Putative chromosomal passenger protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

chromosomal passenger complex 2

Species:

Leishmania major

UniProt:

Q4Q5B6_LEIMA

TriTrypDb:

LmjF.32.1640 , LMJLV39_320022600 , LMJSD75_320022600

Length:

222

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005874	microtubule	6	2
GO:0005875	microtubule associated complex	2	2
GO:0005876	spindle microtubule	7	2
GO:0032133	chromosome passenger complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0099080	supramolecular complex	2	2
GO:0099081	supramolecular polymer	3	2
GO:0099512	supramolecular fiber	4	2
GO:0099513	polymeric cytoskeletal fiber	5	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q5B6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5B6

Function

Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	2
GO:0000281	mitotic cytokinesis	4	2
GO:0000910	cytokinesis	3	2
GO:0006996	organelle organization	4	2
GO:0007010	cytoskeleton organization	5	2
GO:0007017	microtubule-based process	2	2
GO:0007051	spindle organization	3	2
GO:0007059	chromosome segregation	2	2
GO:0009987	cellular process	1	2
GO:0010564	regulation of cell cycle process	5	2
GO:0016043	cellular component organization	3	2
GO:0022402	cell cycle process	2	2
GO:0022607	cellular component assembly	4	2
GO:0033043	regulation of organelle organization	5	2
GO:0033044	regulation of chromosome organization	6	2
GO:0033045	regulation of sister chromatid segregation	5	2
GO:0033047	regulation of mitotic sister chromatid segregation	6	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051128	regulation of cellular component organization	4	2
GO:0051225	spindle assembly	4	2
GO:0051726	regulation of cell cycle	4	2
GO:0051983	regulation of chromosome segregation	4	2
GO:0061640	cytoskeleton-dependent cytokinesis	4	2
GO:0065007	biological regulation	1	2
GO:0070925	organelle assembly	5	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0140694	non-membrane-bounded organelle assembly	6	2
GO:1903047	mitotic cell cycle process	3	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	101	105	PF00656	0.452
CLV_NRD_NRD_1	101	103	PF00675	0.535
CLV_NRD_NRD_1	193	195	PF00675	0.638
CLV_PCSK_KEX2_1	97	99	PF00082	0.531
CLV_PCSK_PC1ET2_1	97	99	PF00082	0.534
DEG_APCC_DBOX_1	24	32	PF00400	0.525
DOC_CKS1_1	156	161	PF01111	0.583
DOC_CKS1_1	203	208	PF01111	0.501
DOC_MAPK_gen_1	78	85	PF00069	0.515
DOC_PP4_FxxP_1	203	206	PF00568	0.505
DOC_USP7_MATH_1	150	154	PF00917	0.538
DOC_USP7_MATH_1	175	179	PF00917	0.639
DOC_USP7_MATH_1	188	192	PF00917	0.528
DOC_USP7_MATH_1	52	56	PF00917	0.473
DOC_WW_Pin1_4	117	122	PF00397	0.569
DOC_WW_Pin1_4	155	160	PF00397	0.557
DOC_WW_Pin1_4	202	207	PF00397	0.502
DOC_WW_Pin1_4	215	220	PF00397	0.551
LIG_14-3-3_CanoR_1	89	96	PF00244	0.534
LIG_AP2alpha_2	9	11	PF02296	0.493
LIG_APCC_ABBA_1	8	13	PF00400	0.524
LIG_BIR_II_1	1	5	PF00653	0.491
LIG_BRCT_BRCA1_1	199	203	PF00533	0.632
LIG_BRCT_BRCA1_1	54	58	PF00533	0.447
LIG_FHA_1	126	132	PF00498	0.670
LIG_FHA_1	162	168	PF00498	0.579
LIG_FHA_1	184	190	PF00498	0.526
LIG_FHA_1	80	86	PF00498	0.435
LIG_FHA_2	117	123	PF00498	0.627
LIG_FHA_2	203	209	PF00498	0.508
LIG_FHA_2	90	96	PF00498	0.522
LIG_LIR_Apic_2	200	206	PF02991	0.509
LIG_LIR_Gen_1	55	66	PF02991	0.480
LIG_LIR_Nem_3	208	212	PF02991	0.496
LIG_LIR_Nem_3	55	61	PF02991	0.407
LIG_LIR_Nem_3	65	70	PF02991	0.392
LIG_LIR_Nem_3	9	14	PF02991	0.397
LIG_SH2_CRK	67	71	PF00017	0.308
LIG_SH2_STAP1	81	85	PF00017	0.510
LIG_SH2_STAT5	39	42	PF00017	0.403
LIG_SH2_STAT5	81	84	PF00017	0.433
LIG_SH3_3	216	222	PF00018	0.578
LIG_SUMO_SIM_par_1	81	86	PF11976	0.416
MOD_CK1_1	157	163	PF00069	0.719
MOD_CK1_1	215	221	PF00069	0.505
MOD_CK1_1	3	9	PF00069	0.569
MOD_CK2_1	127	133	PF00069	0.511
MOD_CK2_1	202	208	PF00069	0.536
MOD_CK2_1	89	95	PF00069	0.522
MOD_GlcNHglycan	152	155	PF01048	0.582
MOD_GlcNHglycan	214	217	PF01048	0.563
MOD_GSK3_1	127	134	PF00069	0.580
MOD_GSK3_1	150	157	PF00069	0.632
MOD_GSK3_1	197	204	PF00069	0.648
MOD_NEK2_1	131	136	PF00069	0.560
MOD_NEK2_1	201	206	PF00069	0.575
MOD_NEK2_1	88	93	PF00069	0.517
MOD_PIKK_1	158	164	PF00454	0.677
MOD_PKA_2	88	94	PF00069	0.503
MOD_Plk_1	132	138	PF00069	0.636
MOD_Plk_4	127	133	PF00069	0.574
MOD_Plk_4	197	203	PF00069	0.610
MOD_ProDKin_1	117	123	PF00069	0.567
MOD_ProDKin_1	155	161	PF00069	0.559
MOD_ProDKin_1	202	208	PF00069	0.501
MOD_ProDKin_1	215	221	PF00069	0.552
TRG_DiLeu_BaEn_1	133	138	PF01217	0.467
TRG_DiLeu_LyEn_5	133	138	PF01217	0.467
TRG_ENDOCYTIC_2	67	70	PF00928	0.305
TRG_Pf-PMV_PEXEL_1	136	140	PF00026	0.548
TRG_Pf-PMV_PEXEL_1	15	20	PF00026	0.520

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P979	Leptomonas seymouri	64%	99%
A0A1X0NUE6	Trypanosomatidae	30%	94%
A0A3S7X5K6	Leishmania donovani	91%	100%
A0A422NL93	Trypanosoma rangeli	34%	96%
A4HKF1	Leishmania braziliensis	76%	100%
A4I7X9	Leishmania infantum	92%	100%
E9B2U0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5BJL0	Trypanosoma cruzi	32%	75%