SpoU_methylase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q5A9_LEIMA

TriTrypDb:

LmjF.32.1710 , LMJLV39_320023300 , LMJSD75_320023300

Length:

671

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q5A9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5A9

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	1
GO:0032259	methylation	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0008168	methyltransferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016741	transferase activity, transferring one-carbon groups	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	346	350	PF00656	0.644
CLV_C14_Caspase3-7	358	362	PF00656	0.617
CLV_C14_Caspase3-7	495	499	PF00656	0.628
CLV_C14_Caspase3-7	588	592	PF00656	0.501
CLV_C14_Caspase3-7	632	636	PF00656	0.731
CLV_NRD_NRD_1	2	4	PF00675	0.745
CLV_NRD_NRD_1	214	216	PF00675	0.552
CLV_NRD_NRD_1	31	33	PF00675	0.567
CLV_NRD_NRD_1	320	322	PF00675	0.623
CLV_NRD_NRD_1	464	466	PF00675	0.433
CLV_NRD_NRD_1	568	570	PF00675	0.570
CLV_PCSK_KEX2_1	2	4	PF00082	0.745
CLV_PCSK_KEX2_1	214	216	PF00082	0.552
CLV_PCSK_KEX2_1	31	33	PF00082	0.575
CLV_PCSK_KEX2_1	319	321	PF00082	0.641
CLV_PCSK_KEX2_1	464	466	PF00082	0.516
CLV_PCSK_KEX2_1	568	570	PF00082	0.570
CLV_PCSK_SKI1_1	215	219	PF00082	0.538
CLV_PCSK_SKI1_1	395	399	PF00082	0.471
CLV_PCSK_SKI1_1	568	572	PF00082	0.586
DEG_Nend_UBRbox_1	1	4	PF02207	0.780
DEG_SPOP_SBC_1	344	348	PF00917	0.726
DOC_CYCLIN_RxL_1	212	222	PF00134	0.586
DOC_CYCLIN_yClb3_PxF_3	374	382	PF00134	0.648
DOC_MAPK_gen_1	232	241	PF00069	0.667
DOC_MAPK_MEF2A_6	198	206	PF00069	0.498
DOC_PP2B_LxvP_1	12	15	PF13499	0.711
DOC_PP2B_LxvP_1	333	336	PF13499	0.678
DOC_PP2B_LxvP_1	522	525	PF13499	0.489
DOC_PP2B_LxvP_1	596	599	PF13499	0.387
DOC_PP4_FxxP_1	296	299	PF00568	0.481
DOC_USP7_MATH_1	122	126	PF00917	0.745
DOC_USP7_MATH_1	344	348	PF00917	0.749
DOC_USP7_MATH_1	350	354	PF00917	0.747
DOC_USP7_MATH_1	355	359	PF00917	0.729
DOC_USP7_MATH_1	407	411	PF00917	0.777
DOC_USP7_MATH_1	416	420	PF00917	0.761
DOC_USP7_MATH_1	472	476	PF00917	0.540
DOC_USP7_MATH_1	494	498	PF00917	0.735
DOC_USP7_MATH_1	556	560	PF00917	0.573
DOC_USP7_MATH_1	59	63	PF00917	0.409
DOC_WW_Pin1_4	133	138	PF00397	0.585
DOC_WW_Pin1_4	148	153	PF00397	0.431
DOC_WW_Pin1_4	242	247	PF00397	0.625
DOC_WW_Pin1_4	301	306	PF00397	0.771
DOC_WW_Pin1_4	364	369	PF00397	0.634
DOC_WW_Pin1_4	419	424	PF00397	0.668
DOC_WW_Pin1_4	476	481	PF00397	0.436
DOC_WW_Pin1_4	487	492	PF00397	0.495
DOC_WW_Pin1_4	557	562	PF00397	0.591
DOC_WW_Pin1_4	70	75	PF00397	0.545
LIG_14-3-3_CanoR_1	16	22	PF00244	0.558
LIG_14-3-3_CanoR_1	2	6	PF00244	0.729
LIG_14-3-3_CanoR_1	214	218	PF00244	0.523
LIG_14-3-3_CanoR_1	232	241	PF00244	0.709
LIG_14-3-3_CanoR_1	659	666	PF00244	0.396
LIG_Actin_WH2_2	384	402	PF00022	0.520
LIG_APCC_ABBA_1	141	146	PF00400	0.554
LIG_Clathr_ClatBox_1	173	177	PF01394	0.401
LIG_FHA_1	233	239	PF00498	0.729
LIG_FHA_1	260	266	PF00498	0.565
LIG_FHA_1	354	360	PF00498	0.783
LIG_FHA_1	365	371	PF00498	0.592
LIG_FHA_1	477	483	PF00498	0.462
LIG_FHA_1	58	64	PF00498	0.461
LIG_FHA_1	612	618	PF00498	0.455
LIG_FHA_2	344	350	PF00498	0.721
LIG_GBD_Chelix_1	267	275	PF00786	0.434
LIG_HP1_1	172	176	PF01393	0.424
LIG_Integrin_RGD_1	630	632	PF01839	0.549
LIG_LIR_Apic_2	146	152	PF02991	0.599
LIG_LIR_Apic_2	295	299	PF02991	0.476
LIG_LIR_Apic_2	475	481	PF02991	0.460
LIG_LIR_Gen_1	324	333	PF02991	0.547
LIG_LIR_Nem_3	136	141	PF02991	0.550
LIG_LIR_Nem_3	324	328	PF02991	0.522
LIG_LIR_Nem_3	427	431	PF02991	0.512
LIG_LIR_Nem_3	457	461	PF02991	0.504
LIG_LIR_Nem_3	82	86	PF02991	0.497
LIG_SH2_CRK	325	329	PF00017	0.504
LIG_SH2_CRK	478	482	PF00017	0.447
LIG_SH2_GRB2like	435	438	PF00017	0.397
LIG_SH2_STAP1	435	439	PF00017	0.445
LIG_SH2_STAP1	539	543	PF00017	0.615
LIG_SH2_STAT3	255	258	PF00017	0.410
LIG_SH2_STAT5	149	152	PF00017	0.551
LIG_SH2_STAT5	255	258	PF00017	0.410
LIG_SH2_STAT5	277	280	PF00017	0.413
LIG_SH2_STAT5	291	294	PF00017	0.535
LIG_SH2_STAT5	380	383	PF00017	0.633
LIG_SH2_STAT5	428	431	PF00017	0.496
LIG_SH2_STAT5	458	461	PF00017	0.365
LIG_SH2_STAT5	478	481	PF00017	0.236
LIG_SH2_STAT5	68	71	PF00017	0.469
LIG_SH3_3	12	18	PF00018	0.743
LIG_SH3_3	236	242	PF00018	0.662
LIG_SH3_3	251	257	PF00018	0.406
LIG_SH3_3	371	377	PF00018	0.499
LIG_SH3_3	485	491	PF00018	0.546
LIG_SH3_3	660	666	PF00018	0.415
LIG_SUMO_SIM_par_1	17	23	PF11976	0.437
LIG_SUMO_SIM_par_1	172	177	PF11976	0.402
LIG_TRAF2_1	314	317	PF00917	0.428
LIG_WW_3	13	17	PF00397	0.627
MOD_CDK_SPK_2	148	153	PF00069	0.387
MOD_CDK_SPK_2	364	369	PF00069	0.669
MOD_CK1_1	151	157	PF00069	0.585
MOD_CK1_1	343	349	PF00069	0.712
MOD_CK1_1	353	359	PF00069	0.785
MOD_CK1_1	419	425	PF00069	0.719
MOD_CK1_1	492	498	PF00069	0.736
MOD_CK1_1	560	566	PF00069	0.566
MOD_CK1_1	582	588	PF00069	0.551
MOD_CK1_1	62	68	PF00069	0.408
MOD_CK1_1	73	79	PF00069	0.407
MOD_CK2_1	582	588	PF00069	0.511
MOD_Cter_Amidation	462	465	PF01082	0.389
MOD_GlcNHglycan	124	127	PF01048	0.718
MOD_GlcNHglycan	129	132	PF01048	0.646
MOD_GlcNHglycan	342	345	PF01048	0.785
MOD_GlcNHglycan	352	355	PF01048	0.716
MOD_GlcNHglycan	401	404	PF01048	0.546
MOD_GlcNHglycan	417	421	PF01048	0.725
MOD_GlcNHglycan	449	452	PF01048	0.441
MOD_GlcNHglycan	502	505	PF01048	0.670
MOD_GlcNHglycan	54	57	PF01048	0.453
MOD_GlcNHglycan	652	655	PF01048	0.460
MOD_GlcNHglycan	660	663	PF01048	0.425
MOD_GlcNHglycan	98	102	PF01048	0.776
MOD_GSK3_1	182	189	PF00069	0.429
MOD_GSK3_1	20	27	PF00069	0.634
MOD_GSK3_1	340	347	PF00069	0.766
MOD_GSK3_1	349	356	PF00069	0.802
MOD_GSK3_1	472	479	PF00069	0.438
MOD_GSK3_1	489	496	PF00069	0.541
MOD_GSK3_1	498	505	PF00069	0.696
MOD_GSK3_1	556	563	PF00069	0.566
MOD_GSK3_1	575	582	PF00069	0.240
MOD_GSK3_1	611	618	PF00069	0.439
MOD_GSK3_1	646	653	PF00069	0.547
MOD_N-GLC_1	340	345	PF02516	0.549
MOD_N-GLC_1	364	369	PF02516	0.644
MOD_N-GLC_1	57	62	PF02516	0.460
MOD_N-GLC_2	169	171	PF02516	0.451
MOD_NEK2_1	1	6	PF00069	0.695
MOD_NEK2_1	292	297	PF00069	0.635
MOD_NEK2_1	399	404	PF00069	0.563
MOD_NEK2_1	429	434	PF00069	0.392
MOD_NEK2_1	447	452	PF00069	0.471
MOD_NEK2_1	500	505	PF00069	0.635
MOD_NEK2_1	57	62	PF00069	0.425
MOD_NEK2_2	59	64	PF00069	0.390
MOD_PIKK_1	193	199	PF00454	0.656
MOD_PIKK_1	646	652	PF00454	0.482
MOD_PKA_2	1	7	PF00069	0.785
MOD_PKA_2	213	219	PF00069	0.559
MOD_PKA_2	27	33	PF00069	0.496
MOD_PKA_2	381	387	PF00069	0.568
MOD_PKA_2	399	405	PF00069	0.514
MOD_PKA_2	658	664	PF00069	0.392
MOD_PKA_2	96	102	PF00069	0.693
MOD_PKB_1	188	196	PF00069	0.430
MOD_Plk_1	539	545	PF00069	0.613
MOD_Plk_1	582	588	PF00069	0.473
MOD_Plk_4	182	188	PF00069	0.436
MOD_Plk_4	424	430	PF00069	0.497
MOD_Plk_4	615	621	PF00069	0.401
MOD_Plk_4	73	79	PF00069	0.391
MOD_ProDKin_1	133	139	PF00069	0.580
MOD_ProDKin_1	148	154	PF00069	0.446
MOD_ProDKin_1	242	248	PF00069	0.610
MOD_ProDKin_1	301	307	PF00069	0.771
MOD_ProDKin_1	364	370	PF00069	0.627
MOD_ProDKin_1	419	425	PF00069	0.659
MOD_ProDKin_1	476	482	PF00069	0.436
MOD_ProDKin_1	487	493	PF00069	0.503
MOD_ProDKin_1	557	563	PF00069	0.583
MOD_ProDKin_1	70	76	PF00069	0.542
TRG_ENDOCYTIC_2	277	280	PF00928	0.426
TRG_ENDOCYTIC_2	325	328	PF00928	0.513
TRG_ENDOCYTIC_2	428	431	PF00928	0.519
TRG_ER_diArg_1	1	3	PF00400	0.752
TRG_ER_diArg_1	187	190	PF00400	0.567
TRG_ER_diArg_1	213	215	PF00400	0.534
TRG_ER_diArg_1	31	33	PF00400	0.560
TRG_ER_diArg_1	318	321	PF00400	0.611
TRG_ER_diArg_1	512	515	PF00400	0.334
TRG_ER_diArg_1	567	569	PF00400	0.588
TRG_ER_FFAT_2	146	154	PF00635	0.513
TRG_NES_CRM1_1	38	51	PF08389	0.452
TRG_Pf-PMV_PEXEL_1	3	8	PF00026	0.542
TRG_Pf-PMV_PEXEL_1	320	324	PF00026	0.637
TRG_Pf-PMV_PEXEL_1	577	581	PF00026	0.442
TRG_Pf-PMV_PEXEL_1	645	650	PF00026	0.498

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P977	Leptomonas seymouri	48%	98%
A0A0S4IV62	Bodo saltans	38%	100%
A0A1X0NUB8	Trypanosomatidae	33%	100%
A0A3Q8IFH0	Leishmania donovani	90%	100%
A0A3R7KBD3	Trypanosoma rangeli	37%	100%
A4HKF8	Leishmania braziliensis	71%	100%
A4I7Y6	Leishmania infantum	90%	100%
D0AA55	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9B2U7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
V5BF12	Trypanosoma cruzi	37%	100%