Putative pumilio/PUF RNA binding protein 7

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pumilio/PUF RNA binding protein 7, putative

Species:

Leishmania major

UniProt:

Q4Q5A5_LEIMA

TriTrypDb:

LmjF.32.1750 , LMJLV39_320023700 , LMJSD75_320023700

Length:

780

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	2
GO:0005737	cytoplasm	2	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q5A5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5A5

Function

Biological processes
Term	Name	Level	Count
GO:0010468	regulation of gene expression	5	2
GO:0010608	post-transcriptional regulation of gene expression	6	2
GO:0019222	regulation of metabolic process	3	2
GO:0050789	regulation of biological process	2	2
GO:0060255	regulation of macromolecule metabolic process	4	2
GO:0065007	biological regulation	1	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003729	mRNA binding	5	2
GO:0005488	binding	1	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	180	184	PF00656	0.418
CLV_C14_Caspase3-7	243	247	PF00656	0.327
CLV_C14_Caspase3-7	416	420	PF00656	0.601
CLV_C14_Caspase3-7	592	596	PF00656	0.697
CLV_NRD_NRD_1	128	130	PF00675	0.379
CLV_NRD_NRD_1	274	276	PF00675	0.717
CLV_NRD_NRD_1	357	359	PF00675	0.455
CLV_NRD_NRD_1	406	408	PF00675	0.559
CLV_NRD_NRD_1	615	617	PF00675	0.518
CLV_NRD_NRD_1	663	665	PF00675	0.349
CLV_NRD_NRD_1	725	727	PF00675	0.566
CLV_NRD_NRD_1	762	764	PF00675	0.553
CLV_NRD_NRD_1	83	85	PF00675	0.352
CLV_PCSK_KEX2_1	128	130	PF00082	0.395
CLV_PCSK_KEX2_1	273	275	PF00082	0.572
CLV_PCSK_KEX2_1	359	361	PF00082	0.284
CLV_PCSK_KEX2_1	724	726	PF00082	0.578
CLV_PCSK_KEX2_1	739	741	PF00082	0.425
CLV_PCSK_KEX2_1	83	85	PF00082	0.352
CLV_PCSK_PC1ET2_1	273	275	PF00082	0.572
CLV_PCSK_PC1ET2_1	359	361	PF00082	0.284
CLV_PCSK_PC1ET2_1	724	726	PF00082	0.644
CLV_PCSK_PC1ET2_1	739	741	PF00082	0.627
CLV_PCSK_PC7_1	735	741	PF00082	0.496
CLV_PCSK_SKI1_1	216	220	PF00082	0.405
CLV_PCSK_SKI1_1	359	363	PF00082	0.469
CLV_PCSK_SKI1_1	434	438	PF00082	0.292
CLV_PCSK_SKI1_1	664	668	PF00082	0.398
CLV_PCSK_SKI1_1	686	690	PF00082	0.326
CLV_PCSK_SKI1_1	735	739	PF00082	0.556
CLV_PCSK_SKI1_1	772	776	PF00082	0.555
CLV_PCSK_SKI1_1	84	88	PF00082	0.464
DEG_APCC_DBOX_1	433	441	PF00400	0.225
DEG_APCC_DBOX_1	685	693	PF00400	0.310
DEG_APCC_DBOX_1	82	90	PF00400	0.371
DEG_SPOP_SBC_1	380	384	PF00917	0.547
DOC_CKS1_1	238	243	PF01111	0.385
DOC_CKS1_1	367	372	PF01111	0.440
DOC_CYCLIN_RxL_1	15	28	PF00134	0.486
DOC_CYCLIN_RxL_1	356	363	PF00134	0.361
DOC_CYCLIN_RxL_1	658	670	PF00134	0.481
DOC_CYCLIN_RxL_1	769	777	PF00134	0.638
DOC_CYCLIN_RxL_1	81	88	PF00134	0.476
DOC_CYCLIN_yCln2_LP_2	367	373	PF00134	0.447
DOC_MAPK_gen_1	236	244	PF00069	0.377
DOC_MAPK_gen_1	358	367	PF00069	0.390
DOC_MAPK_gen_1	83	89	PF00069	0.419
DOC_MAPK_MEF2A_6	341	348	PF00069	0.307
DOC_MAPK_MEF2A_6	434	442	PF00069	0.224
DOC_MAPK_MEF2A_6	525	532	PF00069	0.246
DOC_MAPK_MEF2A_6	57	66	PF00069	0.344
DOC_PP1_RVXF_1	3	9	PF00149	0.405
DOC_PP1_RVXF_1	703	710	PF00149	0.391
DOC_PP1_RVXF_1	745	752	PF00149	0.487
DOC_PP1_SILK_1	735	740	PF00149	0.437
DOC_USP7_MATH_1	225	229	PF00917	0.468
DOC_USP7_MATH_1	250	254	PF00917	0.431
DOC_USP7_MATH_1	380	384	PF00917	0.728
DOC_USP7_MATH_1	406	410	PF00917	0.609
DOC_USP7_MATH_1	412	416	PF00917	0.790
DOC_USP7_MATH_1	420	424	PF00917	0.486
DOC_USP7_MATH_1	432	436	PF00917	0.193
DOC_USP7_MATH_1	465	469	PF00917	0.374
DOC_USP7_MATH_1	507	511	PF00917	0.391
DOC_USP7_MATH_1	531	535	PF00917	0.432
DOC_USP7_MATH_1	547	551	PF00917	0.257
DOC_USP7_MATH_1	634	638	PF00917	0.249
DOC_USP7_UBL2_3	398	402	PF12436	0.747
DOC_USP7_UBL2_3	404	408	PF12436	0.690
DOC_USP7_UBL2_3	41	45	PF12436	0.339
DOC_USP7_UBL2_3	608	612	PF12436	0.670
DOC_USP7_UBL2_3	613	617	PF12436	0.587
DOC_WW_Pin1_4	237	242	PF00397	0.478
DOC_WW_Pin1_4	366	371	PF00397	0.538
DOC_WW_Pin1_4	468	473	PF00397	0.330
DOC_WW_Pin1_4	678	683	PF00397	0.339
DOC_WW_Pin1_4	89	94	PF00397	0.265
LIG_14-3-3_CanoR_1	407	414	PF00244	0.530
LIG_Actin_WH2_2	40	58	PF00022	0.423
LIG_APCC_ABBA_1	438	443	PF00400	0.235
LIG_BIR_III_4	754	758	PF00653	0.508
LIG_BRCT_BRCA1_1	496	500	PF00533	0.534
LIG_CaM_IQ_9	645	661	PF13499	0.245
LIG_EH1_1	645	653	PF00400	0.265
LIG_eIF4E_1	646	652	PF01652	0.308
LIG_FHA_1	230	236	PF00498	0.435
LIG_FHA_1	262	268	PF00498	0.425
LIG_FHA_1	286	292	PF00498	0.536
LIG_FHA_1	428	434	PF00498	0.340
LIG_FHA_1	452	458	PF00498	0.552
LIG_FHA_1	499	505	PF00498	0.427
LIG_FHA_1	57	63	PF00498	0.365
LIG_FHA_1	655	661	PF00498	0.398
LIG_FHA_2	238	244	PF00498	0.421
LIG_FHA_2	446	452	PF00498	0.437
LIG_FHA_2	575	581	PF00498	0.407
LIG_FHA_2	63	69	PF00498	0.372
LIG_Integrin_RGD_1	275	277	PF01839	0.494
LIG_LIR_Apic_2	258	262	PF02991	0.388
LIG_LIR_Apic_2	278	284	PF02991	0.550
LIG_LIR_Gen_1	322	331	PF02991	0.406
LIG_LIR_Gen_1	497	508	PF02991	0.504
LIG_LIR_Nem_3	124	130	PF02991	0.356
LIG_LIR_Nem_3	322	327	PF02991	0.404
LIG_LIR_Nem_3	497	503	PF02991	0.513
LIG_NRBOX	230	236	PF00104	0.334
LIG_NRBOX	490	496	PF00104	0.434
LIG_NRBOX	62	68	PF00104	0.361
LIG_PCNA_yPIPBox_3	96	109	PF02747	0.258
LIG_PTB_Apo_2	703	710	PF02174	0.348
LIG_SH2_CRK	308	312	PF00017	0.519
LIG_SH2_CRK	33	37	PF00017	0.431
LIG_SH2_SRC	177	180	PF00017	0.381
LIG_SH2_STAP1	308	312	PF00017	0.346
LIG_SH2_STAP1	536	540	PF00017	0.328
LIG_SH2_STAP1	638	642	PF00017	0.341
LIG_SH2_STAT3	646	649	PF00017	0.262
LIG_SH2_STAT5	177	180	PF00017	0.416
LIG_SH2_STAT5	259	262	PF00017	0.335
LIG_SH2_STAT5	646	649	PF00017	0.308
LIG_SH3_3	149	155	PF00018	0.404
LIG_SH3_3	466	472	PF00018	0.337
LIG_SH3_3	501	507	PF00018	0.364
LIG_SH3_3	521	527	PF00018	0.220
LIG_SUMO_SIM_par_1	240	246	PF11976	0.414
LIG_SUMO_SIM_par_1	423	431	PF11976	0.475
LIG_SUMO_SIM_par_1	528	534	PF11976	0.335
LIG_SUMO_SIM_par_1	62	68	PF11976	0.396
LIG_SxIP_EBH_1	294	307	PF03271	0.385
LIG_TRAF2_1	224	227	PF00917	0.451
LIG_TRAF2_1	577	580	PF00917	0.430
LIG_UBA3_1	333	341	PF00899	0.338
LIG_UBA3_1	667	672	PF00899	0.346
MOD_CK1_1	292	298	PF00069	0.727
MOD_CK1_1	325	331	PF00069	0.399
MOD_CK1_1	468	474	PF00069	0.433
MOD_CK1_1	502	508	PF00069	0.399
MOD_CK1_1	574	580	PF00069	0.491
MOD_CK1_1	694	700	PF00069	0.493
MOD_CK1_1	717	723	PF00069	0.570
MOD_CK2_1	192	198	PF00069	0.449
MOD_CK2_1	221	227	PF00069	0.401
MOD_CK2_1	237	243	PF00069	0.480
MOD_CK2_1	445	451	PF00069	0.293
MOD_CK2_1	574	580	PF00069	0.460
MOD_CK2_1	612	618	PF00069	0.568
MOD_CK2_1	756	762	PF00069	0.707
MOD_GlcNHglycan	223	226	PF01048	0.404
MOD_GlcNHglycan	291	294	PF01048	0.613
MOD_GlcNHglycan	308	311	PF01048	0.464
MOD_GlcNHglycan	324	327	PF01048	0.540
MOD_GlcNHglycan	487	490	PF01048	0.442
MOD_GlcNHglycan	696	699	PF01048	0.396
MOD_GlcNHglycan	759	762	PF01048	0.618
MOD_GSK3_1	221	228	PF00069	0.421
MOD_GSK3_1	285	292	PF00069	0.666
MOD_GSK3_1	375	382	PF00069	0.647
MOD_GSK3_1	387	394	PF00069	0.578
MOD_GSK3_1	494	501	PF00069	0.544
MOD_GSK3_1	51	58	PF00069	0.387
MOD_GSK3_1	561	568	PF00069	0.370
MOD_GSK3_1	602	609	PF00069	0.696
MOD_N-GLC_1	375	380	PF02516	0.679
MOD_N-GLC_1	495	500	PF02516	0.348
MOD_N-GLC_1	55	60	PF02516	0.423
MOD_NEK2_1	18	23	PF00069	0.494
MOD_NEK2_1	214	219	PF00069	0.351
MOD_NEK2_1	229	234	PF00069	0.251
MOD_NEK2_1	365	370	PF00069	0.418
MOD_NEK2_1	512	517	PF00069	0.386
MOD_NEK2_1	540	545	PF00069	0.483
MOD_NEK2_1	55	60	PF00069	0.334
MOD_NEK2_1	774	779	PF00069	0.550
MOD_NEK2_1	9	14	PF00069	0.490
MOD_PIKK_1	451	457	PF00454	0.437
MOD_PKA_1	612	618	PF00069	0.636
MOD_PKA_2	406	412	PF00069	0.789
MOD_PKA_2	421	427	PF00069	0.469
MOD_PKA_2	445	451	PF00069	0.479
MOD_Plk_1	214	220	PF00069	0.378
MOD_Plk_1	225	231	PF00069	0.321
MOD_Plk_1	498	504	PF00069	0.500
MOD_Plk_1	561	567	PF00069	0.343
MOD_Plk_4	214	220	PF00069	0.461
MOD_Plk_4	225	231	PF00069	0.408
MOD_Plk_4	421	427	PF00069	0.495
MOD_Plk_4	499	505	PF00069	0.368
MOD_Plk_4	507	513	PF00069	0.274
MOD_Plk_4	531	537	PF00069	0.472
MOD_Plk_4	561	567	PF00069	0.279
MOD_Plk_4	62	68	PF00069	0.304
MOD_Plk_4	688	694	PF00069	0.390
MOD_Plk_4	94	100	PF00069	0.398
MOD_ProDKin_1	237	243	PF00069	0.482
MOD_ProDKin_1	366	372	PF00069	0.553
MOD_ProDKin_1	468	474	PF00069	0.328
MOD_ProDKin_1	678	684	PF00069	0.335
MOD_ProDKin_1	89	95	PF00069	0.265
MOD_SUMO_rev_2	394	401	PF00179	0.592
MOD_SUMO_rev_2	579	589	PF00179	0.534
MOD_SUMO_rev_2	600	609	PF00179	0.624
MOD_SUMO_rev_2	661	667	PF00179	0.463
MOD_SUMO_rev_2	756	766	PF00179	0.691
TRG_DiLeu_BaEn_1	499	504	PF01217	0.373
TRG_DiLeu_BaEn_1	663	668	PF01217	0.484
TRG_DiLeu_BaEn_4	226	232	PF01217	0.448
TRG_ENDOCYTIC_2	308	311	PF00928	0.330
TRG_ENDOCYTIC_2	628	631	PF00928	0.562
TRG_ER_diArg_1	127	129	PF00400	0.352
TRG_ER_diArg_1	358	361	PF00400	0.277
TRG_ER_diArg_1	655	658	PF00400	0.337
TRG_ER_diArg_1	82	84	PF00400	0.332
TRG_NLS_Bipartite_1	752	774	PF00514	0.599
TRG_NLS_MonoCore_2	271	276	PF00514	0.495
TRG_NLS_MonoCore_2	401	406	PF00514	0.606
TRG_NLS_MonoCore_2	769	774	PF00514	0.688
TRG_NLS_MonoExtC_3	271	277	PF00514	0.566
TRG_NLS_MonoExtC_3	357	363	PF00514	0.267
TRG_NLS_MonoExtC_3	402	407	PF00514	0.693
TRG_NLS_MonoExtN_4	399	406	PF00514	0.774
TRG_NLS_MonoExtN_4	723	728	PF00514	0.625
TRG_NLS_MonoExtN_4	767	774	PF00514	0.566
TRG_Pf-PMV_PEXEL_1	128	132	PF00026	0.362
TRG_Pf-PMV_PEXEL_1	658	663	PF00026	0.375
TRG_Pf-PMV_PEXEL_1	84	88	PF00026	0.330

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ICI6	Leptomonas seymouri	67%	100%
A0A0S4JFA8	Bodo saltans	41%	100%
A0A1X0NUE8	Trypanosomatidae	42%	100%
A0A3Q8IJA2	Leishmania donovani	93%	100%
A0A422NH58	Trypanosoma rangeli	45%	100%
A4HKG2	Leishmania braziliensis	79%	100%
A4I7Z0	Leishmania infantum	93%	100%
D0AA57	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9B2V1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5DFW5	Trypanosoma cruzi	45%	100%