Coatomer subunit epsilon

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

coatomer subunit epsilon

Species:

Leishmania major

UniProt:

Q4Q5A7_LEIMA

TriTrypDb:

LmjF.32.1730 , LMJLV39_320023500 , LMJSD75_320023500

Length:

323

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	yes	yes: 4
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000139	Golgi membrane	5	11
GO:0005794	Golgi apparatus	5	3
GO:0016020	membrane	2	12
GO:0030117	membrane coat	3	2
GO:0030120	vesicle coat	4	2
GO:0030126	COPI vesicle coat	5	2
GO:0031090	organelle membrane	3	11
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0098588	bounding membrane of organelle	4	11
GO:0098796	membrane protein complex	2	2
GO:0110165	cellular anatomical entity	1	12
GO:0031410	cytoplasmic vesicle	6	10
GO:0031982	vesicle	4	10
GO:0097708	intracellular vesicle	5	10

Expansion

Sequence features

Q4Q5A7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5A7

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	4	2
GO:0006890	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	6	12
GO:0006891	intra-Golgi vesicle-mediated transport	6	2
GO:0008104	protein localization	4	11
GO:0009987	cellular process	1	11
GO:0015031	protein transport	4	11
GO:0016192	vesicle-mediated transport	4	12
GO:0033036	macromolecule localization	2	11
GO:0045184	establishment of protein localization	3	11
GO:0046907	intracellular transport	3	2
GO:0048193	Golgi vesicle transport	5	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0051641	cellular localization	2	11
GO:0051649	establishment of localization in cell	3	2
GO:0070727	cellular macromolecule localization	3	11
GO:0071702	organic substance transport	4	11
GO:0071705	nitrogen compound transport	4	11

Molecular functions
Term	Name	Level	Count
GO:0005198	structural molecule activity	1	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	185	189	PF00656	0.589
CLV_C14_Caspase3-7	255	259	PF00656	0.504
CLV_NRD_NRD_1	154	156	PF00675	0.357
CLV_PCSK_KEX2_1	154	156	PF00082	0.403
CLV_PCSK_KEX2_1	182	184	PF00082	0.382
CLV_PCSK_PC1ET2_1	182	184	PF00082	0.334
CLV_PCSK_SKI1_1	117	121	PF00082	0.370
CLV_PCSK_SKI1_1	179	183	PF00082	0.377
CLV_PCSK_SKI1_1	254	258	PF00082	0.279
CLV_PCSK_SKI1_1	9	13	PF00082	0.318
DEG_APCC_DBOX_1	253	261	PF00400	0.490
DOC_CYCLIN_RxL_1	251	258	PF00134	0.490
DOC_MAPK_gen_1	154	160	PF00069	0.565
DOC_USP7_MATH_1	121	125	PF00917	0.430
DOC_USP7_MATH_1	217	221	PF00917	0.597
DOC_USP7_MATH_1	22	26	PF00917	0.490
DOC_USP7_MATH_1	252	256	PF00917	0.508
DOC_USP7_MATH_1	261	265	PF00917	0.494
DOC_USP7_MATH_1	274	278	PF00917	0.536
DOC_USP7_MATH_1	29	33	PF00917	0.490
LIG_14-3-3_CanoR_1	102	110	PF00244	0.605
LIG_14-3-3_CanoR_1	154	159	PF00244	0.574
LIG_14-3-3_CanoR_1	28	37	PF00244	0.546
LIG_FHA_1	121	127	PF00498	0.541
LIG_FHA_1	155	161	PF00498	0.582
LIG_FHA_1	163	169	PF00498	0.582
LIG_FHA_1	98	104	PF00498	0.600
LIG_FHA_2	76	82	PF00498	0.594
LIG_LIR_Gen_1	78	86	PF02991	0.530
LIG_LIR_Gen_1	88	96	PF02991	0.530
LIG_LIR_Nem_3	113	119	PF02991	0.575
LIG_LIR_Nem_3	194	200	PF02991	0.530
LIG_LIR_Nem_3	220	225	PF02991	0.544
LIG_LIR_Nem_3	78	82	PF02991	0.539
LIG_LIR_Nem_3	88	92	PF02991	0.558
LIG_Pex14_1	301	305	PF04695	0.479
LIG_SH2_CRK	116	120	PF00017	0.599
LIG_SH2_CRK	197	201	PF00017	0.546
LIG_SH2_CRK	89	93	PF00017	0.499
LIG_SH2_NCK_1	249	253	PF00017	0.546
LIG_SH2_STAP1	156	160	PF00017	0.534
LIG_SH2_STAT3	290	293	PF00017	0.490
LIG_SH2_STAT5	156	159	PF00017	0.601
LIG_SH2_STAT5	290	293	PF00017	0.497
LIG_SUMO_SIM_par_1	67	75	PF11976	0.559
LIG_TYR_ITIM	195	200	PF00017	0.546
MOD_CK2_1	102	108	PF00069	0.597
MOD_CK2_1	261	267	PF00069	0.586
MOD_CK2_1	75	81	PF00069	0.576
MOD_GlcNHglycan	197	200	PF01048	0.291
MOD_GlcNHglycan	219	222	PF01048	0.328
MOD_GlcNHglycan	276	279	PF01048	0.319
MOD_GlcNHglycan	313	319	PF01048	0.433
MOD_GlcNHglycan	43	47	PF01048	0.253
MOD_GSK3_1	191	198	PF00069	0.490
MOD_GSK3_1	229	236	PF00069	0.575
MOD_GSK3_1	60	67	PF00069	0.545
MOD_GSK3_1	90	97	PF00069	0.629
MOD_N-GLC_1	97	102	PF02516	0.385
MOD_NEK2_1	120	125	PF00069	0.522
MOD_NEK2_1	72	77	PF00069	0.585
MOD_NEK2_2	199	204	PF00069	0.504
MOD_PIKK_1	60	66	PF00454	0.522
MOD_PIKK_1	97	103	PF00454	0.530
MOD_PKA_1	154	160	PF00069	0.499
MOD_PKA_2	154	160	PF00069	0.561
MOD_Plk_1	252	258	PF00069	0.508
MOD_Plk_1	266	272	PF00069	0.582
MOD_Plk_1	314	320	PF00069	0.592
MOD_Plk_1	42	48	PF00069	0.578
MOD_Plk_4	121	127	PF00069	0.430
MOD_Plk_4	191	197	PF00069	0.515
MOD_Plk_4	229	235	PF00069	0.479
MOD_Plk_4	266	272	PF00069	0.600
MOD_SUMO_rev_2	175	184	PF00179	0.547
TRG_DiLeu_LyEn_5	68	73	PF01217	0.582
TRG_ENDOCYTIC_2	116	119	PF00928	0.599
TRG_ENDOCYTIC_2	197	200	PF00928	0.530
TRG_ENDOCYTIC_2	89	92	PF00928	0.534
TRG_ER_diArg_1	154	156	PF00400	0.576
TRG_NES_CRM1_1	311	322	PF08389	0.523
TRG_Pf-PMV_PEXEL_1	140	144	PF00026	0.346
TRG_Pf-PMV_PEXEL_1	254	258	PF00026	0.290
TRG_Pf-PMV_PEXEL_1	289	293	PF00026	0.346
TRG_Pf-PMV_PEXEL_1	310	314	PF00026	0.382

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P9J3	Leptomonas seymouri	73%	100%
A0A0S4JK00	Bodo saltans	42%	100%
A0A1X0NVS2	Trypanosomatidae	47%	97%
A0A3Q8IFX8	Leishmania donovani	93%	100%
A0A3R7RKY5	Trypanosoma rangeli	45%	100%
A2XY73	Oryza sativa subsp. indica	25%	100%
A4HKG0	Leishmania braziliensis	84%	100%
A4I7Y8	Leishmania infantum	93%	100%
D0AA50	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9B2U9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
O14579	Homo sapiens	28%	100%
O62246	Caenorhabditis elegans	26%	100%
O89079	Mus musculus	27%	100%
P0C541	Oryza sativa subsp. japonica	25%	100%
Q28104	Bos taurus	28%	100%
Q5RFR8	Pongo abelii	28%	100%
Q5ZIK9	Gallus gallus	27%	100%
Q60445	Cricetulus griseus	27%	100%
Q9MAX6	Oryza sativa subsp. japonica	25%	100%
Q9SA78	Arabidopsis thaliana	25%	100%
V5BJL5	Trypanosoma cruzi	47%	100%