Putative zinc finger protein 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

zinc finger protein 2, putative

Species:

Leishmania major

UniProt:

Q4Q5A6_LEIMA

TriTrypDb:

LmjF.32.1740 , LMJLV39_320023600 , LMJSD75_320023600

Length:

129

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 19
NetGPI	no	yes: 0, no: 19

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

Q4Q5A6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5A6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	3
GO:0003723	RNA binding	4	3
GO:0005488	binding	1	20
GO:0043167	ion binding	2	20
GO:0043169	cation binding	3	20
GO:0046872	metal ion binding	4	20
GO:0097159	organic cyclic compound binding	2	3
GO:1901363	heterocyclic compound binding	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	120	124	PF00656	0.451
CLV_NRD_NRD_1	75	77	PF00675	0.540
CLV_PCSK_FUR_1	73	77	PF00082	0.570
CLV_PCSK_KEX2_1	75	77	PF00082	0.540
DEG_Nend_UBRbox_3	1	3	PF02207	0.596
DEG_SCF_FBW7_2	33	40	PF00400	0.421
DOC_MAPK_gen_1	82	91	PF00069	0.464
DOC_PP4_MxPP_1	20	23	PF00568	0.700
DOC_USP7_MATH_1	106	110	PF00917	0.330
DOC_USP7_MATH_1	64	68	PF00917	0.503
DOC_USP7_UBL2_3	82	86	PF12436	0.467
DOC_WW_Pin1_4	33	38	PF00397	0.382
LIG_14-3-3_CanoR_1	49	56	PF00244	0.315
LIG_KLC1_Yacidic_2	40	45	PF13176	0.311
LIG_LIR_Apic_2	50	56	PF02991	0.298
LIG_LIR_Apic_2	67	71	PF02991	0.528
LIG_LIR_Gen_1	16	25	PF02991	0.672
LIG_Pex14_1	31	35	PF04695	0.308
LIG_SH2_CRK	68	72	PF00017	0.527
LIG_SH2_SRC	43	46	PF00017	0.320
LIG_SH2_STAP1	17	21	PF00017	0.509
LIG_SH2_STAT3	59	62	PF00017	0.633
LIG_SH2_STAT5	10	13	PF00017	0.574
LIG_SH2_STAT5	35	38	PF00017	0.315
LIG_SH2_STAT5	43	46	PF00017	0.277
LIG_SH2_STAT5	59	62	PF00017	0.499
LIG_SH3_3	18	24	PF00018	0.553
LIG_TRAF2_1	108	111	PF00917	0.531
MOD_CK2_1	105	111	PF00069	0.338
MOD_GlcNHglycan	119	122	PF01048	0.627
MOD_GlcNHglycan	126	129	PF01048	0.671
MOD_GSK3_1	106	113	PF00069	0.529
MOD_GSK3_1	78	85	PF00069	0.539
MOD_GSK3_1	9	16	PF00069	0.535
MOD_N-GLC_1	13	18	PF02516	0.535
MOD_PKA_2	48	54	PF00069	0.346
MOD_Plk_1	13	19	PF00069	0.537
MOD_Plk_1	57	63	PF00069	0.476
MOD_ProDKin_1	33	39	PF00069	0.382
TRG_ENDOCYTIC_2	17	20	PF00928	0.530
TRG_ER_diArg_1	73	76	PF00400	0.567

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4E5	Leptomonas seymouri	47%	100%
A0A0N0P975	Leptomonas seymouri	80%	100%
A0A0S4IT37	Bodo saltans	46%	90%
A0A1X0NLL7	Trypanosomatidae	45%	98%
A0A1X0NUY8	Trypanosomatidae	63%	66%
A0A3R7NZE2	Trypanosoma rangeli	40%	90%
A0A3S7X0B7	Leishmania donovani	48%	85%
A0A3S7X5L3	Leishmania donovani	96%	100%
A0A422NH81	Trypanosoma rangeli	61%	74%
A4HFD2	Leishmania braziliensis	48%	100%
A4HKG1	Leishmania braziliensis	88%	100%
A4I363	Leishmania infantum	48%	85%
A4I7Y9	Leishmania infantum	96%	100%
C9ZKV1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	99%
D0AA56	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	93%
E9ACZ0	Leishmania major	49%	86%
E9AYR5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	100%
E9B2V0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%