Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q5B9_LEIMA

TriTrypDb:

LmjF.32.1620 , LMJLV39_320022400 , LMJSD75_320022400

Length:

767

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q5B9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5B9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	123	127	PF00656	0.376
CLV_C14_Caspase3-7	152	156	PF00656	0.593
CLV_C14_Caspase3-7	730	734	PF00656	0.616
CLV_NRD_NRD_1	133	135	PF00675	0.406
CLV_NRD_NRD_1	233	235	PF00675	0.354
CLV_NRD_NRD_1	480	482	PF00675	0.402
CLV_NRD_NRD_1	484	486	PF00675	0.376
CLV_NRD_NRD_1	632	634	PF00675	0.563
CLV_NRD_NRD_1	717	719	PF00675	0.566
CLV_PCSK_KEX2_1	133	135	PF00082	0.406
CLV_PCSK_KEX2_1	233	235	PF00082	0.354
CLV_PCSK_KEX2_1	237	239	PF00082	0.346
CLV_PCSK_KEX2_1	480	482	PF00082	0.452
CLV_PCSK_KEX2_1	484	486	PF00082	0.426
CLV_PCSK_KEX2_1	632	634	PF00082	0.564
CLV_PCSK_KEX2_1	639	641	PF00082	0.380
CLV_PCSK_KEX2_1	717	719	PF00082	0.566
CLV_PCSK_PC1ET2_1	237	239	PF00082	0.346
CLV_PCSK_PC1ET2_1	639	641	PF00082	0.395
CLV_PCSK_PC7_1	233	239	PF00082	0.346
CLV_PCSK_PC7_1	480	486	PF00082	0.346
CLV_PCSK_SKI1_1	234	238	PF00082	0.349
CLV_PCSK_SKI1_1	455	459	PF00082	0.388
CLV_PCSK_SKI1_1	506	510	PF00082	0.461
CLV_PCSK_SKI1_1	533	537	PF00082	0.422
CLV_PCSK_SKI1_1	542	546	PF00082	0.329
CLV_Separin_Metazoa	249	253	PF03568	0.408
DEG_APCC_DBOX_1	505	513	PF00400	0.467
DOC_CYCLIN_RxL_1	503	511	PF00134	0.461
DOC_CYCLIN_RxL_1	530	540	PF00134	0.422
DOC_CYCLIN_yCln2_LP_2	180	186	PF00134	0.483
DOC_CYCLIN_yCln2_LP_2	220	226	PF00134	0.467
DOC_CYCLIN_yCln2_LP_2	681	687	PF00134	0.467
DOC_MAPK_DCC_7	237	247	PF00069	0.387
DOC_MAPK_DCC_7	333	343	PF00069	0.361
DOC_MAPK_DCC_7	592	601	PF00069	0.489
DOC_MAPK_gen_1	233	242	PF00069	0.477
DOC_MAPK_gen_1	51	58	PF00069	0.442
DOC_MAPK_MEF2A_6	238	247	PF00069	0.385
DOC_MAPK_MEF2A_6	592	601	PF00069	0.489
DOC_PP1_RVXF_1	131	138	PF00149	0.446
DOC_PP1_RVXF_1	631	638	PF00149	0.477
DOC_PP2B_LxvP_1	240	243	PF13499	0.471
DOC_PP2B_LxvP_1	31	34	PF13499	0.488
DOC_PP2B_LxvP_1	594	597	PF13499	0.458
DOC_PP2B_PxIxI_1	596	602	PF00149	0.286
DOC_PP4_FxxP_1	397	400	PF00568	0.409
DOC_PP4_MxPP_1	757	760	PF00568	0.527
DOC_USP7_MATH_1	355	359	PF00917	0.618
DOC_USP7_MATH_1	42	46	PF00917	0.496
DOC_USP7_MATH_1	491	495	PF00917	0.559
DOC_USP7_MATH_1	555	559	PF00917	0.659
DOC_USP7_MATH_1	618	622	PF00917	0.606
DOC_USP7_MATH_1	626	630	PF00917	0.465
DOC_USP7_MATH_2	106	112	PF00917	0.491
DOC_WW_Pin1_4	11	16	PF00397	0.417
DOC_WW_Pin1_4	111	116	PF00397	0.538
LIG_14-3-3_CanoR_1	189	197	PF00244	0.460
LIG_14-3-3_CanoR_1	209	218	PF00244	0.226
LIG_14-3-3_CanoR_1	233	237	PF00244	0.350
LIG_14-3-3_CanoR_1	292	299	PF00244	0.596
LIG_14-3-3_CanoR_1	390	400	PF00244	0.538
LIG_14-3-3_CanoR_1	557	565	PF00244	0.531
LIG_14-3-3_CanoR_1	608	614	PF00244	0.480
LIG_14-3-3_CanoR_1	702	710	PF00244	0.587
LIG_14-3-3_CanoR_1	99	103	PF00244	0.460
LIG_Actin_WH2_2	440	457	PF00022	0.470
LIG_BIR_II_1	1	5	PF00653	0.484
LIG_BRCT_BRCA1_1	678	682	PF00533	0.717
LIG_CtBP_PxDLS_1	80	84	PF00389	0.377
LIG_deltaCOP1_diTrp_1	404	408	PF00928	0.320
LIG_EH1_1	261	269	PF00400	0.481
LIG_FHA_1	12	18	PF00498	0.566
LIG_FHA_1	26	32	PF00498	0.462
LIG_FHA_1	416	422	PF00498	0.334
LIG_FHA_1	557	563	PF00498	0.581
LIG_FHA_1	658	664	PF00498	0.487
LIG_FHA_1	705	711	PF00498	0.599
LIG_FHA_2	433	439	PF00498	0.510
LIG_FHA_2	447	453	PF00498	0.397
LIG_FHA_2	474	480	PF00498	0.564
LIG_FHA_2	585	591	PF00498	0.574
LIG_FHA_2	728	734	PF00498	0.666
LIG_FHA_2	82	88	PF00498	0.382
LIG_LIR_Apic_2	394	400	PF02991	0.296
LIG_LIR_Gen_1	35	43	PF02991	0.516
LIG_LIR_Gen_1	370	381	PF02991	0.441
LIG_LIR_Gen_1	404	414	PF02991	0.308
LIG_LIR_Gen_1	418	427	PF02991	0.393
LIG_LIR_Nem_3	126	132	PF02991	0.460
LIG_LIR_Nem_3	200	204	PF02991	0.390
LIG_LIR_Nem_3	35	40	PF02991	0.516
LIG_LIR_Nem_3	359	365	PF02991	0.600
LIG_LIR_Nem_3	370	376	PF02991	0.398
LIG_LIR_Nem_3	404	409	PF02991	0.317
LIG_LIR_Nem_3	418	422	PF02991	0.329
LIG_LIR_Nem_3	657	662	PF02991	0.403
LIG_LIR_Nem_3	679	685	PF02991	0.462
LIG_LYPXL_yS_3	201	204	PF13949	0.354
LIG_Pex14_1	380	384	PF04695	0.319
LIG_PTB_Apo_2	507	514	PF02174	0.345
LIG_Rb_pABgroove_1	507	515	PF01858	0.394
LIG_SH2_CRK	132	136	PF00017	0.384
LIG_SH2_CRK	459	463	PF00017	0.368
LIG_SH2_CRK	68	72	PF00017	0.364
LIG_SH2_CRK	690	694	PF00017	0.648
LIG_SH2_GRB2like	443	446	PF00017	0.358
LIG_SH2_NCK_1	690	694	PF00017	0.648
LIG_SH2_SRC	254	257	PF00017	0.535
LIG_SH2_SRC	443	446	PF00017	0.431
LIG_SH2_STAP1	526	530	PF00017	0.414
LIG_SH2_STAP1	546	550	PF00017	0.231
LIG_SH2_STAP1	72	76	PF00017	0.342
LIG_SH2_STAT5	23	26	PF00017	0.493
LIG_SH2_STAT5	373	376	PF00017	0.345
LIG_SH2_STAT5	384	387	PF00017	0.311
LIG_SH2_STAT5	443	446	PF00017	0.553
LIG_SH3_3	220	226	PF00018	0.467
LIG_SH3_3	242	248	PF00018	0.424
LIG_SUMO_SIM_par_1	28	35	PF11976	0.465
LIG_SUMO_SIM_par_1	660	666	PF11976	0.509
LIG_SUMO_SIM_par_1	79	84	PF11976	0.372
LIG_TRAF2_1	174	177	PF00917	0.571
LIG_TRAF2_1	587	590	PF00917	0.423
LIG_TRAF2_1	751	754	PF00917	0.786
LIG_TYR_ITIM	441	446	PF00017	0.398
LIG_TYR_ITIM	457	462	PF00017	0.255
LIG_UBA3_1	324	330	PF00899	0.398
MOD_CK1_1	110	116	PF00069	0.616
MOD_CK1_1	156	162	PF00069	0.595
MOD_CK1_1	191	197	PF00069	0.393
MOD_CK1_1	278	284	PF00069	0.458
MOD_CK1_1	309	315	PF00069	0.551
MOD_CK1_1	32	38	PF00069	0.453
MOD_CK1_1	356	362	PF00069	0.586
MOD_CK1_1	584	590	PF00069	0.680
MOD_CK1_1	621	627	PF00069	0.442
MOD_CK1_1	701	707	PF00069	0.721
MOD_CK2_1	432	438	PF00069	0.575
MOD_CK2_1	473	479	PF00069	0.561
MOD_CK2_1	576	582	PF00069	0.635
MOD_CK2_1	584	590	PF00069	0.675
MOD_CK2_1	6	12	PF00069	0.457
MOD_CK2_1	671	677	PF00069	0.698
MOD_CK2_1	748	754	PF00069	0.747
MOD_CK2_1	81	87	PF00069	0.439
MOD_CMANNOS	656	659	PF00535	0.461
MOD_CMANNOS	86	89	PF00535	0.342
MOD_GlcNHglycan	139	142	PF01048	0.528
MOD_GlcNHglycan	155	158	PF01048	0.414
MOD_GlcNHglycan	190	193	PF01048	0.429
MOD_GlcNHglycan	280	283	PF01048	0.462
MOD_GlcNHglycan	309	312	PF01048	0.601
MOD_GlcNHglycan	354	358	PF01048	0.674
MOD_GlcNHglycan	582	586	PF01048	0.704
MOD_GlcNHglycan	609	612	PF01048	0.521
MOD_GlcNHglycan	620	623	PF01048	0.517
MOD_GlcNHglycan	668	671	PF01048	0.503
MOD_GlcNHglycan	674	677	PF01048	0.567
MOD_GlcNHglycan	73	77	PF01048	0.424
MOD_GlcNHglycan	736	739	PF01048	0.680
MOD_GlcNHglycan	750	753	PF01048	0.758
MOD_GlcNHglycan	8	11	PF01048	0.503
MOD_GSK3_1	107	114	PF00069	0.599
MOD_GSK3_1	156	163	PF00069	0.531
MOD_GSK3_1	164	171	PF00069	0.400
MOD_GSK3_1	25	32	PF00069	0.463
MOD_GSK3_1	271	278	PF00069	0.501
MOD_GSK3_1	293	300	PF00069	0.599
MOD_GSK3_1	302	309	PF00069	0.575
MOD_GSK3_1	380	387	PF00069	0.416
MOD_GSK3_1	469	476	PF00069	0.466
MOD_GSK3_1	480	487	PF00069	0.454
MOD_GSK3_1	657	664	PF00069	0.545
MOD_GSK3_1	672	679	PF00069	0.606
MOD_GSK3_1	741	748	PF00069	0.743
MOD_N-GLC_1	25	30	PF02516	0.437
MOD_N-GLC_1	365	370	PF02516	0.435
MOD_NEK2_1	109	114	PF00069	0.615
MOD_NEK2_1	124	129	PF00069	0.373
MOD_NEK2_1	212	217	PF00069	0.463
MOD_NEK2_1	275	280	PF00069	0.384
MOD_NEK2_1	293	298	PF00069	0.364
MOD_NEK2_1	306	311	PF00069	0.576
MOD_NEK2_1	365	370	PF00069	0.420
MOD_NEK2_1	513	518	PF00069	0.567
MOD_NEK2_1	545	550	PF00069	0.465
MOD_NEK2_1	761	766	PF00069	0.662
MOD_NEK2_1	81	86	PF00069	0.437
MOD_NEK2_2	626	631	PF00069	0.347
MOD_PIKK_1	25	31	PF00454	0.532
MOD_PIKK_1	365	371	PF00454	0.454
MOD_PK_1	241	247	PF00069	0.393
MOD_PKA_1	480	486	PF00069	0.501
MOD_PKA_2	188	194	PF00069	0.401
MOD_PKA_2	232	238	PF00069	0.351
MOD_PKA_2	291	297	PF00069	0.669
MOD_PKA_2	389	395	PF00069	0.550
MOD_PKA_2	480	486	PF00069	0.454
MOD_PKA_2	556	562	PF00069	0.557
MOD_PKA_2	607	613	PF00069	0.475
MOD_PKA_2	698	704	PF00069	0.710
MOD_PKA_2	740	746	PF00069	0.753
MOD_PKA_2	98	104	PF00069	0.464
MOD_Plk_1	513	519	PF00069	0.543
MOD_Plk_1	676	682	PF00069	0.468
MOD_Plk_1	753	759	PF00069	0.643
MOD_Plk_2-3	651	657	PF00069	0.434
MOD_Plk_4	124	130	PF00069	0.529
MOD_Plk_4	160	166	PF00069	0.652
MOD_Plk_4	168	174	PF00069	0.472
MOD_Plk_4	212	218	PF00069	0.388
MOD_Plk_4	275	281	PF00069	0.496
MOD_Plk_4	32	38	PF00069	0.515
MOD_Plk_4	323	329	PF00069	0.470
MOD_Plk_4	380	386	PF00069	0.405
MOD_Plk_4	42	48	PF00069	0.384
MOD_Plk_4	457	463	PF00069	0.432
MOD_Plk_4	491	497	PF00069	0.422
MOD_Plk_4	545	551	PF00069	0.539
MOD_Plk_4	626	632	PF00069	0.399
MOD_Plk_4	651	657	PF00069	0.523
MOD_ProDKin_1	11	17	PF00069	0.415
MOD_ProDKin_1	111	117	PF00069	0.524
MOD_SUMO_for_1	174	177	PF00179	0.328
MOD_SUMO_rev_2	255	264	PF00179	0.455
MOD_SUMO_rev_2	538	544	PF00179	0.467
MOD_SUMO_rev_2	584	594	PF00179	0.484
TRG_DiLeu_BaEn_1	590	595	PF01217	0.425
TRG_DiLeu_BaEn_1	658	663	PF01217	0.512
TRG_DiLeu_BaLyEn_6	199	204	PF01217	0.363
TRG_DiLeu_LyEn_5	12	17	PF01217	0.406
TRG_ENDOCYTIC_2	128	131	PF00928	0.454
TRG_ENDOCYTIC_2	132	135	PF00928	0.455
TRG_ENDOCYTIC_2	201	204	PF00928	0.370
TRG_ENDOCYTIC_2	37	40	PF00928	0.421
TRG_ENDOCYTIC_2	373	376	PF00928	0.428
TRG_ENDOCYTIC_2	443	446	PF00928	0.392
TRG_ENDOCYTIC_2	459	462	PF00928	0.261
TRG_ENDOCYTIC_2	546	549	PF00928	0.483
TRG_ENDOCYTIC_2	68	71	PF00928	0.323
TRG_ER_diArg_1	132	134	PF00400	0.402
TRG_ER_diArg_1	232	234	PF00400	0.363
TRG_ER_diArg_1	58	61	PF00400	0.407
TRG_ER_diArg_1	631	633	PF00400	0.572
TRG_NES_CRM1_1	540	553	PF08389	0.437
TRG_NES_CRM1_1	560	574	PF08389	0.256
TRG_NLS_MonoExtN_4	759	766	PF00514	0.683
TRG_Pf-PMV_PEXEL_1	318	322	PF00026	0.489
TRG_Pf-PMV_PEXEL_1	506	511	PF00026	0.467
TRG_Pf-PMV_PEXEL_1	533	538	PF00026	0.421

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P980	Leptomonas seymouri	41%	100%
A0A1X0NUC5	Trypanosomatidae	25%	100%
A0A3Q8IG63	Leishmania donovani	91%	100%
A0A422NL86	Trypanosoma rangeli	28%	100%
A4HKE9	Leishmania braziliensis	71%	100%
A4I7X7	Leishmania infantum	91%	100%
D0AA42	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9B2T8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5AZI4	Trypanosoma cruzi	26%	100%