Zinc_ribbon_16 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q5B5_LEIMA

TriTrypDb:

LmjF.32.1650 , LMJLV39_320022700 , LMJSD75_320022700

Length:

923

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0000159	protein phosphatase type 2A complex	5	7
GO:0005829	cytosol	2	2
GO:0008287	protein serine/threonine phosphatase complex	4	7
GO:0032991	protein-containing complex	1	7
GO:0110165	cellular anatomical entity	1	2
GO:1902494	catalytic complex	2	7
GO:1903293	phosphatase complex	3	7

Expansion

Sequence features

Q4Q5B5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5B5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0019208	phosphatase regulator activity	3	7
GO:0019888	protein phosphatase regulator activity	4	7
GO:0030234	enzyme regulator activity	2	7
GO:0098772	molecular function regulator activity	1	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	295	299	PF00656	0.729
CLV_C14_Caspase3-7	847	851	PF00656	0.399
CLV_C14_Caspase3-7	89	93	PF00656	0.606
CLV_NRD_NRD_1	438	440	PF00675	0.599
CLV_NRD_NRD_1	507	509	PF00675	0.445
CLV_NRD_NRD_1	561	563	PF00675	0.424
CLV_NRD_NRD_1	698	700	PF00675	0.505
CLV_NRD_NRD_1	7	9	PF00675	0.656
CLV_NRD_NRD_1	750	752	PF00675	0.433
CLV_NRD_NRD_1	90	92	PF00675	0.666
CLV_NRD_NRD_1	917	919	PF00675	0.446
CLV_PCSK_KEX2_1	145	147	PF00082	0.663
CLV_PCSK_KEX2_1	438	440	PF00082	0.599
CLV_PCSK_KEX2_1	507	509	PF00082	0.445
CLV_PCSK_KEX2_1	561	563	PF00082	0.424
CLV_PCSK_KEX2_1	90	92	PF00082	0.666
CLV_PCSK_PC1ET2_1	145	147	PF00082	0.663
CLV_PCSK_PC7_1	503	509	PF00082	0.475
CLV_PCSK_SKI1_1	165	169	PF00082	0.764
CLV_PCSK_SKI1_1	503	507	PF00082	0.494
CLV_PCSK_SKI1_1	553	557	PF00082	0.380
CLV_PCSK_SKI1_1	890	894	PF00082	0.430
CLV_Separin_Metazoa	283	287	PF03568	0.671
CLV_Separin_Metazoa	504	508	PF03568	0.483
DEG_APCC_DBOX_1	164	172	PF00400	0.765
DEG_Nend_Nbox_1	1	3	PF02207	0.552
DEG_SCF_FBW7_1	144	151	PF00400	0.628
DEG_SPOP_SBC_1	314	318	PF00917	0.649
DOC_CDC14_PxL_1	405	413	PF14671	0.423
DOC_CYCLIN_yCln2_LP_2	227	233	PF00134	0.552
DOC_MAPK_MEF2A_6	740	747	PF00069	0.367
DOC_MAPK_NFAT4_5	740	748	PF00069	0.368
DOC_PP1_RVXF_1	529	536	PF00149	0.379
DOC_PP2B_LxvP_1	649	652	PF13499	0.455
DOC_PP2B_LxvP_1	856	859	PF13499	0.476
DOC_PP4_FxxP_1	377	380	PF00568	0.742
DOC_PP4_FxxP_1	54	57	PF00568	0.587
DOC_PP4_FxxP_1	731	734	PF00568	0.387
DOC_PP4_FxxP_1	827	830	PF00568	0.460
DOC_USP7_MATH_1	121	125	PF00917	0.665
DOC_USP7_MATH_1	167	171	PF00917	0.709
DOC_USP7_MATH_1	180	184	PF00917	0.629
DOC_USP7_MATH_1	278	282	PF00917	0.710
DOC_USP7_MATH_1	307	311	PF00917	0.697
DOC_USP7_MATH_1	314	318	PF00917	0.625
DOC_USP7_MATH_1	389	393	PF00917	0.476
DOC_USP7_MATH_1	520	524	PF00917	0.468
DOC_USP7_MATH_1	65	69	PF00917	0.739
DOC_USP7_MATH_1	670	674	PF00917	0.418
DOC_USP7_MATH_1	702	706	PF00917	0.468
DOC_USP7_MATH_1	808	812	PF00917	0.606
DOC_USP7_MATH_1	83	87	PF00917	0.780
DOC_USP7_MATH_1	859	863	PF00917	0.635
DOC_USP7_MATH_1	93	97	PF00917	0.614
DOC_USP7_MATH_2	115	121	PF00917	0.775
DOC_USP7_UBL2_3	512	516	PF12436	0.425
DOC_USP7_UBL2_3	9	13	PF12436	0.670
DOC_WW_Pin1_4	140	145	PF00397	0.645
DOC_WW_Pin1_4	16	21	PF00397	0.669
DOC_WW_Pin1_4	265	270	PF00397	0.670
DOC_WW_Pin1_4	287	292	PF00397	0.643
DOC_WW_Pin1_4	343	348	PF00397	0.626
DOC_WW_Pin1_4	478	483	PF00397	0.641
DOC_WW_Pin1_4	49	54	PF00397	0.578
DOC_WW_Pin1_4	538	543	PF00397	0.478
DOC_WW_Pin1_4	563	568	PF00397	0.465
DOC_WW_Pin1_4	81	86	PF00397	0.650
LIG_14-3-3_CanoR_1	194	200	PF00244	0.725
LIG_14-3-3_CanoR_1	216	222	PF00244	0.478
LIG_14-3-3_CanoR_1	286	291	PF00244	0.599
LIG_14-3-3_CanoR_1	315	324	PF00244	0.698
LIG_14-3-3_CanoR_1	438	444	PF00244	0.598
LIG_14-3-3_CanoR_1	507	515	PF00244	0.421
LIG_14-3-3_CanoR_1	902	908	PF00244	0.382
LIG_14-3-3_CanoR_1	918	922	PF00244	0.513
LIG_AP2alpha_2	825	827	PF02296	0.457
LIG_BRCT_BRCA1_1	347	351	PF00533	0.604
LIG_BRCT_BRCA1_1	373	377	PF00533	0.594
LIG_BRCT_BRCA1_1	584	588	PF00533	0.495
LIG_BRCT_BRCA1_1	672	676	PF00533	0.403
LIG_EH_1	711	715	PF12763	0.576
LIG_eIF4E_1	907	913	PF01652	0.417
LIG_FHA_1	257	263	PF00498	0.567
LIG_FHA_1	491	497	PF00498	0.570
LIG_FHA_1	886	892	PF00498	0.444
LIG_FHA_2	1	7	PF00498	0.548
LIG_FHA_2	245	251	PF00498	0.786
LIG_FHA_2	381	387	PF00498	0.752
LIG_FHA_2	398	404	PF00498	0.346
LIG_FHA_2	547	553	PF00498	0.374
LIG_FHA_2	866	872	PF00498	0.619
LIG_FHA_2	87	93	PF00498	0.782
LIG_Integrin_isoDGR_2	909	911	PF01839	0.432
LIG_LIR_Apic_2	374	380	PF02991	0.734
LIG_LIR_Apic_2	52	57	PF02991	0.585
LIG_LIR_Apic_2	730	734	PF02991	0.397
LIG_LIR_Apic_2	825	830	PF02991	0.472
LIG_LIR_Gen_1	384	395	PF02991	0.420
LIG_LIR_Gen_1	566	574	PF02991	0.494
LIG_LIR_Gen_1	585	596	PF02991	0.491
LIG_LIR_Gen_1	620	630	PF02991	0.369
LIG_LIR_Gen_1	739	750	PF02991	0.370
LIG_LIR_Gen_1	777	787	PF02991	0.402
LIG_LIR_Nem_3	218	224	PF02991	0.447
LIG_LIR_Nem_3	384	390	PF02991	0.475
LIG_LIR_Nem_3	423	427	PF02991	0.392
LIG_LIR_Nem_3	563	568	PF02991	0.483
LIG_LIR_Nem_3	585	591	PF02991	0.498
LIG_LIR_Nem_3	602	606	PF02991	0.410
LIG_LIR_Nem_3	620	625	PF02991	0.373
LIG_LIR_Nem_3	739	745	PF02991	0.363
LIG_LIR_Nem_3	777	783	PF02991	0.408
LIG_MAD2	890	898	PF02301	0.404
LIG_MLH1_MIPbox_1	584	588	PF16413	0.495
LIG_MYND_1	16	20	PF01753	0.672
LIG_PCNA_yPIPBox_3	551	562	PF02747	0.387
LIG_Pex14_2	356	360	PF04695	0.576
LIG_Pex14_2	631	635	PF04695	0.385
LIG_PTB_Apo_2	359	366	PF02174	0.657
LIG_Rb_pABgroove_1	793	801	PF01858	0.365
LIG_SH2_CRK	211	215	PF00017	0.539
LIG_SH2_CRK	224	228	PF00017	0.454
LIG_SH2_CRK	387	391	PF00017	0.447
LIG_SH2_GRB2like	774	777	PF00017	0.438
LIG_SH2_SRC	701	704	PF00017	0.635
LIG_SH2_SRC	719	722	PF00017	0.287
LIG_SH2_SRC	769	772	PF00017	0.378
LIG_SH2_STAP1	719	723	PF00017	0.404
LIG_SH2_STAP1	799	803	PF00017	0.420
LIG_SH2_STAT5	424	427	PF00017	0.396
LIG_SH2_STAT5	529	532	PF00017	0.376
LIG_SH2_STAT5	547	550	PF00017	0.361
LIG_SH2_STAT5	587	590	PF00017	0.508
LIG_SH2_STAT5	742	745	PF00017	0.376
LIG_SH2_STAT5	765	768	PF00017	0.399
LIG_SH2_STAT5	769	772	PF00017	0.400
LIG_SH2_STAT5	905	908	PF00017	0.406
LIG_SH2_STAT5	914	917	PF00017	0.415
LIG_SH3_1	136	142	PF00018	0.709
LIG_SH3_3	136	142	PF00018	0.709
LIG_SH3_3	19	25	PF00018	0.668
LIG_SH3_3	258	264	PF00018	0.724
LIG_SH3_3	47	53	PF00018	0.632
LIG_SH3_3	589	595	PF00018	0.494
LIG_SH3_3	750	756	PF00018	0.415
LIG_SH3_3	802	808	PF00018	0.368
LIG_SH3_CIN85_PxpxPR_1	267	272	PF14604	0.649
LIG_SUMO_SIM_anti_2	392	397	PF11976	0.411
LIG_SUMO_SIM_par_1	783	789	PF11976	0.391
LIG_TRAF2_1	868	871	PF00917	0.664
LIG_TYR_ITIM	422	427	PF00017	0.388
LIG_UBA3_1	1	9	PF00899	0.552
LIG_UBA3_1	597	601	PF00899	0.430
LIG_UBA3_1	759	768	PF00899	0.403
MOD_CDC14_SPxK_1	143	146	PF00782	0.629
MOD_CDK_SPK_2	140	145	PF00069	0.627
MOD_CDK_SPxK_1	140	146	PF00069	0.648
MOD_CDK_SPxxK_3	265	272	PF00069	0.665
MOD_CK1_1	120	126	PF00069	0.671
MOD_CK1_1	161	167	PF00069	0.763
MOD_CK1_1	316	322	PF00069	0.654
MOD_CK1_1	34	40	PF00069	0.668
MOD_CK1_1	343	349	PF00069	0.735
MOD_CK1_1	487	493	PF00069	0.671
MOD_CK1_1	52	58	PF00069	0.794
MOD_CK1_1	543	549	PF00069	0.412
MOD_CK1_1	695	701	PF00069	0.554
MOD_CK1_1	705	711	PF00069	0.429
MOD_CK1_1	727	733	PF00069	0.375
MOD_CK1_1	811	817	PF00069	0.595
MOD_CK1_1	84	90	PF00069	0.818
MOD_CK1_1	862	868	PF00069	0.755
MOD_CK1_1	96	102	PF00069	0.561
MOD_CK2_1	121	127	PF00069	0.663
MOD_CK2_1	195	201	PF00069	0.595
MOD_CK2_1	244	250	PF00069	0.655
MOD_CK2_1	380	386	PF00069	0.617
MOD_CK2_1	546	552	PF00069	0.372
MOD_CK2_1	769	775	PF00069	0.420
MOD_CK2_1	865	871	PF00069	0.614
MOD_GlcNHglycan	117	122	PF01048	0.667
MOD_GlcNHglycan	160	163	PF01048	0.656
MOD_GlcNHglycan	165	168	PF01048	0.700
MOD_GlcNHglycan	177	180	PF01048	0.816
MOD_GlcNHglycan	182	185	PF01048	0.681
MOD_GlcNHglycan	309	312	PF01048	0.673
MOD_GlcNHglycan	321	324	PF01048	0.624
MOD_GlcNHglycan	327	330	PF01048	0.597
MOD_GlcNHglycan	337	340	PF01048	0.637
MOD_GlcNHglycan	368	371	PF01048	0.591
MOD_GlcNHglycan	386	390	PF01048	0.593
MOD_GlcNHglycan	405	408	PF01048	0.484
MOD_GlcNHglycan	417	421	PF01048	0.392
MOD_GlcNHglycan	478	481	PF01048	0.740
MOD_GlcNHglycan	489	492	PF01048	0.535
MOD_GlcNHglycan	54	57	PF01048	0.699
MOD_GlcNHglycan	615	618	PF01048	0.398
MOD_GlcNHglycan	652	655	PF01048	0.482
MOD_GlcNHglycan	681	684	PF01048	0.408
MOD_GlcNHglycan	726	729	PF01048	0.488
MOD_GlcNHglycan	788	793	PF01048	0.400
MOD_GlcNHglycan	800	803	PF01048	0.366
MOD_GlcNHglycan	86	89	PF01048	0.795
MOD_GSK3_1	117	124	PF00069	0.714
MOD_GSK3_1	140	147	PF00069	0.658
MOD_GSK3_1	163	170	PF00069	0.687
MOD_GSK3_1	252	259	PF00069	0.619
MOD_GSK3_1	309	316	PF00069	0.645
MOD_GSK3_1	31	38	PF00069	0.667
MOD_GSK3_1	318	325	PF00069	0.652
MOD_GSK3_1	341	348	PF00069	0.787
MOD_GSK3_1	385	392	PF00069	0.530
MOD_GSK3_1	39	46	PF00069	0.690
MOD_GSK3_1	425	432	PF00069	0.585
MOD_GSK3_1	433	440	PF00069	0.622
MOD_GSK3_1	464	471	PF00069	0.623
MOD_GSK3_1	490	497	PF00069	0.662
MOD_GSK3_1	578	585	PF00069	0.490
MOD_GSK3_1	631	638	PF00069	0.453
MOD_GSK3_1	66	73	PF00069	0.768
MOD_GSK3_1	664	671	PF00069	0.406
MOD_GSK3_1	701	708	PF00069	0.580
MOD_GSK3_1	77	84	PF00069	0.813
MOD_GSK3_1	811	818	PF00069	0.474
MOD_GSK3_1	859	866	PF00069	0.644
MOD_GSK3_1	93	100	PF00069	0.669
MOD_N-GLC_1	298	303	PF02516	0.691
MOD_N-GLC_1	334	339	PF02516	0.606
MOD_N-GLC_1	356	361	PF02516	0.640
MOD_N-GLC_1	366	371	PF02516	0.552
MOD_N-GLC_1	433	438	PF02516	0.724
MOD_N-GLC_1	494	499	PF02516	0.667
MOD_N-GLC_1	775	780	PF02516	0.419
MOD_N-GLC_2	483	485	PF02516	0.761
MOD_NEK2_1	158	163	PF00069	0.763
MOD_NEK2_1	210	215	PF00069	0.531
MOD_NEK2_1	285	290	PF00069	0.694
MOD_NEK2_1	35	40	PF00069	0.669
MOD_NEK2_1	373	378	PF00069	0.560
MOD_NEK2_1	425	430	PF00069	0.444
MOD_NEK2_1	514	519	PF00069	0.451
MOD_NEK2_1	582	587	PF00069	0.505
MOD_NEK2_1	676	681	PF00069	0.371
MOD_NEK2_1	798	803	PF00069	0.457
MOD_NEK2_1	809	814	PF00069	0.412
MOD_NEK2_1	815	820	PF00069	0.400
MOD_NEK2_1	844	849	PF00069	0.416
MOD_NEK2_1	903	908	PF00069	0.382
MOD_NEK2_2	167	172	PF00069	0.784
MOD_NEK2_2	433	438	PF00069	0.682
MOD_NEK2_2	769	774	PF00069	0.399
MOD_PIKK_1	702	708	PF00454	0.580
MOD_PIKK_1	850	856	PF00454	0.584
MOD_PIKK_1	863	869	PF00454	0.656
MOD_PKA_1	507	513	PF00069	0.423
MOD_PKA_2	121	127	PF00069	0.657
MOD_PKA_2	215	221	PF00069	0.475
MOD_PKA_2	285	291	PF00069	0.600
MOD_PKA_2	314	320	PF00069	0.688
MOD_PKA_2	35	41	PF00069	0.683
MOD_PKA_2	437	443	PF00069	0.591
MOD_PKA_2	464	470	PF00069	0.621
MOD_PKA_2	507	513	PF00069	0.423
MOD_PKA_2	66	72	PF00069	0.666
MOD_PKA_2	679	685	PF00069	0.384
MOD_PKA_2	695	701	PF00069	0.510
MOD_PKA_2	77	83	PF00069	0.668
MOD_PKA_2	862	868	PF00069	0.622
MOD_PKA_2	917	923	PF00069	0.623
MOD_PKA_2	97	103	PF00069	0.661
MOD_PKB_1	861	869	PF00069	0.629
MOD_Plk_1	356	362	PF00069	0.702
MOD_Plk_1	385	391	PF00069	0.551
MOD_Plk_1	433	439	PF00069	0.727
MOD_Plk_1	775	781	PF00069	0.416
MOD_Plk_1	844	850	PF00069	0.420
MOD_Plk_2-3	244	250	PF00069	0.787
MOD_Plk_2-3	775	781	PF00069	0.416
MOD_Plk_4	391	397	PF00069	0.425
MOD_Plk_4	439	445	PF00069	0.601
MOD_Plk_4	531	537	PF00069	0.391
MOD_Plk_4	540	546	PF00069	0.440
MOD_Plk_4	618	624	PF00069	0.386
MOD_Plk_4	671	677	PF00069	0.403
MOD_Plk_4	727	733	PF00069	0.375
MOD_Plk_4	769	775	PF00069	0.406
MOD_Plk_4	790	796	PF00069	0.391
MOD_Plk_4	815	821	PF00069	0.563
MOD_ProDKin_1	140	146	PF00069	0.648
MOD_ProDKin_1	16	22	PF00069	0.669
MOD_ProDKin_1	265	271	PF00069	0.661
MOD_ProDKin_1	287	293	PF00069	0.644
MOD_ProDKin_1	343	349	PF00069	0.624
MOD_ProDKin_1	478	484	PF00069	0.642
MOD_ProDKin_1	49	55	PF00069	0.578
MOD_ProDKin_1	538	544	PF00069	0.471
MOD_ProDKin_1	563	569	PF00069	0.462
MOD_ProDKin_1	81	87	PF00069	0.650
TRG_DiLeu_BaEn_1	658	663	PF01217	0.451
TRG_ENDOCYTIC_2	211	214	PF00928	0.527
TRG_ENDOCYTIC_2	224	227	PF00928	0.444
TRG_ENDOCYTIC_2	387	390	PF00928	0.454
TRG_ENDOCYTIC_2	424	427	PF00928	0.396
TRG_ENDOCYTIC_2	719	722	PF00928	0.414
TRG_ENDOCYTIC_2	742	745	PF00928	0.368
TRG_ER_diArg_1	437	439	PF00400	0.590
TRG_ER_diArg_1	500	503	PF00400	0.535
TRG_ER_diArg_1	506	508	PF00400	0.469
TRG_ER_diArg_1	536	539	PF00400	0.462
TRG_ER_diArg_1	560	562	PF00400	0.396
TRG_ER_diArg_1	861	864	PF00400	0.622

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMN7	Leptomonas seymouri	70%	99%
A0A3S7X5H5	Leishmania donovani	93%	100%
A4HKF2	Leishmania braziliensis	81%	100%
A4I7Y0	Leishmania infantum	93%	100%
E9B2U1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%