
LIG_LIR_Nem_3	175	180	PF02991	0.331
LIG_LIR_Nem_3	259	265	PF02991	0.500
LIG_LIR_Nem_3	4	10	PF02991	0.579
LIG_LIR_Nem_3	45	51	PF02991	0.436
LIG_Pex14_2	138	142	PF04695	0.383
LIG_Pex14_2	262	266	PF04695	0.347
LIG_PTB_Apo_2	108	115	PF02174	0.356
LIG_SH2_NCK_1	123	127	PF00017	0.342
LIG_SH2_SRC	123	126	PF00017	0.388
LIG_SH3_3	152	158	PF00018	0.550
LIG_SUMO_SIM_anti_2	125	130	PF11976	0.459
LIG_SUMO_SIM_anti_2	247	254	PF11976	0.449
LIG_SUMO_SIM_par_1	102	108	PF11976	0.301
LIG_SUMO_SIM_par_1	213	218	PF11976	0.327
LIG_TRAF2_1	43	46	PF00917	0.541
LIG_UBA3_1	233	237	PF00899	0.555
LIG_WRC_WIRS_1	134	139	PF05994	0.445
MOD_CK1_1	13	19	PF00069	0.715
MOD_CK1_1	140	146	PF00069	0.453
MOD_CK1_1	151	157	PF00069	0.546
MOD_CK1_1	89	95	PF00069	0.471
MOD_CK2_1	151	157	PF00069	0.468
MOD_CK2_1	172	178	PF00069	0.447
MOD_CK2_1	40	46	PF00069	0.399
MOD_GlcNHglycan	42	45	PF01048	0.555
MOD_GlcNHglycan	67	70	PF01048	0.605
MOD_GSK3_1	133	140	PF00069	0.434
MOD_GSK3_1	168	175	PF00069	0.602
MOD_GSK3_1	211	218	PF00069	0.430
MOD_GSK3_1	244	251	PF00069	0.537
MOD_N-GLC_1	286	291	PF02516	0.555
MOD_NEK2_1	133	138	PF00069	0.314
MOD_NEK2_1	273	278	PF00069	0.498
MOD_PK_1	162	168	PF00069	0.621
MOD_PKA_2	273	279	PF00069	0.509
MOD_PKA_2	280	286	PF00069	0.575
MOD_PKA_2	89	95	PF00069	0.376
MOD_Plk_1	151	157	PF00069	0.459
MOD_Plk_1	3	9	PF00069	0.596
MOD_Plk_4	211	217	PF00069	0.501
MOD_Plk_4	248	254	PF00069	0.538
MOD_ProDKin_1	186	192	PF00069	0.360
TRG_DiLeu_BaEn_3	45	51	PF01217	0.512
TRG_DiLeu_BaLyEn_6	229	234	PF01217	0.504
TRG_ENDOCYTIC_2	123	126	PF00928	0.478
TRG_ENDOCYTIC_2	91	94	PF00928	0.513
TRG_ER_diArg_1	228	231	PF00400	0.453
TRG_NES_CRM1_1	207	220	PF08389	0.517
TRG_Pf-PMV_PEXEL_1	174	178	PF00026	0.482

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMW3	Leptomonas seymouri	66%	98%
A0A1X0NUU9	Trypanosomatidae	46%	94%
A0A3S7X5I4	Leishmania donovani	96%	100%
A0A422NL68	Trypanosoma rangeli	40%	100%
A4HKE8	Leishmania braziliensis	79%	98%
A4I7X6	Leishmania infantum	96%	100%
D0AA41	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	93%
E9B2T7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5BF01	Trypanosoma cruzi	38%	100%