Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q5B0_LEIMA

TriTrypDb:

LmjF.32.1700 , LMJLV39_320023200 , LMJSD75_320023200

Length:

518

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q5B0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5B0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	412	416	PF00656	0.644
CLV_C14_Caspase3-7	505	509	PF00656	0.563
CLV_NRD_NRD_1	219	221	PF00675	0.598
CLV_NRD_NRD_1	284	286	PF00675	0.758
CLV_NRD_NRD_1	325	327	PF00675	0.671
CLV_PCSK_KEX2_1	219	221	PF00082	0.610
CLV_PCSK_KEX2_1	284	286	PF00082	0.631
CLV_PCSK_KEX2_1	325	327	PF00082	0.671
CLV_PCSK_KEX2_1	407	409	PF00082	0.672
CLV_PCSK_KEX2_1	63	65	PF00082	0.822
CLV_PCSK_PC1ET2_1	407	409	PF00082	0.688
CLV_PCSK_PC1ET2_1	63	65	PF00082	0.822
CLV_PCSK_SKI1_1	408	412	PF00082	0.691
CLV_PCSK_SKI1_1	84	88	PF00082	0.685
DEG_APCC_DBOX_1	83	91	PF00400	0.671
DEG_Nend_UBRbox_3	1	3	PF02207	0.692
DEG_SPOP_SBC_1	237	241	PF00917	0.678
DOC_CKS1_1	301	306	PF01111	0.726
DOC_CKS1_1	318	323	PF01111	0.638
DOC_CKS1_1	445	450	PF01111	0.700
DOC_CYCLIN_RxL_1	89	100	PF00134	0.534
DOC_MAPK_gen_1	132	141	PF00069	0.446
DOC_MAPK_MEF2A_6	134	143	PF00069	0.437
DOC_MAPK_MEF2A_6	483	492	PF00069	0.580
DOC_PP1_RVXF_1	267	274	PF00149	0.659
DOC_PP4_FxxP_1	293	296	PF00568	0.809
DOC_USP7_MATH_1	163	167	PF00917	0.669
DOC_USP7_MATH_1	173	177	PF00917	0.526
DOC_USP7_MATH_1	210	214	PF00917	0.633
DOC_USP7_MATH_1	218	222	PF00917	0.623
DOC_USP7_MATH_1	238	242	PF00917	0.682
DOC_USP7_MATH_1	329	333	PF00917	0.550
DOC_USP7_MATH_1	37	41	PF00917	0.632
DOC_USP7_MATH_1	465	469	PF00917	0.810
DOC_USP7_MATH_1	7	11	PF00917	0.637
DOC_WW_Pin1_4	20	25	PF00397	0.791
DOC_WW_Pin1_4	300	305	PF00397	0.826
DOC_WW_Pin1_4	317	322	PF00397	0.544
DOC_WW_Pin1_4	354	359	PF00397	0.670
DOC_WW_Pin1_4	429	434	PF00397	0.830
DOC_WW_Pin1_4	43	48	PF00397	0.775
DOC_WW_Pin1_4	444	449	PF00397	0.591
DOC_WW_Pin1_4	463	468	PF00397	0.510
DOC_WW_Pin1_4	484	489	PF00397	0.697
DOC_WW_Pin1_4	9	14	PF00397	0.785
LIG_14-3-3_CanoR_1	126	130	PF00244	0.668
LIG_14-3-3_CanoR_1	200	205	PF00244	0.581
LIG_14-3-3_CanoR_1	269	274	PF00244	0.653
LIG_14-3-3_CanoR_1	287	296	PF00244	0.494
LIG_14-3-3_CanoR_1	325	333	PF00244	0.785
LIG_14-3-3_CanoR_1	364	372	PF00244	0.573
LIG_14-3-3_CanoR_1	440	444	PF00244	0.677
LIG_14-3-3_CanoR_1	499	506	PF00244	0.788
LIG_Actin_WH2_2	271	289	PF00022	0.693
LIG_Actin_WH2_2	340	357	PF00022	0.664
LIG_deltaCOP1_diTrp_1	104	111	PF00928	0.505
LIG_EH1_1	454	462	PF00400	0.797
LIG_FHA_1	265	271	PF00498	0.623
LIG_FHA_1	296	302	PF00498	0.805
LIG_FHA_1	33	39	PF00498	0.564
LIG_FHA_1	343	349	PF00498	0.425
LIG_FHA_1	395	401	PF00498	0.671
LIG_FHA_1	44	50	PF00498	0.568
LIG_FHA_2	128	134	PF00498	0.693
LIG_FHA_2	187	193	PF00498	0.733
LIG_FHA_2	248	254	PF00498	0.699
LIG_FHA_2	503	509	PF00498	0.566
LIG_GBD_Chelix_1	139	147	PF00786	0.428
LIG_LIR_Apic_2	291	296	PF02991	0.803
LIG_LIR_Gen_1	108	118	PF02991	0.496
LIG_LIR_Gen_1	231	238	PF02991	0.569
LIG_LIR_Gen_1	350	359	PF02991	0.660
LIG_LIR_Gen_1	375	383	PF02991	0.635
LIG_LIR_Nem_3	108	114	PF02991	0.504
LIG_LIR_Nem_3	231	235	PF02991	0.573
LIG_LIR_Nem_3	350	354	PF02991	0.639
LIG_LIR_Nem_3	357	363	PF02991	0.570
LIG_LIR_Nem_3	375	379	PF02991	0.357
LIG_LIR_Nem_3	42	48	PF02991	0.775
LIG_LIR_Nem_3	480	485	PF02991	0.698
LIG_MAD2	459	467	PF02301	0.685
LIG_NRBOX	343	349	PF00104	0.556
LIG_PCNA_yPIPBox_3	338	348	PF02747	0.557
LIG_Pex14_1	111	115	PF04695	0.610
LIG_Pex14_2	195	199	PF04695	0.716
LIG_Pex14_2	372	376	PF04695	0.650
LIG_SH2_CRK	115	119	PF00017	0.611
LIG_SH2_CRK	482	486	PF00017	0.703
LIG_SH2_SRC	206	209	PF00017	0.725
LIG_SH2_STAT3	85	88	PF00017	0.559
LIG_SH2_STAT5	115	118	PF00017	0.604
LIG_SH2_STAT5	206	209	PF00017	0.725
LIG_SH2_STAT5	85	88	PF00017	0.675
LIG_SH3_3	172	178	PF00018	0.599
LIG_SH3_3	204	210	PF00018	0.615
LIG_SH3_3	21	27	PF00018	0.787
LIG_SH3_3	232	238	PF00018	0.797
LIG_SH3_3	442	448	PF00018	0.691
LIG_SH3_3	77	83	PF00018	0.550
LIG_SUMO_SIM_par_1	397	403	PF11976	0.746
LIG_TRAF2_1	102	105	PF00917	0.668
LIG_UBA3_1	270	279	PF00899	0.418
LIG_UBA3_1	399	407	PF00899	0.650
LIG_WRC_WIRS_1	270	275	PF05994	0.645
LIG_WRC_WIRS_1	348	353	PF05994	0.649
MOD_CDK_SPxK_1	444	450	PF00069	0.821
MOD_CDK_SPxK_1	9	15	PF00069	0.668
MOD_CK1_1	128	134	PF00069	0.553
MOD_CK1_1	150	156	PF00069	0.523
MOD_CK1_1	240	246	PF00069	0.800
MOD_CK1_1	327	333	PF00069	0.542
MOD_CK1_1	394	400	PF00069	0.733
MOD_CK1_1	420	426	PF00069	0.829
MOD_CK1_1	429	435	PF00069	0.690
MOD_CK1_1	468	474	PF00069	0.829
MOD_CK1_1	502	508	PF00069	0.685
MOD_CK1_1	51	57	PF00069	0.554
MOD_CK2_1	222	228	PF00069	0.780
MOD_CK2_1	247	253	PF00069	0.708
MOD_CK2_1	378	384	PF00069	0.642
MOD_DYRK1A_RPxSP_1	444	448	PF00069	0.708
MOD_GlcNHglycan	149	152	PF01048	0.495
MOD_GlcNHglycan	212	215	PF01048	0.636
MOD_GlcNHglycan	220	223	PF01048	0.619
MOD_GlcNHglycan	328	332	PF01048	0.552
MOD_GlcNHglycan	380	383	PF01048	0.447
MOD_GlcNHglycan	39	42	PF01048	0.541
MOD_GlcNHglycan	393	396	PF01048	0.573
MOD_GlcNHglycan	428	431	PF01048	0.751
MOD_GlcNHglycan	467	470	PF01048	0.817
MOD_GlcNHglycan	471	474	PF01048	0.770
MOD_GlcNHglycan	50	53	PF01048	0.506
MOD_GlcNHglycan	501	504	PF01048	0.578
MOD_GlcNHglycan	9	12	PF01048	0.637
MOD_GSK3_1	121	128	PF00069	0.512
MOD_GSK3_1	218	225	PF00069	0.727
MOD_GSK3_1	236	243	PF00069	0.664
MOD_GSK3_1	265	272	PF00069	0.505
MOD_GSK3_1	316	323	PF00069	0.808
MOD_GSK3_1	343	350	PF00069	0.668
MOD_GSK3_1	416	423	PF00069	0.770
MOD_GSK3_1	428	435	PF00069	0.643
MOD_GSK3_1	459	466	PF00069	0.803
MOD_GSK3_1	469	476	PF00069	0.672
MOD_GSK3_1	48	55	PF00069	0.561
MOD_LATS_1	277	283	PF00433	0.556
MOD_N-GLC_1	30	35	PF02516	0.793
MOD_N-GLC_1	423	428	PF02516	0.718
MOD_NEK2_1	147	152	PF00069	0.482
MOD_NEK2_1	185	190	PF00069	0.724
MOD_NEK2_1	242	247	PF00069	0.680
MOD_NEK2_1	347	352	PF00069	0.487
MOD_NEK2_1	400	405	PF00069	0.702
MOD_NEK2_1	48	53	PF00069	0.549
MOD_PIKK_1	288	294	PF00454	0.784
MOD_PIKK_1	402	408	PF00454	0.668
MOD_PIKK_1	473	479	PF00454	0.794
MOD_PIKK_1	66	72	PF00454	0.821
MOD_PK_1	417	423	PF00069	0.744
MOD_PK_1	76	82	PF00069	0.629
MOD_PKA_1	279	285	PF00069	0.585
MOD_PKA_2	125	131	PF00069	0.671
MOD_PKA_2	147	153	PF00069	0.486
MOD_PKA_2	199	205	PF00069	0.627
MOD_PKA_2	218	224	PF00069	0.683
MOD_PKA_2	324	330	PF00069	0.789
MOD_PKA_2	363	369	PF00069	0.570
MOD_PKA_2	416	422	PF00069	0.769
MOD_PKA_2	439	445	PF00069	0.673
MOD_PKA_2	473	479	PF00069	0.812
MOD_PKB_1	497	505	PF00069	0.697
MOD_Plk_1	254	260	PF00069	0.688
MOD_Plk_1	400	406	PF00069	0.622
MOD_Plk_1	417	423	PF00069	0.823
MOD_Plk_2-3	254	260	PF00069	0.688
MOD_Plk_4	113	119	PF00069	0.611
MOD_Plk_4	269	275	PF00069	0.519
MOD_Plk_4	343	349	PF00069	0.676
MOD_Plk_4	76	82	PF00069	0.597
MOD_ProDKin_1	20	26	PF00069	0.789
MOD_ProDKin_1	300	306	PF00069	0.824
MOD_ProDKin_1	317	323	PF00069	0.540
MOD_ProDKin_1	354	360	PF00069	0.664
MOD_ProDKin_1	429	435	PF00069	0.830
MOD_ProDKin_1	43	49	PF00069	0.775
MOD_ProDKin_1	444	450	PF00069	0.588
MOD_ProDKin_1	463	469	PF00069	0.512
MOD_ProDKin_1	484	490	PF00069	0.697
MOD_ProDKin_1	9	15	PF00069	0.785
TRG_DiLeu_BaEn_1	180	185	PF01217	0.729
TRG_DiLeu_BaEn_1	254	259	PF01217	0.571
TRG_DiLeu_BaLyEn_6	266	271	PF01217	0.552
TRG_DiLeu_BaLyEn_6	382	387	PF01217	0.562
TRG_DiLeu_BaLyEn_6	395	400	PF01217	0.512
TRG_DiLeu_BaLyEn_6	44	49	PF01217	0.545
TRG_DiLeu_BaLyEn_6	92	97	PF01217	0.545
TRG_ENDOCYTIC_2	115	118	PF00928	0.604
TRG_ENDOCYTIC_2	482	485	PF00928	0.702
TRG_ER_diArg_1	284	287	PF00400	0.754
TRG_ER_diArg_1	352	355	PF00400	0.644
TRG_ER_diArg_1	443	446	PF00400	0.719
TRG_Pf-PMV_PEXEL_1	256	260	PF00026	0.589
TRG_Pf-PMV_PEXEL_1	408	412	PF00026	0.574
TRG_Pf-PMV_PEXEL_1	95	99	PF00026	0.619

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H7S0	Leishmania donovani	86%	100%
A4HKF7	Leishmania braziliensis	67%	100%